SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKM0_LEIMU

TriTrypDb:

LmxM.05.1130

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.585
CLV_C14_Caspase3-7	242	246	PF00656	0.669
CLV_C14_Caspase3-7	547	551	PF00656	0.761
CLV_NRD_NRD_1	121	123	PF00675	0.499
CLV_NRD_NRD_1	279	281	PF00675	0.472
CLV_NRD_NRD_1	29	31	PF00675	0.474
CLV_NRD_NRD_1	73	75	PF00675	0.690
CLV_PCSK_KEX2_1	121	123	PF00082	0.499
CLV_PCSK_KEX2_1	279	281	PF00082	0.472
CLV_PCSK_KEX2_1	414	416	PF00082	0.456
CLV_PCSK_KEX2_1	73	75	PF00082	0.557
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.382
CLV_PCSK_SKI1_1	160	164	PF00082	0.423
CLV_PCSK_SKI1_1	23	27	PF00082	0.465
CLV_PCSK_SKI1_1	271	275	PF00082	0.311
CLV_PCSK_SKI1_1	341	345	PF00082	0.420
CLV_PCSK_SKI1_1	369	373	PF00082	0.356
CLV_PCSK_SKI1_1	485	489	PF00082	0.549
CLV_PCSK_SKI1_1	516	520	PF00082	0.386
CLV_PCSK_SKI1_1	60	64	PF00082	0.458
DEG_Nend_UBRbox_2	1	3	PF02207	0.489
DEG_SCF_FBW7_1	426	433	PF00400	0.355
DEG_SPOP_SBC_1	502	506	PF00917	0.511
DOC_CKS1_1	237	242	PF01111	0.609
DOC_CKS1_1	427	432	PF01111	0.572
DOC_CKS1_1	9	14	PF01111	0.488
DOC_CYCLIN_RxL_1	20	29	PF00134	0.472
DOC_CYCLIN_RxL_1	390	400	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.354
DOC_MAPK_DCC_7	13	21	PF00069	0.498
DOC_MAPK_gen_1	13	21	PF00069	0.487
DOC_MAPK_gen_1	483	492	PF00069	0.459
DOC_MAPK_gen_1	514	522	PF00069	0.365
DOC_MAPK_MEF2A_6	13	21	PF00069	0.487
DOC_MAPK_MEF2A_6	271	278	PF00069	0.351
DOC_MAPK_MEF2A_6	393	401	PF00069	0.426
DOC_MAPK_MEF2A_6	514	522	PF00069	0.420
DOC_MAPK_RevD_3	17	31	PF00069	0.466
DOC_PP2B_LxvP_1	395	398	PF13499	0.375
DOC_PP2B_LxvP_1	399	402	PF13499	0.327
DOC_PP2B_LxvP_1	420	423	PF13499	0.343
DOC_SPAK_OSR1_1	224	228	PF12202	0.509
DOC_SPAK_OSR1_1	405	409	PF12202	0.316
DOC_USP7_MATH_1	284	288	PF00917	0.315
DOC_USP7_MATH_1	391	395	PF00917	0.517
DOC_USP7_MATH_1	494	498	PF00917	0.477
DOC_USP7_MATH_1	91	95	PF00917	0.465
DOC_USP7_UBL2_3	65	69	PF12436	0.606
DOC_USP7_UBL2_3	71	75	PF12436	0.646
DOC_WW_Pin1_4	108	113	PF00397	0.391
DOC_WW_Pin1_4	179	184	PF00397	0.397
DOC_WW_Pin1_4	233	238	PF00397	0.549
DOC_WW_Pin1_4	426	431	PF00397	0.538
DOC_WW_Pin1_4	444	449	PF00397	0.392
DOC_WW_Pin1_4	5	10	PF00397	0.498
DOC_WW_Pin1_4	554	559	PF00397	0.610
LIG_14-3-3_CanoR_1	127	131	PF00244	0.375
LIG_14-3-3_CanoR_1	142	149	PF00244	0.415
LIG_14-3-3_CanoR_1	30	38	PF00244	0.477
LIG_14-3-3_CanoR_1	5	9	PF00244	0.496
LIG_Actin_WH2_2	197	215	PF00022	0.509
