Putative ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ATPase

Gene product:

ATPase, putative

Species:

Leishmania mexicana

UniProt:

E9AKL3_LEIMU

TriTrypDb:

LmxM.05.1061

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKL3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.371
CLV_NRD_NRD_1	27	29	PF00675	0.612
CLV_PCSK_KEX2_1	26	28	PF00082	0.601
CLV_PCSK_KEX2_1	68	70	PF00082	0.296
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.371
CLV_PCSK_SKI1_1	148	152	PF00082	0.397
CLV_PCSK_SKI1_1	226	230	PF00082	0.315
CLV_PCSK_SKI1_1	68	72	PF00082	0.296
DEG_Nend_UBRbox_1	1	3	PF02207	0.461
DEG_SCF_FBW7_1	135	140	PF00400	0.388
DOC_CKS1_1	134	139	PF01111	0.458
DOC_CYCLIN_RxL_1	223	233	PF00134	0.315
DOC_CYCLIN_RxL_1	63	73	PF00134	0.375
DOC_MAPK_DCC_7	99	108	PF00069	0.296
DOC_MAPK_gen_1	224	231	PF00069	0.315
DOC_MAPK_gen_1	305	312	PF00069	0.550
DOC_MAPK_MEF2A_6	145	153	PF00069	0.316
DOC_MAPK_MEF2A_6	76	83	PF00069	0.315
DOC_MAPK_MEF2A_6	99	108	PF00069	0.296
DOC_PP2B_LxvP_1	252	255	PF13499	0.540
DOC_PP2B_LxvP_1	310	313	PF13499	0.545
DOC_USP7_MATH_1	137	141	PF00917	0.401
DOC_USP7_MATH_1	287	291	PF00917	0.584
DOC_WW_Pin1_4	133	138	PF00397	0.371
DOC_WW_Pin1_4	26	31	PF00397	0.579
LIG_14-3-3_CanoR_1	43	51	PF00244	0.371
LIG_14-3-3_CanoR_1	69	75	PF00244	0.371
LIG_APCC_ABBA_1	102	107	PF00400	0.315
LIG_APCC_ABBA_1	34	39	PF00400	0.315
LIG_BRCT_BRCA1_1	298	302	PF00533	0.437
LIG_Clathr_ClatBox_1	228	232	PF01394	0.339
LIG_Clathr_ClatBox_1	50	54	PF01394	0.296
LIG_FHA_1	13	19	PF00498	0.666
LIG_FHA_1	205	211	PF00498	0.296
LIG_LIR_Apic_2	132	137	PF02991	0.300
LIG_LIR_Gen_1	143	153	PF02991	0.293
LIG_LIR_Gen_1	195	205	PF02991	0.294
LIG_LIR_Gen_1	225	235	PF02991	0.401
LIG_LIR_Gen_1	306	316	PF02991	0.572
LIG_LIR_Nem_3	143	149	PF02991	0.291
LIG_LIR_Nem_3	195	201	PF02991	0.293
LIG_LIR_Nem_3	204	208	PF02991	0.287
LIG_LIR_Nem_3	225	230	PF02991	0.401
LIG_LIR_Nem_3	306	312	PF02991	0.554
LIG_LIR_Nem_3	73	77	PF02991	0.373
LIG_PCNA_yPIPBox_3	86	99	PF02747	0.458
LIG_Pex14_2	146	150	PF04695	0.269
LIG_Pex14_2	205	209	PF04695	0.296
LIG_SH2_GRB2like	218	221	PF00017	0.458
LIG_SH2_NCK_1	198	202	PF00017	0.315
LIG_SH2_SRC	218	221	PF00017	0.458
LIG_SH2_SRC	309	312	PF00017	0.471
LIG_SH2_STAP1	198	202	PF00017	0.296
LIG_SH2_STAT5	134	137	PF00017	0.296
LIG_SH2_STAT5	182	185	PF00017	0.414
LIG_SH2_STAT5	309	312	PF00017	0.406
LIG_SH3_3	168	174	PF00018	0.339
LIG_SH3_3	211	217	PF00018	0.371
LIG_SH3_3	244	250	PF00018	0.427
LIG_SH3_3	310	316	PF00018	0.536
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.316
LIG_SUMO_SIM_par_1	227	233	PF11976	0.339
LIG_SUMO_SIM_par_1	78	85	PF11976	0.315
LIG_TRAF2_1	4	7	PF00917	0.682
LIG_UBA3_1	114	119	PF00899	0.353
LIG_UBA3_1	149	155	PF00899	0.371
LIG_UBA3_1	301	307	PF00899	0.447
LIG_WRC_WIRS_1	71	76	PF05994	0.414
MOD_CK1_1	140	146	PF00069	0.337
MOD_CK2_1	1	7	PF00069	0.696
MOD_CK2_1	141	147	PF00069	0.377
MOD_CK2_1	271	277	PF00069	0.588
MOD_CK2_1	43	49	PF00069	0.306
MOD_GlcNHglycan	279	282	PF01048	0.604
MOD_GlcNHglycan	288	292	PF01048	0.486
MOD_GSK3_1	133	140	PF00069	0.325
MOD_GSK3_1	218	225	PF00069	0.338
MOD_N-GLC_1	12	17	PF02516	0.652
MOD_N-GLC_1	141	146	PF02516	0.414
MOD_N-GLC_1	20	25	PF02516	0.709
MOD_NEK2_1	230	235	PF00069	0.371
MOD_NEK2_1	70	75	PF00069	0.414
MOD_PKA_2	277	283	PF00069	0.564
MOD_Plk_1	287	293	PF00069	0.505
MOD_Plk_2-3	271	277	PF00069	0.648
MOD_Plk_4	130	136	PF00069	0.296
MOD_Plk_4	204	210	PF00069	0.303
MOD_Plk_4	230	236	PF00069	0.364
MOD_Plk_4	70	76	PF00069	0.414
MOD_ProDKin_1	133	139	PF00069	0.371
MOD_ProDKin_1	26	32	PF00069	0.575
MOD_SUMO_for_1	255	258	PF00179	0.629
MOD_SUMO_rev_2	219	225	PF00179	0.407
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.409
TRG_ENDOCYTIC_2	182	185	PF00928	0.379
TRG_ENDOCYTIC_2	198	201	PF00928	0.189
TRG_ENDOCYTIC_2	309	312	PF00928	0.510
TRG_ER_diArg_1	26	28	PF00400	0.685
TRG_NES_CRM1_1	293	308	PF08389	0.488
TRG_NES_CRM1_1	49	60	PF08389	0.296
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P494	Leptomonas seymouri	80%	68%
A0A0S4J9H9	Bodo saltans	52%	73%
A0A1X0NK74	Trypanosomatidae	62%	68%
A0A1X0NN10	Trypanosomatidae	28%	71%
A0A3R7K771	Trypanosoma rangeli	59%	68%
A0A3R7L848	Trypanosoma rangeli	26%	72%
A0A3S5H5L6	Leishmania donovani	96%	68%
A4H4F1	Leishmania braziliensis	91%	100%
A4HSM8	Leishmania infantum	97%	68%
C9ZU69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	66%
E9AKL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O42895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	71%
P46441	Haematobia irritans	37%	70%
P64612	Escherichia coli (strain K12)	29%	86%
P64613	Escherichia coli O157:H7	29%	86%
Q32PX9	Rattus norvegicus	34%	68%
Q3V384	Mus musculus	34%	68%
Q4QJ96	Leishmania major	96%	100%
Q8WV93	Homo sapiens	34%	67%