TGc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynein regulatory complex subunit 7, putative

Species:

Leishmania mexicana

UniProt:

E9AKK8_LEIMU

TriTrypDb:

LmxM.05.1020

Length:

919

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0005856	cytoskeleton	5	1

Expansion

Sequence features

E9AKK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKK8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0048870	cell motility	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.647
CLV_C14_Caspase3-7	285	289	PF00656	0.508
CLV_NRD_NRD_1	351	353	PF00675	0.506
CLV_NRD_NRD_1	379	381	PF00675	0.559
CLV_NRD_NRD_1	417	419	PF00675	0.420
CLV_NRD_NRD_1	457	459	PF00675	0.369
CLV_NRD_NRD_1	492	494	PF00675	0.464
CLV_NRD_NRD_1	54	56	PF00675	0.397
CLV_NRD_NRD_1	549	551	PF00675	0.397
CLV_NRD_NRD_1	618	620	PF00675	0.528
CLV_NRD_NRD_1	628	630	PF00675	0.459
CLV_NRD_NRD_1	709	711	PF00675	0.369
CLV_NRD_NRD_1	775	777	PF00675	0.441
CLV_NRD_NRD_1	779	781	PF00675	0.437
CLV_NRD_NRD_1	851	853	PF00675	0.502
CLV_PCSK_FUR_1	377	381	PF00082	0.514
CLV_PCSK_KEX2_1	351	353	PF00082	0.450
CLV_PCSK_KEX2_1	379	381	PF00082	0.527
CLV_PCSK_KEX2_1	417	419	PF00082	0.420
CLV_PCSK_KEX2_1	457	459	PF00082	0.365
CLV_PCSK_KEX2_1	628	630	PF00082	0.331
CLV_PCSK_KEX2_1	775	777	PF00082	0.500
CLV_PCSK_KEX2_1	846	848	PF00082	0.419
CLV_PCSK_PC1ET2_1	846	848	PF00082	0.484
CLV_PCSK_SKI1_1	270	274	PF00082	0.406
CLV_PCSK_SKI1_1	351	355	PF00082	0.508
CLV_PCSK_SKI1_1	523	527	PF00082	0.325
CLV_PCSK_SKI1_1	550	554	PF00082	0.319
CLV_PCSK_SKI1_1	56	60	PF00082	0.432
CLV_PCSK_SKI1_1	874	878	PF00082	0.391
DEG_APCC_DBOX_1	54	62	PF00400	0.340
DEG_APCC_DBOX_1	709	717	PF00400	0.465
DEG_SPOP_SBC_1	344	348	PF00917	0.390
DEG_SPOP_SBC_1	359	363	PF00917	0.523
DEG_SPOP_SBC_1	467	471	PF00917	0.517
DOC_CDC14_PxL_1	595	603	PF14671	0.512
DOC_CYCLIN_yCln2_LP_2	791	797	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	802	808	PF00134	0.353
DOC_MAPK_DCC_7	214	224	PF00069	0.459
DOC_MAPK_gen_1	577	586	PF00069	0.422
DOC_MAPK_gen_1	619	627	PF00069	0.241
DOC_MAPK_gen_1	710	718	PF00069	0.460
DOC_MAPK_gen_1	725	734	PF00069	0.465
DOC_MAPK_gen_1	836	844	PF00069	0.341
DOC_PP1_RVXF_1	492	499	PF00149	0.447
DOC_PP1_RVXF_1	839	845	PF00149	0.344
DOC_PP1_SILK_1	657	662	PF00149	0.483
DOC_PP2B_LxvP_1	259	262	PF13499	0.329
DOC_PP2B_LxvP_1	791	794	PF13499	0.401
DOC_PP2B_LxvP_1	802	805	PF13499	0.426
DOC_PP4_FxxP_1	273	276	PF00568	0.331
DOC_PP4_FxxP_1	315	318	PF00568	0.273
DOC_PP4_FxxP_1	59	62	PF00568	0.409
DOC_PP4_FxxP_1	627	630	PF00568	0.459
DOC_PP4_FxxP_1	666	669	PF00568	0.463
DOC_PP4_FxxP_1	75	78	PF00568	0.226
DOC_USP7_MATH_1	253	257	PF00917	0.434
