Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type, putative

Species:

Leishmania mexicana

UniProt:

E9AKJ1_LEIMU

TriTrypDb:

LmxM.05.0850

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.528
CLV_C14_Caspase3-7	452	456	PF00656	0.450
CLV_NRD_NRD_1	401	403	PF00675	0.702
CLV_NRD_NRD_1	498	500	PF00675	0.504
CLV_NRD_NRD_1	609	611	PF00675	0.303
CLV_PCSK_KEX2_1	21	23	PF00082	0.493
CLV_PCSK_KEX2_1	213	215	PF00082	0.543
CLV_PCSK_KEX2_1	317	319	PF00082	0.530
CLV_PCSK_KEX2_1	401	403	PF00082	0.702
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.481
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.543
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.530
CLV_PCSK_SKI1_1	128	132	PF00082	0.464
CLV_PCSK_SKI1_1	389	393	PF00082	0.711
CLV_PCSK_SKI1_1	499	503	PF00082	0.564
CLV_PCSK_SKI1_1	623	627	PF00082	0.452
DEG_SPOP_SBC_1	241	245	PF00917	0.690
DOC_CKS1_1	135	140	PF01111	0.467
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.712
DOC_MAPK_DCC_7	83	92	PF00069	0.653
DOC_MAPK_gen_1	477	485	PF00069	0.399
DOC_MAPK_MEF2A_6	477	485	PF00069	0.383
DOC_MAPK_MEF2A_6	83	92	PF00069	0.653
DOC_PP2B_LxvP_1	283	286	PF13499	0.665
DOC_PP2B_LxvP_1	588	591	PF13499	0.450
DOC_PP2B_LxvP_1	90	93	PF13499	0.666
DOC_PP4_MxPP_1	445	448	PF00568	0.650
DOC_USP7_MATH_1	191	195	PF00917	0.663
DOC_USP7_MATH_1	241	245	PF00917	0.702
DOC_USP7_MATH_1	301	305	PF00917	0.639
DOC_USP7_MATH_1	381	385	PF00917	0.630
DOC_USP7_MATH_1	47	51	PF00917	0.796
DOC_USP7_MATH_1	57	61	PF00917	0.526
DOC_USP7_MATH_1	68	72	PF00917	0.548
DOC_USP7_MATH_1	93	97	PF00917	0.728
DOC_WW_Pin1_4	107	112	PF00397	0.599
DOC_WW_Pin1_4	134	139	PF00397	0.510
DOC_WW_Pin1_4	154	159	PF00397	0.614
DOC_WW_Pin1_4	232	237	PF00397	0.718
DOC_WW_Pin1_4	242	247	PF00397	0.739
DOC_WW_Pin1_4	345	350	PF00397	0.685
DOC_WW_Pin1_4	43	48	PF00397	0.652
DOC_WW_Pin1_4	58	63	PF00397	0.678
DOC_WW_Pin1_4	6	11	PF00397	0.625
DOC_WW_Pin1_4	66	71	PF00397	0.635
DOC_WW_Pin1_4	96	101	PF00397	0.742
LIG_14-3-3_CanoR_1	261	270	PF00244	0.624
LIG_14-3-3_CanoR_1	332	337	PF00244	0.727
LIG_14-3-3_CanoR_1	480	484	PF00244	0.365
LIG_14-3-3_CanoR_1	8	18	PF00244	0.593
LIG_14-3-3_CanoR_1	94	100	PF00244	0.527
LIG_Actin_WH2_2	193	208	PF00022	0.520
LIG_APCC_ABBA_1	306	311	PF00400	0.558
LIG_BRCT_BRCA1_1	353	357	PF00533	0.582
LIG_FHA_1	10	16	PF00498	0.549
LIG_FHA_1	331	337	PF00498	0.760
LIG_LIR_Gen_1	61	70	PF02991	0.631
LIG_LIR_Nem_3	61	67	PF02991	0.633
LIG_NRP_CendR_1	638	639	PF00754	0.594
LIG_Pex14_1	437	441	PF04695	0.661
LIG_PTAP_UEV_1	407	412	PF05743	0.577
LIG_SH2_CRK	378	382	PF00017	0.639
LIG_SH2_CRK	64	68	PF00017	0.639
LIG_SH2_NCK_1	64	68	PF00017	0.689
LIG_SH2_STAP1	599	603	PF00017	0.475
LIG_SH2_STAT5	121	124	PF00017	0.541
LIG_SH2_STAT5	211	214	PF00017	0.562
LIG_SH2_STAT5	64	67	PF00017	0.694
LIG_SH3_3	152	158	PF00018	0.546
LIG_SH3_3	340	346	PF00018	0.562
LIG_SH3_3	374	380	PF00018	0.648
LIG_SH3_3	405	411	PF00018	0.613
LIG_SH3_3	588	594	PF00018	0.564
LIG_SH3_3	600	606	PF00018	0.325
LIG_SH3_3	64	70	PF00018	0.516
LIG_SH3_3	82	88	PF00018	0.748
LIG_SUMO_SIM_par_1	168	174	PF11976	0.657
LIG_TRAF2_1	464	467	PF00917	0.572
LIG_TRAF2_1	468	471	PF00917	0.356
MOD_CDC14_SPxK_1	110	113	PF00782	0.669
