Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKH9_LEIMU

TriTrypDb:

LmxM.05.0730

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.694
CLV_NRD_NRD_1	164	166	PF00675	0.611
CLV_NRD_NRD_1	304	306	PF00675	0.661
CLV_NRD_NRD_1	390	392	PF00675	0.706
CLV_NRD_NRD_1	399	401	PF00675	0.656
CLV_NRD_NRD_1	535	537	PF00675	0.691
CLV_NRD_NRD_1	563	565	PF00675	0.624
CLV_NRD_NRD_1	597	599	PF00675	0.593
CLV_NRD_NRD_1	693	695	PF00675	0.397
CLV_PCSK_FUR_1	691	695	PF00082	0.532
CLV_PCSK_KEX2_1	117	119	PF00082	0.694
CLV_PCSK_KEX2_1	164	166	PF00082	0.611
CLV_PCSK_KEX2_1	292	294	PF00082	0.568
CLV_PCSK_KEX2_1	304	306	PF00082	0.661
CLV_PCSK_KEX2_1	390	392	PF00082	0.785
CLV_PCSK_KEX2_1	399	401	PF00082	0.684
CLV_PCSK_KEX2_1	535	537	PF00082	0.695
CLV_PCSK_KEX2_1	563	565	PF00082	0.615
CLV_PCSK_KEX2_1	597	599	PF00082	0.594
CLV_PCSK_KEX2_1	693	695	PF00082	0.539
CLV_PCSK_KEX2_1	9	11	PF00082	0.410
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.568
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.410
CLV_PCSK_SKI1_1	296	300	PF00082	0.546
CLV_PCSK_SKI1_1	304	308	PF00082	0.481
CLV_PCSK_SKI1_1	33	37	PF00082	0.550
CLV_PCSK_SKI1_1	563	567	PF00082	0.535
CLV_PCSK_SKI1_1	598	602	PF00082	0.489
CLV_PCSK_SKI1_1	635	639	PF00082	0.557
CLV_PCSK_SKI1_1	655	659	PF00082	0.351
CLV_PCSK_SKI1_1	694	698	PF00082	0.532
DEG_APCC_DBOX_1	32	40	PF00400	0.551
DEG_SCF_FBW7_1	210	215	PF00400	0.540
DEG_SCF_FBW7_1	508	515	PF00400	0.713
DEG_SPOP_SBC_1	156	160	PF00917	0.572
DEG_SPOP_SBC_1	177	181	PF00917	0.722
DEG_SPOP_SBC_1	354	358	PF00917	0.544
DOC_CKS1_1	131	136	PF01111	0.622
DOC_CKS1_1	509	514	PF01111	0.714
DOC_CYCLIN_RxL_1	292	303	PF00134	0.542
DOC_CYCLIN_RxL_1	595	604	PF00134	0.489
DOC_MAPK_gen_1	233	240	PF00069	0.684
DOC_MAPK_MEF2A_6	233	240	PF00069	0.622
DOC_MAPK_MEF2A_6	664	673	PF00069	0.557
DOC_PP1_RVXF_1	12	18	PF00149	0.425
DOC_PP1_RVXF_1	699	705	PF00149	0.515
DOC_PP2B_LxvP_1	210	213	PF13499	0.541
DOC_PP2B_LxvP_1	283	286	PF13499	0.626
DOC_PP2B_LxvP_1	365	368	PF13499	0.678
DOC_USP7_MATH_1	177	181	PF00917	0.740
DOC_USP7_MATH_1	190	194	PF00917	0.628
DOC_USP7_MATH_1	28	32	PF00917	0.488
DOC_USP7_MATH_1	354	358	PF00917	0.654
DOC_USP7_MATH_1	435	439	PF00917	0.607
DOC_USP7_MATH_1	467	471	PF00917	0.753
DOC_USP7_MATH_1	474	478	PF00917	0.661
DOC_USP7_MATH_1	550	554	PF00917	0.498
DOC_USP7_UBL2_3	595	599	PF12436	0.480
DOC_WW_Pin1_4	130	135	PF00397	0.654
