Mercaptopyruvate sulfurtransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mercaptopyruvate sulfurtransferase

Species:

Leishmania mexicana

UniProt:

E9AKK3_LEIMU

TriTrypDb:

LmxM.05.0970

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKK3

PDB structure(s): 1okg_A

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	1
GO:0000097	sulfur amino acid biosynthetic process	5	1
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006534	cysteine metabolic process	5	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008652	amino acid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009069	serine family amino acid metabolic process	5	1
GO:0009070	serine family amino acid biosynthetic process	6	1
GO:0009092	homoserine metabolic process	6	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019343	cysteine biosynthetic process via cystathionine	7	1
GO:0019344	cysteine biosynthetic process	6	1
GO:0019346	transsulfuration	6	1
GO:0019499	cyanide metabolic process	3	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044272	sulfur compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0050667	homocysteine metabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1
GO:1901607	alpha-amino acid biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016740	transferase activity	2	13
GO:0016782	transferase activity, transferring sulphur-containing groups	3	13
GO:0016783	sulfurtransferase activity	4	13
GO:0016784	3-mercaptopyruvate sulfurtransferase activity	5	8
GO:0004792	thiosulfate sulfurtransferase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.370
CLV_C14_Caspase3-7	332	336	PF00656	0.366
CLV_PCSK_SKI1_1	13	17	PF00082	0.377
CLV_PCSK_SKI1_1	159	163	PF00082	0.361
CLV_PCSK_SKI1_1	359	363	PF00082	0.370
CLV_PCSK_SKI1_1	66	70	PF00082	0.253
DEG_SPOP_SBC_1	68	72	PF00917	0.498
DOC_CKS1_1	306	311	PF01111	0.426
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	271	277	PF00134	0.352
DOC_MAPK_gen_1	356	365	PF00069	0.341
DOC_MAPK_HePTP_8	353	365	PF00069	0.317
DOC_MAPK_MEF2A_6	356	365	PF00069	0.314
DOC_PP1_RVXF_1	110	116	PF00149	0.538
DOC_PP2B_LxvP_1	149	152	PF13499	0.309
DOC_PP4_FxxP_1	15	18	PF00568	0.513
DOC_PP4_FxxP_1	288	291	PF00568	0.489
DOC_USP7_MATH_1	209	213	PF00917	0.436
DOC_USP7_UBL2_3	49	53	PF12436	0.553
DOC_USP7_UBL2_3	9	13	PF12436	0.480
DOC_WW_Pin1_4	305	310	PF00397	0.346
LIG_14-3-3_CanoR_1	185	191	PF00244	0.360
LIG_14-3-3_CanoR_1	34	38	PF00244	0.492
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_BRCT_BRCA1_1	247	251	PF00533	0.499
LIG_BRCT_BRCA1_1	284	288	PF00533	0.414
LIG_EH1_1	299	307	PF00400	0.156
LIG_eIF4E_1	300	306	PF01652	0.156
LIG_FHA_1	256	262	PF00498	0.295
LIG_FHA_1	306	312	PF00498	0.397
LIG_FHA_1	319	325	PF00498	0.253
LIG_FHA_1	360	366	PF00498	0.294
LIG_FHA_2	214	220	PF00498	0.552
LIG_Integrin_RGD_1	217	219	PF01839	0.508
LIG_LIR_Apic_2	285	291	PF02991	0.477
LIG_LIR_Nem_3	27	31	PF02991	0.474
