Methyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase-like protein

Species:

Leishmania mexicana

UniProt:

E9AKK7_LEIMU

TriTrypDb:

LmxM.05.1010

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKK7

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009451	RNA modification	5	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0032259	methylation	2	10
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043414	macromolecule methylation	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004809	tRNA (guanine-N2-)-methyltransferase activity	6	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008175	tRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016423	tRNA (guanine) methyltransferase activity	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.471
CLV_C14_Caspase3-7	514	518	PF00656	0.563
CLV_C14_Caspase3-7	559	563	PF00656	0.764
CLV_C14_Caspase3-7	572	576	PF00656	0.562
CLV_MEL_PAP_1	466	472	PF00089	0.429
CLV_NRD_NRD_1	222	224	PF00675	0.408
CLV_NRD_NRD_1	301	303	PF00675	0.309
CLV_NRD_NRD_1	379	381	PF00675	0.216
CLV_NRD_NRD_1	476	478	PF00675	0.328
CLV_NRD_NRD_1	481	483	PF00675	0.350
CLV_NRD_NRD_1	529	531	PF00675	0.547
CLV_NRD_NRD_1	566	568	PF00675	0.630
CLV_PCSK_FUR_1	525	529	PF00082	0.591
CLV_PCSK_KEX2_1	149	151	PF00082	0.420
CLV_PCSK_KEX2_1	158	160	PF00082	0.450
CLV_PCSK_KEX2_1	224	226	PF00082	0.217
CLV_PCSK_KEX2_1	301	303	PF00082	0.309
CLV_PCSK_KEX2_1	476	478	PF00082	0.328
CLV_PCSK_KEX2_1	527	529	PF00082	0.496
CLV_PCSK_KEX2_1	531	533	PF00082	0.481
CLV_PCSK_KEX2_1	566	568	PF00082	0.666
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.485
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.490
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.230
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.496
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.481
CLV_PCSK_SKI1_1	213	217	PF00082	0.449
CLV_PCSK_SKI1_1	302	306	PF00082	0.309
CLV_PCSK_SKI1_1	591	595	PF00082	0.601
CLV_PCSK_SKI1_1	69	73	PF00082	0.268
DEG_APCC_DBOX_1	468	476	PF00400	0.361
DEG_APCC_DBOX_1	59	67	PF00400	0.395
DEG_Nend_UBRbox_1	1	4	PF02207	0.403
DEG_SCF_FBW7_1	486	493	PF00400	0.353
DEG_SPOP_SBC_1	383	387	PF00917	0.383
DOC_CDC14_PxL_1	80	88	PF14671	0.410
DOC_CKS1_1	487	492	PF01111	0.353
DOC_CKS1_1	548	553	PF01111	0.709
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.447
DOC_MAPK_gen_1	473	481	PF00069	0.442
DOC_MAPK_gen_1	500	508	PF00069	0.424
DOC_MAPK_MEF2A_6	501	510	PF00069	0.495
DOC_MAPK_RevD_3	470	483	PF00069	0.409
DOC_PP2B_LxvP_1	28	31	PF13499	0.450
DOC_PP2B_LxvP_1	335	338	PF13499	0.428
DOC_PP4_FxxP_1	16	19	PF00568	0.358
DOC_PP4_FxxP_1	441	444	PF00568	0.344
DOC_PP4_FxxP_1	54	57	PF00568	0.439
DOC_USP7_MATH_1	104	108	PF00917	0.581
DOC_USP7_MATH_1	235	239	PF00917	0.509
DOC_USP7_MATH_1	242	246	PF00917	0.509
DOC_USP7_MATH_1	394	398	PF00917	0.698
DOC_USP7_MATH_1	542	546	PF00917	0.611
DOC_USP7_MATH_1	58	62	PF00917	0.405
DOC_USP7_UBL2_3	527	531	PF12436	0.488
DOC_WW_Pin1_4	108	113	PF00397	0.673
DOC_WW_Pin1_4	291	296	PF00397	0.509
DOC_WW_Pin1_4	384	389	PF00397	0.416
