L-type lectin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Legume-like lectin family, putative

Species:

Leishmania mexicana

UniProt:

E9AKL4_LEIMU

TriTrypDb:

LmxM.05.1070

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 6
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0000139	Golgi membrane	5	1
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AKL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKL4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007029	endoplasmic reticulum organization	5	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005537	mannose binding	4	1
GO:0030246	carbohydrate binding	2	2
GO:0036094	small molecule binding	2	1
GO:0048029	monosaccharide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.494
CLV_NRD_NRD_1	222	224	PF00675	0.634
CLV_NRD_NRD_1	227	229	PF00675	0.614
CLV_NRD_NRD_1	235	237	PF00675	0.644
CLV_NRD_NRD_1	3	5	PF00675	0.385
CLV_NRD_NRD_1	327	329	PF00675	0.566
CLV_NRD_NRD_1	384	386	PF00675	0.503
CLV_NRD_NRD_1	445	447	PF00675	0.630
CLV_NRD_NRD_1	448	450	PF00675	0.649
CLV_NRD_NRD_1	503	505	PF00675	0.586
CLV_PCSK_FUR_1	446	450	PF00082	0.655
CLV_PCSK_KEX2_1	222	224	PF00082	0.625
CLV_PCSK_KEX2_1	227	229	PF00082	0.607
CLV_PCSK_KEX2_1	235	237	PF00082	0.650
CLV_PCSK_KEX2_1	239	241	PF00082	0.596
CLV_PCSK_KEX2_1	3	5	PF00082	0.385
CLV_PCSK_KEX2_1	327	329	PF00082	0.458
CLV_PCSK_KEX2_1	384	386	PF00082	0.505
CLV_PCSK_KEX2_1	390	392	PF00082	0.557
CLV_PCSK_KEX2_1	447	449	PF00082	0.666
CLV_PCSK_KEX2_1	503	505	PF00082	0.583
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.623
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.610
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.599
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.682
CLV_PCSK_PC7_1	223	229	PF00082	0.647
CLV_PCSK_PC7_1	235	241	PF00082	0.590
CLV_PCSK_PC7_1	323	329	PF00082	0.474
CLV_PCSK_SKI1_1	222	226	PF00082	0.636
CLV_PCSK_SKI1_1	235	239	PF00082	0.573
CLV_PCSK_SKI1_1	359	363	PF00082	0.649
CLV_PCSK_SKI1_1	441	445	PF00082	0.713
CLV_PCSK_SKI1_1	452	456	PF00082	0.691
CLV_PCSK_SKI1_1	461	465	PF00082	0.638
CLV_Separin_Metazoa	408	412	PF03568	0.392
DEG_APCC_DBOX_1	447	455	PF00400	0.526
DEG_APCC_DBOX_1	472	480	PF00400	0.297
DEG_Nend_UBRbox_3	1	3	PF02207	0.577
DOC_CYCLIN_RxL_1	229	242	PF00134	0.488
DOC_MAPK_gen_1	249	258	PF00069	0.388
DOC_MAPK_gen_1	373	383	PF00069	0.296
DOC_MAPK_gen_1	460	468	PF00069	0.506
DOC_MAPK_gen_1	503	509	PF00069	0.475
DOC_MAPK_MEF2A_6	249	258	PF00069	0.388
DOC_MAPK_MEF2A_6	376	383	PF00069	0.292