MOD_CDC14_SPxK_1	46	49	PF00782	0.573
MOD_CDK_SPK_2	43	48	PF00069	0.539
MOD_CDK_SPxK_1	107	113	PF00069	0.683
MOD_CDK_SPxK_1	43	49	PF00069	0.556
MOD_CK1_1	104	110	PF00069	0.749
MOD_CK1_1	166	172	PF00069	0.610
MOD_CK1_1	174	180	PF00069	0.711
MOD_CK1_1	201	207	PF00069	0.478
MOD_CK1_1	275	281	PF00069	0.525
MOD_CK1_1	348	354	PF00069	0.511
MOD_CK1_1	396	402	PF00069	0.690
MOD_CK1_1	406	412	PF00069	0.715
MOD_CK1_1	69	75	PF00069	0.676
MOD_CK1_1	96	102	PF00069	0.685
MOD_CK2_1	301	307	PF00069	0.631
MOD_Cter_Amidation	399	402	PF01082	0.546
MOD_Cter_Amidation	608	611	PF01082	0.303
MOD_DYRK1A_RPxSP_1	154	158	PF00069	0.637
MOD_GlcNHglycan	103	106	PF01048	0.732
MOD_GlcNHglycan	158	161	PF01048	0.587
MOD_GlcNHglycan	180	183	PF01048	0.713
MOD_GlcNHglycan	189	192	PF01048	0.742
MOD_GlcNHglycan	319	322	PF01048	0.717
MOD_GlcNHglycan	350	353	PF01048	0.792
MOD_GlcNHglycan	359	362	PF01048	0.675
MOD_GlcNHglycan	384	387	PF01048	0.751
MOD_GlcNHglycan	395	398	PF01048	0.584
MOD_GlcNHglycan	414	417	PF01048	0.758
MOD_GlcNHglycan	451	454	PF01048	0.491
MOD_GlcNHglycan	49	52	PF01048	0.708
MOD_GlcNHglycan	524	527	PF01048	0.642
MOD_GlcNHglycan	584	587	PF01048	0.588
MOD_GlcNHglycan	71	74	PF01048	0.789
MOD_GSK3_1	103	110	PF00069	0.612
MOD_GSK3_1	174	181	PF00069	0.641
MOD_GSK3_1	187	194	PF00069	0.588
MOD_GSK3_1	201	208	PF00069	0.419
MOD_GSK3_1	257	264	PF00069	0.575
MOD_GSK3_1	275	282	PF00069	0.549
MOD_GSK3_1	43	50	PF00069	0.621
MOD_GSK3_1	518	525	PF00069	0.606
MOD_GSK3_1	53	60	PF00069	0.655
MOD_GSK3_1	62	69	PF00069	0.681
MOD_GSK3_1	74	81	PF00069	0.626
MOD_GSK3_1	92	99	PF00069	0.672
MOD_N-GLC_1	174	179	PF02516	0.674
MOD_N-GLC_1	275	280	PF02516	0.579
MOD_N-GLC_1	58	63	PF02516	0.663
MOD_N-GLC_2	176	178	PF02516	0.481
MOD_NEK2_1	171	176	PF00069	0.622
MOD_NEK2_1	196	201	PF00069	0.537
MOD_NEK2_1	205	210	PF00069	0.470
MOD_NEK2_1	249	254	PF00069	0.704
MOD_NEK2_1	257	262	PF00069	0.712
MOD_NEK2_1	357	362	PF00069	0.684
MOD_NEK2_1	479	484	PF00069	0.325
MOD_PIKK_1	128	134	PF00454	0.536
MOD_PIKK_1	255	261	PF00454	0.681
MOD_PKA_1	317	323	PF00069	0.530
MOD_PKA_2	205	211	PF00069	0.511
MOD_PKA_2	317	323	PF00069	0.530
MOD_PKA_2	406	412	PF00069	0.703
MOD_PKA_2	479	485	PF00069	0.303
MOD_PKA_2	93	99	PF00069	0.653
MOD_Plk_4	166	172	PF00069	0.609
MOD_ProDKin_1	107	113	PF00069	0.594
MOD_ProDKin_1	134	140	PF00069	0.508
MOD_ProDKin_1	154	160	PF00069	0.612
MOD_ProDKin_1	232	238	PF00069	0.717
MOD_ProDKin_1	242	248	PF00069	0.741
MOD_ProDKin_1	345	351	PF00069	0.689
MOD_ProDKin_1	43	49	PF00069	0.657
MOD_ProDKin_1	58	64	PF00069	0.682
MOD_ProDKin_1	6	12	PF00069	0.618
MOD_ProDKin_1	66	72	PF00069	0.639
MOD_ProDKin_1	96	102	PF00069	0.743
MOD_SUMO_for_1	212	215	PF00179	0.534
MOD_SUMO_rev_2	124	130	PF00179	0.455
MOD_SUMO_rev_2	311	319	PF00179	0.527
TRG_ENDOCYTIC_2	64	67	PF00928	0.644
TRG_ER_diArg_1	401	403	PF00400	0.701
TRG_ER_diArg_1	637	639	PF00400	0.647
TRG_NLS_MonoCore_2	325	330	PF00514	0.688
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II98	Leptomonas seymouri	55%	98%
A0A3S7WP70	Leishmania donovani	83%	96%
A0A422MWH7	Trypanosoma rangeli	35%	100%
A4H4C7	Leishmania braziliensis	70%	99%
A4HSK7	Leishmania infantum	84%	96%
Q4QJB7	Leishmania major	84%	100%