LIG_LIR_Nem_3	280	284	PF02991	0.311
LIG_PTB_Apo_2	125	132	PF02174	0.482
LIG_SH2_CRK	284	288	PF00017	0.449
LIG_SH2_STAP1	210	214	PF00017	0.488
LIG_SH2_STAP1	35	39	PF00017	0.498
LIG_SH2_STAT5	125	128	PF00017	0.442
LIG_SH2_STAT5	166	169	PF00017	0.503
LIG_SH2_STAT5	275	278	PF00017	0.321
LIG_SH2_STAT5	354	357	PF00017	0.426
LIG_SH3_2	8	13	PF14604	0.508
LIG_SH3_3	363	369	PF00018	0.370
LIG_SH3_3	5	11	PF00018	0.541
LIG_SH3_3	73	79	PF00018	0.520
LIG_SUMO_SIM_par_1	359	364	PF11976	0.324
LIG_TRAF2_1	225	228	PF00917	0.464
MOD_CK1_1	252	258	PF00069	0.410
MOD_CK1_1	282	288	PF00069	0.384
MOD_CK1_1	340	346	PF00069	0.322
MOD_CK2_1	222	228	PF00069	0.494
MOD_CK2_1	277	283	PF00069	0.327
MOD_GlcNHglycan	1	4	PF01048	0.701
MOD_GlcNHglycan	142	145	PF01048	0.510
MOD_GlcNHglycan	181	184	PF01048	0.455
MOD_GlcNHglycan	254	257	PF01048	0.356
MOD_GlcNHglycan	283	287	PF01048	0.426
MOD_GlcNHglycan	339	342	PF01048	0.346
MOD_GlcNHglycan	356	359	PF01048	0.346
MOD_GlcNHglycan	53	56	PF01048	0.330
MOD_GSK3_1	140	147	PF00069	0.595
MOD_GSK3_1	175	182	PF00069	0.467
MOD_GSK3_1	209	216	PF00069	0.325
MOD_GSK3_1	241	248	PF00069	0.499
MOD_N-GLC_1	62	67	PF02516	0.316
MOD_NEK2_1	116	121	PF00069	0.496
MOD_NEK2_1	186	191	PF00069	0.388
MOD_NEK2_1	249	254	PF00069	0.422
MOD_NEK2_1	67	72	PF00069	0.382
MOD_NEK2_2	33	38	PF00069	0.553
MOD_PKA_2	33	39	PF00069	0.510
MOD_Plk_1	244	250	PF00069	0.443
MOD_Plk_2-3	41	47	PF00069	0.428
MOD_Plk_4	232	238	PF00069	0.443
MOD_Plk_4	245	251	PF00069	0.308
MOD_Plk_4	349	355	PF00069	0.447
MOD_ProDKin_1	305	311	PF00069	0.346
TRG_ENDOCYTIC_2	28	31	PF00928	0.474
TRG_ENDOCYTIC_2	284	287	PF00928	0.461
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3F3	Leptomonas seymouri	64%	100%
A0A1X0NGL1	Trypanosomatidae	52%	100%
A0A1X0NKY9	Trypanosomatidae	50%	98%
A0A3S5H5L1	Leishmania donovani	95%	100%
A0A422NHF2	Trypanosoma rangeli	47%	68%
A0A422NMA2	Trypanosoma rangeli	47%	100%
A4H4E2	Leishmania braziliensis	86%	100%
A4HSL9	Leishmania infantum	95%	100%
C9ZTR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	99%
O64530	Arabidopsis thaliana	27%	98%
P00586	Bos taurus	30%	100%
P24329	Rattus norvegicus	31%	100%
P25324	Gallus gallus	30%	100%
P25325	Homo sapiens	30%	100%
P31142	Escherichia coli (strain K12)	29%	100%
P46635	Cricetulus griseus	30%	100%
P52196	Mus musculus	29%	100%
P58388	Escherichia coli O157:H7	29%	100%
P97532	Rattus norvegicus	29%	100%
P9WHF4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	30%	100%
P9WHF5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
Q08686	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q16762	Homo sapiens	31%	100%
Q24JL3	Arabidopsis thaliana	26%	100%
Q7K9G0	Leishmania major	96%	100%
Q99J99	Mus musculus	29%	100%
Q9I452	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	34%	100%
Q9RXT9	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	25%	100%
Q9USJ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
V5BNL9	Trypanosoma cruzi	52%	96%