DOC_PP1_RVXF_1	504	510	PF00149	0.430
DOC_PP2B_LxvP_1	302	305	PF13499	0.350
DOC_PP4_FxxP_1	65	68	PF00568	0.244
DOC_SPAK_OSR1_1	123	127	PF12202	0.244
DOC_USP7_MATH_1	36	40	PF00917	0.434
DOC_USP7_MATH_1	450	454	PF00917	0.546
DOC_USP7_MATH_1	68	72	PF00917	0.398
DOC_WW_Pin1_4	169	174	PF00397	0.507
DOC_WW_Pin1_4	326	331	PF00397	0.321
DOC_WW_Pin1_4	513	518	PF00397	0.394
LIG_14-3-3_CanoR_1	12	18	PF00244	0.532
LIG_14-3-3_CanoR_1	22	28	PF00244	0.310
LIG_14-3-3_CanoR_1	240	245	PF00244	0.442
LIG_14-3-3_CanoR_1	334	338	PF00244	0.439
LIG_14-3-3_CanoR_1	449	455	PF00244	0.479
LIG_14-3-3_CanoR_1	95	101	PF00244	0.257
LIG_deltaCOP1_diTrp_1	116	124	PF00928	0.338
LIG_deltaCOP1_diTrp_1	183	191	PF00928	0.476
LIG_FHA_1	108	114	PF00498	0.275
LIG_FHA_1	293	299	PF00498	0.392
LIG_FHA_1	378	384	PF00498	0.340
LIG_FHA_1	402	408	PF00498	0.426
LIG_FHA_1	489	495	PF00498	0.492
LIG_FHA_1	96	102	PF00498	0.275
LIG_FHA_2	207	213	PF00498	0.532
LIG_FHA_2	240	246	PF00498	0.427
LIG_FHA_2	360	366	PF00498	0.347
LIG_FHA_2	410	416	PF00498	0.384
LIG_FHA_2	462	468	PF00498	0.377
LIG_FHA_2	6	12	PF00498	0.548
LIG_FHA_2	95	101	PF00498	0.345
LIG_LIR_Apic_2	62	68	PF02991	0.244
LIG_LIR_Gen_1	296	305	PF02991	0.406
LIG_LIR_Gen_1	462	471	PF02991	0.414
LIG_LIR_Gen_1	91	101	PF02991	0.269
LIG_LIR_Nem_3	231	237	PF02991	0.385
LIG_LIR_Nem_3	296	302	PF02991	0.400
LIG_LIR_Nem_3	462	466	PF02991	0.425
LIG_LIR_Nem_3	91	96	PF02991	0.269
LIG_PDZ_Class_3	517	522	PF00595	0.497
LIG_Pex14_2	234	238	PF04695	0.488
LIG_Pex14_2	261	265	PF04695	0.340
LIG_PTB_Apo_2	87	94	PF02174	0.257
LIG_SH2_STAP1	167	171	PF00017	0.479
LIG_SH2_STAP1	413	417	PF00017	0.410
LIG_SH2_STAP1	488	492	PF00017	0.409
LIG_SH2_STAT3	152	155	PF00017	0.257
LIG_SH2_STAT3	374	377	PF00017	0.286
LIG_SH2_STAT5	152	155	PF00017	0.244
LIG_SH2_STAT5	299	302	PF00017	0.397
LIG_SH2_STAT5	413	416	PF00017	0.349
LIG_SH3_1	511	517	PF00018	0.436
LIG_SH3_3	343	349	PF00018	0.485
LIG_SH3_3	511	517	PF00018	0.438
LIG_SUMO_SIM_anti_2	365	372	PF11976	0.292
LIG_SUMO_SIM_anti_2	404	412	PF11976	0.398
LIG_TRAF2_1	209	212	PF00917	0.464
LIG_TRAF2_1	363	366	PF00917	0.376
LIG_TRAF2_1	64	67	PF00917	0.400
LIG_UBA3_1	233	239	PF00899	0.623
MOD_CDK_SPxxK_3	169	176	PF00069	0.645
MOD_CK1_1	311	317	PF00069	0.559
MOD_CK1_1	435	441	PF00069	0.399
MOD_CK1_1	5	11	PF00069	0.512
MOD_CK1_1	516	522	PF00069	0.515
MOD_CK2_1	206	212	PF00069	0.657
MOD_CK2_1	244	250	PF00069	0.503
MOD_CK2_1	359	365	PF00069	0.492
MOD_CK2_1	409	415	PF00069	0.479
MOD_CK2_1	5	11	PF00069	0.452
MOD_CK2_1	61	67	PF00069	0.412
MOD_GlcNHglycan	310	313	PF01048	0.643
