MYND zinc finger (ZnF) domain-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MYND zinc finger (ZnF) domain-like protein

Species:

Leishmania mexicana

UniProt:

E9AKI6_LEIMU

TriTrypDb:

LmxM.05.0800

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKI6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.670
CLV_C14_Caspase3-7	270	274	PF00656	0.514
CLV_NRD_NRD_1	245	247	PF00675	0.524
CLV_NRD_NRD_1	401	403	PF00675	0.510
CLV_NRD_NRD_1	77	79	PF00675	0.548
CLV_PCSK_KEX2_1	245	247	PF00082	0.524
CLV_PCSK_KEX2_1	311	313	PF00082	0.401
CLV_PCSK_KEX2_1	401	403	PF00082	0.510
CLV_PCSK_KEX2_1	77	79	PF00082	0.553
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.401
CLV_PCSK_SKI1_1	245	249	PF00082	0.463
CLV_PCSK_SKI1_1	378	382	PF00082	0.706
CLV_PCSK_SKI1_1	49	53	PF00082	0.513
CLV_PCSK_SKI1_1	80	84	PF00082	0.611
DEG_APCC_KENBOX_2	137	141	PF00400	0.529
DEG_SPOP_SBC_1	193	197	PF00917	0.685
DEG_SPOP_SBC_1	314	318	PF00917	0.425
DEG_SPOP_SBC_1	61	65	PF00917	0.651
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.534
DOC_MAPK_gen_1	376	388	PF00069	0.629
DOC_MAPK_gen_1	77	87	PF00069	0.653
DOC_MAPK_MEF2A_6	381	390	PF00069	0.728
DOC_PP1_RVXF_1	278	285	PF00149	0.625
DOC_PP1_RVXF_1	81	88	PF00149	0.554
DOC_PP2B_LxvP_1	388	391	PF13499	0.550
DOC_PP4_FxxP_1	53	56	PF00568	0.704
DOC_PP4_MxPP_1	1	4	PF00568	0.606
DOC_USP7_MATH_1	153	157	PF00917	0.578
DOC_USP7_MATH_1	193	197	PF00917	0.719
DOC_USP7_MATH_1	28	32	PF00917	0.634
DOC_USP7_MATH_1	287	291	PF00917	0.602
DOC_USP7_MATH_1	314	318	PF00917	0.468
DOC_USP7_MATH_1	60	64	PF00917	0.627
DOC_USP7_UBL2_3	203	207	PF12436	0.494
DOC_USP7_UBL2_3	377	381	PF12436	0.710
DOC_WW_Pin1_4	348	353	PF00397	0.484
DOC_WW_Pin1_4	63	68	PF00397	0.672
LIG_14-3-3_CanoR_1	326	335	PF00244	0.394
LIG_14-3-3_CanoR_1	423	427	PF00244	0.507
LIG_Actin_WH2_2	69	85	PF00022	0.626
LIG_APCC_ABBA_1	50	55	PF00400	0.671
LIG_APCC_ABBAyCdc20_2	280	286	PF00400	0.646
LIG_APCC_ABBAyCdc20_2	49	55	PF00400	0.670
LIG_BIR_III_4	168	172	PF00653	0.695
LIG_BRCT_BRCA1_1	394	398	PF00533	0.642
LIG_Clathr_ClatBox_1	282	286	PF01394	0.557
LIG_Clathr_ClatBox_1	50	54	PF01394	0.520
LIG_FHA_1	102	108	PF00498	0.551
LIG_FHA_1	121	127	PF00498	0.573
LIG_FHA_1	287	293	PF00498	0.549
LIG_FHA_1	380	386	PF00498	0.652
LIG_FHA_2	162	168	PF00498	0.658
LIG_FHA_2	21	27	PF00498	0.522
LIG_FHA_2	226	232	PF00498	0.667
LIG_LIR_Gen_1	16	27	PF02991	0.509
LIG_LIR_Gen_1	31	42	PF02991	0.490
LIG_LIR_Gen_1	343	352	PF02991	0.444
LIG_LIR_Gen_1	409	420	PF02991	0.523
LIG_LIR_Gen_1	99	108	PF02991	0.581
LIG_LIR_Nem_3	16	22	PF02991	0.510
LIG_LIR_Nem_3	31	37	PF02991	0.488
LIG_LIR_Nem_3	343	348	PF02991	0.427
LIG_LIR_Nem_3	409	415	PF02991	0.511
LIG_LIR_Nem_3	416	420	PF02991	0.458
LIG_LIR_Nem_3	99	105	PF02991	0.591
LIG_MLH1_MIPbox_1	394	398	PF16413	0.642
LIG_PROFILIN_1	2	8	PF00235	0.605
LIG_PTB_Apo_2	81	88	PF02174	0.540
LIG_REV1ctd_RIR_1	395	406	PF16727	0.653
