Double-strand-break repair protein rad21 homolog,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

double-strand-break repair protein rad21 homolog, putative

Species:

Leishmania mexicana

UniProt:

E9AKL6_LEIMU

TriTrypDb:

LmxM.05.1090

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0008278	cohesin complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0044815	DNA packaging complex	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

E9AKL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKL6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0007062	sister chromatid cohesion	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022402	cell cycle process	2	12
GO:0051276	chromosome organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1990414	replication-born double-strand break repair via sister chromatid exchange	8	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.692
CLV_C14_Caspase3-7	465	469	PF00656	0.732
CLV_NRD_NRD_1	309	311	PF00675	0.630
CLV_NRD_NRD_1	346	348	PF00675	0.592
CLV_NRD_NRD_1	419	421	PF00675	0.731
CLV_NRD_NRD_1	459	461	PF00675	0.685
CLV_NRD_NRD_1	501	503	PF00675	0.662
CLV_NRD_NRD_1	529	531	PF00675	0.267
CLV_PCSK_FUR_1	459	463	PF00082	0.782
CLV_PCSK_KEX2_1	25	27	PF00082	0.303
CLV_PCSK_KEX2_1	346	348	PF00082	0.592
CLV_PCSK_KEX2_1	419	421	PF00082	0.643
CLV_PCSK_KEX2_1	459	461	PF00082	0.679
CLV_PCSK_KEX2_1	528	530	PF00082	0.268
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.340
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.668
CLV_PCSK_PC7_1	525	531	PF00082	0.302
CLV_PCSK_SKI1_1	25	29	PF00082	0.274
CLV_PCSK_SKI1_1	327	331	PF00082	0.635
CLV_PCSK_SKI1_1	72	76	PF00082	0.287
DEG_Nend_Nbox_1	1	3	PF02207	0.476
DOC_ANK_TNKS_1	463	470	PF00023	0.678
DOC_CYCLIN_RxL_1	69	79	PF00134	0.487
DOC_MAPK_gen_1	205	213	PF00069	0.565
DOC_MAPK_gen_1	235	244	PF00069	0.642
DOC_MAPK_gen_1	25	34	PF00069	0.487
DOC_MAPK_gen_1	307	317	PF00069	0.633
DOC_MAPK_gen_1	489	496	PF00069	0.527
DOC_MAPK_HePTP_8	51	63	PF00069	0.476
DOC_MAPK_MEF2A_6	235	244	PF00069	0.675
DOC_MAPK_MEF2A_6	46	53	PF00069	0.501
DOC_MAPK_MEF2A_6	489	496	PF00069	0.555
DOC_MAPK_MEF2A_6	54	63	PF00069	0.448
DOC_MAPK_NFAT4_5	489	497	PF00069	0.565
DOC_PP4_FxxP_1	287	290	PF00568	0.683
DOC_USP7_MATH_1	217	221	PF00917	0.708
DOC_USP7_MATH_1	335	339	PF00917	0.667
DOC_USP7_MATH_1	418	422	PF00917	0.669
DOC_USP7_MATH_1	477	481	PF00917	0.603
DOC_USP7_MATH_1	541	545	PF00917	0.497
DOC_USP7_UBL2_3	72	76	PF12436	0.501
LIG_14-3-3_CanoR_1	104	112	PF00244	0.755
LIG_14-3-3_CanoR_1	358	362	PF00244	0.671