DOC_WW_Pin1_4	208	213	PF00397	0.701
DOC_WW_Pin1_4	238	243	PF00397	0.720
DOC_WW_Pin1_4	265	270	PF00397	0.733
DOC_WW_Pin1_4	298	303	PF00397	0.645
DOC_WW_Pin1_4	350	355	PF00397	0.717
DOC_WW_Pin1_4	456	461	PF00397	0.734
DOC_WW_Pin1_4	46	51	PF00397	0.583
DOC_WW_Pin1_4	508	513	PF00397	0.713
DOC_WW_Pin1_4	55	60	PF00397	0.607
DOC_WW_Pin1_4	564	569	PF00397	0.658
DOC_WW_Pin1_4	576	581	PF00397	0.500
DOC_WW_Pin1_4	717	722	PF00397	0.661
DOC_WW_Pin1_4	84	89	PF00397	0.657
LIG_14-3-3_CanoR_1	182	192	PF00244	0.726
LIG_14-3-3_CanoR_1	304	311	PF00244	0.454
LIG_14-3-3_CanoR_1	342	352	PF00244	0.687
LIG_14-3-3_CanoR_1	414	423	PF00244	0.601
LIG_14-3-3_CanoR_1	536	542	PF00244	0.701
LIG_14-3-3_CanoR_1	655	665	PF00244	0.442
LIG_14-3-3_CanoR_1	684	692	PF00244	0.560
LIG_Actin_WH2_2	692	709	PF00022	0.523
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_FHA_1	183	189	PF00498	0.676
LIG_FHA_1	22	28	PF00498	0.542
LIG_FHA_1	509	515	PF00498	0.663
LIG_FHA_1	616	622	PF00498	0.663
LIG_FHA_2	157	163	PF00498	0.634
LIG_FHA_2	305	311	PF00498	0.476
LIG_FHA_2	643	649	PF00498	0.579
LIG_FHA_2	658	664	PF00498	0.618
LIG_LIR_Gen_1	682	692	PF02991	0.570
LIG_LIR_Nem_3	241	246	PF02991	0.526
LIG_LIR_Nem_3	420	426	PF02991	0.700
LIG_LIR_Nem_3	682	688	PF02991	0.588
LIG_NRBOX	61	67	PF00104	0.501
LIG_PCNA_yPIPBox_3	684	696	PF02747	0.552
LIG_SH2_CRK	175	179	PF00017	0.681
LIG_SH2_CRK	423	427	PF00017	0.611
LIG_SH2_CRK	685	689	PF00017	0.563
LIG_SH2_STAT5	175	178	PF00017	0.543
LIG_SH2_STAT5	204	207	PF00017	0.694
LIG_SH2_STAT5	42	45	PF00017	0.528
LIG_SH2_STAT5	510	513	PF00017	0.663
LIG_SH2_STAT5	620	623	PF00017	0.665
LIG_SH2_STAT5	685	688	PF00017	0.566
LIG_SH3_1	120	126	PF00018	0.622
LIG_SH3_1	225	231	PF00018	0.551
LIG_SH3_2	228	233	PF14604	0.685
LIG_SH3_3	119	125	PF00018	0.715
LIG_SH3_3	225	231	PF00018	0.684
LIG_SH3_3	294	300	PF00018	0.635
LIG_SH3_3	364	370	PF00018	0.708
LIG_SH3_3	476	482	PF00018	0.710
LIG_SH3_3	491	497	PF00018	0.504
LIG_SH3_3	506	512	PF00018	0.708
LIG_SH3_3	542	548	PF00018	0.747
LIG_SH3_3	605	611	PF00018	0.591
LIG_SH3_3	622	628	PF00018	0.610
LIG_SH3_4	170	177	PF00018	0.682
LIG_SH3_CIN85_PxpxPR_1	228	233	PF14604	0.609
LIG_SUMO_SIM_anti_2	67	74	PF11976	0.398
LIG_SUMO_SIM_par_1	67	74	PF11976	0.465
LIG_TRAF2_1	307	310	PF00917	0.586
LIG_TRAF2_1	316	319	PF00917	0.501
LIG_TRAF2_1	646	649	PF00917	0.566
LIG_WW_3	230	234	PF00397	0.595
MOD_CDC14_SPxK_1	301	304	PF00782	0.617
