Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKI8_LEIMU

TriTrypDb:

LmxM.05.0820

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.320
CLV_C14_Caspase3-7	903	907	PF00656	0.419
CLV_MEL_PAP_1	413	419	PF00089	0.605
CLV_MEL_PAP_1	747	753	PF00089	0.256
CLV_NRD_NRD_1	189	191	PF00675	0.360
CLV_NRD_NRD_1	229	231	PF00675	0.508
CLV_NRD_NRD_1	323	325	PF00675	0.272
CLV_NRD_NRD_1	719	721	PF00675	0.307
CLV_NRD_NRD_1	8	10	PF00675	0.567
CLV_NRD_NRD_1	826	828	PF00675	0.330
CLV_NRD_NRD_1	886	888	PF00675	0.506
CLV_PCSK_FUR_1	227	231	PF00082	0.512
CLV_PCSK_KEX2_1	188	190	PF00082	0.358
CLV_PCSK_KEX2_1	229	231	PF00082	0.542
CLV_PCSK_KEX2_1	322	324	PF00082	0.281
CLV_PCSK_KEX2_1	7	9	PF00082	0.550
CLV_PCSK_KEX2_1	826	828	PF00082	0.328
CLV_PCSK_KEX2_1	885	887	PF00082	0.491
CLV_PCSK_KEX2_1	895	897	PF00082	0.521
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.294
CLV_PCSK_PC1ET2_1	885	887	PF00082	0.491
CLV_PCSK_PC1ET2_1	895	897	PF00082	0.521
CLV_PCSK_PC7_1	319	325	PF00082	0.288
CLV_PCSK_SKI1_1	127	131	PF00082	0.398
CLV_PCSK_SKI1_1	141	145	PF00082	0.367
CLV_PCSK_SKI1_1	319	323	PF00082	0.291
CLV_PCSK_SKI1_1	572	576	PF00082	0.488
CLV_PCSK_SKI1_1	660	664	PF00082	0.304
CLV_PCSK_SKI1_1	787	791	PF00082	0.285
CLV_PCSK_SKI1_1	805	809	PF00082	0.323
DEG_APCC_DBOX_1	786	794	PF00400	0.482
DEG_APCC_DBOX_1	826	834	PF00400	0.489
DEG_ODPH_VHL_1	458	471	PF01847	0.421
DEG_SCF_FBW7_1	35	42	PF00400	0.574
DEG_SCF_FBW7_2	96	103	PF00400	0.492
DEG_SPOP_SBC_1	108	112	PF00917	0.712
DEG_SPOP_SBC_1	269	273	PF00917	0.459
DEG_SPOP_SBC_1	286	290	PF00917	0.558
DEG_SPOP_SBC_1	367	371	PF00917	0.553
DOC_CKS1_1	36	41	PF01111	0.641
DOC_CKS1_1	97	102	PF01111	0.496
DOC_CYCLIN_RxL_1	138	148	PF00134	0.578
DOC_CYCLIN_RxL_1	464	475	PF00134	0.515
DOC_CYCLIN_RxL_1	802	809	PF00134	0.552
DOC_MAPK_gen_1	877	884	PF00069	0.304
DOC_MAPK_MEF2A_6	406	413	PF00069	0.424
DOC_MAPK_MEF2A_6	877	884	PF00069	0.399
DOC_PP1_RVXF_1	570	577	PF00149	0.469
DOC_PP1_RVXF_1	748	754	PF00149	0.483
DOC_PP2B_LxvP_1	106	109	PF13499	0.556
DOC_PP2B_LxvP_1	645	648	PF13499	0.349
DOC_PP4_FxxP_1	98	101	PF00568	0.667
DOC_USP7_MATH_1	109	113	PF00917	0.624
DOC_USP7_MATH_1	155	159	PF00917	0.598
DOC_USP7_MATH_1	254	258	PF00917	0.576
DOC_USP7_MATH_1	309	313	PF00917	0.600
DOC_USP7_MATH_1	367	371	PF00917	0.549
DOC_USP7_MATH_1	375	379	PF00917	0.529
DOC_USP7_MATH_1	614	618	PF00917	0.352
DOC_USP7_MATH_1	648	652	PF00917	0.404
DOC_USP7_MATH_1	755	759	PF00917	0.590
DOC_USP7_MATH_1	799	803	PF00917	0.606
DOC_USP7_UBL2_3	11	15	PF12436	0.802
DOC_USP7_UBL2_3	924	928	PF12436	0.410
DOC_WW_Pin1_4	270	275	PF00397	0.500
