LeishMANIAdb
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Putative glutaminyl cyclase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glutaminyl cyclase
Gene product:
glutaminyl cyclase, putative
Species:
Leishmania mexicana
UniProt:
E9AKK1_LEIMU
TriTrypDb:
LmxM.05.0950
Length:
908

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9AKK1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKK1

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase 7 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018199 peptidyl-glutamine modification 6 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016740 transferase activity 2 7
GO:0016746 acyltransferase activity 3 7
GO:0005488 binding 1 1
GO:0008270 zinc ion binding 6 1
GO:0016603 glutaminyl-peptide cyclotransferase activity 4 4
GO:0016755 aminoacyltransferase activity 3 4
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0046914 transition metal ion binding 5 1
GO:0140096 catalytic activity, acting on a protein 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 184 188 PF00656 0.531
CLV_C14_Caspase3-7 229 233 PF00656 0.524
CLV_C14_Caspase3-7 276 280 PF00656 0.493
CLV_NRD_NRD_1 11 13 PF00675 0.493
CLV_NRD_NRD_1 126 128 PF00675 0.705
CLV_NRD_NRD_1 14 16 PF00675 0.466
CLV_NRD_NRD_1 143 145 PF00675 0.569
CLV_NRD_NRD_1 162 164 PF00675 0.567
CLV_NRD_NRD_1 18 20 PF00675 0.443
CLV_NRD_NRD_1 246 248 PF00675 0.720
CLV_NRD_NRD_1 337 339 PF00675 0.590
CLV_NRD_NRD_1 366 368 PF00675 0.662
CLV_NRD_NRD_1 372 374 PF00675 0.668
CLV_NRD_NRD_1 721 723 PF00675 0.649
CLV_NRD_NRD_1 748 750 PF00675 0.710
CLV_NRD_NRD_1 838 840 PF00675 0.478
CLV_NRD_NRD_1 905 907 PF00675 0.667
CLV_PCSK_FUR_1 12 16 PF00082 0.495
CLV_PCSK_KEX2_1 10 12 PF00082 0.503
CLV_PCSK_KEX2_1 14 16 PF00082 0.462
CLV_PCSK_KEX2_1 142 144 PF00082 0.701
CLV_PCSK_KEX2_1 162 164 PF00082 0.566
CLV_PCSK_KEX2_1 18 20 PF00082 0.438
CLV_PCSK_KEX2_1 230 232 PF00082 0.665
CLV_PCSK_KEX2_1 245 247 PF00082 0.666
CLV_PCSK_KEX2_1 30 32 PF00082 0.443
CLV_PCSK_KEX2_1 337 339 PF00082 0.590
CLV_PCSK_KEX2_1 365 367 PF00082 0.672
CLV_PCSK_KEX2_1 721 723 PF00082 0.649
CLV_PCSK_KEX2_1 748 750 PF00082 0.716
CLV_PCSK_KEX2_1 838 840 PF00082 0.486
CLV_PCSK_PC1ET2_1 142 144 PF00082 0.631
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.665
CLV_PCSK_PC1ET2_1 30 32 PF00082 0.458
CLV_PCSK_PC7_1 10 16 PF00082 0.481
CLV_PCSK_SKI1_1 14 18 PF00082 0.409
CLV_PCSK_SKI1_1 151 155 PF00082 0.680
CLV_PCSK_SKI1_1 231 235 PF00082 0.792
CLV_PCSK_SKI1_1 267 271 PF00082 0.702
CLV_PCSK_SKI1_1 272 276 PF00082 0.690
CLV_PCSK_SKI1_1 352 356 PF00082 0.707
CLV_PCSK_SKI1_1 374 378 PF00082 0.749
