Phosphatidylinositol 4-phosphate 5-kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphatidylinositol 4-phosphate 5-kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AKL5_LEIMU

TriTrypDb:

LmxM.05.1080

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKL5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.661
CLV_C14_Caspase3-7	40	44	PF00656	0.542
CLV_C14_Caspase3-7	580	584	PF00656	0.525
CLV_NRD_NRD_1	679	681	PF00675	0.498
CLV_NRD_NRD_1	718	720	PF00675	0.599
CLV_PCSK_FUR_1	114	118	PF00082	0.361
CLV_PCSK_KEX2_1	113	115	PF00082	0.350
CLV_PCSK_KEX2_1	116	118	PF00082	0.351
CLV_PCSK_KEX2_1	161	163	PF00082	0.543
CLV_PCSK_KEX2_1	215	217	PF00082	0.574
CLV_PCSK_KEX2_1	302	304	PF00082	0.357
CLV_PCSK_KEX2_1	515	517	PF00082	0.435
CLV_PCSK_KEX2_1	679	681	PF00082	0.534
CLV_PCSK_KEX2_1	718	720	PF00082	0.492
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.350
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.351
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.549
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.574
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.409
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.435
CLV_PCSK_SKI1_1	113	117	PF00082	0.367
DEG_APCC_DBOX_1	705	713	PF00400	0.512
DEG_APCC_KENBOX_2	251	255	PF00400	0.409
DEG_SIAH_1	685	693	PF03145	0.559
DOC_CDC14_PxL_1	450	458	PF14671	0.248
DOC_CKS1_1	695	700	PF01111	0.545
DOC_CYCLIN_yCln2_LP_2	602	605	PF00134	0.601
DOC_MAPK_gen_1	215	222	PF00069	0.546
DOC_MAPK_gen_1	48	58	PF00069	0.634
DOC_MAPK_MEF2A_6	215	224	PF00069	0.497
DOC_MAPK_MEF2A_6	412	421	PF00069	0.461
DOC_PP1_RVXF_1	257	264	PF00149	0.411
DOC_PP1_SILK_1	404	409	PF00149	0.389
DOC_PP2B_LxvP_1	419	422	PF13499	0.567
DOC_PP2B_LxvP_1	537	540	PF13499	0.536
DOC_PP2B_LxvP_1	601	604	PF13499	0.562
DOC_USP7_MATH_1	26	30	PF00917	0.542
DOC_USP7_MATH_1	289	293	PF00917	0.285
DOC_USP7_MATH_1	312	316	PF00917	0.284
DOC_USP7_MATH_1	520	524	PF00917	0.435
DOC_USP7_MATH_1	615	619	PF00917	0.524
DOC_USP7_MATH_1	646	650	PF00917	0.606
DOC_USP7_UBL2_3	302	306	PF12436	0.325
DOC_WW_Pin1_4	368	373	PF00397	0.182
DOC_WW_Pin1_4	553	558	PF00397	0.631
DOC_WW_Pin1_4	694	699	PF00397	0.563
LIG_14-3-3_CanoR_1	117	123	PF00244	0.490
LIG_14-3-3_CanoR_1	458	464	PF00244	0.405
LIG_14-3-3_CanoR_1	570	577	PF00244	0.638
LIG_14-3-3_CanoR_1	680	686	PF00244	0.498
LIG_14-3-3_CanoR_1	687	691	PF00244	0.545
LIG_14-3-3_CanoR_1	92	96	PF00244	0.378
LIG_Actin_WH2_2	443	460	PF00022	0.504
LIG_APCC_ABBA_1	413	418	PF00400	0.533
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BIR_III_4	583	587	PF00653	0.459
LIG_CaM_NSCaTE_8	459	466	PF13499	0.433
LIG_CtBP_PxDLS_1	191	195	PF00389	0.520
LIG_FHA_1	329	335	PF00498	0.325
LIG_FHA_1	596	602	PF00498	0.373
LIG_FHA_1	648	654	PF00498	0.499
LIG_FHA_2	142	148	PF00498	0.538