DOC_USP7_MATH_1	286	290	PF00917	0.483
DOC_USP7_MATH_1	321	325	PF00917	0.363
DOC_USP7_MATH_1	467	471	PF00917	0.668
DOC_USP7_MATH_1	6	10	PF00917	0.371
DOC_USP7_MATH_1	667	671	PF00917	0.532
DOC_USP7_MATH_2	184	190	PF00917	0.554
DOC_USP7_UBL2_3	553	557	PF12436	0.434
DOC_USP7_UBL2_3	620	624	PF12436	0.469
DOC_WW_Pin1_4	125	130	PF00397	0.303
DOC_WW_Pin1_4	17	22	PF00397	0.461
DOC_WW_Pin1_4	240	245	PF00397	0.626
DOC_WW_Pin1_4	314	319	PF00397	0.481
LIG_14-3-3_CanoR_1	214	219	PF00244	0.542
LIG_14-3-3_CanoR_1	265	269	PF00244	0.369
LIG_14-3-3_CanoR_1	290	295	PF00244	0.386
LIG_14-3-3_CanoR_1	457	462	PF00244	0.369
LIG_14-3-3_CanoR_1	503	512	PF00244	0.495
LIG_14-3-3_CanoR_1	530	537	PF00244	0.431
LIG_14-3-3_CanoR_1	566	571	PF00244	0.293
LIG_14-3-3_CanoR_1	605	611	PF00244	0.445
LIG_14-3-3_CanoR_1	691	696	PF00244	0.492
LIG_14-3-3_CanoR_1	725	734	PF00244	0.423
LIG_14-3-3_CanoR_1	910	917	PF00244	0.518
LIG_Actin_WH2_2	200	216	PF00022	0.624
LIG_APCC_ABBA_1	704	709	PF00400	0.515
LIG_APCC_ABBA_1	80	85	PF00400	0.229
LIG_BRCT_BRCA1_1	568	572	PF00533	0.221
LIG_BRCT_BRCA1_1	606	610	PF00533	0.444
LIG_Clathr_ClatBox_1	86	90	PF01394	0.442
LIG_deltaCOP1_diTrp_1	134	141	PF00928	0.343
LIG_deltaCOP1_diTrp_1	561	568	PF00928	0.313
LIG_deltaCOP1_diTrp_1	647	652	PF00928	0.296
LIG_eIF4E_1	537	543	PF01652	0.419
LIG_FHA_1	164	170	PF00498	0.480
LIG_FHA_1	210	216	PF00498	0.620
LIG_FHA_1	241	247	PF00498	0.709
LIG_FHA_1	276	282	PF00498	0.332
LIG_FHA_1	353	359	PF00498	0.401
LIG_FHA_1	367	373	PF00498	0.564
LIG_FHA_1	407	413	PF00498	0.244
LIG_FHA_1	538	544	PF00498	0.446
LIG_FHA_2	129	135	PF00498	0.430
LIG_FHA_2	175	181	PF00498	0.475
LIG_FHA_2	215	221	PF00498	0.625
LIG_FHA_2	29	35	PF00498	0.398
LIG_FHA_2	290	296	PF00498	0.361
LIG_FHA_2	40	46	PF00498	0.349
LIG_FHA_2	505	511	PF00498	0.480
LIG_FHA_2	573	579	PF00498	0.451
LIG_FHA_2	642	648	PF00498	0.411
LIG_FHA_2	760	766	PF00498	0.482
LIG_HP1_1	202	206	PF01393	0.425
LIG_IBAR_NPY_1	201	203	PF08397	0.586
LIG_LIR_Apic_2	314	318	PF02991	0.279
LIG_LIR_Apic_2	567	573	PF02991	0.384
LIG_LIR_Apic_2	626	630	PF02991	0.430
LIG_LIR_Apic_2	74	78	PF02991	0.274
LIG_LIR_Apic_2	782	786	PF02991	0.354
LIG_LIR_Gen_1	256	262	PF02991	0.321
LIG_LIR_Gen_1	288	298	PF02991	0.475
LIG_LIR_Gen_1	324	330	PF02991	0.507
LIG_LIR_Gen_1	41	52	PF02991	0.424
LIG_LIR_Gen_1	436	447	PF02991	0.410
LIG_LIR_Gen_1	647	656	PF02991	0.327
LIG_LIR_Gen_1	750	759	PF02991	0.426
LIG_LIR_Gen_1	798	808	PF02991	0.414
LIG_LIR_Gen_1	895	906	PF02991	0.372
LIG_LIR_Nem_3	256	260	PF02991	0.311
LIG_LIR_Nem_3	288	294	PF02991	0.357
LIG_LIR_Nem_3	324	329	PF02991	0.498
LIG_LIR_Nem_3	41	47	PF02991	0.384
LIG_LIR_Nem_3	425	430	PF02991	0.378