LIG_BIR_III_2	550	554	PF00653	0.469
LIG_BIR_III_4	453	457	PF00653	0.321
LIG_BRCT_BRCA1_1	127	131	PF00533	0.394
LIG_deltaCOP1_diTrp_1	409	416	PF00928	0.333
LIG_FHA_1	180	186	PF00498	0.365
LIG_FHA_1	249	255	PF00498	0.413
LIG_FHA_1	361	367	PF00498	0.369
LIG_FHA_1	370	376	PF00498	0.382
LIG_FHA_1	475	481	PF00498	0.445
LIG_FHA_1	53	59	PF00498	0.366
LIG_FHA_1	65	71	PF00498	0.568
LIG_FHA_2	127	133	PF00498	0.370
LIG_FHA_2	240	246	PF00498	0.662
LIG_FHA_2	350	356	PF00498	0.503
LIG_FHA_2	427	433	PF00498	0.492
LIG_FHA_2	464	470	PF00498	0.519
LIG_FHA_2	502	508	PF00498	0.431
LIG_GSK3_LRP6_1	426	431	PF00069	0.452
LIG_Integrin_RGD_1	353	355	PF01839	0.439
LIG_LIR_Gen_1	45	54	PF02991	0.394
LIG_LIR_Gen_1	466	475	PF02991	0.544
LIG_LIR_Gen_1	61	70	PF02991	0.497
LIG_LIR_LC3C_4	517	521	PF02991	0.422
LIG_LIR_Nem_3	400	406	PF02991	0.384
LIG_LIR_Nem_3	410	416	PF02991	0.304
LIG_LIR_Nem_3	45	50	PF02991	0.416
LIG_LIR_Nem_3	466	470	PF02991	0.419
LIG_LIR_Nem_3	497	502	PF02991	0.409
LIG_LIR_Nem_3	61	66	PF02991	0.478
LIG_NRBOX	21	27	PF00104	0.466
LIG_PCNA_PIPBox_1	205	214	PF02747	0.404
LIG_Pex14_1	413	417	PF04695	0.363
LIG_Pex14_2	153	157	PF04695	0.424
LIG_Pex14_2	412	416	PF04695	0.324
LIG_PTB_Apo_2	287	294	PF02174	0.427
LIG_REV1ctd_RIR_1	60	69	PF16727	0.479
LIG_SH2_CRK	321	325	PF00017	0.350
LIG_SH2_CRK	417	421	PF00017	0.456
LIG_SH2_CRK	499	503	PF00017	0.514
LIG_SH2_SRC	499	502	PF00017	0.377
LIG_SH2_STAT5	24	27	PF00017	0.462
LIG_SH2_STAT5	268	271	PF00017	0.297
LIG_SH2_STAT5	361	364	PF00017	0.356
LIG_SH2_STAT5	450	453	PF00017	0.411
LIG_SH3_1	73	79	PF00018	0.576
LIG_SH3_3	11	17	PF00018	0.491
LIG_SH3_3	234	240	PF00018	0.670
LIG_SH3_3	3	9	PF00018	0.502
LIG_SH3_3	420	426	PF00018	0.371
LIG_SH3_3	550	556	PF00018	0.728
LIG_SH3_3	73	79	PF00018	0.553
LIG_SH3_3	87	93	PF00018	0.331
LIG_SH3_CIN85_PxpxPR_1	10	15	PF14604	0.486
LIG_Sin3_3	309	316	PF02671	0.368
LIG_SUMO_SIM_anti_2	517	524	PF11976	0.459
LIG_SUMO_SIM_par_1	517	524	PF11976	0.404
LIG_TRAF2_1	192	195	PF00917	0.430
LIG_TRAF2_1	429	432	PF00917	0.504
LIG_TYR_ITIM	22	27	PF00017	0.466
LIG_TYR_ITIM	319	324	PF00017	0.352
LIG_WRC_WIRS_1	464	469	PF05994	0.403
LIG_WRC_WIRS_1	47	52	PF05994	0.507
LIG_WRC_WIRS_1	522	527	PF05994	0.533
LIG_WRC_WIRS_1	59	64	PF05994	0.448
MOD_CDK_SPK_2	236	241	PF00069	0.603
MOD_CDK_SPK_2	8	13	PF00069	0.489
MOD_CDK_SPxxK_3	179	186	PF00069	0.389
MOD_CDK_SPxxK_3	554	561	PF00069	0.612
MOD_CDK_SPxxK_3	8	15	PF00069	0.487
MOD_CK1_1	49	55	PF00069	0.356
