Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKJ4_LEIMU

TriTrypDb:

LmxM.05.0880

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AKJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.371
CLV_NRD_NRD_1	155	157	PF00675	0.628
CLV_NRD_NRD_1	31	33	PF00675	0.419
CLV_NRD_NRD_1	49	51	PF00675	0.443
CLV_PCSK_KEX2_1	115	117	PF00082	0.371
CLV_PCSK_KEX2_1	157	159	PF00082	0.653
CLV_PCSK_KEX2_1	192	194	PF00082	0.635
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.653
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.635
CLV_PCSK_SKI1_1	158	162	PF00082	0.675
CLV_PCSK_SKI1_1	33	37	PF00082	0.435
DEG_APCC_DBOX_1	2	10	PF00400	0.554
DEG_Nend_UBRbox_3	1	3	PF02207	0.724
DOC_CKS1_1	147	152	PF01111	0.477
DOC_CKS1_1	24	29	PF01111	0.698
DOC_CYCLIN_RxL_1	29	37	PF00134	0.630
DOC_MAPK_gen_1	115	123	PF00069	0.472
DOC_MAPK_MEF2A_6	116	125	PF00069	0.472
DOC_PP2B_LxvP_1	175	178	PF13499	0.510
DOC_PP4_FxxP_1	36	39	PF00568	0.629
DOC_USP7_MATH_1	164	168	PF00917	0.366
DOC_USP7_MATH_1	17	21	PF00917	0.634
DOC_USP7_UBL2_3	157	161	PF12436	0.509
DOC_USP7_UBL2_3	63	67	PF12436	0.606
DOC_WW_Pin1_4	13	18	PF00397	0.690
DOC_WW_Pin1_4	146	151	PF00397	0.480
DOC_WW_Pin1_4	23	28	PF00397	0.688
LIG_14-3-3_CanoR_1	193	198	PF00244	0.510
LIG_14-3-3_CanoR_1	3	7	PF00244	0.640
LIG_Actin_WH2_2	28	45	PF00022	0.709
LIG_Actin_WH2_2	76	94	PF00022	0.621
LIG_APCC_ABBAyCdc20_2	107	113	PF00400	0.586
LIG_BIR_III_4	163	167	PF00653	0.341
LIG_BRCT_BRCA1_1	27	31	PF00533	0.700
LIG_BRCT_BRCA1_2	27	33	PF00533	0.699
LIG_FHA_1	134	140	PF00498	0.408
LIG_FHA_1	142	148	PF00498	0.411
LIG_FHA_1	63	69	PF00498	0.664
LIG_FHA_2	177	183	PF00498	0.495
LIG_FHA_2	92	98	PF00498	0.632
LIG_LIR_Apic_2	142	148	PF02991	0.398
LIG_LIR_Apic_2	34	39	PF02991	0.629
LIG_LIR_Nem_3	114	120	PF02991	0.458
LIG_SH2_GRB2like	117	120	PF00017	0.302
LIG_SH2_PTP2	120	123	PF00017	0.321
LIG_SH2_STAP1	117	121	PF00017	0.321
LIG_SH2_STAP1	135	139	PF00017	0.404
LIG_SH2_STAT5	120	123	PF00017	0.302
LIG_SH2_STAT5	135	138	PF00017	0.414
LIG_SUMO_SIM_par_1	173	180	PF11976	0.463
MOD_CDK_SPxK_1	23	29	PF00069	0.699
MOD_CK1_1	12	18	PF00069	0.707
MOD_CK2_1	176	182	PF00069	0.502
MOD_CK2_1	91	97	PF00069	0.640
MOD_GlcNHglycan	165	169	PF01048	0.737
MOD_GlcNHglycan	19	22	PF01048	0.534
MOD_GSK3_1	193	200	PF00069	0.513
MOD_GSK3_1	9	16	PF00069	0.716
MOD_GSK3_1	96	103	PF00069	0.614
MOD_NEK2_1	100	105	PF00069	0.606
MOD_NEK2_1	128	133	PF00069	0.420
MOD_NEK2_1	68	73	PF00069	0.589
MOD_NEK2_1	91	96	PF00069	0.641
MOD_PIKK_1	151	157	PF00454	0.432
MOD_PIKK_1	91	97	PF00454	0.649
MOD_PKA_1	192	198	PF00069	0.502
MOD_PKA_2	192	198	PF00069	0.502
MOD_PKA_2	2	8	PF00069	0.630
MOD_PKA_2	91	97	PF00069	0.640
MOD_ProDKin_1	13	19	PF00069	0.691
MOD_ProDKin_1	146	152	PF00069	0.478
MOD_ProDKin_1	23	29	PF00069	0.685
MOD_SUMO_rev_2	37	44	PF00179	0.638
TRG_ENDOCYTIC_2	120	123	PF00928	0.302
TRG_ER_diArg_1	115	117	PF00400	0.571
TRG_ER_diArg_1	156	159	PF00400	0.509
TRG_ER_diArg_1	89	92	PF00400	0.644
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSV2	Leptomonas seymouri	89%	96%
A0A0S4J1S7	Bodo saltans	62%	98%
A0A1X0NK70	Trypanosomatidae	67%	69%
A0A3R7RHS1	Trypanosoma rangeli	65%	86%
A0A3S5H5K7	Leishmania donovani	98%	98%
A4H4D0	Leishmania braziliensis	91%	100%
A4HSL0	Leishmania infantum	98%	98%
C9ZU79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	67%
Q4QJB4	Leishmania major	97%	100%