LIG_FHA_2	196	202	PF00498	0.545
LIG_FHA_2	441	447	PF00498	0.441
LIG_FHA_2	553	559	PF00498	0.704
LIG_HP1_1	544	548	PF01393	0.366
LIG_LIR_Gen_1	133	143	PF02991	0.493
LIG_LIR_Gen_1	193	202	PF02991	0.497
LIG_LIR_Gen_1	329	340	PF02991	0.408
LIG_LIR_Gen_1	54	63	PF02991	0.652
LIG_LIR_Gen_1	649	660	PF02991	0.400
LIG_LIR_LC3C_4	418	421	PF02991	0.474
LIG_LIR_Nem_3	193	199	PF02991	0.491
LIG_LIR_Nem_3	329	335	PF02991	0.408
LIG_LIR_Nem_3	54	58	PF02991	0.697
LIG_LIR_Nem_3	649	655	PF02991	0.407
LIG_LYPXL_yS_3	453	456	PF13949	0.235
LIG_MYND_1	701	705	PF01753	0.584
LIG_MYND_1	707	711	PF01753	0.485
LIG_NRBOX	532	538	PF00104	0.482
LIG_Pex14_2	340	344	PF04695	0.329
LIG_Rb_pABgroove_1	707	715	PF01858	0.509
LIG_SH2_NCK_1	492	496	PF00017	0.563
LIG_SH2_PTP2	18	21	PF00017	0.414
LIG_SH2_PTP2	223	226	PF00017	0.455
LIG_SH2_PTP2	55	58	PF00017	0.695
LIG_SH2_PTP2	652	655	PF00017	0.409
LIG_SH2_SRC	18	21	PF00017	0.414
LIG_SH2_SRC	309	312	PF00017	0.300
LIG_SH2_STAP1	132	136	PF00017	0.578
LIG_SH2_STAP1	622	626	PF00017	0.586
LIG_SH2_STAP1	713	717	PF00017	0.490
LIG_SH2_STAT5	110	113	PF00017	0.356
LIG_SH2_STAT5	18	21	PF00017	0.542
LIG_SH2_STAT5	223	226	PF00017	0.452
LIG_SH2_STAT5	271	274	PF00017	0.322
LIG_SH2_STAT5	294	297	PF00017	0.292
LIG_SH2_STAT5	309	312	PF00017	0.304
LIG_SH2_STAT5	363	366	PF00017	0.297
LIG_SH2_STAT5	378	381	PF00017	0.448
LIG_SH2_STAT5	55	58	PF00017	0.671
LIG_SH2_STAT5	652	655	PF00017	0.374
LIG_SH3_1	223	229	PF00018	0.552
LIG_SH3_3	223	229	PF00018	0.552
LIG_SH3_3	417	423	PF00018	0.446
LIG_SH3_3	514	520	PF00018	0.593
LIG_SH3_3	689	695	PF00018	0.539
LIG_SH3_3	7	13	PF00018	0.551
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.591
LIG_SUMO_SIM_anti_2	34	43	PF11976	0.484
LIG_SUMO_SIM_anti_2	501	507	PF11976	0.479
LIG_SUMO_SIM_anti_2	531	538	PF11976	0.385
LIG_SUMO_SIM_anti_2	543	549	PF11976	0.489
LIG_SUMO_SIM_par_1	506	512	PF11976	0.484
LIG_SUMO_SIM_par_1	533	538	PF11976	0.404
LIG_SUMO_SIM_par_1	543	549	PF11976	0.358
LIG_TRAF2_1	181	184	PF00917	0.698
LIG_TYR_ITIM	194	199	PF00017	0.492
LIG_TYR_ITSM	648	655	PF00017	0.527
LIG_WRC_WIRS_1	341	346	PF05994	0.474
MOD_CK1_1	25	31	PF00069	0.596
MOD_CK1_1	426	432	PF00069	0.659
MOD_CK1_1	462	468	PF00069	0.451
MOD_CK1_1	551	557	PF00069	0.696
MOD_CK1_1	572	578	PF00069	0.496
MOD_CK1_1	595	601	PF00069	0.585
MOD_CK2_1	141	147	PF00069	0.569
MOD_CK2_1	178	184	PF00069	0.760
MOD_CK2_1	26	32	PF00069	0.759
MOD_Cter_Amidation	300	303	PF01082	0.409
MOD_Cter_Amidation	513	516	PF01082	0.453
MOD_DYRK1A_RPxSP_1	694	698	PF00069	0.561
MOD_GlcNHglycan	170	173	PF01048	0.538
MOD_GlcNHglycan	24	27	PF01048	0.657
MOD_GlcNHglycan	242	245	PF01048	0.533
MOD_GlcNHglycan	303	306	PF01048	0.378
MOD_GlcNHglycan	328	331	PF01048	0.391
MOD_GlcNHglycan	350	353	PF01048	0.368
MOD_GlcNHglycan	357	360	PF01048	0.397