LIG_LIR_Nem_3	436	442	PF02991	0.312
LIG_LIR_Nem_3	647	652	PF02991	0.339
LIG_LIR_Nem_3	750	755	PF02991	0.426
LIG_LIR_Nem_3	798	804	PF02991	0.445
LIG_LIR_Nem_3	866	872	PF02991	0.372
LIG_LIR_Nem_3	895	901	PF02991	0.376
LIG_LIR_Nem_3	98	102	PF02991	0.353
LIG_LYPXL_S_1	597	601	PF13949	0.387
LIG_LYPXL_yS_3	598	601	PF13949	0.481
LIG_MYND_1	599	603	PF01753	0.471
LIG_MYND_1	78	82	PF01753	0.248
LIG_Pex14_1	326	330	PF04695	0.467
LIG_Pex14_1	564	568	PF04695	0.412
LIG_Pex14_2	568	572	PF04695	0.215
LIG_Rb_LxCxE_1	866	885	PF01857	0.481
LIG_RPA_C_Fungi	285	297	PF08784	0.349
LIG_SH2_CRK	570	574	PF00017	0.466
LIG_SH2_CRK	752	756	PF00017	0.494
LIG_SH2_CRK	898	902	PF00017	0.389
LIG_SH2_GRB2like	28	31	PF00017	0.497
LIG_SH2_GRB2like	411	414	PF00017	0.347
LIG_SH2_NCK_1	291	295	PF00017	0.452
LIG_SH2_PTP2	159	162	PF00017	0.264
LIG_SH2_PTP2	203	206	PF00017	0.425
LIG_SH2_SRC	106	109	PF00017	0.506
LIG_SH2_SRC	411	414	PF00017	0.354
LIG_SH2_SRC	517	520	PF00017	0.458
LIG_SH2_STAP1	111	115	PF00017	0.465
LIG_SH2_STAP1	398	402	PF00017	0.359
LIG_SH2_STAP1	449	453	PF00017	0.391
LIG_SH2_STAP1	83	87	PF00017	0.375
LIG_SH2_STAT5	159	162	PF00017	0.264
LIG_SH2_STAT5	203	206	PF00017	0.472
LIG_SH2_STAT5	28	31	PF00017	0.381
LIG_SH2_STAT5	291	294	PF00017	0.335
LIG_SH2_STAT5	382	385	PF00017	0.461
LIG_SH2_STAT5	411	414	PF00017	0.496
LIG_SH2_STAT5	51	54	PF00017	0.373
LIG_SH2_STAT5	537	540	PF00017	0.448
LIG_SH2_STAT5	676	679	PF00017	0.558
LIG_SH2_STAT5	783	786	PF00017	0.356
LIG_SH2_STAT5	787	790	PF00017	0.356
LIG_SH2_STAT5	801	804	PF00017	0.392
LIG_SH2_STAT5	872	875	PF00017	0.362
LIG_SH2_STAT5	99	102	PF00017	0.321
LIG_SH3_3	18	24	PF00018	0.492
LIG_SH3_3	306	312	PF00018	0.386
LIG_SH3_3	429	435	PF00018	0.394
LIG_SH3_3	583	589	PF00018	0.426
LIG_SH3_3	682	688	PF00018	0.540
LIG_SH3_3	690	696	PF00018	0.415
LIG_SUMO_SIM_anti_2	142	147	PF11976	0.217
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.321
LIG_SUMO_SIM_par_1	144	149	PF11976	0.199
LIG_SUMO_SIM_par_1	220	225	PF11976	0.425
LIG_SUMO_SIM_par_1	31	42	PF11976	0.336
LIG_SUMO_SIM_par_1	747	754	PF11976	0.464
LIG_TRAF2_1	336	339	PF00917	0.402
LIG_TRAF2_1	672	675	PF00917	0.591
LIG_TRAF2_1	696	699	PF00917	0.474
LIG_TRAF2_1	818	821	PF00917	0.428
LIG_TYR_ITIM	100	105	PF00017	0.203
LIG_TYR_ITIM	81	86	PF00017	0.523
LIG_WRC_WIRS_1	565	570	PF05994	0.416
LIG_WRC_WIRS_1	72	77	PF05994	0.276
MOD_CDK_SPxxK_3	240	247	PF00069	0.623
MOD_CK1_1	128	134	PF00069	0.299
MOD_CK1_1	289	295	PF00069	0.553
MOD_CK1_1	314	320	PF00069	0.401
MOD_CK1_1	328	334	PF00069	0.515
MOD_CK1_1	347	353	PF00069	0.482
MOD_CK1_1	375	381	PF00069	0.656
MOD_CK1_1	4	10	PF00069	0.435
MOD_CK1_1	471	477	PF00069	0.643