MOD_CK1_1	61	67	PF00069	0.499
MOD_CK1_1	8	14	PF00069	0.488
MOD_CK2_1	112	118	PF00069	0.493
MOD_CK2_1	426	432	PF00069	0.487
MOD_CK2_1	501	507	PF00069	0.424
MOD_CK2_1	554	560	PF00069	0.610
MOD_DYRK1A_RPxSP_1	5	9	PF00069	0.496
MOD_GlcNHglycan	533	536	PF01048	0.510
MOD_GlcNHglycan	546	549	PF01048	0.488
MOD_GSK3_1	108	115	PF00069	0.454
MOD_GSK3_1	239	246	PF00069	0.690
MOD_GSK3_1	320	327	PF00069	0.493
MOD_GSK3_1	356	363	PF00069	0.386
MOD_GSK3_1	365	372	PF00069	0.299
MOD_GSK3_1	373	380	PF00069	0.290
MOD_GSK3_1	4	11	PF00069	0.497
MOD_GSK3_1	42	49	PF00069	0.447
MOD_GSK3_1	426	433	PF00069	0.574
MOD_GSK3_1	50	57	PF00069	0.356
MOD_GSK3_1	61	68	PF00069	0.581
MOD_NEK2_1	26	31	PF00069	0.459
MOD_NEK2_1	324	329	PF00069	0.562
MOD_NEK2_1	349	354	PF00069	0.484
MOD_NEK2_1	50	55	PF00069	0.376
MOD_NEK2_2	243	248	PF00069	0.614
MOD_PKA_2	126	132	PF00069	0.376
MOD_PKA_2	141	147	PF00069	0.414
MOD_PKA_2	29	35	PF00069	0.470
MOD_PKA_2	4	10	PF00069	0.497
MOD_PKA_2	42	48	PF00069	0.403
MOD_PKA_2	531	537	PF00069	0.548
MOD_Plk_1	262	268	PF00069	0.428
MOD_Plk_1	298	304	PF00069	0.402
MOD_Plk_4	126	132	PF00069	0.356
MOD_Plk_4	263	269	PF00069	0.405
MOD_Plk_4	284	290	PF00069	0.332
MOD_Plk_4	54	60	PF00069	0.354
MOD_ProDKin_1	108	114	PF00069	0.393
MOD_ProDKin_1	179	185	PF00069	0.389
MOD_ProDKin_1	233	239	PF00069	0.553
MOD_ProDKin_1	426	432	PF00069	0.541
MOD_ProDKin_1	444	450	PF00069	0.379
MOD_ProDKin_1	5	11	PF00069	0.496
MOD_ProDKin_1	554	560	PF00069	0.610
MOD_SUMO_rev_2	431	435	PF00179	0.558
MOD_SUMO_rev_2	482	490	PF00179	0.416
TRG_DiLeu_BaEn_1	184	189	PF01217	0.512
TRG_DiLeu_BaEn_1	340	345	PF01217	0.405
TRG_DiLeu_BaEn_4	262	268	PF01217	0.415
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.364
TRG_ENDOCYTIC_2	24	27	PF00928	0.462
TRG_ENDOCYTIC_2	321	324	PF00928	0.343
TRG_ENDOCYTIC_2	403	406	PF00928	0.332
TRG_ENDOCYTIC_2	417	420	PF00928	0.456
TRG_ENDOCYTIC_2	499	502	PF00928	0.392
TRG_ER_diArg_1	12	15	PF00400	0.495
TRG_ER_diArg_1	278	280	PF00400	0.483
TRG_ER_diArg_1	300	303	PF00400	0.384
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F7	Leptomonas seymouri	79%	100%
A0A0S4IPB6	Bodo saltans	43%	100%
A0A1X0NKA7	Trypanosomatidae	51%	96%
A0A3R7NCC1	Trypanosoma rangeli	55%	100%
A0A3S7WPA3	Leishmania donovani	96%	100%
A4H4F8	Leishmania braziliensis	86%	100%
A4HSN5	Leishmania infantum	96%	100%
C9ZND9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	85%
Q4QJ89	Leishmania major	93%	100%
V5D7S2	Trypanosoma cruzi	55%	100%