CLV_PCSK_SKI1_1 410 414 PF00082 0.752
CLV_PCSK_SKI1_1 421 425 PF00082 0.744
CLV_PCSK_SKI1_1 486 490 PF00082 0.478
CLV_PCSK_SKI1_1 50 54 PF00082 0.284
CLV_PCSK_SKI1_1 529 533 PF00082 0.671
CLV_PCSK_SKI1_1 693 697 PF00082 0.570
CLV_PCSK_SKI1_1 748 752 PF00082 0.729
CLV_PCSK_SKI1_1 841 845 PF00082 0.508
DEG_APCC_DBOX_1 142 150 PF00400 0.503
DEG_APCC_DBOX_1 266 274 PF00400 0.374
DEG_APCC_DBOX_1 49 57 PF00400 0.481
DEG_APCC_DBOX_1 537 545 PF00400 0.411
DEG_APCC_DBOX_1 587 595 PF00400 0.333
DEG_Nend_UBRbox_3 1 3 PF02207 0.690
DOC_CDC14_PxL_1 466 474 PF14671 0.308
DOC_CKS1_1 91 96 PF01111 0.419
DOC_CYCLIN_RxL_1 10 21 PF00134 0.594
DOC_CYCLIN_RxL_1 261 271 PF00134 0.485
DOC_CYCLIN_yCln2_LP_2 544 550 PF00134 0.400
DOC_MAPK_DCC_7 30 38 PF00069 0.622
DOC_MAPK_DCC_7 858 867 PF00069 0.337
DOC_MAPK_FxFP_2 201 204 PF00069 0.453
DOC_MAPK_FxFP_2 328 331 PF00069 0.354
DOC_MAPK_gen_1 30 38 PF00069 0.622
DOC_MAPK_gen_1 48 56 PF00069 0.544
DOC_MAPK_gen_1 721 730 PF00069 0.481
DOC_MAPK_gen_1 838 845 PF00069 0.308
DOC_MAPK_MEF2A_6 30 38 PF00069 0.622
DOC_MAPK_MEF2A_6 50 58 PF00069 0.492
DOC_MAPK_MEF2A_6 721 730 PF00069 0.455
DOC_MAPK_MEF2A_6 858 867 PF00069 0.337
DOC_PP2B_LxvP_1 202 205 PF13499 0.451
DOC_PP2B_PxIxI_1 597 603 PF00149 0.360
DOC_PP4_FxxP_1 201 204 PF00568 0.453
DOC_PP4_FxxP_1 328 331 PF00568 0.358
DOC_PP4_FxxP_1 558 561 PF00568 0.403
DOC_PP4_FxxP_1 828 831 PF00568 0.278
DOC_USP7_MATH_1 109 113 PF00917 0.411
DOC_USP7_MATH_1 164 168 PF00917 0.491
DOC_USP7_MATH_1 206 210 PF00917 0.379
DOC_USP7_MATH_1 331 335 PF00917 0.343
DOC_USP7_MATH_1 342 346 PF00917 0.439
DOC_USP7_MATH_1 474 478 PF00917 0.298
DOC_USP7_MATH_1 507 511 PF00917 0.481
DOC_USP7_MATH_1 673 677 PF00917 0.422
DOC_USP7_MATH_1 738 742 PF00917 0.446
DOC_USP7_MATH_1 809 813 PF00917 0.419
DOC_USP7_MATH_1 89 93 PF00917 0.562
DOC_USP7_UBL2_3 502 506 PF12436 0.311
DOC_WW_Pin1_4 260 265 PF00397 0.578
DOC_WW_Pin1_4 405 410 PF00397 0.474
DOC_WW_Pin1_4 422 427 PF00397 0.485
DOC_WW_Pin1_4 543 548 PF00397 0.407
DOC_WW_Pin1_4 630 635 PF00397 0.430
DOC_WW_Pin1_4 731 736 PF00397 0.494
DOC_WW_Pin1_4 76 81 PF00397 0.452
DOC_WW_Pin1_4 769 774 PF00397 0.416
DOC_WW_Pin1_4 827 832 PF00397 0.278
DOC_WW_Pin1_4 90 95 PF00397 0.509
LIG_14-3-3_CanoR_1 143 147 PF00244 0.507
LIG_14-3-3_CanoR_1 163 173 PF00244 0.372
LIG_14-3-3_CanoR_1 299 305 PF00244 0.368
LIG_14-3-3_CanoR_1 44 52 PF00244 0.616
LIG_14-3-3_CanoR_1 529 537 PF00244 0.403
LIG_14-3-3_CanoR_1 540 545 PF00244 0.396
LIG_14-3-3_CanoR_1 560 565 PF00244 0.338
LIG_14-3-3_CanoR_1 629 634 PF00244 0.488
LIG_14-3-3_CanoR_1 784 788 PF00244 0.275
LIG_14-3-3_CanoR_1 818 827 PF00244 0.202