DOC_WW_Pin1_4	341	346	PF00397	0.480
DOC_WW_Pin1_4	35	40	PF00397	0.733
DOC_WW_Pin1_4	369	374	PF00397	0.550
DOC_WW_Pin1_4	44	49	PF00397	0.684
DOC_WW_Pin1_4	575	580	PF00397	0.420
DOC_WW_Pin1_4	756	761	PF00397	0.433
DOC_WW_Pin1_4	812	817	PF00397	0.650
DOC_WW_Pin1_4	901	906	PF00397	0.435
DOC_WW_Pin1_4	96	101	PF00397	0.619
LIG_14-3-3_CanoR_1	188	193	PF00244	0.533
LIG_14-3-3_CanoR_1	284	294	PF00244	0.570
LIG_14-3-3_CanoR_1	416	423	PF00244	0.392
LIG_14-3-3_CanoR_1	446	450	PF00244	0.407
LIG_14-3-3_CanoR_1	515	525	PF00244	0.572
LIG_14-3-3_CanoR_1	660	667	PF00244	0.412
LIG_14-3-3_CanoR_1	750	754	PF00244	0.565
LIG_Actin_WH2_2	70	87	PF00022	0.535
LIG_APCC_ABBA_1	197	202	PF00400	0.534
LIG_APCC_ABBA_1	851	856	PF00400	0.291
LIG_APCC_ABBAyCdc20_2	669	675	PF00400	0.592
LIG_BIR_III_2	86	90	PF00653	0.427
LIG_Clathr_ClatBox_1	277	281	PF01394	0.509
LIG_eIF4E_1	565	571	PF01652	0.289
LIG_FHA_1	236	242	PF00498	0.580
LIG_FHA_1	271	277	PF00498	0.578
LIG_FHA_1	334	340	PF00498	0.422
LIG_FHA_1	385	391	PF00498	0.330
LIG_FHA_1	446	452	PF00498	0.404
LIG_FHA_1	511	517	PF00498	0.574
LIG_FHA_1	597	603	PF00498	0.434
LIG_FHA_1	640	646	PF00498	0.267
LIG_FHA_1	661	667	PF00498	0.407
LIG_FHA_1	698	704	PF00498	0.552
LIG_FHA_1	766	772	PF00498	0.540
LIG_FHA_1	837	843	PF00498	0.171
LIG_FHA_1	892	898	PF00498	0.355
LIG_FHA_2	115	121	PF00498	0.608
LIG_FHA_2	189	195	PF00498	0.563
LIG_FHA_2	23	29	PF00498	0.660
LIG_FHA_2	287	293	PF00498	0.522
LIG_FHA_2	390	396	PF00498	0.386
LIG_FHA_2	587	593	PF00498	0.397
LIG_FHA_2	739	745	PF00498	0.531
LIG_FHA_2	847	853	PF00498	0.389
LIG_GBD_Chelix_1	461	469	PF00786	0.526
LIG_GBD_Chelix_1	639	647	PF00786	0.531
LIG_LIR_Apic_2	573	579	PF02991	0.347
LIG_LIR_Apic_2	99	105	PF02991	0.710
LIG_LIR_Gen_1	194	200	PF02991	0.635
LIG_LIR_Gen_1	288	299	PF02991	0.628
LIG_LIR_Gen_1	57	66	PF02991	0.584
LIG_LIR_Gen_1	809	819	PF02991	0.552
LIG_LIR_Gen_1	908	917	PF02991	0.350
LIG_LIR_Nem_3	194	199	PF02991	0.663
LIG_LIR_Nem_3	288	294	PF02991	0.568
LIG_LIR_Nem_3	562	567	PF02991	0.319
LIG_LIR_Nem_3	57	63	PF02991	0.606
LIG_LIR_Nem_3	658	662	PF02991	0.501
LIG_LIR_Nem_3	809	814	PF02991	0.546
LIG_LIR_Nem_3	908	913	PF02991	0.318
LIG_NRBOX	139	145	PF00104	0.415
LIG_NRBOX	275	281	PF00104	0.492
LIG_NRBOX	338	344	PF00104	0.335
LIG_NRBOX	440	446	PF00104	0.360
LIG_NRBOX	91	97	PF00104	0.529
LIG_Pex14_1	196	200	PF04695	0.598
LIG_RPA_C_Fungi	510	522	PF08784	0.363
LIG_SH2_CRK	811	815	PF00017	0.426
LIG_SH2_PTP2	243	246	PF00017	0.200
LIG_SH2_STAP1	302	306	PF00017	0.488
LIG_SH2_STAT3	923	926	PF00017	0.320
LIG_SH2_STAT5	243	246	PF00017	0.433
LIG_SH2_STAT5	883	886	PF00017	0.476
