Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AKM2_LEIMU

TriTrypDb:

LmxM.05.1160

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

E9AKM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.630
CLV_C14_Caspase3-7	223	227	PF00656	0.830
CLV_NRD_NRD_1	138	140	PF00675	0.644
CLV_NRD_NRD_1	386	388	PF00675	0.668
CLV_NRD_NRD_1	7	9	PF00675	0.687
CLV_NRD_NRD_1	766	768	PF00675	0.685
CLV_PCSK_KEX2_1	138	140	PF00082	0.585
CLV_PCSK_KEX2_1	386	388	PF00082	0.668
CLV_PCSK_KEX2_1	576	578	PF00082	0.842
CLV_PCSK_KEX2_1	7	9	PF00082	0.687
CLV_PCSK_KEX2_1	765	767	PF00082	0.682
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.842
CLV_PCSK_SKI1_1	138	142	PF00082	0.366
CLV_PCSK_SKI1_1	386	390	PF00082	0.675
CLV_PCSK_SKI1_1	619	623	PF00082	0.737
CLV_PCSK_SKI1_1	671	675	PF00082	0.741
CLV_PCSK_SKI1_1	790	794	PF00082	0.658
CLV_PCSK_SKI1_1	90	94	PF00082	0.649
DEG_SPOP_SBC_1	506	510	PF00917	0.802
DEG_SPOP_SBC_1	512	516	PF00917	0.708
DEG_SPOP_SBC_1	65	69	PF00917	0.695
DEG_SPOP_SBC_1	681	685	PF00917	0.744
DEG_SPOP_SBC_1	691	695	PF00917	0.636
DOC_CDC14_PxL_1	563	571	PF14671	0.535
DOC_CKS1_1	388	393	PF01111	0.700
DOC_CKS1_1	622	627	PF01111	0.842
DOC_CKS1_1	666	671	PF01111	0.709
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.620
DOC_CYCLIN_yCln2_LP_2	520	526	PF00134	0.702
DOC_CYCLIN_yCln2_LP_2	564	570	PF00134	0.726
DOC_CYCLIN_yCln2_LP_2	843	849	PF00134	0.699
DOC_MAPK_gen_1	138	145	PF00069	0.554
DOC_MAPK_gen_1	556	566	PF00069	0.784
DOC_MAPK_gen_1	628	637	PF00069	0.838
DOC_MAPK_MEF2A_6	215	222	PF00069	0.541
DOC_MAPK_MEF2A_6	317	324	PF00069	0.647
DOC_MAPK_RevD_3	752	766	PF00069	0.663
DOC_PP2B_LxvP_1	160	163	PF13499	0.724
DOC_PP2B_LxvP_1	564	567	PF13499	0.808
DOC_PP2B_LxvP_1	623	626	PF13499	0.844
DOC_PP2B_LxvP_1	843	846	PF13499	0.787
DOC_PP2B_LxvP_1	847	850	PF13499	0.756
DOC_PP4_FxxP_1	361	364	PF00568	0.405
DOC_PP4_FxxP_1	622	625	PF00568	0.846
DOC_USP7_MATH_1	127	131	PF00917	0.481
DOC_USP7_MATH_1	183	187	PF00917	0.672
DOC_USP7_MATH_1	237	241	PF00917	0.564
DOC_USP7_MATH_1	270	274	PF00917	0.686
DOC_USP7_MATH_1	276	280	PF00917	0.723
DOC_USP7_MATH_1	284	288	PF00917	0.632
DOC_USP7_MATH_1	393	397	PF00917	0.632
DOC_USP7_MATH_1	398	402	PF00917	0.671
DOC_USP7_MATH_1	472	476	PF00917	0.782
DOC_USP7_MATH_1	507	511	PF00917	0.738
DOC_USP7_MATH_1	513	517	PF00917	0.700
DOC_USP7_MATH_1	65	69	PF00917	0.587
DOC_USP7_MATH_1	682	686	PF00917	0.595
DOC_USP7_MATH_1	691	695	PF00917	0.685
DOC_USP7_MATH_1	737	741	PF00917	0.809
DOC_USP7_MATH_1	75	79	PF00917	0.611
DOC_USP7_MATH_1	91	95	PF00917	0.634
DOC_WW_Pin1_4	169	174	PF00397	0.737
DOC_WW_Pin1_4	231	236	PF00397	0.722
DOC_WW_Pin1_4	297	302	PF00397	0.721
