Vta1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vta1 like, putative

Species:

Leishmania mexicana

UniProt:

E9AKI0_LEIMU

TriTrypDb:

LmxM.05.0740

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0010008	endosome membrane	5	8
GO:0012506	vesicle membrane	4	8
GO:0016020	membrane	2	8
GO:0030659	cytoplasmic vesicle membrane	5	8
GO:0031090	organelle membrane	3	8
GO:0098588	bounding membrane of organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9AKI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKI0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0007034	vacuolar transport	4	8
GO:0008104	protein localization	4	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0016192	vesicle-mediated transport	4	8
GO:0016197	endosomal transport	4	8
GO:0032509	endosome transport via multivesicular body sorting pathway	5	8
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	8
GO:0033036	macromolecule localization	2	8
GO:0045184	establishment of protein localization	3	8
GO:0045324	late endosome to vacuole transport	5	8
GO:0046907	intracellular transport	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0051649	establishment of localization in cell	3	8
GO:0070727	cellular macromolecule localization	3	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8
GO:0071985	multivesicular body sorting pathway	5	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.541
CLV_PCSK_SKI1_1	146	150	PF00082	0.308
CLV_PCSK_SKI1_1	156	160	PF00082	0.266
CLV_PCSK_SKI1_1	20	24	PF00082	0.285
CLV_PCSK_SKI1_1	87	91	PF00082	0.324
CLV_PCSK_SKI1_1	92	96	PF00082	0.309
DEG_COP1_1	289	297	PF00400	0.719
DOC_CKS1_1	235	240	PF01111	0.684
DOC_CKS1_1	245	250	PF01111	0.698
DOC_PP2B_LxvP_1	231	234	PF13499	0.755
DOC_PP4_FxxP_1	207	210	PF00568	0.779
DOC_USP7_MATH_1	136	140	PF00917	0.556
DOC_USP7_MATH_1	142	146	PF00917	0.522
DOC_USP7_MATH_1	222	226	PF00917	0.700
DOC_USP7_MATH_1	293	297	PF00917	0.796
DOC_USP7_MATH_1	299	303	PF00917	0.691
DOC_USP7_MATH_1	312	316	PF00917	0.757
DOC_USP7_UBL2_3	157	161	PF12436	0.525
DOC_WW_Pin1_4	164	169	PF00397	0.548
DOC_WW_Pin1_4	234	239	PF00397	0.715
DOC_WW_Pin1_4	244	249	PF00397	0.703
DOC_WW_Pin1_4	256	261	PF00397	0.572
LIG_14-3-3_CanoR_1	116	125	PF00244	0.529
LIG_14-3-3_CanoR_1	209	214	PF00244	0.668
LIG_14-3-3_CanoR_1	287	297	PF00244	0.702
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_BIR_III_4	189	193	PF00653	0.680
LIG_BRCT_BRCA1_1	121	125	PF00533	0.515
LIG_BRCT_BRCA1_1	25	29	PF00533	0.529
LIG_eIF4E_1	119	125	PF01652	0.491
LIG_EVH1_1	231	235	PF00568	0.754
LIG_FHA_1	118	124	PF00498	0.529
LIG_FHA_1	240	246	PF00498	0.677
LIG_FHA_1	58	64	PF00498	0.491
LIG_FHA_2	224	230	PF00498	0.797
LIG_FHA_2	4	10	PF00498	0.287
LIG_FHA_2	63	69	PF00498	0.580
LIG_LIR_Apic_2	163	168	PF02991	0.544
LIG_LIR_Apic_2	205	210	PF02991	0.773
LIG_LIR_Gen_1	91	101	PF02991	0.529
LIG_LIR_Nem_3	145	150	PF02991	0.476
LIG_MYND_1	295	299	PF01753	0.698
LIG_NRBOX	62	68	PF00104	0.529
