Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation of very long chain fatty acids protein, putative

Species:

Leishmania mexicana

UniProt:

E9AKM3_LEIMU

TriTrypDb:

LmxM.05.1170

Length:

249

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AKM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKM3

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006629	lipid metabolic process	3	12
GO:0006631	fatty acid metabolic process	4	12
GO:0006633	fatty acid biosynthetic process	5	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0016053	organic acid biosynthetic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0032787	monocarboxylic acid metabolic process	6	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044283	small molecule biosynthetic process	3	12
GO:0046394	carboxylic acid biosynthetic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:0072330	monocarboxylic acid biosynthetic process	6	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0000038	very long-chain fatty acid metabolic process	5	1
GO:0001676	long-chain fatty acid metabolic process	5	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019367	fatty acid elongation, saturated fatty acid	7	1
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	1
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	1
GO:0042759	long-chain fatty acid biosynthetic process	6	1
GO:0042761	very long-chain fatty acid biosynthetic process	6	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004312	fatty acid synthase activity	5	12
GO:0009922	fatty acid elongase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.258
CLV_NRD_NRD_1	236	238	PF00675	0.287
CLV_NRD_NRD_1	240	242	PF00675	0.279
CLV_NRD_NRD_1	244	246	PF00675	0.270
CLV_PCSK_KEX2_1	244	246	PF00082	0.291
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.304
CLV_PCSK_SKI1_1	186	190	PF00082	0.235
DEG_Nend_UBRbox_1	1	4	PF02207	0.525
DOC_CDC14_PxL_1	24	32	PF14671	0.405
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.513
DOC_MAPK_gen_1	121	129	PF00069	0.443
DOC_USP7_MATH_1	23	27	PF00917	0.195
DOC_USP7_UBL2_3	238	242	PF12436	0.472
DOC_USP7_UBL2_3	244	248	PF12436	0.453
DOC_WW_Pin1_4	208	213	PF00397	0.302
LIG_14-3-3_CanoR_1	237	241	PF00244	0.431
LIG_AP2alpha_1	109	113	PF02296	0.425
LIG_BRCT_BRCA1_1	13	17	PF00533	0.417
LIG_deltaCOP1_diTrp_1	98	102	PF00928	0.264
LIG_eIF4E_1	37	43	PF01652	0.160
LIG_FHA_1	105	111	PF00498	0.310
LIG_FHA_1	113	119	PF00498	0.372
LIG_FHA_1	179	185	PF00498	0.537
LIG_FHA_1	33	39	PF00498	0.160
LIG_FHA_1	50	56	PF00498	0.529
LIG_FHA_1	63	69	PF00498	0.311
LIG_FHA_1	92	98	PF00498	0.307
LIG_Integrin_isoDGR_2	90	92	PF01839	0.473
LIG_LIR_Apic_2	177	183	PF02991	0.464
LIG_LIR_Gen_1	107	117	PF02991	0.305
LIG_LIR_Gen_1	128	136	PF02991	0.305