LIG_SH2_CRK	34	38	PF00017	0.554
LIG_SH2_STAP1	29	33	PF00017	0.635
LIG_SH2_STAP1	417	421	PF00017	0.574
LIG_SH2_STAT3	143	146	PF00017	0.613
LIG_SH2_STAT5	143	146	PF00017	0.572
LIG_SH2_STAT5	335	338	PF00017	0.344
LIG_SH2_STAT5	403	406	PF00017	0.496
LIG_SH2_STAT5	420	423	PF00017	0.483
LIG_SH2_STAT5	424	427	PF00017	0.576
LIG_SH3_2	4	9	PF14604	0.685
LIG_SH3_3	1	7	PF00018	0.641
LIG_SH3_3	388	394	PF00018	0.534
LIG_SH3_CIN85_PxpxPR_1	4	9	PF14604	0.685
LIG_SUMO_SIM_anti_2	103	110	PF11976	0.571
LIG_SUMO_SIM_anti_2	384	389	PF11976	0.578
LIG_SUMO_SIM_par_1	11	16	PF11976	0.592
LIG_SUMO_SIM_par_1	234	243	PF11976	0.572
LIG_SUMO_SIM_par_1	35	41	PF11976	0.506
LIG_SUMO_SIM_par_1	384	389	PF11976	0.636
LIG_TYR_ITIM	333	338	PF00017	0.272
LIG_WW_3	6	10	PF00397	0.660
MOD_CDK_SPxK_1	348	354	PF00069	0.444
MOD_CK1_1	116	122	PF00069	0.728
MOD_CK1_1	192	198	PF00069	0.730
MOD_CK1_1	63	69	PF00069	0.659
MOD_CK2_1	225	231	PF00069	0.644
MOD_Cter_Amidation	374	377	PF01082	0.685
MOD_GlcNHglycan	115	118	PF01048	0.701
MOD_GlcNHglycan	123	126	PF01048	0.698
MOD_GlcNHglycan	166	172	PF01048	0.517
MOD_GlcNHglycan	191	194	PF01048	0.708
MOD_GlcNHglycan	199	202	PF01048	0.666
MOD_GlcNHglycan	254	257	PF01048	0.685
MOD_GlcNHglycan	318	321	PF01048	0.412
MOD_GlcNHglycan	373	376	PF01048	0.639
MOD_GSK3_1	116	123	PF00069	0.658
MOD_GSK3_1	167	174	PF00069	0.491
MOD_GSK3_1	188	195	PF00069	0.697
MOD_GSK3_1	294	301	PF00069	0.489
MOD_GSK3_1	367	374	PF00069	0.625
MOD_GSK3_1	422	429	PF00069	0.615
MOD_N-GLC_1	188	193	PF02516	0.788
MOD_N-GLC_1	225	230	PF02516	0.559
MOD_N-GLC_1	370	375	PF02516	0.486
MOD_NEK2_1	325	330	PF00069	0.439
MOD_NEK2_1	397	402	PF00069	0.512
MOD_NEK2_1	422	427	PF00069	0.587
MOD_PKA_2	213	219	PF00069	0.713
MOD_PKA_2	252	258	PF00069	0.731
MOD_PKA_2	325	331	PF00069	0.401
MOD_PKA_2	422	428	PF00069	0.482
MOD_Plk_1	171	177	PF00069	0.694
MOD_Plk_1	408	414	PF00069	0.509
MOD_Plk_2-3	11	17	PF00069	0.586
MOD_Plk_4	103	109	PF00069	0.643
MOD_Plk_4	153	159	PF00069	0.623
MOD_Plk_4	287	293	PF00069	0.549
MOD_Plk_4	392	398	PF00069	0.518
MOD_ProDKin_1	348	354	PF00069	0.484
MOD_ProDKin_1	63	69	PF00069	0.670
MOD_SUMO_rev_2	124	133	PF00179	0.650
MOD_SUMO_rev_2	26	33	PF00179	0.623
MOD_SUMO_rev_2	374	382	PF00179	0.544
TRG_DiLeu_BaEn_1	103	108	PF01217	0.570
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.408
TRG_ENDOCYTIC_2	335	338	PF00928	0.272
TRG_ENDOCYTIC_2	34	37	PF00928	0.596
TRG_ER_diArg_1	244	246	PF00400	0.539
TRG_ER_diArg_1	401	403	PF00400	0.510
TRG_ER_diArg_1	76	78	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V4	Leptomonas seymouri	62%	100%
A0A3S5H5K2	Leishmania donovani	88%	85%
A0A422NJC5	Trypanosoma rangeli	46%	98%
A4H4C3	Leishmania braziliensis	81%	100%
A4HSK2	Leishmania infantum	88%	87%
C9ZU91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
Q4QJC2	Leishmania major	88%	100%
V5BG20	Trypanosoma cruzi	42%	98%