MOD_CK1_1	478	484	PF00069	0.570
MOD_CK2_1	174	180	PF00069	0.420
MOD_CK2_1	186	192	PF00069	0.463
MOD_CK2_1	289	295	PF00069	0.390
MOD_CK2_1	321	327	PF00069	0.418
MOD_CK2_1	333	339	PF00069	0.557
MOD_CK2_1	467	473	PF00069	0.571
MOD_CK2_1	504	510	PF00069	0.496
MOD_CK2_1	572	578	PF00069	0.448
MOD_CK2_1	641	647	PF00069	0.483
MOD_CK2_1	668	674	PF00069	0.568
MOD_CK2_1	759	765	PF00069	0.507
MOD_CK2_1	855	861	PF00069	0.600
MOD_GlcNHglycan	163	166	PF01048	0.398
MOD_GlcNHglycan	232	235	PF01048	0.670
MOD_GlcNHglycan	284	287	PF01048	0.460
MOD_GlcNHglycan	4	7	PF01048	0.521
MOD_GlcNHglycan	464	467	PF01048	0.336
MOD_GlcNHglycan	477	480	PF01048	0.390
MOD_GlcNHglycan	592	595	PF01048	0.521
MOD_GlcNHglycan	635	638	PF01048	0.701
MOD_GlcNHglycan	679	682	PF01048	0.603
MOD_GlcNHglycan	856	860	PF01048	0.554
MOD_GlcNHglycan	911	914	PF01048	0.364
MOD_GSK3_1	169	176	PF00069	0.498
MOD_GSK3_1	182	189	PF00069	0.402
MOD_GSK3_1	2	9	PF00069	0.436
MOD_GSK3_1	209	216	PF00069	0.567
MOD_GSK3_1	222	229	PF00069	0.487
MOD_GSK3_1	26	33	PF00069	0.331
MOD_GSK3_1	282	289	PF00069	0.479
MOD_GSK3_1	321	328	PF00069	0.573
MOD_GSK3_1	339	346	PF00069	0.458
MOD_GSK3_1	358	365	PF00069	0.498
MOD_GSK3_1	457	464	PF00069	0.382
MOD_GSK3_1	467	474	PF00069	0.542
MOD_GSK3_1	475	482	PF00069	0.648
MOD_GSK3_1	629	636	PF00069	0.551
MOD_GSK3_1	747	754	PF00069	0.434
MOD_GSK3_1	800	807	PF00069	0.503
MOD_N-GLC_1	29	34	PF02516	0.463
MOD_N-GLC_1	505	510	PF02516	0.542
MOD_N-GLC_1	590	595	PF02516	0.625
MOD_N-GLC_1	612	617	PF02516	0.403
MOD_N-GLC_2	64	66	PF02516	0.265
MOD_NEK2_1	1	6	PF00069	0.497
MOD_NEK2_1	141	146	PF00069	0.262
MOD_NEK2_1	330	335	PF00069	0.541
MOD_NEK2_1	343	348	PF00069	0.524
MOD_NEK2_1	358	363	PF00069	0.427
MOD_NEK2_1	373	378	PF00069	0.559
MOD_NEK2_1	442	447	PF00069	0.383
MOD_NEK2_1	456	461	PF00069	0.431
MOD_NEK2_1	475	480	PF00069	0.672
MOD_NEK2_1	71	76	PF00069	0.307
MOD_NEK2_1	89	94	PF00069	0.308
MOD_NEK2_2	623	628	PF00069	0.236
MOD_PIKK_1	321	327	PF00454	0.367
MOD_PIKK_1	39	45	PF00454	0.409
MOD_PIKK_1	420	426	PF00454	0.460
MOD_PIKK_1	604	610	PF00454	0.418
MOD_PK_1	226	232	PF00069	0.614
MOD_PK_1	290	296	PF00069	0.383
MOD_PK_1	612	618	PF00069	0.473
MOD_PKA_1	226	232	PF00069	0.570
MOD_PKA_1	457	463	PF00069	0.332
MOD_PKA_2	213	219	PF00069	0.546
MOD_PKA_2	264	270	PF00069	0.379
MOD_PKA_2	289	295	PF00069	0.396
MOD_PKA_2	456	462	PF00069	0.322
MOD_PKA_2	604	610	PF00069	0.337
MOD_PKA_2	76	82	PF00069	0.380
MOD_PKA_2	909	915	PF00069	0.501
MOD_Plk_1	115	121	PF00069	0.440
MOD_Plk_1	141	147	PF00069	0.255
MOD_Plk_1	321	327	PF00069	0.566
MOD_Plk_1	407	413	PF00069	0.478
MOD_Plk_1	505	511	PF00069	0.480
MOD_Plk_1	544	550	PF00069	0.437