LIG_14-3-3_CanoR_1	419	427	PF00244	0.728
LIG_14-3-3_CanoR_1	506	514	PF00244	0.587
LIG_14-3-3_CanoR_1	86	91	PF00244	0.537
LIG_Actin_WH2_2	378	393	PF00022	0.656
LIG_Actin_WH2_2	38	56	PF00022	0.531
LIG_Actin_WH2_2	62	78	PF00022	0.501
LIG_AP2alpha_2	285	287	PF02296	0.649
LIG_BIR_III_2	378	382	PF00653	0.661
LIG_FHA_1	103	109	PF00498	0.651
LIG_FHA_1	277	283	PF00498	0.619
LIG_FHA_1	3	9	PF00498	0.476
LIG_FHA_1	80	86	PF00498	0.487
LIG_FHA_2	104	110	PF00498	0.695
LIG_FHA_2	166	172	PF00498	0.719
LIG_FHA_2	26	32	PF00498	0.476
LIG_FHA_2	53	59	PF00498	0.476
LIG_FHA_2	533	539	PF00498	0.580
LIG_FHA_2	560	566	PF00498	0.589
LIG_LIR_Apic_2	285	290	PF02991	0.678
LIG_LIR_Gen_1	147	157	PF02991	0.521
LIG_LIR_Gen_1	199	208	PF02991	0.510
LIG_LIR_Gen_1	535	543	PF02991	0.499
LIG_LIR_Gen_1	82	91	PF02991	0.556
LIG_LIR_Nem_3	147	153	PF02991	0.515
LIG_LIR_Nem_3	177	182	PF02991	0.607
LIG_LIR_Nem_3	199	203	PF02991	0.511
LIG_LIR_Nem_3	535	539	PF02991	0.499
LIG_LIR_Nem_3	82	87	PF02991	0.562
LIG_MYND_1	286	290	PF01753	0.696
LIG_SH2_NCK_1	200	204	PF00017	0.528
LIG_SH2_SRC	200	203	PF00017	0.531
LIG_SH2_STAP1	200	204	PF00017	0.528
LIG_SH2_STAP1	394	398	PF00017	0.533
LIG_SH2_STAP1	67	71	PF00017	0.467
LIG_SH2_STAT3	180	183	PF00017	0.690
LIG_SH2_STAT3	350	353	PF00017	0.594
LIG_SH2_STAT5	180	183	PF00017	0.647
LIG_SH2_STAT5	359	362	PF00017	0.715
LIG_SH2_STAT5	547	550	PF00017	0.562
LIG_SH2_STAT5	6	9	PF00017	0.476
LIG_SH3_3	108	114	PF00018	0.700
LIG_SH3_3	257	263	PF00018	0.652
LIG_SH3_3	265	271	PF00018	0.666
LIG_SH3_3	280	286	PF00018	0.714
LIG_SH3_3	382	388	PF00018	0.631
LIG_SH3_3	44	50	PF00018	0.476
LIG_SH3_4	504	511	PF00018	0.525
LIG_SUMO_SIM_anti_2	535	541	PF11976	0.501
LIG_SUMO_SIM_par_1	33	38	PF11976	0.537
LIG_SUMO_SIM_par_1	49	56	PF11976	0.395
LIG_SUMO_SIM_par_1	538	544	PF11976	0.476
LIG_TRAF2_1	352	355	PF00917	0.657
LIG_TRAF2_1	451	454	PF00917	0.606
MOD_CK1_1	226	232	PF00069	0.656
MOD_CK1_1	364	370	PF00069	0.519
MOD_CK1_1	509	515	PF00069	0.629
MOD_CK2_1	115	121	PF00069	0.699
MOD_CK2_1	165	171	PF00069	0.721
MOD_CK2_1	228	234	PF00069	0.745
MOD_CK2_1	25	31	PF00069	0.487
MOD_CK2_1	52	58	PF00069	0.476
MOD_CK2_1	559	565	PF00069	0.586
MOD_Cter_Amidation	308	311	PF01082	0.763
MOD_GlcNHglycan	176	179	PF01048	0.577
MOD_GlcNHglycan	217	220	PF01048	0.617
MOD_GlcNHglycan	221	224	PF01048	0.644
MOD_GlcNHglycan	363	366	PF01048	0.657
MOD_GlcNHglycan	382	385	PF01048	0.647
MOD_GlcNHglycan	400	403	PF01048	0.335
MOD_GlcNHglycan	444	448	PF01048	0.652
MOD_GlcNHglycan	479	482	PF01048	0.518
MOD_GlcNHglycan	508	511	PF01048	0.536
MOD_GlcNHglycan	548	551	PF01048	0.345
