Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKM4_LEIMU

TriTrypDb:

LmxM.05.1180

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.435
CLV_NRD_NRD_1	178	180	PF00675	0.476
CLV_NRD_NRD_1	278	280	PF00675	0.715
CLV_NRD_NRD_1	37	39	PF00675	0.495
CLV_NRD_NRD_1	406	408	PF00675	0.532
CLV_PCSK_KEX2_1	175	177	PF00082	0.435
CLV_PCSK_KEX2_1	334	336	PF00082	0.563
CLV_PCSK_KEX2_1	36	38	PF00082	0.485
CLV_PCSK_KEX2_1	426	428	PF00082	0.802
CLV_PCSK_KEX2_1	58	60	PF00082	0.497
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.552
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.695
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.497
CLV_PCSK_PC7_1	171	177	PF00082	0.459
CLV_PCSK_PC7_1	422	428	PF00082	0.800
CLV_PCSK_SKI1_1	143	147	PF00082	0.445
CLV_PCSK_SKI1_1	224	228	PF00082	0.602
CLV_PCSK_SKI1_1	269	273	PF00082	0.636
CLV_PCSK_SKI1_1	292	296	PF00082	0.602
CLV_PCSK_SKI1_1	50	54	PF00082	0.462
DEG_MDM2_SWIB_1	161	168	PF02201	0.530
DEG_SCF_FBW7_2	384	390	PF00400	0.536
DOC_CKS1_1	356	361	PF01111	0.668
DOC_CKS1_1	384	389	PF01111	0.536
DOC_CYCLIN_RxL_1	403	414	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.544
DOC_MAPK_gen_1	36	45	PF00069	0.596
DOC_MAPK_gen_1	56	63	PF00069	0.546
DOC_PP1_RVXF_1	127	134	PF00149	0.398
DOC_PP2B_LxvP_1	373	376	PF13499	0.570
DOC_PP4_FxxP_1	432	435	PF00568	0.631
DOC_USP7_MATH_2	281	287	PF00917	0.601
DOC_USP7_UBL2_3	180	184	PF12436	0.522
DOC_WW_Pin1_4	355	360	PF00397	0.689
DOC_WW_Pin1_4	383	388	PF00397	0.543
LIG_14-3-3_CanoR_1	103	109	PF00244	0.646
LIG_14-3-3_CanoR_1	117	123	PF00244	0.631
LIG_14-3-3_CanoR_1	143	152	PF00244	0.434
LIG_14-3-3_CanoR_1	250	256	PF00244	0.552
LIG_BIR_III_2	379	383	PF00653	0.573
LIG_BIR_III_4	109	113	PF00653	0.524
LIG_BRCT_BRCA1_1	251	255	PF00533	0.652
LIG_CtBP_PxDLS_1	282	288	PF00389	0.651
LIG_deltaCOP1_diTrp_1	195	202	PF00928	0.407
LIG_FHA_1	113	119	PF00498	0.650
LIG_FHA_1	145	151	PF00498	0.511
LIG_FHA_1	27	33	PF00498	0.523
LIG_FHA_1	293	299	PF00498	0.560
LIG_FHA_1	384	390	PF00498	0.566
LIG_FHA_2	252	258	PF00498	0.572
LIG_FHA_2	383	389	PF00498	0.541
LIG_Integrin_RGD_1	207	209	PF01839	0.451
LIG_Integrin_RGD_1	302	304	PF01839	0.563
LIG_LIR_Gen_1	162	172	PF02991	0.569
LIG_LIR_Gen_1	252	263	PF02991	0.565
LIG_LIR_Gen_1	327	333	PF02991	0.602
LIG_LIR_Nem_3	121	125	PF02991	0.494
LIG_LIR_Nem_3	135	141	PF02991	0.367
LIG_LIR_Nem_3	162	168	PF02991	0.540
LIG_LIR_Nem_3	252	258	PF02991	0.558
LIG_LIR_Nem_3	327	331	PF02991	0.606
