Protein phosphatase type 1 regulator-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase type 1 regulator-like protein

Species:

Leishmania mexicana

UniProt:

E9AKM7_LEIMU

TriTrypDb:

LmxM.05.1210

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AKM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.421
CLV_C14_Caspase3-7	234	238	PF00656	0.454
CLV_C14_Caspase3-7	35	39	PF00656	0.736
CLV_C14_Caspase3-7	372	376	PF00656	0.398
CLV_NRD_NRD_1	122	124	PF00675	0.379
CLV_NRD_NRD_1	164	166	PF00675	0.468
CLV_NRD_NRD_1	245	247	PF00675	0.413
CLV_NRD_NRD_1	393	395	PF00675	0.570
CLV_NRD_NRD_1	93	95	PF00675	0.376
CLV_PCSK_KEX2_1	358	360	PF00082	0.403
CLV_PCSK_KEX2_1	393	395	PF00082	0.582
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.403
CLV_PCSK_PC7_1	389	395	PF00082	0.664
CLV_PCSK_SKI1_1	126	130	PF00082	0.404
CLV_PCSK_SKI1_1	165	169	PF00082	0.504
CLV_PCSK_SKI1_1	73	77	PF00082	0.497
DEG_COP1_1	127	137	PF00400	0.527
DEG_Nend_Nbox_1	1	3	PF02207	0.685
DEG_SCF_FBW7_1	26	33	PF00400	0.593
DOC_CYCLIN_RxL_1	175	184	PF00134	0.362
DOC_CYCLIN_yClb5_NLxxxL_5	94	101	PF00134	0.378
DOC_MAPK_gen_1	358	368	PF00069	0.381
DOC_MAPK_MEF2A_6	361	370	PF00069	0.375
DOC_MAPK_NFAT4_5	363	371	PF00069	0.362
DOC_MAPK_RevD_3	80	95	PF00069	0.391
DOC_USP7_MATH_1	288	292	PF00917	0.481
DOC_USP7_MATH_1	30	34	PF00917	0.749
DOC_WW_Pin1_4	26	31	PF00397	0.692
LIG_14-3-3_CanoR_1	220	226	PF00244	0.449
LIG_14-3-3_CanoR_1	246	251	PF00244	0.326
LIG_14-3-3_CanoR_1	73	78	PF00244	0.395
LIG_14-3-3_CterR_2	393	396	PF00244	0.689
LIG_Actin_WH2_2	150	167	PF00022	0.490
LIG_Actin_WH2_2	367	383	PF00022	0.254
LIG_Clathr_ClatBox_1	112	116	PF01394	0.456
LIG_Clathr_ClatBox_1	74	78	PF01394	0.392
LIG_deltaCOP1_diTrp_1	330	337	PF00928	0.441
LIG_FHA_1	344	350	PF00498	0.351
LIG_FHA_1	88	94	PF00498	0.405
LIG_FHA_2	153	159	PF00498	0.346
LIG_FHA_2	166	172	PF00498	0.359
LIG_FHA_2	174	180	PF00498	0.316
LIG_FHA_2	302	308	PF00498	0.530
LIG_FHA_2	35	41	PF00498	0.570
LIG_FHA_2	370	376	PF00498	0.442
LIG_FHA_2	63	69	PF00498	0.500
LIG_FHA_2	74	80	PF00498	0.471
LIG_IBAR_NPY_1	268	270	PF08397	0.425
LIG_LIR_Gen_1	158	167	PF02991	0.344
LIG_LIR_Gen_1	195	204	PF02991	0.434
LIG_LIR_Gen_1	330	337	PF02991	0.214
LIG_LIR_Gen_1	362	371	PF02991	0.367
LIG_LIR_Nem_3	158	164	PF02991	0.347
LIG_LIR_Nem_3	195	199	PF02991	0.490
LIG_LIR_Nem_3	296	302	PF02991	0.334
LIG_LIR_Nem_3	330	334	PF02991	0.352
LIG_LIR_Nem_3	362	368	PF02991	0.371
LIG_LIR_Nem_3	375	380	PF02991	0.399
LIG_LRP6_Inhibitor_1	117	123	PF00058	0.377
LIG_LRP6_Inhibitor_1	182	188	PF00058	0.354
LIG_LRP6_Inhibitor_1	204	210	PF00058	0.337
LIG_MAD2	16	24	PF02301	0.706
LIG_MYND_3	315	319	PF01753	0.434
LIG_PCNA_PIPBox_1	315	324	PF02747	0.381
LIG_PTB_Apo_2	364	371	PF02174	0.506
LIG_SH2_CRK	161	165	PF00017	0.360
LIG_SH2_CRK	365	369	PF00017	0.389
LIG_SH2_GRB2like	365	368	PF00017	0.514
LIG_SH2_STAT5	181	184	PF00017	0.354
LIG_SH2_STAT5	270	273	PF00017	0.363
LIG_SH2_STAT5	275	278	PF00017	0.323
LIG_SH2_STAT5	348	351	PF00017	0.369