LIG_Actin_RPEL_3 750 769 PF02755 0.507
LIG_Actin_WH2_2 487 504 PF00022 0.277
LIG_AP2alpha_2 725 727 PF02296 0.485
LIG_BIR_III_4 427 431 PF00653 0.520
LIG_BRCT_BRCA1_1 462 466 PF00533 0.337
LIG_BRCT_BRCA1_1 675 679 PF00533 0.409
LIG_eIF4E_1 649 655 PF01652 0.377
LIG_FHA_1 148 154 PF00498 0.350
LIG_FHA_1 306 312 PF00498 0.413
LIG_FHA_1 418 424 PF00498 0.528
LIG_FHA_1 631 637 PF00498 0.522
LIG_FHA_1 696 702 PF00498 0.325
LIG_FHA_1 745 751 PF00498 0.433
LIG_FHA_1 784 790 PF00498 0.308
LIG_FHA_1 854 860 PF00498 0.347
LIG_FHA_2 135 141 PF00498 0.453
LIG_FHA_2 167 173 PF00498 0.546
LIG_FHA_2 227 233 PF00498 0.469
LIG_FHA_2 366 372 PF00498 0.574
LIG_FHA_2 531 537 PF00498 0.530
LIG_FHA_2 579 585 PF00498 0.483
LIG_FHA_2 587 593 PF00498 0.318
LIG_FHA_2 783 789 PF00498 0.364
LIG_FHA_2 871 877 PF00498 0.334
LIG_FHA_2 883 889 PF00498 0.232
LIG_FHA_2 894 900 PF00498 0.323
LIG_LIR_Apic_2 198 204 PF02991 0.511
LIG_LIR_Gen_1 182 191 PF02991 0.444
LIG_LIR_Gen_1 194 204 PF02991 0.496
LIG_LIR_Gen_1 301 312 PF02991 0.354
LIG_LIR_Gen_1 463 474 PF02991 0.337
LIG_LIR_Gen_1 647 657 PF02991 0.317
LIG_LIR_Gen_1 666 673 PF02991 0.354
LIG_LIR_Gen_1 725 735 PF02991 0.498
LIG_LIR_Gen_1 793 801 PF02991 0.398
LIG_LIR_Nem_3 137 141 PF02991 0.448
LIG_LIR_Nem_3 182 186 PF02991 0.480
LIG_LIR_Nem_3 194 199 PF02991 0.442
LIG_LIR_Nem_3 301 307 PF02991 0.356
LIG_LIR_Nem_3 463 469 PF02991 0.288
LIG_LIR_Nem_3 647 652 PF02991 0.325
LIG_LIR_Nem_3 653 658 PF02991 0.305
LIG_LIR_Nem_3 725 730 PF02991 0.506
LIG_LIR_Nem_3 766 770 PF02991 0.430
LIG_LIR_Nem_3 793 798 PF02991 0.398
LIG_MAD2 858 866 PF02301 0.278
LIG_MLH1_MIPbox_1 462 466 PF16413 0.337
LIG_MYND_1 260 264 PF01753 0.528
LIG_NRBOX 540 546 PF00104 0.396
LIG_NRBOX 66 72 PF00104 0.317
LIG_NRBOX 888 894 PF00104 0.337
LIG_Pex14_1 461 465 PF04695 0.337
LIG_Pex14_2 791 795 PF04695 0.308
LIG_Pex14_2 867 871 PF04695 0.278
LIG_PTB_Apo_2 322 329 PF02174 0.412
LIG_Rb_pABgroove_1 652 660 PF01858 0.304
LIG_REV1ctd_RIR_1 555 560 PF16727 0.459
LIG_SH2_CRK 680 684 PF00017 0.346
LIG_SH2_CRK 770 774 PF00017 0.278
LIG_SH2_NCK_1 649 653 PF00017 0.384
LIG_SH2_STAP1 697 701 PF00017 0.447
LIG_SH2_STAP1 746 750 PF00017 0.473
LIG_SH2_STAP1 787 791 PF00017 0.202
LIG_SH2_STAT3 672 675 PF00017 0.376
LIG_SH2_STAT5 392 395 PF00017 0.427
LIG_SH2_STAT5 465 468 PF00017 0.398
LIG_SH2_STAT5 556 559 PF00017 0.396
LIG_SH2_STAT5 697 700 PF00017 0.326
LIG_SH2_STAT5 73 76 PF00017 0.391
LIG_SH2_STAT5 746 749 PF00017 0.472
LIG_SH2_STAT5 819 822 PF00017 0.337
LIG_SH3_1 77 83 PF00018 0.360
LIG_SH3_3 168 174 PF00018 0.405
LIG_SH3_3 254 260 PF00018 0.533
LIG_SH3_3 275 281 PF00018 0.493