MOD_CDK_SPK_2	130	135	PF00069	0.654
MOD_CDK_SPxK_1	298	304	PF00069	0.620
MOD_CDK_SPxK_1	512	518	PF00069	0.715
MOD_CDK_SPxxK_3	298	305	PF00069	0.672
MOD_CDK_SPxxK_3	564	571	PF00069	0.479
MOD_CK1_1	138	144	PF00069	0.832
MOD_CK1_1	157	163	PF00069	0.578
MOD_CK1_1	180	186	PF00069	0.800
MOD_CK1_1	21	27	PF00069	0.491
MOD_CK1_1	221	227	PF00069	0.599
MOD_CK1_1	337	343	PF00069	0.692
MOD_CK1_1	353	359	PF00069	0.615
MOD_CK1_1	379	385	PF00069	0.699
MOD_CK1_1	4	10	PF00069	0.528
MOD_CK1_1	401	407	PF00069	0.719
MOD_CK1_1	412	418	PF00069	0.661
MOD_CK1_1	450	456	PF00069	0.587
MOD_CK1_1	472	478	PF00069	0.702
MOD_CK1_1	579	585	PF00069	0.566
MOD_CK2_1	133	139	PF00069	0.731
MOD_CK2_1	156	162	PF00069	0.607
MOD_CK2_1	304	310	PF00069	0.454
MOD_CK2_1	551	557	PF00069	0.667
MOD_CK2_1	642	648	PF00069	0.592
MOD_CK2_1	657	663	PF00069	0.535
MOD_CK2_1	89	95	PF00069	0.716
MOD_DYRK1A_RPxSP_1	576	580	PF00069	0.598
MOD_DYRK1A_RPxSP_1	717	721	PF00069	0.603
MOD_GlcNHglycan	206	209	PF01048	0.726
MOD_GlcNHglycan	252	255	PF01048	0.754
MOD_GlcNHglycan	270	273	PF01048	0.610
MOD_GlcNHglycan	288	291	PF01048	0.485
MOD_GlcNHglycan	323	327	PF01048	0.665
MOD_GlcNHglycan	359	362	PF01048	0.666
MOD_GlcNHglycan	393	396	PF01048	0.725
MOD_GlcNHglycan	411	414	PF01048	0.541
MOD_GlcNHglycan	442	445	PF01048	0.746
MOD_GlcNHglycan	476	479	PF01048	0.550
MOD_GlcNHglycan	568	571	PF01048	0.698
MOD_GSK3_1	154	161	PF00069	0.720
MOD_GSK3_1	176	183	PF00069	0.776
MOD_GSK3_1	18	25	PF00069	0.485
MOD_GSK3_1	204	211	PF00069	0.707
MOD_GSK3_1	350	357	PF00069	0.721
MOD_GSK3_1	401	408	PF00069	0.747
MOD_GSK3_1	435	442	PF00069	0.699
MOD_GSK3_1	447	454	PF00069	0.668
MOD_GSK3_1	469	476	PF00069	0.753
MOD_GSK3_1	498	505	PF00069	0.685
MOD_GSK3_1	508	515	PF00069	0.607
MOD_GSK3_1	551	558	PF00069	0.702
MOD_GSK3_1	60	67	PF00069	0.406
MOD_GSK3_1	615	622	PF00069	0.712
MOD_GSK3_1	653	660	PF00069	0.573
MOD_GSK3_1	683	690	PF00069	0.575
MOD_GSK3_1	713	720	PF00069	0.718
MOD_GSK3_1	96	103	PF00069	0.584
MOD_LATS_1	612	618	PF00433	0.521
MOD_N-GLC_1	550	555	PF02516	0.675
MOD_NEK2_1	178	183	PF00069	0.700
MOD_NEK2_1	22	27	PF00069	0.504
MOD_NEK2_1	449	454	PF00069	0.782
MOD_NEK2_1	619	624	PF00069	0.666
MOD_NEK2_1	667	672	PF00069	0.514
MOD_NEK2_2	615	620	PF00069	0.663
MOD_PIKK_1	212	218	PF00454	0.712
MOD_PIKK_1	374	380	PF00454	0.567
MOD_PIKK_1	498	504	PF00454	0.685
MOD_PIKK_1	539	545	PF00454	0.713
