Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AKN1_LEIMU

TriTrypDb:

LmxM.06.0030

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	23
GO:0032991	protein-containing complex	1	23
GO:0043226	organelle	2	23
GO:0043228	non-membrane-bounded organelle	3	23
GO:0043229	intracellular organelle	3	23
GO:0043232	intracellular non-membrane-bounded organelle	4	23
GO:0110165	cellular anatomical entity	1	23
GO:1990904	ribonucleoprotein complex	2	23
GO:0005730	nucleolus	5	6
GO:0097361	CIA complex	3	1
GO:0140535	intracellular protein-containing complex	2	1
GO:0000974	Prp19 complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AKN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKN1

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	4
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	4
GO:0000398	mRNA splicing, via spliceosome	8	4
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	4
GO:0006397	mRNA processing	7	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	5
GO:0008380	RNA splicing	7	4
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:0006790	sulfur compound metabolic process	3	1
GO:0016043	cellular component organization	3	2
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0022607	cellular component assembly	4	2
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	2
GO:0000027	ribosomal large subunit assembly	7	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.673
CLV_C14_Caspase3-7	524	528	PF00656	0.507
CLV_NRD_NRD_1	170	172	PF00675	0.526
CLV_NRD_NRD_1	173	175	PF00675	0.546
CLV_NRD_NRD_1	23	25	PF00675	0.544
CLV_NRD_NRD_1	241	243	PF00675	0.603
CLV_NRD_NRD_1	295	297	PF00675	0.482
CLV_NRD_NRD_1	342	344	PF00675	0.503
CLV_NRD_NRD_1	671	673	PF00675	0.363
CLV_PCSK_KEX2_1	124	126	PF00082	0.593
CLV_PCSK_KEX2_1	23	25	PF00082	0.602
CLV_PCSK_KEX2_1	671	673	PF00082	0.542
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.593
CLV_PCSK_SKI1_1	105	109	PF00082	0.470
CLV_PCSK_SKI1_1	453	457	PF00082	0.295
CLV_PCSK_SKI1_1	465	469	PF00082	0.417
CLV_PCSK_SKI1_1	507	511	PF00082	0.319
CLV_PCSK_SKI1_1	539	543	PF00082	0.282
CLV_PCSK_SKI1_1	54	58	PF00082	0.407
CLV_PCSK_SKI1_1	550	554	PF00082	0.308
CLV_PCSK_SKI1_1	572	576	PF00082	0.319
CLV_PCSK_SKI1_1	655	659	PF00082	0.357
DEG_APCC_DBOX_1	549	557	PF00400	0.230
DEG_SCF_FBW7_1	275	282	PF00400	0.391
DEG_SPOP_SBC_1	446	450	PF00917	0.545
DOC_CKS1_1	276	281	PF01111	0.399
DOC_CYCLIN_RxL_1	102	109	PF00134	0.407
DOC_MAPK_gen_1	111	120	PF00069	0.533
DOC_MAPK_gen_1	124	131	PF00069	0.528
DOC_MAPK_gen_1	23	33	PF00069	0.429
DOC_MAPK_gen_1	292	302	PF00069	0.463
DOC_MAPK_HePTP_8	252	264	PF00069	0.620
DOC_MAPK_HePTP_8	290	302	PF00069	0.524
DOC_MAPK_MEF2A_6	24	33	PF00069	0.455
DOC_MAPK_MEF2A_6	255	264	PF00069	0.619
DOC_MAPK_MEF2A_6	293	302	PF00069	0.522
DOC_PP1_RVXF_1	3	9	PF00149	0.442
DOC_USP7_MATH_1	191	195	PF00917	0.796
DOC_USP7_MATH_1	197	201	PF00917	0.747
DOC_USP7_MATH_1	254	258	PF00917	0.719
DOC_USP7_MATH_1	279	283	PF00917	0.554
DOC_USP7_MATH_1	362	366	PF00917	0.675
DOC_USP7_MATH_1	447	451	PF00917	0.479
DOC_USP7_MATH_1	91	95	PF00917	0.674
DOC_USP7_UBL2_3	175	179	PF12436	0.599
DOC_USP7_UBL2_3	293	297	PF12436	0.389