LIG_LRP6_Inhibitor_1	137	143	PF00058	0.428
LIG_Pex14_1	134	138	PF04695	0.377
LIG_Pex14_1	296	300	PF04695	0.543
LIG_Pex14_2	157	161	PF04695	0.366
LIG_SH2_CRK	189	193	PF00017	0.476
LIG_SH2_GRB2like	138	141	PF00017	0.366
LIG_SH2_STAT3	222	225	PF00017	0.493
LIG_SH2_STAT3	333	336	PF00017	0.558
LIG_SH2_STAT5	104	107	PF00017	0.522
LIG_SH2_STAT5	141	144	PF00017	0.398
LIG_SH2_STAT5	34	37	PF00017	0.621
LIG_SH3_3	353	359	PF00018	0.601
LIG_SH3_3	428	434	PF00018	0.622
LIG_TRAF2_1	214	217	PF00917	0.456
LIG_TRAF2_1	254	257	PF00917	0.555
LIG_TRAF2_1	281	284	PF00917	0.652
LIG_TRAF2_1	62	65	PF00917	0.523
LIG_UBA3_1	14	19	PF00899	0.560
MOD_CK1_1	13	19	PF00069	0.576
MOD_CK1_1	449	455	PF00069	0.645
MOD_CK2_1	209	215	PF00069	0.452
MOD_CK2_1	251	257	PF00069	0.547
MOD_CK2_1	382	388	PF00069	0.546
MOD_CMANNOS	199	202	PF00535	0.398
MOD_GlcNHglycan	283	288	PF01048	0.595
MOD_GlcNHglycan	3	6	PF01048	0.629
MOD_GlcNHglycan	453	456	PF01048	0.692
MOD_GSK3_1	13	20	PF00069	0.537
MOD_GSK3_1	351	358	PF00069	0.689
MOD_N-GLC_1	10	15	PF02516	0.532
MOD_NEK2_1	1	6	PF00069	0.640
MOD_NEK2_1	118	123	PF00069	0.551
MOD_NEK2_1	161	166	PF00069	0.383
MOD_NEK2_2	112	117	PF00069	0.520
MOD_PIKK_1	144	150	PF00454	0.433
MOD_PIKK_1	249	255	PF00454	0.522
MOD_PIKK_1	309	315	PF00454	0.663
MOD_PIKK_1	435	441	PF00454	0.676
MOD_PKA_1	179	185	PF00069	0.542
MOD_PKA_2	249	255	PF00069	0.660
MOD_PKA_2	274	280	PF00069	0.612
MOD_PKA_2	7	13	PF00069	0.518
MOD_PKB_1	391	399	PF00069	0.603
MOD_Plk_1	10	16	PF00069	0.531
MOD_Plk_1	112	118	PF00069	0.518
MOD_Plk_1	309	315	PF00069	0.676
MOD_Plk_1	446	452	PF00069	0.649
MOD_Plk_1	99	105	PF00069	0.631
MOD_Plk_2-3	209	215	PF00069	0.452
MOD_Plk_4	10	16	PF00069	0.568
MOD_ProDKin_1	355	361	PF00069	0.679
MOD_ProDKin_1	383	389	PF00069	0.541
MOD_SUMO_for_1	68	71	PF00179	0.461
MOD_SUMO_rev_2	276	281	PF00179	0.698
MOD_SUMO_rev_2	64	68	PF00179	0.496
TRG_ENDOCYTIC_2	189	192	PF00928	0.463
TRG_ER_diArg_1	175	177	PF00400	0.436
TRG_ER_diArg_1	35	38	PF00400	0.630
TRG_ER_diArg_1	391	394	PF00400	0.571
TRG_ER_diArg_1	6	9	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF1	Leptomonas seymouri	90%	92%
A0A0S4IU67	Bodo saltans	64%	100%
A0A1X0NK32	Trypanosomatidae	75%	93%
A0A3S7WP90	Leishmania donovani	99%	100%
A4H4G2	Leishmania braziliensis	96%	100%
A4HSN9	Leishmania infantum	99%	100%
C9ZNE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	93%
Q4QJ84	Leishmania major	98%	100%
V5BGD5	Trypanosoma cruzi	76%	100%