LIG_SH3_3	33	39	PF00018	0.703
LIG_SH3_3	476	482	PF00018	0.267
LIG_SH3_3	587	593	PF00018	0.581
LIG_SH3_3	813	819	PF00018	0.482
LIG_SH3_3	860	866	PF00018	0.324
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.437
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.470
LIG_SUMO_SIM_anti_2	641	647	PF11976	0.317
LIG_SUMO_SIM_anti_2	744	749	PF11976	0.346
LIG_SUMO_SIM_par_1	250	257	PF11976	0.428
LIG_SUMO_SIM_par_1	275	281	PF11976	0.328
LIG_SUMO_SIM_par_1	338	344	PF11976	0.475
LIG_SUMO_SIM_par_1	626	633	PF11976	0.343
LIG_TRAF2_1	118	121	PF00917	0.805
LIG_TYR_ITIM	241	246	PF00017	0.209
LIG_UBA3_1	714	721	PF00899	0.323
LIG_WRC_WIRS_1	422	427	PF05994	0.513
LIG_WW_1	819	822	PF00397	0.312
MOD_CDC14_SPxK_1	815	818	PF00782	0.336
MOD_CDK_SPxK_1	756	762	PF00069	0.252
MOD_CDK_SPxK_1	812	818	PF00069	0.333
MOD_CK1_1	110	116	PF00069	0.724
MOD_CK1_1	235	241	PF00069	0.586
MOD_CK1_1	368	374	PF00069	0.717
MOD_CK1_1	418	424	PF00069	0.468
MOD_CK1_1	578	584	PF00069	0.538
MOD_CK1_1	697	703	PF00069	0.474
MOD_CK1_1	723	729	PF00069	0.456
MOD_CK1_1	756	762	PF00069	0.481
MOD_CK1_1	901	907	PF00069	0.545
MOD_CK2_1	114	120	PF00069	0.788
MOD_CK2_1	188	194	PF00069	0.432
MOD_CK2_1	22	28	PF00069	0.582
MOD_CK2_1	286	292	PF00069	0.486
MOD_CK2_1	648	654	PF00069	0.176
MOD_Cter_Amidation	803	806	PF01082	0.406
MOD_GlcNHglycan	112	115	PF01048	0.734
MOD_GlcNHglycan	12	15	PF01048	0.781
MOD_GlcNHglycan	157	160	PF01048	0.641
MOD_GlcNHglycan	164	167	PF01048	0.568
MOD_GlcNHglycan	234	237	PF01048	0.595
MOD_GlcNHglycan	297	300	PF01048	0.558
MOD_GlcNHglycan	357	360	PF01048	0.628
MOD_GlcNHglycan	373	376	PF01048	0.759
MOD_GlcNHglycan	378	381	PF01048	0.487
MOD_GlcNHglycan	559	562	PF01048	0.335
MOD_GlcNHglycan	582	586	PF01048	0.712
MOD_GlcNHglycan	696	699	PF01048	0.428
MOD_GlcNHglycan	725	728	PF01048	0.605
MOD_GlcNHglycan	741	744	PF01048	0.318
MOD_GlcNHglycan	754	758	PF01048	0.486
MOD_GSK3_1	110	117	PF00069	0.761
MOD_GSK3_1	268	275	PF00069	0.539
MOD_GSK3_1	286	293	PF00069	0.516
MOD_GSK3_1	328	335	PF00069	0.423
MOD_GSK3_1	35	42	PF00069	0.590
MOD_GSK3_1	363	370	PF00069	0.671
MOD_GSK3_1	371	378	PF00069	0.713
MOD_GSK3_1	380	387	PF00069	0.369
MOD_GSK3_1	417	424	PF00069	0.447
MOD_GSK3_1	506	513	PF00069	0.450
MOD_GSK3_1	726	733	PF00069	0.601
MOD_GSK3_1	749	756	PF00069	0.472
MOD_GSK3_1	761	768	PF00069	0.335
MOD_N-GLC_1	346	351	PF02516	0.392
MOD_N-GLC_1	536	541	PF02516	0.525
MOD_N-GLC_2	916	918	PF02516	0.431
MOD_NEK2_1	1	6	PF00069	0.695
MOD_NEK2_1	328	333	PF00069	0.404
MOD_NEK2_1	354	359	PF00069	0.559
MOD_NEK2_1	389	394	PF00069	0.407
MOD_NEK2_1	417	422	PF00069	0.463