LIG_LIR_Gen_1	20	29	PF02991	0.184
LIG_LIR_Gen_1	227	236	PF02991	0.361
LIG_LIR_Gen_1	35	45	PF02991	0.145
LIG_LIR_Gen_1	98	106	PF02991	0.252
LIG_LIR_LC3C_4	35	40	PF02991	0.279
LIG_LIR_Nem_3	111	116	PF02991	0.267
LIG_LIR_Nem_3	128	132	PF02991	0.305
LIG_LIR_Nem_3	20	24	PF02991	0.342
LIG_LIR_Nem_3	26	30	PF02991	0.211
LIG_LIR_Nem_3	35	40	PF02991	0.184
LIG_LIR_Nem_3	98	103	PF02991	0.239
LIG_LYPXL_S_1	17	21	PF13949	0.535
LIG_LYPXL_yS_3	27	30	PF13949	0.405
LIG_LYPXL_yS_3	58	61	PF13949	0.557
LIG_PCNA_yPIPBox_3	80	92	PF02747	0.232
LIG_PDZ_Class_1	244	249	PF00595	0.349
LIG_Pex14_2	109	113	PF04695	0.423
LIG_Pex14_2	156	160	PF04695	0.320
LIG_Pex14_2	17	21	PF04695	0.335
LIG_Pex14_2	43	47	PF04695	0.160
LIG_SH2_CRK	175	179	PF00017	0.525
LIG_SH2_CRK	180	184	PF00017	0.499
LIG_SH2_CRK	63	67	PF00017	0.168
LIG_SH2_GRB2like	180	183	PF00017	0.530
LIG_SH2_NCK_1	63	67	PF00017	0.317
LIG_SH2_STAT3	187	190	PF00017	0.538
LIG_SH2_STAT5	105	108	PF00017	0.221
LIG_SH2_STAT5	116	119	PF00017	0.452
LIG_SH2_STAT5	170	173	PF00017	0.314
LIG_SH2_STAT5	175	178	PF00017	0.444
LIG_SH2_STAT5	180	183	PF00017	0.441
LIG_SH2_STAT5	187	190	PF00017	0.421
LIG_SH2_STAT5	230	233	PF00017	0.390
LIG_SH2_STAT5	37	40	PF00017	0.309
LIG_SH2_STAT5	54	57	PF00017	0.538
LIG_SH3_3	22	28	PF00018	0.313
LIG_SUMO_SIM_anti_2	35	42	PF11976	0.326
LIG_SxIP_EBH_1	206	215	PF03271	0.374
LIG_TYR_ITIM	25	30	PF00017	0.390
LIG_TYR_ITSM	33	40	PF00017	0.160
LIG_UBA3_1	41	46	PF00899	0.396
MOD_CDK_SPxxK_3	208	215	PF00069	0.302
MOD_GSK3_1	174	181	PF00069	0.413
MOD_GSK3_1	236	243	PF00069	0.425
MOD_N-GLC_1	151	156	PF02516	0.477
MOD_N-GLC_1	161	166	PF02516	0.339
MOD_NEK2_1	112	117	PF00069	0.305
MOD_NEK2_1	174	179	PF00069	0.304
MOD_NEK2_1	240	245	PF00069	0.381
MOD_NEK2_1	62	67	PF00069	0.361
MOD_NEK2_2	236	241	PF00069	0.420
MOD_PIKK_1	186	192	PF00454	0.538
MOD_PKA_2	236	242	PF00069	0.359
MOD_PKA_2	91	97	PF00069	0.265
MOD_Plk_1	161	167	PF00069	0.219
MOD_Plk_4	112	118	PF00069	0.320
MOD_Plk_4	125	131	PF00069	0.452
MOD_Plk_4	224	230	PF00069	0.362
MOD_Plk_4	33	39	PF00069	0.267
MOD_ProDKin_1	208	214	PF00069	0.302
TRG_DiLeu_BaEn_2	124	130	PF01217	0.373
TRG_DiLeu_BaEn_2	19	25	PF01217	0.462
TRG_DiLeu_BaEn_2	97	103	PF01217	0.264
TRG_ENDOCYTIC_2	116	119	PF00928	0.452
TRG_ENDOCYTIC_2	133	136	PF00928	0.405
TRG_ENDOCYTIC_2	175	178	PF00928	0.528
TRG_ENDOCYTIC_2	18	21	PF00928	0.401
TRG_ENDOCYTIC_2	230	233	PF00928	0.381
TRG_ENDOCYTIC_2	27	30	PF00928	0.324
TRG_ENDOCYTIC_2	37	40	PF00928	0.267
TRG_ENDOCYTIC_2	45	48	PF00928	0.443
TRG_ENDOCYTIC_2	58	61	PF00928	0.417
TRG_ENDOCYTIC_2	63	66	PF00928	0.162
TRG_ENDOCYTIC_2	84	87	PF00928	0.337
TRG_ER_diLys_1	244	249	PF00400	0.546
TRG_NLS_MonoExtC_3	240	245	PF00514	0.502
TRG_NLS_MonoExtN_4	238	245	PF00514	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	32%	85%
