Mitochondrial glyco protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial glycoprotein, putative

Species:

Leishmania mexicana

UniProt:

E9AKI5_LEIMU

TriTrypDb:

LmxM.05.0790

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AKI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.363
CLV_C14_Caspase3-7	175	179	PF00656	0.755
CLV_C14_Caspase3-7	213	217	PF00656	0.578
CLV_C14_Caspase3-7	290	294	PF00656	0.458
CLV_C14_Caspase3-7	342	346	PF00656	0.482
CLV_NRD_NRD_1	145	147	PF00675	0.455
CLV_NRD_NRD_1	172	174	PF00675	0.779
CLV_NRD_NRD_1	27	29	PF00675	0.719
CLV_NRD_NRD_1	3	5	PF00675	0.747
CLV_PCSK_FUR_1	25	29	PF00082	0.693
CLV_PCSK_KEX2_1	145	147	PF00082	0.455
CLV_PCSK_KEX2_1	172	174	PF00082	0.606
CLV_PCSK_KEX2_1	27	29	PF00082	0.719
CLV_PCSK_KEX2_1	3	5	PF00082	0.750
CLV_PCSK_SKI1_1	109	113	PF00082	0.535
CLV_PCSK_SKI1_1	193	197	PF00082	0.704
CLV_PCSK_SKI1_1	205	209	PF00082	0.457
CLV_PCSK_SKI1_1	88	92	PF00082	0.597
DEG_Nend_Nbox_1	1	3	PF02207	0.617
DEG_SPOP_SBC_1	152	156	PF00917	0.642
DEG_SPOP_SBC_1	177	181	PF00917	0.492
DEG_SPOP_SBC_1	313	317	PF00917	0.709
DEG_SPOP_SBC_1	33	37	PF00917	0.712
DOC_MAPK_DCC_7	120	129	PF00069	0.587
DOC_MAPK_MEF2A_6	120	129	PF00069	0.587
DOC_MAPK_MEF2A_6	205	212	PF00069	0.426
DOC_PP2B_LxvP_1	147	150	PF13499	0.601
DOC_PP4_MxPP_1	149	152	PF00568	0.587
DOC_USP7_MATH_1	153	157	PF00917	0.662
DOC_USP7_MATH_1	176	180	PF00917	0.716
DOC_USP7_MATH_1	263	267	PF00917	0.759
DOC_USP7_MATH_1	314	318	PF00917	0.750
DOC_USP7_MATH_1	327	331	PF00917	0.190
DOC_USP7_MATH_1	33	37	PF00917	0.760
DOC_USP7_MATH_1	99	103	PF00917	0.509
DOC_USP7_UBL2_3	105	109	PF12436	0.457
DOC_WW_Pin1_4	16	21	PF00397	0.742
DOC_WW_Pin1_4	48	53	PF00397	0.777
LIG_14-3-3_CanoR_1	200	204	PF00244	0.512
LIG_14-3-3_CanoR_1	209	219	PF00244	0.469
LIG_14-3-3_CanoR_1	3	7	PF00244	0.707
LIG_14-3-3_CanoR_1	45	53	PF00244	0.696
LIG_CSL_BTD_1	147	150	PF09270	0.459
LIG_EH_1	325	329	PF12763	0.626
LIG_FHA_1	137	143	PF00498	0.538
LIG_FHA_2	211	217	PF00498	0.459
LIG_Integrin_RGD_1	173	175	PF01839	0.612
LIG_LIR_Apic_2	330	334	PF02991	0.379
LIG_LIR_Gen_1	204	212	PF02991	0.536
LIG_LIR_Nem_3	204	210	PF02991	0.532
LIG_LIR_Nem_3	325	331	PF02991	0.583
LIG_PDZ_Class_2	384	389	PF00595	0.482
LIG_Pex14_2	230	234	PF04695	0.473
LIG_REV1ctd_RIR_1	232	240	PF16727	0.494
LIG_SH2_CRK	303	307	PF00017	0.606
LIG_SH2_CRK	324	328	PF00017	0.529
LIG_SH2_GRB2like	281	284	PF00017	0.581
LIG_SH2_GRB2like	324	327	PF00017	0.575