LIG_SH3_3	131	137	PF00018	0.483
LIG_SH3_3	306	312	PF00018	0.449
LIG_SUMO_SIM_par_1	111	116	PF11976	0.458
LIG_TYR_ITIM	159	164	PF00017	0.333
LIG_UBA3_1	1	10	PF00899	0.648
LIG_WRC_WIRS_1	193	198	PF05994	0.497
MOD_CDK_SPxK_1	26	32	PF00069	0.695
MOD_CK1_1	172	178	PF00069	0.491
MOD_CK1_1	214	220	PF00069	0.419
MOD_CK1_1	221	227	PF00069	0.378
MOD_CK2_1	173	179	PF00069	0.353
MOD_CK2_1	254	260	PF00069	0.385
MOD_CK2_1	279	285	PF00069	0.479
MOD_CK2_1	301	307	PF00069	0.497
MOD_CK2_1	34	40	PF00069	0.650
MOD_GlcNHglycan	100	104	PF01048	0.514
MOD_GlcNHglycan	130	133	PF01048	0.479
MOD_GlcNHglycan	138	141	PF01048	0.548
MOD_GlcNHglycan	213	216	PF01048	0.360
MOD_GSK3_1	136	143	PF00069	0.543
MOD_GSK3_1	165	172	PF00069	0.455
MOD_GSK3_1	214	221	PF00069	0.381
MOD_GSK3_1	231	238	PF00069	0.234
MOD_GSK3_1	26	33	PF00069	0.657
MOD_GSK3_1	369	376	PF00069	0.447
MOD_GSK3_1	48	55	PF00069	0.650
MOD_GSK3_1	83	90	PF00069	0.375
MOD_NEK2_1	128	133	PF00069	0.388
MOD_NEK2_1	157	162	PF00069	0.321
MOD_NEK2_1	173	178	PF00069	0.346
MOD_NEK2_1	295	300	PF00069	0.412
MOD_NEK2_1	340	345	PF00069	0.358
MOD_NEK2_2	288	293	PF00069	0.492
MOD_PIKK_1	369	375	PF00454	0.475
MOD_PK_1	231	237	PF00069	0.360
MOD_PK_1	254	260	PF00069	0.399
MOD_PKA_1	165	171	PF00069	0.488
MOD_PKA_1	246	252	PF00069	0.410
MOD_PKA_2	253	259	PF00069	0.358
MOD_Plk_1	157	163	PF00069	0.330
MOD_Plk_1	295	301	PF00069	0.345
MOD_Plk_1	99	105	PF00069	0.447
MOD_Plk_4	192	198	PF00069	0.387
MOD_Plk_4	221	227	PF00069	0.454
MOD_ProDKin_1	26	32	PF00069	0.695
MOD_SUMO_rev_2	114	122	PF00179	0.343
MOD_SUMO_rev_2	179	187	PF00179	0.350
MOD_SUMO_rev_2	330	337	PF00179	0.438
MOD_SUMO_rev_2	6	11	PF00179	0.545
MOD_SUMO_rev_2	81	91	PF00179	0.525
TRG_DiLeu_BaEn_1	386	391	PF01217	0.641
TRG_DiLeu_LyEn_5	386	391	PF01217	0.641
TRG_ENDOCYTIC_2	161	164	PF00928	0.350
TRG_ENDOCYTIC_2	365	368	PF00928	0.368
TRG_NES_CRM1_1	106	119	PF08389	0.383
TRG_NES_CRM1_1	171	184	PF08389	0.320
TRG_NES_CRM1_1	191	203	PF08389	0.244
TRG_NES_CRM1_1	68	81	PF08389	0.421
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2J8	Leptomonas seymouri	75%	99%
A0A0S4IT07	Bodo saltans	57%	100%
A0A1X0NLS5	Trypanosomatidae	59%	99%
A0A3R7JZE2	Trypanosoma rangeli	59%	99%
A0A3S7WPA7	Leishmania donovani	97%	100%
A4H4G5	Leishmania braziliensis	92%	100%
A4HSP2	Leishmania infantum	97%	100%
C9ZNE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	98%
P21793	Bos taurus	26%	100%
P22194	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P36047	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P45969	Caenorhabditis elegans	35%	100%
Q15435	Homo sapiens	39%	100%
Q32PL1	Danio rerio	37%	100%
Q3T0W4	Bos taurus	37%	100%
Q3UM45	Mus musculus	38%	100%
Q4QJ81	Leishmania major	96%	100%
Q54Q39	Dictyostelium discoideum	36%	100%
Q5HZV9	Rattus norvegicus	38%	100%
Q5RFS7	Pongo abelii	38%	100%
Q6DIQ3	Xenopus tropicalis	38%	100%
Q84WJ9	Arabidopsis thaliana	36%	100%
Q8AVI4	Xenopus laevis	27%	69%
Q9DE68	Coturnix japonica	28%	100%
Q9XSD9	Sus scrofa	26%	100%
V5ARU0	Trypanosoma cruzi	58%	99%