Mercaptopyruvate sulfurtransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mercaptopyruvate sulfurtransferase

Species:

Leishmania mexicana

UniProt:

E9AKK3_LEIMU

TriTrypDb:

LmxM.05.0970

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AKK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKK3

PDB structure(s): 1okg_A

Function

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Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	1
GO:0000097	sulfur amino acid biosynthetic process	5	1
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006534	cysteine metabolic process	5	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008652	amino acid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004792	thiosulfate sulfurtransferase activity	5	4
GO:0016740	transferase activity	2	13
GO:0016782	transferase activity, transferring sulphur-containing groups	3	13
GO:0016783	sulfurtransferase activity	4	13
GO:0016784	3-mercaptopyruvate sulfurtransferase activity	5	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.370
CLV_C14_Caspase3-7	332	336	PF00656	0.366
CLV_PCSK_SKI1_1	13	17	PF00082	0.377
CLV_PCSK_SKI1_1	159	163	PF00082	0.361
CLV_PCSK_SKI1_1	359	363	PF00082	0.370
CLV_PCSK_SKI1_1	66	70	PF00082	0.253
DEG_SPOP_SBC_1	68	72	PF00917	0.498
DOC_CKS1_1	306	311	PF01111	0.426
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	271	277	PF00134	0.352

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3F3	Leptomonas seymouri	64%	100%
A0A1X0NGL1	Trypanosomatidae	52%	100%
A0A1X0NKY9	Trypanosomatidae	50%	98%
A0A3S5H5L1	Leishmania donovani	95%	100%
A0A422NHF2	Trypanosoma rangeli	47%	68%
A0A422NMA2	Trypanosoma rangeli	47%	100%
A4H4E2	Leishmania braziliensis	86%	100%
A4HSL9	Leishmania infantum	95%	100%
C9ZTR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	99%
O64530	Arabidopsis thaliana	27%	98%

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