MOD_Plk_1	590	596	PF00069	0.627
MOD_Plk_1	612	618	PF00069	0.489
MOD_Plk_1	855	861	PF00069	0.587
MOD_Plk_1	874	880	PF00069	0.226
MOD_Plk_2-3	186	192	PF00069	0.495
MOD_Plk_2-3	699	705	PF00069	0.511
MOD_Plk_4	106	112	PF00069	0.422
MOD_Plk_4	146	152	PF00069	0.228
MOD_Plk_4	174	180	PF00069	0.508
MOD_Plk_4	226	232	PF00069	0.614
MOD_Plk_4	253	259	PF00069	0.318
MOD_Plk_4	311	317	PF00069	0.411
MOD_Plk_4	325	331	PF00069	0.579
MOD_Plk_4	339	345	PF00069	0.447
MOD_Plk_4	407	413	PF00069	0.524
MOD_Plk_4	457	463	PF00069	0.453
MOD_Plk_4	471	477	PF00069	0.650
MOD_Plk_4	580	586	PF00069	0.383
MOD_Plk_4	655	661	PF00069	0.397
MOD_Plk_4	71	77	PF00069	0.269
MOD_Plk_4	747	753	PF00069	0.429
MOD_ProDKin_1	125	131	PF00069	0.301
MOD_ProDKin_1	17	23	PF00069	0.456
MOD_ProDKin_1	240	246	PF00069	0.624
MOD_ProDKin_1	314	320	PF00069	0.475
MOD_SUMO_for_1	789	792	PF00179	0.410
MOD_SUMO_rev_2	172	177	PF00179	0.420
MOD_SUMO_rev_2	632	636	PF00179	0.586
MOD_SUMO_rev_2	703	713	PF00179	0.390
TRG_DiLeu_BaEn_1	339	344	PF01217	0.507
TRG_DiLeu_BaEn_1	717	722	PF01217	0.471
TRG_DiLeu_BaLyEn_6	822	827	PF01217	0.360
TRG_DiLeu_BaLyEn_6	883	888	PF01217	0.413
TRG_ENDOCYTIC_2	102	105	PF00928	0.192
TRG_ENDOCYTIC_2	159	162	PF00928	0.264
TRG_ENDOCYTIC_2	203	206	PF00928	0.488
TRG_ENDOCYTIC_2	291	294	PF00928	0.317
TRG_ENDOCYTIC_2	427	430	PF00928	0.387
TRG_ENDOCYTIC_2	439	442	PF00928	0.323
TRG_ENDOCYTIC_2	565	568	PF00928	0.408
TRG_ENDOCYTIC_2	598	601	PF00928	0.481
TRG_ENDOCYTIC_2	663	666	PF00928	0.421
TRG_ENDOCYTIC_2	752	755	PF00928	0.501
TRG_ENDOCYTIC_2	801	804	PF00928	0.392
TRG_ENDOCYTIC_2	83	86	PF00928	0.507
TRG_ENDOCYTIC_2	898	901	PF00928	0.374
TRG_ER_diArg_1	377	380	PF00400	0.534
TRG_ER_diArg_1	416	418	PF00400	0.414
TRG_ER_diArg_1	456	458	PF00400	0.362
TRG_ER_diArg_1	529	532	PF00400	0.396
TRG_ER_diArg_1	627	629	PF00400	0.477
TRG_ER_diArg_1	755	758	PF00400	0.412
TRG_NES_CRM1_1	782	796	PF08389	0.417
TRG_Pf-PMV_PEXEL_1	513	518	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	768	772	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	881	885	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0W5	Leptomonas seymouri	67%	100%
A0A0S4JUW0	Bodo saltans	43%	100%
A0A1X0NLT5	Trypanosomatidae	44%	94%
A0A3R7LNV4	Trypanosoma rangeli	44%	94%
A0A3S7WP94	Leishmania donovani	92%	100%
A4H4E7	Leishmania braziliensis	83%	100%
A4HSM4	Leishmania infantum	92%	100%
G2HE57	Pan troglodytes	27%	100%
Q0V9S9	Xenopus tropicalis	29%	100%
Q2T9M4	Bos taurus	26%	100%
Q4QJA0	Leishmania major	90%	100%
Q4V516	Drosophila melanogaster	23%	100%
Q6V3W6	Mus musculus	26%	100%
Q8IY82	Homo sapiens	27%	100%
Q95JL1	Macaca fascicularis	27%	100%
V5BGF3	Trypanosoma cruzi	45%	94%