DOC_WW_Pin1_4	387	392	PF00397	0.687
DOC_WW_Pin1_4	394	399	PF00397	0.671
DOC_WW_Pin1_4	470	475	PF00397	0.793
DOC_WW_Pin1_4	519	524	PF00397	0.806
DOC_WW_Pin1_4	578	583	PF00397	0.780
DOC_WW_Pin1_4	589	594	PF00397	0.687
DOC_WW_Pin1_4	621	626	PF00397	0.845
DOC_WW_Pin1_4	646	651	PF00397	0.733
DOC_WW_Pin1_4	665	670	PF00397	0.606
DOC_WW_Pin1_4	837	842	PF00397	0.540
LIG_14-3-3_CanoR_1	138	143	PF00244	0.356
LIG_14-3-3_CanoR_1	264	269	PF00244	0.613
LIG_14-3-3_CanoR_1	330	335	PF00244	0.548
LIG_14-3-3_CanoR_1	363	372	PF00244	0.623
LIG_14-3-3_CanoR_1	448	458	PF00244	0.566
LIG_14-3-3_CanoR_1	463	472	PF00244	0.502
LIG_14-3-3_CanoR_1	501	507	PF00244	0.674
LIG_14-3-3_CanoR_1	671	676	PF00244	0.657
LIG_14-3-3_CanoR_1	773	781	PF00244	0.580
LIG_14-3-3_CanoR_1	90	96	PF00244	0.636
LIG_Actin_WH2_2	9	26	PF00022	0.694
LIG_BIR_III_2	298	302	PF00653	0.721
LIG_BRCT_BRCA1_1	452	456	PF00533	0.613
LIG_EH_1	422	426	PF12763	0.377
LIG_FHA_1	115	121	PF00498	0.593
LIG_FHA_1	18	24	PF00498	0.554
LIG_FHA_1	236	242	PF00498	0.758
LIG_FHA_1	29	35	PF00498	0.602
LIG_FHA_1	380	386	PF00498	0.391
LIG_FHA_1	536	542	PF00498	0.740
LIG_FHA_1	691	697	PF00498	0.842
LIG_FHA_1	740	746	PF00498	0.743
LIG_FHA_1	777	783	PF00498	0.682
LIG_FHA_1	840	846	PF00498	0.662
LIG_FHA_1	94	100	PF00498	0.447
LIG_FHA_2	127	133	PF00498	0.623
LIG_FHA_2	139	145	PF00498	0.411
LIG_FHA_2	368	374	PF00498	0.604
LIG_FHA_2	786	792	PF00498	0.656
LIG_GBD_Chelix_1	431	439	PF00786	0.429
LIG_IRF3_LxIS_1	415	421	PF10401	0.445
LIG_LIR_Apic_2	358	364	PF02991	0.437
LIG_LIR_Gen_1	141	150	PF02991	0.552
LIG_LIR_Gen_1	174	183	PF02991	0.771
LIG_LIR_Gen_1	219	229	PF02991	0.717
LIG_LIR_Gen_1	515	526	PF02991	0.801
LIG_LIR_Nem_3	141	145	PF02991	0.555
LIG_LIR_Nem_3	146	150	PF02991	0.549
LIG_LIR_Nem_3	174	179	PF02991	0.776
LIG_LIR_Nem_3	219	225	PF02991	0.718
LIG_LIR_Nem_3	515	521	PF02991	0.803
LIG_LIR_Nem_3	695	701	PF02991	0.844
LIG_MYND_1	567	571	PF01753	0.536
LIG_NRBOX	94	100	PF00104	0.600
LIG_PCNA_yPIPBox_3	488	501	PF02747	0.735
LIG_Pex14_2	361	365	PF04695	0.393
LIG_SH2_CRK	176	180	PF00017	0.671
LIG_SH2_NCK_1	147	151	PF00017	0.603
LIG_SH2_PTP2	142	145	PF00017	0.589
LIG_SH2_STAP1	574	578	PF00017	0.726
LIG_SH2_STAT5	142	145	PF00017	0.589
LIG_SH2_STAT5	378	381	PF00017	0.506
LIG_SH3_2	666	671	PF14604	0.709
LIG_SH3_3	298	304	PF00018	0.639
LIG_SH3_3	392	398	PF00018	0.660
LIG_SH3_3	476	482	PF00018	0.641
LIG_SH3_3	645	651	PF00018	0.741
LIG_SH3_3	663	669	PF00018	0.632
LIG_SH3_3	672	678	PF00018	0.713
LIG_SH3_3	830	836	PF00018	0.648
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.526
LIG_SUMO_SIM_anti_2	216	224	PF11976	0.548