DOC_USP7_UBL2_3	5	9	PF12436	0.472
DOC_USP7_UBL2_3	75	79	PF12436	0.562
DOC_WW_Pin1_4	275	280	PF00397	0.500
DOC_WW_Pin1_4	395	400	PF00397	0.548
DOC_WW_Pin1_4	437	442	PF00397	0.532
LIG_14-3-3_CanoR_1	296	301	PF00244	0.352
LIG_14-3-3_CanoR_1	354	359	PF00244	0.733
LIG_14-3-3_CanoR_1	445	455	PF00244	0.491
LIG_14-3-3_CanoR_1	512	517	PF00244	0.480
LIG_14-3-3_CanoR_1	593	598	PF00244	0.455
LIG_APCC_ABBA_1	317	322	PF00400	0.411
LIG_APCC_ABBA_1	62	67	PF00400	0.583
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_BRCT_BRCA1_1	298	302	PF00533	0.312
LIG_BRCT_BRCA1_1	519	523	PF00533	0.491
LIG_Clathr_ClatBox_1	308	312	PF01394	0.359
LIG_deltaCOP1_diTrp_1	622	628	PF00928	0.482
LIG_eIF4E_1	303	309	PF01652	0.433
LIG_FHA_1	137	143	PF00498	0.621
LIG_FHA_1	190	196	PF00498	0.590
LIG_FHA_1	270	276	PF00498	0.609
LIG_FHA_1	365	371	PF00498	0.628
LIG_FHA_1	410	416	PF00498	0.635
LIG_FHA_1	452	458	PF00498	0.496
LIG_FHA_1	494	500	PF00498	0.527
LIG_FHA_1	513	519	PF00498	0.536
LIG_FHA_1	656	662	PF00498	0.499
LIG_FHA_2	155	161	PF00498	0.524
LIG_FHA_2	286	292	PF00498	0.446
LIG_FHA_2	43	49	PF00498	0.509
LIG_Integrin_RGD_1	400	402	PF01839	0.266
LIG_LIR_Gen_1	159	168	PF02991	0.469
LIG_LIR_Gen_1	282	290	PF02991	0.433
LIG_LIR_Gen_1	561	567	PF02991	0.615
LIG_LIR_Gen_1	578	589	PF02991	0.477
LIG_LIR_Gen_1	622	627	PF02991	0.470
LIG_LIR_Nem_3	116	120	PF02991	0.475
LIG_LIR_Nem_3	159	165	PF02991	0.497
LIG_LIR_Nem_3	282	286	PF02991	0.436
LIG_LIR_Nem_3	561	566	PF02991	0.627
LIG_LIR_Nem_3	578	584	PF02991	0.429
LIG_Pex14_1	563	567	PF04695	0.482
LIG_Pex14_2	519	523	PF04695	0.482
LIG_SH2_CRK	276	280	PF00017	0.408
LIG_SH2_GRB2like	372	375	PF00017	0.554
LIG_SH2_PTP2	117	120	PF00017	0.416
LIG_SH2_STAP1	581	585	PF00017	0.587
LIG_SH2_STAT5	117	120	PF00017	0.633
LIG_SH2_STAT5	263	266	PF00017	0.422
LIG_SH2_STAT5	385	388	PF00017	0.478
LIG_SH2_STAT5	393	396	PF00017	0.485
LIG_SH2_STAT5	477	480	PF00017	0.509
LIG_SH2_STAT5	573	576	PF00017	0.587
LIG_SH2_STAT5	615	618	PF00017	0.490
LIG_SH3_2	339	344	PF14604	0.540
LIG_SH3_3	149	155	PF00018	0.584
LIG_SH3_3	336	342	PF00018	0.481
LIG_SUMO_SIM_anti_2	551	557	PF11976	0.426
LIG_SUMO_SIM_anti_2	57	65	PF11976	0.365
LIG_SUMO_SIM_par_1	514	520	PF11976	0.434
LIG_TRAF2_1	133	136	PF00917	0.449
LIG_TRAF2_1	156	159	PF00917	0.546
LIG_TYR_ITIM	115	120	PF00017	0.608
LIG_UBA3_1	28	34	PF00899	0.420
LIG_WRC_WIRS_1	144	149	PF05994	0.499
LIG_WRC_WIRS_1	43	48	PF05994	0.582
MOD_CDK_SPK_2	395	400	PF00069	0.545
MOD_CDK_SPK_2	437	442	PF00069	0.491
MOD_CK1_1	153	159	PF00069	0.435
MOD_CK1_1	173	179	PF00069	0.574
MOD_CK1_1	492	498	PF00069	0.480
MOD_CK2_1	130	136	PF00069	0.583
MOD_CK2_1	153	159	PF00069	0.502
MOD_CK2_1	206	212	PF00069	0.559
MOD_CK2_1	285	291	PF00069	0.420
MOD_CK2_1	370	376	PF00069	0.546
MOD_CK2_1	42	48	PF00069	0.520
MOD_Cter_Amidation	122	125	PF01082	0.460
MOD_Cter_Amidation	294	297	PF01082	0.447
MOD_GlcNHglycan	121	124	PF01048	0.518
MOD_GlcNHglycan	199	202	PF01048	0.714
MOD_GlcNHglycan	256	259	PF01048	0.656
MOD_GlcNHglycan	358	361	PF01048	0.590
MOD_GlcNHglycan	483	486	PF01048	0.327
MOD_GlcNHglycan	489	492	PF01048	0.308
MOD_GlcNHglycan	533	536	PF01048	0.323
MOD_GlcNHglycan	575	578	PF01048	0.344