LIG_SH3_3 403 409 PF00018 0.547
LIG_SH3_3 420 426 PF00018 0.495
LIG_SH3_3 431 437 PF00018 0.460
LIG_SH3_3 77 83 PF00018 0.468
LIG_SH3_3 85 91 PF00018 0.515
LIG_SH3_3 93 99 PF00018 0.447
LIG_SUMO_SIM_anti_2 114 119 PF11976 0.473
LIG_SUMO_SIM_anti_2 63 69 PF11976 0.304
LIG_SUMO_SIM_par_1 895 902 PF11976 0.383
LIG_TRAF2_2 831 836 PF00917 0.308
LIG_TYR_ITIM 678 683 PF00017 0.412
LIG_UBA3_1 484 489 PF00899 0.316
LIG_UBA3_1 70 77 PF00899 0.414
LIG_UBA3_1 862 869 PF00899 0.277
MOD_CDK_SPK_2 260 265 PF00069 0.662
MOD_CDK_SPK_2 405 410 PF00069 0.488
MOD_CDK_SPK_2 92 97 PF00069 0.518
MOD_CDK_SPxxK_3 260 267 PF00069 0.611
MOD_CDK_SPxxK_3 422 429 PF00069 0.662
MOD_CDK_SPxxK_3 90 97 PF00069 0.517
MOD_CK1_1 543 549 PF00069 0.578
MOD_CK1_1 632 638 PF00069 0.563
MOD_CK1_1 699 705 PF00069 0.534
MOD_CK1_1 75 81 PF00069 0.562
MOD_CK1_1 756 762 PF00069 0.559
MOD_CK1_1 870 876 PF00069 0.419
MOD_CK1_1 92 98 PF00069 0.597
MOD_CK2_1 134 140 PF00069 0.631
MOD_CK2_1 153 159 PF00069 0.438
MOD_CK2_1 166 172 PF00069 0.559
MOD_CK2_1 316 322 PF00069 0.551
MOD_CK2_1 365 371 PF00069 0.468
MOD_CK2_1 530 536 PF00069 0.505
MOD_CK2_1 578 584 PF00069 0.658
MOD_CK2_1 681 687 PF00069 0.452
MOD_CK2_1 731 737 PF00069 0.576
MOD_CK2_1 769 775 PF00069 0.299
MOD_CK2_1 893 899 PF00069 0.383
MOD_CK2_1 902 908 PF00069 0.594
MOD_CMANNOS 590 593 PF00535 0.383
MOD_Cter_Amidation 160 163 PF01082 0.594
MOD_Cter_Amidation 243 246 PF01082 0.643
MOD_GlcNHglycan 166 169 PF01048 0.713
MOD_GlcNHglycan 344 347 PF01048 0.562
MOD_GlcNHglycan 439 442 PF01048 0.736
MOD_GlcNHglycan 476 479 PF01048 0.332
MOD_GlcNHglycan 508 512 PF01048 0.701
MOD_GlcNHglycan 614 617 PF01048 0.504
MOD_GlcNHglycan 641 644 PF01048 0.426
MOD_GlcNHglycan 675 678 PF01048 0.429
MOD_GlcNHglycan 698 701 PF01048 0.608
MOD_GSK3_1 342 349 PF00069 0.564
MOD_GSK3_1 39 46 PF00069 0.675
MOD_GSK3_1 632 639 PF00069 0.480
MOD_GSK3_1 644 651 PF00069 0.426
MOD_GSK3_1 695 702 PF00069 0.488
MOD_GSK3_1 72 79 PF00069 0.399
MOD_GSK3_1 759 766 PF00069 0.592
MOD_GSK3_1 778 785 PF00069 0.296
MOD_GSK3_1 872 879 PF00069 0.270
MOD_N-GLC_1 305 310 PF02516 0.409
MOD_N-GLC_1 529 534 PF02516 0.582
MOD_N-GLC_1 753 758 PF02516 0.647
MOD_NEK2_1 195 200 PF00069 0.693
MOD_NEK2_1 24 29 PF00069 0.493
MOD_NEK2_1 484 489 PF00069 0.364
MOD_NEK2_1 501 506 PF00069 0.506
MOD_NEK2_1 524 529 PF00069 0.520
MOD_NEK2_1 60 65 PF00069 0.376
MOD_NEK2_1 695 700 PF00069 0.515
MOD_NEK2_1 892 897 PF00069 0.388
MOD_PIKK_1 206 212 PF00454 0.454
MOD_PIKK_1 331 337 PF00454 0.395
MOD_PIKK_1 390 396 PF00454 0.630
MOD_PIKK_1 445 451 PF00454 0.595
MOD_PIKK_1 671 677 PF00454 0.437
MOD_PIKK_1 681 687 PF00454 0.410