MOD_GlcNHglycan	434	437	PF01048	0.363
MOD_GlcNHglycan	85	88	PF01048	0.300
MOD_GSK3_1	165	172	PF00069	0.641
MOD_GSK3_1	240	247	PF00069	0.514
MOD_GSK3_1	307	314	PF00069	0.579
MOD_GSK3_1	355	362	PF00069	0.590
MOD_GSK3_1	397	404	PF00069	0.475
MOD_GSK3_1	409	416	PF00069	0.417
MOD_N-GLC_1	135	140	PF02516	0.395
MOD_N-GLC_1	305	310	PF02516	0.548
MOD_NEK2_1	135	140	PF00069	0.369
MOD_NEK2_1	18	23	PF00069	0.411
MOD_NEK2_1	432	437	PF00069	0.343
MOD_NEK2_1	486	491	PF00069	0.486
MOD_NEK2_1	507	512	PF00069	0.631
MOD_NEK2_1	94	99	PF00069	0.425
MOD_NEK2_2	122	127	PF00069	0.195
MOD_NEK2_2	450	455	PF00069	0.581
MOD_PK_1	240	246	PF00069	0.561
MOD_PKA_1	222	228	PF00069	0.645
MOD_PKA_1	239	245	PF00069	0.471
MOD_PKA_2	11	17	PF00069	0.239
MOD_PKA_2	122	128	PF00069	0.279
MOD_PKA_2	2	8	PF00069	0.627
MOD_PKA_2	222	228	PF00069	0.621
MOD_PKA_2	239	245	PF00069	0.432
MOD_PKA_2	333	339	PF00069	0.483
MOD_PKA_2	94	100	PF00069	0.298
MOD_Plk_1	391	397	PF00069	0.523
MOD_Plk_1	61	67	PF00069	0.298
MOD_Plk_2-3	206	212	PF00069	0.666
MOD_Plk_2-3	392	398	PF00069	0.454
MOD_Plk_4	23	29	PF00069	0.350
MOD_Plk_4	294	300	PF00069	0.463
MOD_Plk_4	311	317	PF00069	0.534
MOD_Plk_4	377	383	PF00069	0.359
MOD_Plk_4	392	398	PF00069	0.464
MOD_ProDKin_1	169	175	PF00069	0.646
MOD_ProDKin_1	326	332	PF00069	0.387
MOD_ProDKin_1	513	519	PF00069	0.492
MOD_SUMO_for_1	389	392	PF00179	0.494
MOD_SUMO_rev_2	453	463	PF00179	0.555
MOD_SUMO_rev_2	478	486	PF00179	0.404
TRG_DiLeu_BaEn_1	366	371	PF01217	0.426
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.439
TRG_ENDOCYTIC_2	299	302	PF00928	0.494
TRG_ER_diArg_1	121	124	PF00400	0.282
TRG_ER_diArg_1	234	236	PF00400	0.549
TRG_ER_diArg_1	326	328	PF00400	0.479
TRG_ER_diArg_1	383	385	PF00400	0.366
TRG_ER_diArg_1	446	449	PF00400	0.625
TRG_NES_CRM1_1	470	482	PF08389	0.552
TRG_NLS_MonoCore_2	225	230	PF00514	0.611
TRG_NLS_MonoCore_2	445	450	PF00514	0.572
TRG_NLS_MonoExtC_3	225	230	PF00514	0.611
TRG_NLS_MonoExtC_3	445	450	PF00514	0.572
TRG_NLS_MonoExtN_4	223	230	PF00514	0.621
TRG_NLS_MonoExtN_4	444	451	PF00514	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIA0	Leptomonas seymouri	77%	100%
A0A1X0NKB0	Trypanosomatidae	43%	81%
A0A3R7LT82	Trypanosoma rangeli	47%	96%
A0A3S5H5L7	Leishmania donovani	92%	86%
A4H4F2	Leishmania braziliensis	88%	100%
A4HSM9	Leishmania infantum	93%	100%
C9ZU67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	84%
E8NHN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
Q4QJ95	Leishmania major	94%	100%
V5ARI9	Trypanosoma cruzi	46%	89%