MOD_GlcNHglycan	395	398	PF01048	0.507
MOD_GlcNHglycan	425	428	PF01048	0.539
MOD_GlcNHglycan	464	467	PF01048	0.591
MOD_GlcNHglycan	60	63	PF01048	0.593
MOD_GlcNHglycan	641	644	PF01048	0.499
MOD_GSK3_1	22	29	PF00069	0.675
MOD_GSK3_1	236	243	PF00069	0.520
MOD_GSK3_1	336	343	PF00069	0.414
MOD_GSK3_1	398	405	PF00069	0.487
MOD_GSK3_1	518	525	PF00069	0.534
MOD_GSK3_1	548	555	PF00069	0.495
MOD_GSK3_1	569	576	PF00069	0.552
MOD_GSK3_1	591	598	PF00069	0.365
MOD_GSK3_1	662	669	PF00069	0.467
MOD_LATS_1	346	352	PF00433	0.380
MOD_N-GLC_1	368	373	PF02516	0.207
MOD_NEK2_1	236	241	PF00069	0.418
MOD_NEK2_1	335	340	PF00069	0.283
MOD_NEK2_1	407	412	PF00069	0.489
MOD_NEK2_1	425	430	PF00069	0.448
MOD_NEK2_1	509	514	PF00069	0.339
MOD_NEK2_1	548	553	PF00069	0.430
MOD_NEK2_1	58	63	PF00069	0.621
MOD_NEK2_1	591	596	PF00069	0.495
MOD_NEK2_2	357	362	PF00069	0.548
MOD_PIKK_1	136	142	PF00454	0.682
MOD_PKA_2	569	575	PF00069	0.510
MOD_PKA_2	627	633	PF00069	0.470
MOD_PKA_2	686	692	PF00069	0.638
MOD_PKA_2	91	97	PF00069	0.381
MOD_PKB_1	516	524	PF00069	0.503
MOD_Plk_1	501	507	PF00069	0.439
MOD_Plk_1	548	554	PF00069	0.519
MOD_Plk_1	572	578	PF00069	0.580
MOD_Plk_1	615	621	PF00069	0.558
MOD_Plk_1	646	652	PF00069	0.333
MOD_Plk_2-3	123	129	PF00069	0.577
MOD_Plk_2-3	178	184	PF00069	0.622
MOD_Plk_2-3	313	319	PF00069	0.279
MOD_Plk_4	236	242	PF00069	0.402
MOD_Plk_4	336	342	PF00069	0.381
MOD_Plk_4	398	404	PF00069	0.620
MOD_Plk_4	501	507	PF00069	0.410
MOD_Plk_4	615	621	PF00069	0.558
MOD_Plk_4	647	653	PF00069	0.410
MOD_Plk_4	91	97	PF00069	0.362
MOD_ProDKin_1	368	374	PF00069	0.182
MOD_ProDKin_1	553	559	PF00069	0.634
MOD_ProDKin_1	694	700	PF00069	0.567
MOD_SUMO_for_1	322	325	PF00179	0.409
MOD_SUMO_rev_2	392	401	PF00179	0.472
MOD_SUMO_rev_2	474	480	PF00179	0.483
MOD_SUMO_rev_2	629	638	PF00179	0.526
MOD_SUMO_rev_2	708	717	PF00179	0.616
TRG_DiLeu_BaEn_1	543	548	PF01217	0.358
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.492
TRG_ENDOCYTIC_2	196	199	PF00928	0.491
TRG_ENDOCYTIC_2	283	286	PF00928	0.391
TRG_ENDOCYTIC_2	332	335	PF00928	0.469
TRG_ENDOCYTIC_2	453	456	PF00928	0.394
TRG_ENDOCYTIC_2	55	58	PF00928	0.695
TRG_ENDOCYTIC_2	652	655	PF00928	0.397
TRG_ER_diArg_1	516	519	PF00400	0.496
TRG_NES_CRM1_1	498	511	PF08389	0.414
TRG_NLS_MonoExtC_3	112	117	PF00514	0.346
TRG_NLS_MonoExtC_3	514	519	PF00514	0.449
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V4	Leptomonas seymouri	71%	100%
A0A0S4IJQ0	Bodo saltans	36%	100%
A0A1X0NLQ2	Trypanosomatidae	43%	86%
A0A3S5H5L8	Leishmania donovani	94%	100%
A0A422NBM9	Trypanosoma rangeli	49%	93%
A4H4F3	Leishmania braziliensis	86%	100%
A4HSN0	Leishmania infantum	94%	100%
C9ZU66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	88%
Q4QJ94	Leishmania major	94%	100%
V5BBF6	Trypanosoma cruzi	50%	100%