MOD_GlcNHglycan	55	58	PF01048	0.274
MOD_GlcNHglycan	565	568	PF01048	0.480
MOD_GSK3_1	174	181	PF00069	0.636
MOD_GSK3_1	2	9	PF00069	0.476
MOD_GSK3_1	215	222	PF00069	0.594
MOD_GSK3_1	225	232	PF00069	0.611
MOD_GSK3_1	319	326	PF00069	0.666
MOD_GSK3_1	357	364	PF00069	0.708
MOD_GSK3_1	414	421	PF00069	0.475
MOD_GSK3_1	479	486	PF00069	0.456
MOD_GSK3_1	559	566	PF00069	0.493
MOD_GSK3_1	85	92	PF00069	0.537
MOD_GSK3_1	98	105	PF00069	0.689
MOD_N-GLC_1	563	568	PF02516	0.511
MOD_N-GLC_2	316	318	PF02516	0.736
MOD_NEK2_1	1	6	PF00069	0.472
MOD_NEK2_1	157	162	PF00069	0.600
MOD_NEK2_1	174	179	PF00069	0.579
MOD_NEK2_1	320	325	PF00069	0.577
MOD_NEK2_1	37	42	PF00069	0.476
MOD_NEK2_1	413	418	PF00069	0.633
MOD_NEK2_1	443	448	PF00069	0.752
MOD_NEK2_1	492	497	PF00069	0.566
MOD_NEK2_1	563	568	PF00069	0.555
MOD_NEK2_1	85	90	PF00069	0.522
MOD_PIKK_1	183	189	PF00454	0.600
MOD_PIKK_1	35	41	PF00454	0.562
MOD_PIKK_1	504	510	PF00454	0.677
MOD_PIKK_1	98	104	PF00454	0.460
MOD_PK_1	104	110	PF00069	0.711
MOD_PKA_1	25	31	PF00069	0.476
MOD_PKA_2	103	109	PF00069	0.756
MOD_PKA_2	215	221	PF00069	0.622
MOD_PKA_2	236	242	PF00069	0.608
MOD_PKA_2	25	31	PF00069	0.484
MOD_PKA_2	357	363	PF00069	0.619
MOD_PKA_2	398	404	PF00069	0.575
MOD_PKA_2	413	419	PF00069	0.577
MOD_PKA_2	53	59	PF00069	0.504
MOD_PKA_2	85	91	PF00069	0.517
MOD_Plk_1	320	326	PF00069	0.610
MOD_Plk_1	470	476	PF00069	0.686
MOD_Plk_1	492	498	PF00069	0.585
MOD_Plk_1	563	569	PF00069	0.517
MOD_Plk_1	79	85	PF00069	0.487
MOD_Plk_2-3	121	127	PF00069	0.610
MOD_Plk_4	2	8	PF00069	0.476
MOD_Plk_4	37	43	PF00069	0.487
MOD_Plk_4	509	515	PF00069	0.618
MOD_Plk_4	79	85	PF00069	0.487
MOD_SUMO_rev_2	495	505	PF00179	0.601
TRG_DiLeu_BaEn_2	79	85	PF01217	0.562
TRG_ENDOCYTIC_2	200	203	PF00928	0.512
TRG_ER_diArg_1	345	347	PF00400	0.612
TRG_ER_diArg_1	459	462	PF00400	0.815
TRG_ER_diArg_1	489	492	PF00400	0.537
TRG_ER_diArg_1	527	530	PF00400	0.501
TRG_NLS_MonoCore_2	502	507	PF00514	0.556
TRG_NLS_MonoExtC_3	309	314	PF00514	0.715
TRG_NLS_MonoExtC_3	459	464	PF00514	0.698
TRG_NLS_MonoExtN_4	307	314	PF00514	0.685
TRG_NLS_MonoExtN_4	459	464	PF00514	0.785
TRG_NLS_MonoExtN_4	500	507	PF00514	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV6	Leptomonas seymouri	66%	100%
A0A0S4ISR7	Bodo saltans	39%	100%
A0A1X0NLU9	Trypanosomatidae	45%	92%
A0A3S5H5L9	Leishmania donovani	95%	100%
A0A422NBQ8	Trypanosoma rangeli	47%	99%
A4H4F4	Leishmania braziliensis	85%	100%
A4HSN1	Leishmania infantum	94%	100%
C9ZU64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	98%
Q4QJ93	Leishmania major	93%	100%
V5D7E1	Trypanosoma cruzi	45%	97%