LIG_SH2_CRK	236	240	PF00017	0.771
LIG_SH2_CRK	270	274	PF00017	0.719
LIG_SH2_CRK	308	312	PF00017	0.598
LIG_SH2_GRB2like	349	352	PF00017	0.515
LIG_SH2_NCK_1	236	240	PF00017	0.771
LIG_SH2_NCK_1	270	274	PF00017	0.719
LIG_SH2_NCK_1	308	312	PF00017	0.598
LIG_SH2_PTP2	165	168	PF00017	0.537
LIG_SH2_SRC	270	273	PF00017	0.718
LIG_SH2_SRC	349	352	PF00017	0.515
LIG_SH2_STAP1	119	123	PF00017	0.491
LIG_SH2_STAP1	147	151	PF00017	0.491
LIG_SH2_STAT5	119	122	PF00017	0.491
LIG_SH2_STAT5	150	153	PF00017	0.491
LIG_SH2_STAT5	165	168	PF00017	0.537
LIG_SH2_STAT5	236	239	PF00017	0.747
LIG_SH2_STAT5	252	255	PF00017	0.641
LIG_SH2_STAT5	39	42	PF00017	0.476
LIG_SH3_1	269	275	PF00018	0.564
LIG_SH3_3	229	235	PF00018	0.755
LIG_SH3_3	245	251	PF00018	0.535
LIG_SH3_3	257	263	PF00018	0.726
LIG_SH3_3	269	275	PF00018	0.663
LIG_SH3_3	292	298	PF00018	0.697
LIG_SH3_3	8	14	PF00018	0.564
LIG_UBA3_1	66	74	PF00899	0.495
LIG_WW_1	249	252	PF00397	0.681
MOD_CDC14_SPxK_1	167	170	PF00782	0.643
MOD_CDC14_SPxK_1	264	267	PF00782	0.593
MOD_CDK_SPxK_1	164	170	PF00069	0.632
MOD_CDK_SPxK_1	261	267	PF00069	0.595
MOD_CK1_1	212	218	PF00069	0.657
MOD_CK1_1	289	295	PF00069	0.762
MOD_CK1_1	3	9	PF00069	0.519
MOD_CK2_1	223	229	PF00069	0.718
MOD_CK2_1	3	9	PF00069	0.587
MOD_GlcNHglycan	291	294	PF01048	0.798
MOD_GlcNHglycan	3	6	PF01048	0.578
MOD_GlcNHglycan	302	305	PF01048	0.743
MOD_GlcNHglycan	312	315	PF01048	0.760
MOD_GlcNHglycan	341	344	PF01048	0.322
MOD_GSK3_1	104	111	PF00069	0.495
MOD_GSK3_1	125	132	PF00069	0.529
MOD_GSK3_1	194	201	PF00069	0.650
MOD_GSK3_1	208	215	PF00069	0.605
MOD_GSK3_1	250	257	PF00069	0.752
MOD_GSK3_1	289	296	PF00069	0.797
MOD_GSK3_1	335	342	PF00069	0.527
MOD_N-GLC_1	108	113	PF02516	0.380
MOD_NEK2_1	1	6	PF00069	0.530
MOD_NEK2_1	117	122	PF00069	0.504
MOD_NEK2_1	125	130	PF00069	0.473
MOD_NEK2_1	288	293	PF00069	0.804
MOD_NEK2_1	356	361	PF00069	0.525
MOD_NEK2_1	62	67	PF00069	0.529
MOD_NEK2_1	70	75	PF00069	0.529
MOD_PIKK_1	209	215	PF00454	0.711
MOD_PIKK_1	239	245	PF00454	0.721
MOD_PIKK_1	250	256	PF00454	0.771
MOD_PIKK_1	276	282	PF00454	0.730
MOD_PIKK_1	335	341	PF00454	0.580
MOD_PIKK_1	76	82	PF00454	0.500
MOD_PKA_2	208	214	PF00069	0.668
MOD_PKA_2	286	292	PF00069	0.731
MOD_Plk_1	108	114	PF00069	0.580
MOD_Plk_4	119	125	PF00069	0.506
MOD_Plk_4	3	9	PF00069	0.530
MOD_Plk_4	62	68	PF00069	0.539
MOD_ProDKin_1	164	170	PF00069	0.561
MOD_ProDKin_1	234	240	PF00069	0.716
MOD_ProDKin_1	244	250	PF00069	0.701
MOD_ProDKin_1	256	262	PF00069	0.571
MOD_SUMO_rev_2	26	34	PF00179	0.580
TRG_DiLeu_BaEn_2	57	63	PF01217	0.487
TRG_ER_diArg_1	49	52	PF00400	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8N6	Leptomonas seymouri	54%	98%
A0A0S4IWD6	Bodo saltans	44%	100%
A0A3S5H5J7	Leishmania donovani	87%	100%
A4H4B7	Leishmania braziliensis	69%	98%
A4HSJ6	Leishmania infantum	87%	100%
Q32L63	Bos taurus	27%	100%
Q4QJC8	Leishmania major	86%	98%
Q5R5W5	Pongo abelii	29%	100%
Q9CR26	Mus musculus	28%	100%
Q9NP79	Homo sapiens	29%	100%