LIG_SH2_NCK_1	324	328	PF00017	0.552
LIG_SH2_STAP1	367	371	PF00017	0.482
LIG_SH2_STAP1	376	380	PF00017	0.482
LIG_SH2_STAT5	324	327	PF00017	0.646
LIG_SH2_STAT5	386	389	PF00017	0.633
LIG_SH3_1	303	309	PF00018	0.573
LIG_SH3_3	122	128	PF00018	0.496
LIG_SH3_3	147	153	PF00018	0.497
LIG_SH3_3	303	309	PF00018	0.623
LIG_TRAF2_1	180	183	PF00917	0.781
LIG_TRAF2_1	274	277	PF00917	0.583
MOD_CK1_1	154	160	PF00069	0.651
MOD_CK1_1	41	47	PF00069	0.783
MOD_CK2_1	177	183	PF00069	0.781
MOD_CK2_1	253	259	PF00069	0.779
MOD_CK2_1	271	277	PF00069	0.367
MOD_CK2_1	91	97	PF00069	0.683
MOD_Cter_Amidation	143	146	PF01082	0.429
MOD_GlcNHglycan	256	259	PF01048	0.668
MOD_GlcNHglycan	316	319	PF01048	0.670
MOD_GlcNHglycan	53	56	PF01048	0.697
MOD_GlcNHglycan	88	91	PF01048	0.640
MOD_GlcNHglycan	93	96	PF01048	0.605
MOD_GSK3_1	129	136	PF00069	0.557
MOD_GSK3_1	151	158	PF00069	0.643
MOD_GSK3_1	177	184	PF00069	0.776
MOD_GSK3_1	211	218	PF00069	0.488
MOD_GSK3_1	250	257	PF00069	0.683
MOD_GSK3_1	259	266	PF00069	0.709
MOD_GSK3_1	308	315	PF00069	0.679
MOD_GSK3_1	34	41	PF00069	0.690
MOD_GSK3_1	47	54	PF00069	0.678
MOD_GSK3_1	99	106	PF00069	0.448
MOD_NEK2_1	129	134	PF00069	0.494
MOD_NEK2_1	2	7	PF00069	0.658
MOD_NEK2_1	34	39	PF00069	0.701
MOD_PIKK_1	178	184	PF00454	0.780
MOD_PIKK_1	263	269	PF00454	0.700
MOD_PKA_2	199	205	PF00069	0.376
MOD_PKA_2	2	8	PF00069	0.715
MOD_PKA_2	254	260	PF00069	0.710
MOD_PKA_2	322	328	PF00069	0.664
MOD_Plk_1	215	221	PF00069	0.592
MOD_Plk_1	276	282	PF00069	0.473
MOD_Plk_1	99	105	PF00069	0.501
MOD_Plk_4	137	143	PF00069	0.437
MOD_Plk_4	160	166	PF00069	0.479
MOD_Plk_4	276	282	PF00069	0.574
MOD_Plk_4	346	352	PF00069	0.556
MOD_Plk_4	365	371	PF00069	0.363
MOD_Plk_4	99	105	PF00069	0.554
MOD_ProDKin_1	16	22	PF00069	0.744
MOD_ProDKin_1	48	54	PF00069	0.776
MOD_SUMO_rev_2	108	116	PF00179	0.607
MOD_SUMO_rev_2	188	197	PF00179	0.628
TRG_DiLeu_BaEn_2	136	142	PF01217	0.553
TRG_ER_diArg_1	145	147	PF00400	0.474
TRG_ER_diArg_1	2	4	PF00400	0.682
TRG_ER_diArg_1	24	27	PF00400	0.713
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY6	Leptomonas seymouri	55%	100%
A0A1X0NK60	Trypanosomatidae	42%	100%
A0A3S5H5K1	Leishmania donovani	90%	100%
A0A422NJ89	Trypanosoma rangeli	48%	100%
A4H4C2	Leishmania braziliensis	80%	98%
A4HSK1	Leishmania infantum	89%	100%
C9ZU92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4QJC3	Leishmania major	91%	99%
V5B710	Trypanosoma cruzi	48%	99%