A0A0N0P5E5	Leptomonas seymouri	30%	83%
A0A0N1HZJ8	Leptomonas seymouri	28%	77%
A0A0N1PBS4	Leptomonas seymouri	76%	100%
A0A0N1PDR8	Leptomonas seymouri	29%	92%
A0A0S4IS29	Bodo saltans	26%	97%
A0A0S4IVS6	Bodo saltans	26%	88%
A0A0S4J4C4	Bodo saltans	62%	95%
A0A0S4JCZ3	Bodo saltans	33%	77%
A0A0S4JH58	Bodo saltans	35%	83%
A0A1X0NNL0	Trypanosomatidae	27%	82%
A0A1X0NNM4	Trypanosomatidae	25%	87%
A0A1X0NUJ4	Trypanosomatidae	32%	69%
A0A1X0P2P0	Trypanosomatidae	55%	100%
A0A3Q8IC05	Leishmania donovani	30%	82%
A0A3R7KG78	Trypanosoma rangeli	29%	88%
A0A3R7NSQ3	Trypanosoma rangeli	28%	86%
A0A3S5H5M3	Leishmania donovani	90%	100%
A0A3S5H6R8	Leishmania donovani	26%	85%
A0A422NYI1	Trypanosoma rangeli	58%	98%
A0JNC4	Bos taurus	31%	89%
A1L3X0	Homo sapiens	33%	89%
A4H4G1	Leishmania braziliensis	80%	100%
A4H7N0	Leishmania braziliensis	28%	100%
A4HSN8	Leishmania infantum	90%	100%
A4HW10	Leishmania infantum	26%	85%
A4HW13	Leishmania infantum	27%	76%
A4HW18	Leishmania infantum	30%	82%
B4QVX4	Drosophila simulans	28%	95%
C9ZPY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	81%
D4A612	Rattus norvegicus	35%	89%
D4ADY9	Rattus norvegicus	31%	89%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	77%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	83%
G5EEE5	Caenorhabditis elegans	30%	86%
O35949	Mus musculus	25%	92%
P49191	Caenorhabditis elegans	28%	78%
Q03574	Caenorhabditis elegans	29%	86%
Q1HRV8	Aedes aegypti	30%	70%
Q20300	Caenorhabditis elegans	27%	91%
Q20303	Caenorhabditis elegans	29%	91%
Q2KJD9	Bos taurus	31%	83%
Q32NI8	Xenopus laevis	31%	84%
Q3S8M4	Macaca mulatta	31%	79%
Q4QFQ9	Leishmania major	32%	83%
Q4QFR7	Leishmania major	25%	100%
Q4QJ85	Leishmania major	89%	100%
Q4R516	Macaca fascicularis	31%	83%
Q54CJ4	Dictyostelium discoideum	30%	92%
Q54TC9	Dictyostelium discoideum	28%	93%
Q5M8U1	Xenopus tropicalis	31%	84%
Q5RFL5	Pongo abelii	31%	83%
Q6PC64	Danio rerio	26%	94%
Q7LKX0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	68%
Q86JM5	Dictyostelium discoideum	29%	84%
Q8BHI7	Mus musculus	33%	83%
Q920L5	Mus musculus	24%	93%
Q920L6	Rattus norvegicus	25%	93%
Q920L7	Rattus norvegicus	32%	83%
Q95K73	Macaca fascicularis	31%	79%
Q9BW60	Homo sapiens	31%	89%
Q9D2Y9	Mus musculus	30%	89%
Q9EQC4	Mus musculus	32%	80%
Q9GZR5	Homo sapiens	32%	79%
Q9H5J4	Homo sapiens	25%	94%
Q9HB03	Homo sapiens	26%	92%
Q9JLJ4	Mus musculus	35%	85%
Q9JLJ5	Mus musculus	31%	89%
Q9NXB9	Homo sapiens	37%	84%
Q9NYP7	Homo sapiens	31%	83%
Q9UTF7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	75%
Q9VH58	Drosophila melanogaster	30%	97%
Q9VHX7	Drosophila melanogaster	31%	76%
Q9VV87	Drosophila melanogaster	29%	79%
Q9XVQ9	Caenorhabditis elegans	27%	91%
V5AUX1	Trypanosoma cruzi	58%	98%
V5BE99	Trypanosoma cruzi	26%	87%
V5DF68	Trypanosoma cruzi	28%	86%