DOC_WW_Pin1_4	486	491	PF00397	0.417
DOC_WW_Pin1_4	499	504	PF00397	0.628
DOC_WW_Pin1_4	53	58	PF00397	0.373
DOC_WW_Pin1_4	544	549	PF00397	0.610
LIG_14-3-3_CanoR_1	29	35	PF00244	0.418
LIG_14-3-3_CanoR_1	342	352	PF00244	0.509
LIG_14-3-3_CanoR_1	469	473	PF00244	0.376
LIG_14-3-3_CanoR_1	74	80	PF00244	0.352
LIG_Actin_WH2_2	459	475	PF00022	0.340
LIG_Actin_WH2_2	59	76	PF00022	0.343
LIG_AP2alpha_2	255	257	PF02296	0.415
LIG_BIR_III_4	278	282	PF00653	0.446
LIG_CSL_BTD_1	441	444	PF09270	0.432
LIG_deltaCOP1_diTrp_1	47	54	PF00928	0.446
LIG_FHA_1	115	121	PF00498	0.579
LIG_FHA_1	123	129	PF00498	0.433
LIG_FHA_1	217	223	PF00498	0.374
LIG_FHA_1	25	31	PF00498	0.353
LIG_FHA_1	258	264	PF00498	0.428
LIG_FHA_1	352	358	PF00498	0.453
LIG_FHA_1	385	391	PF00498	0.540
LIG_FHA_1	416	422	PF00498	0.383
LIG_FHA_1	429	435	PF00498	0.417
LIG_FHA_2	31	37	PF00498	0.429
LIG_FHA_2	315	321	PF00498	0.444
LIG_FHA_2	448	454	PF00498	0.392
LIG_FHA_2	551	557	PF00498	0.637
LIG_FHA_2	76	82	PF00498	0.427
LIG_FHA_2	83	89	PF00498	0.407
LIG_LIR_Apic_2	15	19	PF02991	0.393
LIG_LIR_Apic_2	165	171	PF02991	0.519
LIG_LIR_Apic_2	440	444	PF02991	0.375
LIG_LIR_Apic_2	52	57	PF02991	0.373
LIG_LIR_Gen_1	20	28	PF02991	0.422
LIG_LIR_Gen_1	431	439	PF02991	0.323
LIG_LIR_Gen_1	48	58	PF02991	0.329
LIG_LIR_Gen_1	87	94	PF02991	0.464
LIG_LIR_LC3C_4	431	435	PF02991	0.329
LIG_LIR_Nem_3	20	24	PF02991	0.410
LIG_LIR_Nem_3	328	333	PF02991	0.420
LIG_LIR_Nem_3	412	416	PF02991	0.533
LIG_LIR_Nem_3	431	435	PF02991	0.433
LIG_LIR_Nem_3	47	53	PF02991	0.363
LIG_LIR_Nem_3	520	524	PF02991	0.531
LIG_LIR_Nem_3	87	93	PF02991	0.459
LIG_Pex14_1	50	54	PF04695	0.417
LIG_SH2_CRK	333	337	PF00017	0.509
LIG_SH2_PTP2	176	179	PF00017	0.362
LIG_SH2_PTP2	3	6	PF00017	0.338
LIG_SH2_STAP1	133	137	PF00017	0.389
LIG_SH2_STAP1	144	148	PF00017	0.316
LIG_SH2_STAT3	133	136	PF00017	0.449
LIG_SH2_STAT5	176	179	PF00017	0.421
LIG_SH2_STAT5	227	230	PF00017	0.415
LIG_SH2_STAT5	252	255	PF00017	0.446
LIG_SH2_STAT5	3	6	PF00017	0.394
LIG_SH2_STAT5	432	435	PF00017	0.422
LIG_SH2_STAT5	449	452	PF00017	0.321
LIG_SH2_STAT5	77	80	PF00017	0.350
LIG_SH3_3	250	256	PF00018	0.444
LIG_SH3_3	385	391	PF00018	0.655
LIG_SH3_3	452	458	PF00018	0.351
LIG_SH3_3	484	490	PF00018	0.481
LIG_SH3_3	545	551	PF00018	0.592
LIG_TRAF2_1	234	237	PF00917	0.509
LIG_TRAF2_1	317	320	PF00917	0.471
LIG_TRFH_1	333	337	PF08558	0.446
LIG_UBA3_1	478	483	PF00899	0.357
MOD_CDK_SPxxK_3	53	60	PF00069	0.384
MOD_CK1_1	107	113	PF00069	0.604
MOD_CK1_1	131	137	PF00069	0.512
MOD_CK1_1	211	217	PF00069	0.398
MOD_CK1_1	325	331	PF00069	0.391
MOD_CK1_1	367	373	PF00069	0.513
MOD_CK1_1	493	499	PF00069	0.485
MOD_CK1_1	546	552	PF00069	0.679
MOD_CK1_1	56	62	PF00069	0.444
MOD_CK1_1	598	604	PF00069	0.421
MOD_CK1_1	9	15	PF00069	0.451
MOD_CK2_1	314	320	PF00069	0.450
MOD_CK2_1	447	453	PF00069	0.404
MOD_CK2_1	49	55	PF00069	0.433
MOD_CK2_1	56	62	PF00069	0.457
MOD_CK2_1	75	81	PF00069	0.205
MOD_Cter_Amidation	140	143	PF01082	0.435
MOD_Cter_Amidation	567	570	PF01082	0.716
MOD_GlcNHglycan	102	105	PF01048	0.621
MOD_GlcNHglycan	144	147	PF01048	0.457