MOD_GlcNHglycan	85	88	PF01048	0.718
MOD_GlcNHglycan	93	96	PF01048	0.657
MOD_GSK3_1	146	153	PF00069	0.413
MOD_GSK3_1	197	204	PF00069	0.760
MOD_GSK3_1	250	257	PF00069	0.606
MOD_GSK3_1	275	282	PF00069	0.489
MOD_GSK3_1	405	412	PF00069	0.482
MOD_GSK3_1	417	424	PF00069	0.412
MOD_GSK3_1	433	440	PF00069	0.521
MOD_GSK3_1	447	454	PF00069	0.533
MOD_GSK3_1	489	496	PF00069	0.528
MOD_GSK3_1	517	524	PF00069	0.544
MOD_GSK3_1	561	568	PF00069	0.506
MOD_N-GLC_1	267	272	PF02516	0.510
MOD_N-GLC_1	458	463	PF02516	0.281
MOD_N-GLC_1	481	486	PF02516	0.289
MOD_NEK2_1	250	255	PF00069	0.634
MOD_NEK2_1	321	326	PF00069	0.439
MOD_NEK2_1	334	339	PF00069	0.455
MOD_NEK2_1	370	375	PF00069	0.581
MOD_NEK2_1	386	391	PF00069	0.574
MOD_NEK2_1	403	408	PF00069	0.553
MOD_NEK2_1	457	462	PF00069	0.635
MOD_NEK2_1	487	492	PF00069	0.475
MOD_NEK2_1	531	536	PF00069	0.571
MOD_NEK2_1	585	590	PF00069	0.654
MOD_NEK2_2	143	148	PF00069	0.546
MOD_NEK2_2	493	498	PF00069	0.482
MOD_PIKK_1	173	179	PF00454	0.570
MOD_PIKK_1	501	507	PF00454	0.542
MOD_PK_1	621	627	PF00069	0.545
MOD_PKA_1	296	302	PF00069	0.346
MOD_PKA_2	170	176	PF00069	0.668
MOD_PKA_2	254	260	PF00069	0.624
MOD_Plk_1	284	290	PF00069	0.400
MOD_Plk_1	321	327	PF00069	0.433
MOD_Plk_1	409	415	PF00069	0.482
MOD_Plk_1	451	457	PF00069	0.520
MOD_Plk_1	493	499	PF00069	0.536
MOD_Plk_1	621	627	PF00069	0.532
MOD_Plk_2-3	154	160	PF00069	0.618
MOD_Plk_2-3	285	291	PF00069	0.492
MOD_Plk_4	113	119	PF00069	0.434
MOD_Plk_4	285	291	PF00069	0.509
MOD_Plk_4	298	304	PF00069	0.423
MOD_Plk_4	421	427	PF00069	0.427
MOD_Plk_4	551	557	PF00069	0.509
MOD_Plk_4	558	564	PF00069	0.486
MOD_Plk_4	635	641	PF00069	0.538
MOD_Plk_4	642	648	PF00069	0.440
MOD_ProDKin_1	275	281	PF00069	0.493
MOD_ProDKin_1	395	401	PF00069	0.548
MOD_ProDKin_1	437	443	PF00069	0.532
MOD_SUMO_rev_2	322	332	PF00179	0.475
MOD_SUMO_rev_2	650	657	PF00179	0.611
MOD_SUMO_rev_2	660	665	PF00179	0.560
MOD_SUMO_rev_2	67	76	PF00179	0.522
TRG_DiLeu_BaEn_1	160	165	PF01217	0.463
TRG_DiLeu_BaEn_1	551	556	PF01217	0.571
TRG_DiLeu_BaEn_3	158	164	PF01217	0.390
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.544
TRG_ENDOCYTIC_2	117	120	PF00928	0.457
TRG_ENDOCYTIC_2	581	584	PF00928	0.592
TRG_ER_diArg_1	23	26	PF00400	0.477
TRG_ER_diArg_1	670	672	PF00400	0.598
TRG_NES_CRM1_1	27	39	PF08389	0.457
TRG_NES_CRM1_1	315	328	PF08389	0.416
TRG_NLS_MonoExtN_4	329	334	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	25%	100%
A0A0N1PBF5	Leptomonas seymouri	66%	97%
A0A0S4JTE0	Bodo saltans	42%	89%
A0A1X0NK47	Trypanosomatidae	48%	96%
A0A3Q8IGC4	Leishmania donovani	26%	100%
A0A3R7K7N9	Trypanosoma rangeli	48%	97%
A0A3S5H5M7	Leishmania donovani	86%	100%
A0A3S7XBP3	Leishmania donovani	27%	100%
A4H4H1	Leishmania braziliensis	67%	99%
A4HDT7	Leishmania braziliensis	26%	100%
A4HPZ9	Leishmania braziliensis	26%	100%
A4HSP6	Leishmania infantum	86%	100%
A4I135	Leishmania infantum	26%	100%
A4IDR0	Leishmania infantum	27%	100%
C9ZT89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	96%
E9ATR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q0T1	Leishmania major	27%	100%
Q4QAA4	Leishmania major	26%	100%
Q4QJ76	Leishmania major	83%	100%
V5BDR9	Trypanosoma cruzi	49%	98%