MOD_PIKK_1	551	557	PF00454	0.487
MOD_PIKK_1	657	663	PF00454	0.535
MOD_PIKK_1	683	689	PF00454	0.579
MOD_PIKK_1	715	721	PF00454	0.588
MOD_PK_1	184	190	PF00069	0.675
MOD_PKA_1	304	310	PF00069	0.454
MOD_PKA_1	390	396	PF00069	0.706
MOD_PKA_1	399	405	PF00069	0.649
MOD_PKA_2	141	147	PF00069	0.720
MOD_PKA_2	183	189	PF00069	0.721
MOD_PKA_2	304	310	PF00069	0.454
MOD_PKA_2	337	343	PF00069	0.662
MOD_PKA_2	390	396	PF00069	0.708
MOD_PKA_2	398	404	PF00069	0.655
MOD_PKA_2	450	456	PF00069	0.632
MOD_PKA_2	517	523	PF00069	0.719
MOD_PKA_2	683	689	PF00069	0.579
MOD_PKA_2	713	719	PF00069	0.558
MOD_PKB_1	182	190	PF00069	0.675
MOD_Plk_1	18	24	PF00069	0.404
MOD_Plk_1	322	328	PF00069	0.454
MOD_Plk_1	4	10	PF00069	0.548
MOD_Plk_1	551	557	PF00069	0.667
MOD_Plk_1	615	621	PF00069	0.526
MOD_Plk_1	642	648	PF00069	0.556
MOD_Plk_1	653	659	PF00069	0.425
MOD_Plk_1	667	673	PF00069	0.525
MOD_Plk_4	184	190	PF00069	0.725
MOD_Plk_4	22	28	PF00069	0.510
MOD_Plk_4	376	382	PF00069	0.680
MOD_Plk_4	556	562	PF00069	0.755
MOD_Plk_4	615	621	PF00069	0.663
MOD_ProDKin_1	130	136	PF00069	0.654
MOD_ProDKin_1	208	214	PF00069	0.700
MOD_ProDKin_1	238	244	PF00069	0.718
MOD_ProDKin_1	265	271	PF00069	0.727
MOD_ProDKin_1	298	304	PF00069	0.644
MOD_ProDKin_1	350	356	PF00069	0.719
MOD_ProDKin_1	456	462	PF00069	0.736
MOD_ProDKin_1	46	52	PF00069	0.584
MOD_ProDKin_1	508	514	PF00069	0.715
MOD_ProDKin_1	55	61	PF00069	0.599
MOD_ProDKin_1	564	570	PF00069	0.658
MOD_ProDKin_1	576	582	PF00069	0.490
MOD_ProDKin_1	717	723	PF00069	0.667
MOD_ProDKin_1	84	90	PF00069	0.660
TRG_DiLeu_BaEn_2	580	586	PF01217	0.600
TRG_DiLeu_BaEn_4	309	315	PF01217	0.584
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.635
TRG_ENDOCYTIC_2	175	178	PF00928	0.730
TRG_ENDOCYTIC_2	423	426	PF00928	0.611
TRG_ENDOCYTIC_2	685	688	PF00928	0.566
TRG_ER_diArg_1	12	15	PF00400	0.497
TRG_ER_diArg_1	226	229	PF00400	0.691
TRG_ER_diArg_1	389	391	PF00400	0.683
TRG_ER_diArg_1	535	537	PF00400	0.698
TRG_ER_diArg_1	563	565	PF00400	0.477
TRG_ER_diArg_1	571	574	PF00400	0.492
TRG_ER_diArg_1	691	694	PF00400	0.356
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	573	578	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	598	603	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WP68	Leishmania donovani	84%	98%
A4H4B6	Leishmania braziliensis	48%	96%
A4HSJ5	Leishmania infantum	83%	100%
Q4QJC9	Leishmania major	79%	100%