MOD_GlcNHglycan	213	216	PF01048	0.399
MOD_GlcNHglycan	244	247	PF01048	0.269
MOD_GlcNHglycan	345	348	PF01048	0.277
MOD_GlcNHglycan	360	363	PF01048	0.364
MOD_GlcNHglycan	413	416	PF01048	0.498
MOD_GlcNHglycan	540	543	PF01048	0.553
MOD_GlcNHglycan	558	561	PF01048	0.681
MOD_GlcNHglycan	9	12	PF01048	0.374
MOD_GSK3_1	104	111	PF00069	0.642
MOD_GSK3_1	123	130	PF00069	0.359
MOD_GSK3_1	382	389	PF00069	0.676
MOD_GSK3_1	411	418	PF00069	0.378
MOD_GSK3_1	443	450	PF00069	0.377
MOD_GSK3_1	45	52	PF00069	0.423
MOD_GSK3_1	486	493	PF00069	0.606
MOD_GSK3_1	538	545	PF00069	0.562
MOD_GSK3_1	546	553	PF00069	0.634
MOD_GSK3_1	604	611	PF00069	0.665
MOD_GSK3_1	75	82	PF00069	0.463
MOD_GSK3_1	96	103	PF00069	0.551
MOD_N-GLC_1	242	247	PF02516	0.309
MOD_N-GLC_1	343	348	PF02516	0.271
MOD_NEK2_1	128	133	PF00069	0.534
MOD_NEK2_1	257	262	PF00069	0.427
MOD_NEK2_1	343	348	PF00069	0.471
MOD_NEK2_1	428	433	PF00069	0.355
MOD_NEK2_1	49	54	PF00069	0.428
MOD_NEK2_1	7	12	PF00069	0.393
MOD_NEK2_1	79	84	PF00069	0.407
MOD_NEK2_2	75	80	PF00069	0.346
MOD_PKA_1	142	148	PF00069	0.437
MOD_PKA_1	569	575	PF00069	0.616
MOD_PKA_2	468	474	PF00069	0.364
MOD_PKA_2	493	499	PF00069	0.511
MOD_PKB_1	567	575	PF00069	0.678
MOD_Plk_1	123	129	PF00069	0.478
MOD_Plk_1	235	241	PF00069	0.471
MOD_Plk_1	343	349	PF00069	0.471
MOD_Plk_2-3	447	453	PF00069	0.492
MOD_Plk_4	235	241	PF00069	0.471
MOD_Plk_4	259	265	PF00069	0.429
MOD_Plk_4	322	328	PF00069	0.391
MOD_Plk_4	364	370	PF00069	0.509
MOD_Plk_4	428	434	PF00069	0.351
MOD_Plk_4	437	443	PF00069	0.329
MOD_Plk_4	45	51	PF00069	0.492
MOD_Plk_4	75	81	PF00069	0.468
MOD_ProDKin_1	108	114	PF00069	0.671
MOD_ProDKin_1	291	297	PF00069	0.509
MOD_ProDKin_1	384	390	PF00069	0.421
MOD_ProDKin_1	486	492	PF00069	0.412
MOD_ProDKin_1	499	505	PF00069	0.631
MOD_ProDKin_1	53	59	PF00069	0.377
MOD_ProDKin_1	544	550	PF00069	0.614
MOD_SUMO_for_1	526	529	PF00179	0.590
MOD_SUMO_rev_2	145	151	PF00179	0.492
MOD_SUMO_rev_2	56	66	PF00179	0.346
TRG_DiLeu_BaEn_1	68	73	PF01217	0.410
TRG_DiLeu_BaEn_4	318	324	PF01217	0.495
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.456
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.387
TRG_ENDOCYTIC_2	175	178	PF00928	0.376
TRG_ENDOCYTIC_2	254	257	PF00928	0.460
TRG_ENDOCYTIC_2	3	6	PF00928	0.338
TRG_ENDOCYTIC_2	432	435	PF00928	0.324
TRG_ENDOCYTIC_2	77	80	PF00928	0.350
TRG_ENDOCYTIC_2	90	93	PF00928	0.408
TRG_ER_diArg_1	222	225	PF00400	0.407
TRG_ER_diArg_1	301	303	PF00400	0.509
TRG_ER_diArg_1	340	343	PF00400	0.428
TRG_ER_diArg_1	475	477	PF00400	0.325
TRG_ER_diArg_1	566	569	PF00400	0.666
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAW4	Leptomonas seymouri	68%	100%
A0A0S4JG90	Bodo saltans	36%	100%
A0A1X0NLX9	Trypanosomatidae	43%	100%
A0A3S7WP82	Leishmania donovani	92%	100%
A0A422N510	Trypanosoma rangeli	45%	100%
A4H4E6	Leishmania braziliensis	86%	100%
A4HSM3	Leishmania infantum	92%	100%
Q12463	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q4QJA1	Leishmania major	92%	100%
Q54QA6	Dictyostelium discoideum	27%	100%
Q9CWH5	Mus musculus	28%	100%
V5B7D5	Trypanosoma cruzi	45%	100%