LIG_SUMO_SIM_anti_2	545	550	PF11976	0.736
LIG_SUMO_SIM_par_1	116	124	PF11976	0.592
LIG_SUMO_SIM_par_1	240	248	PF11976	0.799
LIG_SUMO_SIM_par_1	319	325	PF11976	0.608
LIG_SUMO_SIM_par_1	742	748	PF11976	0.501
LIG_SxIP_EBH_1	386	398	PF03271	0.460
LIG_TRAF2_1	799	802	PF00917	0.553
LIG_TRAF2_1	81	84	PF00917	0.721
LIG_TYR_ITIM	140	145	PF00017	0.595
LIG_WW_3	625	629	PF00397	0.838
LIG_WW_3	668	672	PF00397	0.727
MOD_CDK_SPxK_1	665	671	PF00069	0.716
MOD_CDK_SPxxK_3	621	628	PF00069	0.842
MOD_CK1_1	146	152	PF00069	0.610
MOD_CK1_1	169	175	PF00069	0.779
MOD_CK1_1	244	250	PF00069	0.779
MOD_CK1_1	258	264	PF00069	0.748
MOD_CK1_1	279	285	PF00069	0.724
MOD_CK1_1	396	402	PF00069	0.785
MOD_CK1_1	438	444	PF00069	0.588
MOD_CK1_1	449	455	PF00069	0.639
MOD_CK1_1	516	522	PF00069	0.770
MOD_CK1_1	589	595	PF00069	0.849
MOD_CK1_1	596	602	PF00069	0.751
MOD_CK1_1	640	646	PF00069	0.798
MOD_CK1_1	683	689	PF00069	0.816
MOD_CK1_1	69	75	PF00069	0.794
MOD_CK1_1	740	746	PF00069	0.630
MOD_CK1_1	78	84	PF00069	0.742
MOD_CK2_1	183	189	PF00069	0.696
MOD_CK2_1	193	199	PF00069	0.667
MOD_CK2_1	686	692	PF00069	0.692
MOD_CK2_1	78	84	PF00069	0.742
MOD_CK2_1	785	791	PF00069	0.656
MOD_GlcNHglycan	168	171	PF01048	0.516
MOD_GlcNHglycan	185	188	PF01048	0.516
MOD_GlcNHglycan	195	198	PF01048	0.662
MOD_GlcNHglycan	257	260	PF01048	0.578
MOD_GlcNHglycan	274	277	PF01048	0.576
MOD_GlcNHglycan	278	281	PF01048	0.681
MOD_GlcNHglycan	293	296	PF01048	0.518
MOD_GlcNHglycan	307	310	PF01048	0.741
MOD_GlcNHglycan	334	337	PF01048	0.463
MOD_GlcNHglycan	341	344	PF01048	0.650
MOD_GlcNHglycan	401	404	PF01048	0.775
MOD_GlcNHglycan	419	423	PF01048	0.413
MOD_GlcNHglycan	465	468	PF01048	0.712
MOD_GlcNHglycan	474	477	PF01048	0.705
MOD_GlcNHglycan	509	512	PF01048	0.801
MOD_GlcNHglycan	588	591	PF01048	0.707
MOD_GlcNHglycan	595	598	PF01048	0.743
MOD_GlcNHglycan	642	645	PF01048	0.848
MOD_GlcNHglycan	663	666	PF01048	0.576
MOD_GlcNHglycan	715	719	PF01048	0.843
MOD_GlcNHglycan	73	76	PF01048	0.785
MOD_GlcNHglycan	733	736	PF01048	0.539
MOD_GlcNHglycan	747	750	PF01048	0.485
MOD_GlcNHglycan	83	89	PF01048	0.660
MOD_GlcNHglycan	851	854	PF01048	0.520
MOD_GSK3_1	231	238	PF00069	0.803
MOD_GSK3_1	241	248	PF00069	0.697
MOD_GSK3_1	272	279	PF00069	0.712
MOD_GSK3_1	351	358	PF00069	0.522
MOD_GSK3_1	394	401	PF00069	0.780
MOD_GSK3_1	446	453	PF00069	0.668
MOD_GSK3_1	459	466	PF00069	0.545
MOD_GSK3_1	470	477	PF00069	0.679
MOD_GSK3_1	502	509	PF00069	0.763
MOD_GSK3_1	512	519	PF00069	0.672
MOD_GSK3_1	589	596	PF00069	0.852
MOD_GSK3_1	61	68	PF00069	0.667
MOD_GSK3_1	627	634	PF00069	0.834
MOD_GSK3_1	661	668	PF00069	0.800
MOD_GSK3_1	680	687	PF00069	0.609
MOD_GSK3_1	71	78	PF00069	0.688