MOD_PIKK_1 829 835 PF00454 0.465
MOD_PIKK_1 853 859 PF00454 0.316
MOD_PK_1 560 566 PF00069 0.622
MOD_PKA_1 10 16 PF00069 0.523
MOD_PKA_1 142 148 PF00069 0.447
MOD_PKA_1 365 371 PF00069 0.640
MOD_PKA_2 10 16 PF00069 0.523
MOD_PKA_2 134 140 PF00069 0.631
MOD_PKA_2 142 148 PF00069 0.550
MOD_PKA_2 298 304 PF00069 0.458
MOD_PKA_2 365 371 PF00069 0.582
MOD_PKA_2 43 49 PF00069 0.459
MOD_PKA_2 639 645 PF00069 0.491
MOD_PKA_2 756 762 PF00069 0.559
MOD_PKA_2 783 789 PF00069 0.312
MOD_PKB_1 538 546 PF00069 0.571
MOD_Plk_1 109 115 PF00069 0.568
MOD_Plk_1 617 623 PF00069 0.391
MOD_Plk_1 710 716 PF00069 0.640
MOD_Plk_1 810 816 PF00069 0.358
MOD_Plk_2-3 586 592 PF00069 0.454
MOD_Plk_4 134 140 PF00069 0.549
MOD_Plk_4 153 159 PF00069 0.515
MOD_Plk_4 24 30 PF00069 0.463
MOD_Plk_4 387 393 PF00069 0.590
MOD_Plk_4 540 546 PF00069 0.603
MOD_Plk_4 60 66 PF00069 0.376
MOD_Plk_4 632 638 PF00069 0.570
MOD_Plk_4 644 650 PF00069 0.362
MOD_Plk_4 893 899 PF00069 0.383
MOD_ProDKin_1 260 266 PF00069 0.727
MOD_ProDKin_1 405 411 PF00069 0.592
MOD_ProDKin_1 422 428 PF00069 0.602
MOD_ProDKin_1 543 549 PF00069 0.496
MOD_ProDKin_1 630 636 PF00069 0.538
MOD_ProDKin_1 731 737 PF00069 0.616
MOD_ProDKin_1 76 82 PF00069 0.569
MOD_ProDKin_1 769 775 PF00069 0.509
MOD_ProDKin_1 827 833 PF00069 0.316
MOD_ProDKin_1 90 96 PF00069 0.640
MOD_SUMO_rev_2 371 376 PF00179 0.626
MOD_SUMO_rev_2 425 431 PF00179 0.617
TRG_DiLeu_BaEn_1 322 327 PF01217 0.502
TRG_DiLeu_BaEn_1 567 572 PF01217 0.570
TRG_DiLeu_BaLyEn_6 726 731 PF01217 0.633
TRG_DiLeu_BaLyEn_6 746 751 PF01217 0.634
TRG_ENDOCYTIC_2 138 141 PF00928 0.554
TRG_ENDOCYTIC_2 554 557 PF00928 0.627
TRG_ENDOCYTIC_2 649 652 PF00928 0.428
TRG_ENDOCYTIC_2 658 661 PF00928 0.299
TRG_ENDOCYTIC_2 680 683 PF00928 0.411
TRG_ENDOCYTIC_2 801 804 PF00928 0.316
TRG_ER_diArg_1 10 12 PF00400 0.626
TRG_ER_diArg_1 14 16 PF00400 0.578
TRG_ER_diArg_1 17 19 PF00400 0.557
TRG_ER_diArg_1 245 247 PF00400 0.662
TRG_ER_diArg_1 264 267 PF00400 0.435
TRG_ER_diArg_1 336 338 PF00400 0.453
TRG_ER_diArg_1 365 367 PF00400 0.650
TRG_ER_diArg_1 637 640 PF00400 0.686
TRG_ER_diArg_1 690 693 PF00400 0.537
TRG_ER_diArg_1 748 750 PF00400 0.624
TRG_ER_diArg_1 837 839 PF00400 0.316
TRG_NES_CRM1_1 646 659 PF08389 0.371
TRG_NLS_Bipartite_1 127 146 PF00514 0.447
TRG_Pf-PMV_PEXEL_1 267 271 PF00026 0.599
TRG_Pf-PMV_PEXEL_1 624 628 PF00026 0.409

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBR2 Leptomonas seymouri 51% 99%
A0A3S7WP80 Leishmania donovani 92% 100%
A4H4D8 Leishmania braziliensis 79% 100%
A4HSL7 Leishmania infantum 92% 100%
Q4QJA7 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS