Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania mexicana

UniProt:

E9AKM8_LEIMU

TriTrypDb:

LmxM.05.1215

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 55

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 30, no: 6
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	37
GO:0042995	cell projection	2	37
GO:0043226	organelle	2	37
GO:0043227	membrane-bounded organelle	3	37
GO:0110165	cellular anatomical entity	1	37
GO:0120025	plasma membrane bounded cell projection	3	37
GO:0016020	membrane	2	10

Expansion

Sequence features

E9AKM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.293
DOC_CDC14_PxL_1	43	51	PF14671	0.282
DOC_MAPK_gen_1	126	135	PF00069	0.376
DOC_PP1_RVXF_1	130	136	PF00149	0.293
DOC_USP7_MATH_1	192	196	PF00917	0.364
DOC_USP7_MATH_1	21	25	PF00917	0.499
DOC_USP7_MATH_1	278	282	PF00917	0.265
DOC_USP7_MATH_1	69	73	PF00917	0.365
DOC_USP7_MATH_2	145	151	PF00917	0.285
LIG_14-3-3_CanoR_1	244	253	PF00244	0.384
LIG_BIR_II_1	1	5	PF00653	0.675
LIG_BRCT_BRCA1_1	155	159	PF00533	0.352
LIG_BRCT_BRCA1_1	239	243	PF00533	0.333
LIG_BRCT_BRCA1_1	81	85	PF00533	0.456
LIG_Clathr_ClatBox_1	154	158	PF01394	0.271
LIG_FHA_1	115	121	PF00498	0.449
LIG_FHA_1	26	32	PF00498	0.409
LIG_FHA_1	267	273	PF00498	0.291
LIG_FHA_1	68	74	PF00498	0.417
LIG_FHA_2	129	135	PF00498	0.451
LIG_FHA_2	88	94	PF00498	0.419
LIG_LIR_Gen_1	123	130	PF02991	0.324
LIG_LIR_Gen_1	195	204	PF02991	0.378
LIG_LIR_Gen_1	35	46	PF02991	0.427
LIG_LIR_Gen_1	82	92	PF02991	0.318
LIG_LIR_Nem_3	123	127	PF02991	0.346
LIG_LIR_Nem_3	160	166	PF02991	0.396
LIG_LIR_Nem_3	195	200	PF02991	0.379
LIG_LIR_Nem_3	82	88	PF02991	0.338
LIG_PDZ_Class_2	279	284	PF00595	0.433
LIG_Pex14_2	193	197	PF04695	0.368
LIG_PTB_Apo_2	158	165	PF02174	0.319
LIG_SH2_CRK	166	170	PF00017	0.270
LIG_SH2_STAT5	163	166	PF00017	0.363
LIG_SH2_STAT5	253	256	PF00017	0.311
LIG_SH3_3	17	23	PF00018	0.536
LIG_SH3_3	252	258	PF00018	0.409
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.440
LIG_SUMO_SIM_par_1	153	158	PF11976	0.323
MOD_CK1_1	125	131	PF00069	0.349
MOD_CK1_1	150	156	PF00069	0.355
MOD_CK1_1	195	201	PF00069	0.357
MOD_CK1_1	220	226	PF00069	0.431
MOD_CK1_1	245	251	PF00069	0.377
MOD_CK1_1	25	31	PF00069	0.537
MOD_CK1_1	4	10	PF00069	0.447
MOD_CK2_1	87	93	PF00069	0.436
MOD_GlcNHglycan	140	143	PF01048	0.703
MOD_GlcNHglycan	24	27	PF01048	0.690
MOD_GlcNHglycan	247	250	PF01048	0.605
MOD_GlcNHglycan	67	70	PF01048	0.537
MOD_GlcNHglycan	81	84	PF01048	0.617
MOD_GSK3_1	116	123	PF00069	0.354
MOD_GSK3_1	153	160	PF00069	0.307
MOD_GSK3_1	192	199	PF00069	0.381
MOD_GSK3_1	21	28	PF00069	0.557
MOD_GSK3_1	216	223	PF00069	0.339
MOD_GSK3_1	245	252	PF00069	0.388
MOD_GSK3_1	65	72	PF00069	0.377
MOD_N-GLC_2	57	59	PF02516	0.475
MOD_NEK2_1	1	6	PF00069	0.512
MOD_NEK2_1	103	108	PF00069	0.377
MOD_NEK2_1	116	121	PF00069	0.432
MOD_NEK2_1	133	138	PF00069	0.315
MOD_NEK2_1	159	164	PF00069	0.342
MOD_NEK2_1	193	198	PF00069	0.352
MOD_NEK2_1	206	211	PF00069	0.294
MOD_NEK2_1	87	92	PF00069	0.390
MOD_PIKK_1	32	38	PF00454	0.381
MOD_PKA_2	114	120	PF00069	0.303
MOD_PKA_2	125	131	PF00069	0.311
MOD_PKA_2	138	144	PF00069	0.382
MOD_Plk_1	94	100	PF00069	0.462
MOD_Plk_4	150	156	PF00069	0.421
MOD_Plk_4	159	165	PF00069	0.413
MOD_Plk_4	278	284	PF00069	0.312
MOD_Plk_4	4	10	PF00069	0.535
MOD_SUMO_rev_2	219	225	PF00179	0.330
TRG_ER_diArg_1	137	140	PF00400	0.302
TRG_NES_CRM1_1	146	158	PF08389	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E6	Leptomonas seymouri	28%	100%
A0A0N0P2L4	Leptomonas seymouri	27%	96%
A0A0N0P4M2	Leptomonas seymouri	33%	100%
A0A0S4IVH1	Bodo saltans	28%	100%
A0A1X0NKN8	Trypanosomatidae	35%	99%
A0A3Q8I9A6	Leishmania donovani	23%	74%
A0A3Q8I9D0	Leishmania donovani	28%	100%
A0A3Q8IIJ9	Leishmania donovani	25%	94%
A0A3S5H6D6	Leishmania donovani	29%	100%
A0A3S7WP69	Leishmania donovani	31%	99%
A0A3S7WPB2	Leishmania donovani	94%	100%
A0A3S7X4J4	Leishmania donovani	25%	94%
A4H4D2	Leishmania braziliensis	29%	100%
A4H4G6	Leishmania braziliensis	79%	100%
A4H5P0	Leishmania braziliensis	32%	100%
A4HJC8	Leishmania braziliensis	22%	100%
A4HSL2	Leishmania infantum	31%	99%
A4HTX9	Leishmania infantum	29%	100%
A4HVB0	Leishmania infantum	24%	70%
A4I6S4	Leishmania infantum	25%	94%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	94%
E9ACQ0	Leishmania major	91%	100%
E9AG65	Leishmania infantum	94%	100%
E9AGG5	Leishmania infantum	25%	68%
E9AGH0	Leishmania infantum	26%	75%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	84%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	73%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	77%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	68%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	83%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	68%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	94%
P58822	Phaseolus vulgaris	25%	83%
Q25331	Leishmania major	29%	74%
Q4Q6B6	Leishmania major	26%	94%
Q4Q6B7	Leishmania major	26%	94%
Q4QGJ4	Leishmania major	29%	74%
Q4QGJ7	Leishmania major	29%	76%
Q4QGK6	Leishmania major	29%	74%
Q4QGL4	Leishmania major	27%	72%
Q4QHW6	Leishmania major	30%	100%
Q4QJB2	Leishmania major	29%	100%