MOD_NEK2_1	445	450	PF00069	0.349
MOD_NEK2_1	472	477	PF00069	0.488
MOD_NEK2_1	493	498	PF00069	0.358
MOD_NEK2_1	516	521	PF00069	0.512
MOD_NEK2_1	557	562	PF00069	0.239
MOD_NEK2_1	694	699	PF00069	0.500
MOD_NEK2_1	714	719	PF00069	0.207
MOD_NEK2_1	761	766	PF00069	0.419
MOD_NEK2_1	772	777	PF00069	0.346
MOD_NEK2_2	838	843	PF00069	0.404
MOD_PIKK_1	235	241	PF00454	0.321
MOD_PIKK_1	516	522	PF00454	0.439
MOD_PIKK_1	604	610	PF00454	0.345
MOD_PIKK_1	660	666	PF00454	0.281
MOD_PKA_1	188	194	PF00069	0.336
MOD_PKA_1	720	726	PF00069	0.443
MOD_PKA_2	188	194	PF00069	0.343
MOD_PKA_2	232	238	PF00069	0.639
MOD_PKA_2	415	421	PF00069	0.582
MOD_PKA_2	445	451	PF00069	0.404
MOD_PKA_2	516	522	PF00069	0.459
MOD_PKA_2	54	60	PF00069	0.419
MOD_PKA_2	749	755	PF00069	0.459
MOD_Plk_1	346	352	PF00069	0.398
MOD_Plk_1	384	390	PF00069	0.525
MOD_Plk_1	418	424	PF00069	0.479
MOD_Plk_1	472	478	PF00069	0.478
MOD_Plk_4	272	278	PF00069	0.335
MOD_Plk_4	290	296	PF00069	0.488
MOD_Plk_4	311	317	PF00069	0.495
MOD_Plk_4	421	427	PF00069	0.470
MOD_Plk_4	559	565	PF00069	0.231
MOD_Plk_4	639	645	PF00069	0.271
MOD_Plk_4	846	852	PF00069	0.484
MOD_ProDKin_1	270	276	PF00069	0.354
MOD_ProDKin_1	341	347	PF00069	0.477
MOD_ProDKin_1	35	41	PF00069	0.685
MOD_ProDKin_1	369	375	PF00069	0.710
MOD_ProDKin_1	44	50	PF00069	0.601
MOD_ProDKin_1	575	581	PF00069	0.539
MOD_ProDKin_1	756	762	PF00069	0.265
MOD_ProDKin_1	812	818	PF00069	0.574
MOD_ProDKin_1	901	907	PF00069	0.545
MOD_ProDKin_1	96	102	PF00069	0.535
MOD_SUMO_rev_2	889	897	PF00179	0.405
TRG_DiLeu_BaEn_2	384	390	PF01217	0.505
TRG_DiLeu_BaEn_4	250	256	PF01217	0.358
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.468
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.347
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.455
TRG_ENDOCYTIC_2	242	245	PF00928	0.437
TRG_ENDOCYTIC_2	60	63	PF00928	0.531
TRG_ENDOCYTIC_2	811	814	PF00928	0.433
TRG_ENDOCYTIC_2	864	867	PF00928	0.354
TRG_ER_diArg_1	188	190	PF00400	0.478
TRG_ER_diArg_1	227	230	PF00400	0.720
TRG_ER_diArg_1	6	9	PF00400	0.714
TRG_ER_diArg_1	826	828	PF00400	0.411
TRG_NES_CRM1_1	626	638	PF08389	0.453
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	610	615	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF34	Leptomonas seymouri	60%	100%
A0A1X0NLT0	Trypanosomatidae	33%	100%
A0A3S5H5K4	Leishmania donovani	87%	99%
A0A422NJC1	Trypanosoma rangeli	36%	100%
A4H4C4	Leishmania braziliensis	78%	99%
A4HSK4	Leishmania infantum	87%	99%
C9ZU88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
Q4QJC0	Leishmania major	88%	100%
V5BBH0	Trypanosoma cruzi	35%	95%