MOD_GSK3_1	714	721	PF00069	0.845
MOD_GSK3_1	737	744	PF00069	0.762
MOD_GSK3_1	772	779	PF00069	0.691
MOD_GSK3_1	835	842	PF00069	0.584
MOD_N-GLC_1	229	234	PF02516	0.555
MOD_N-GLC_1	34	39	PF02516	0.502
MOD_N-GLC_1	427	432	PF02516	0.702
MOD_NEK2_1	121	126	PF00069	0.591
MOD_NEK2_1	193	198	PF00069	0.515
MOD_NEK2_1	245	250	PF00069	0.730
MOD_NEK2_1	322	327	PF00069	0.600
MOD_NEK2_1	34	39	PF00069	0.610
MOD_NEK2_1	372	377	PF00069	0.604
MOD_NEK2_1	418	423	PF00069	0.602
MOD_NEK2_1	435	440	PF00069	0.441
MOD_NEK2_1	48	53	PF00069	0.575
MOD_NEK2_1	494	499	PF00069	0.731
MOD_NEK2_1	728	733	PF00069	0.711
MOD_NEK2_2	133	138	PF00069	0.363
MOD_NEK2_2	513	518	PF00069	0.809
MOD_PIKK_1	250	256	PF00454	0.577
MOD_PIKK_1	285	291	PF00454	0.719
MOD_PK_1	631	637	PF00069	0.840
MOD_PKA_1	138	144	PF00069	0.415
MOD_PKA_2	138	144	PF00069	0.415
MOD_PKA_2	270	276	PF00069	0.706
MOD_PKA_2	627	633	PF00069	0.835
MOD_PKA_2	772	778	PF00069	0.693
MOD_PKB_1	328	336	PF00069	0.541
MOD_Plk_1	143	149	PF00069	0.587
MOD_Plk_1	188	194	PF00069	0.507
MOD_Plk_1	446	452	PF00069	0.671
MOD_Plk_1	544	550	PF00069	0.741
MOD_Plk_1	631	637	PF00069	0.807
MOD_Plk_1	691	697	PF00069	0.842
MOD_Plk_1	776	782	PF00069	0.685
MOD_Plk_1	785	791	PF00069	0.510
MOD_Plk_1	84	90	PF00069	0.655
MOD_Plk_4	104	110	PF00069	0.535
MOD_Plk_4	116	122	PF00069	0.465
MOD_Plk_4	138	144	PF00069	0.350
MOD_Plk_4	513	519	PF00069	0.808
MOD_Plk_4	544	550	PF00069	0.741
MOD_Plk_4	637	643	PF00069	0.846
MOD_ProDKin_1	169	175	PF00069	0.736
MOD_ProDKin_1	231	237	PF00069	0.720
MOD_ProDKin_1	297	303	PF00069	0.722
MOD_ProDKin_1	387	393	PF00069	0.699
MOD_ProDKin_1	394	400	PF00069	0.672
MOD_ProDKin_1	470	476	PF00069	0.795
MOD_ProDKin_1	519	525	PF00069	0.808
MOD_ProDKin_1	578	584	PF00069	0.777
MOD_ProDKin_1	589	595	PF00069	0.682
MOD_ProDKin_1	621	627	PF00069	0.843
MOD_ProDKin_1	646	652	PF00069	0.736
MOD_ProDKin_1	665	671	PF00069	0.614
MOD_ProDKin_1	837	843	PF00069	0.542
MOD_SUMO_rev_2	786	795	PF00179	0.657
TRG_DiLeu_BaEn_1	216	221	PF01217	0.544
TRG_DiLeu_BaEn_4	84	90	PF01217	0.655
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.722
TRG_ENDOCYTIC_2	142	145	PF00928	0.589
TRG_ENDOCYTIC_2	147	150	PF00928	0.513
TRG_ENDOCYTIC_2	176	179	PF00928	0.672
TRG_ER_diArg_1	138	140	PF00400	0.644
TRG_ER_diArg_1	329	332	PF00400	0.652
TRG_ER_diArg_1	385	387	PF00400	0.663
TRG_ER_diArg_1	764	767	PF00400	0.679
TRG_NES_CRM1_1	813	826	PF08389	0.540
TRG_Pf-PMV_PEXEL_1	769	774	PF00026	0.689
TRG_Pf-PMV_PEXEL_1	780	785	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPA4	Leishmania donovani	81%	93%
A4H4G0	Leishmania braziliensis	62%	96%
A4HSN7	Leishmania infantum	81%	93%