Sre-2/carboxylate carrier-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sre-2/carboxylate carrier-like protein

Species:

Leishmania mexicana

UniProt:

E9AKH4_LEIMU

TriTrypDb:

LmxM.05.0680

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	7
GO:0016020	membrane	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AKH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKH4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0006865	amino acid transport	5	8
GO:0015849	organic acid transport	5	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8
GO:0003333	amino acid transmembrane transport	5	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006820	monoatomic anion transport	5	1
GO:0009987	cellular process	1	1
GO:0015711	organic anion transport	5	1
GO:0015804	neutral amino acid transport	6	1
GO:0032329	serine transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0046942	carboxylic acid transport	6	1
GO:0055085	transmembrane transport	2	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:0140300	serine import into mitochondrion	4	1
GO:1903825	organic acid transmembrane transport	3	1
GO:1905039	carboxylic acid transmembrane transport	4	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0015075	monoatomic ion transmembrane transporter activity	3	8
GO:0022857	transmembrane transporter activity	2	8
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0015175	neutral L-amino acid transmembrane transporter activity	6	1
GO:0022889	serine transmembrane transporter activity	5	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.265
CLV_C14_Caspase3-7	230	234	PF00656	0.268
CLV_C14_Caspase3-7	74	78	PF00656	0.473
CLV_NRD_NRD_1	283	285	PF00675	0.298
CLV_NRD_NRD_1	62	64	PF00675	0.327
CLV_PCSK_KEX2_1	283	285	PF00082	0.287
CLV_PCSK_KEX2_1	62	64	PF00082	0.290
CLV_PCSK_SKI1_1	124	128	PF00082	0.487
CLV_PCSK_SKI1_1	214	218	PF00082	0.487
CLV_PCSK_SKI1_1	41	45	PF00082	0.268
CLV_PCSK_SKI1_1	49	53	PF00082	0.206
CLV_PCSK_SKI1_1	92	96	PF00082	0.287
DEG_APCC_DBOX_1	213	221	PF00400	0.287
DEG_Nend_UBRbox_1	1	4	PF02207	0.630
DEG_SPOP_SBC_1	182	186	PF00917	0.468
DOC_CKS1_1	119	124	PF01111	0.293
DOC_CYCLIN_RxL_1	27	38	PF00134	0.487
DOC_CYCLIN_yClb5_NLxxxL_5	106	115	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.343
DOC_CYCLIN_yCln2_LP_2	261	264	PF00134	0.283
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.444
DOC_MAPK_DCC_7	252	261	PF00069	0.283
DOC_MAPK_gen_1	283	291	PF00069	0.441
DOC_MAPK_MEF2A_6	252	261	PF00069	0.283
DOC_MAPK_MEF2A_6	283	291	PF00069	0.441
DOC_MAPK_MEF2A_6	99	106	PF00069	0.397
DOC_MAPK_NFAT4_5	284	292	PF00069	0.571
DOC_PP1_RVXF_1	273	280	PF00149	0.470
DOC_PP1_RVXF_1	28	35	PF00149	0.487
DOC_PP2B_LxvP_1	193	196	PF13499	0.343
DOC_PP2B_LxvP_1	261	264	PF13499	0.283
DOC_PP2B_LxvP_1	287	290	PF13499	0.444
DOC_USP7_MATH_1	182	186	PF00917	0.505
DOC_USP7_MATH_1	22	26	PF00917	0.470
DOC_WW_Pin1_4	118	123	PF00397	0.250
DOC_WW_Pin1_4	2	7	PF00397	0.604
DOC_WW_Pin1_4	43	48	PF00397	0.487
LIG_14-3-3_CanoR_1	33	38	PF00244	0.517
LIG_14-3-3_CanoR_1	41	47	PF00244	0.479
LIG_14-3-3_CanoR_1	49	57	PF00244	0.536
LIG_14-3-3_CanoR_1	99	103	PF00244	0.444
LIG_Actin_WH2_2	204	220	PF00022	0.316
LIG_FHA_1	132	138	PF00498	0.251
LIG_FHA_1	272	278	PF00498	0.479
LIG_FHA_1	67	73	PF00498	0.505
LIG_FHA_2	225	231	PF00498	0.276
LIG_FHA_2	336	342	PF00498	0.374
LIG_FHA_2	7	13	PF00498	0.579
LIG_GBD_Chelix_1	296	304	PF00786	0.343
LIG_IRF3_LxIS_1	151	158	PF10401	0.268
LIG_LIR_Gen_1	64	75	PF02991	0.486
LIG_LIR_Nem_3	64	70	PF02991	0.486
LIG_MYND_1	93	97	PF01753	0.487
LIG_PCNA_yPIPBox_3	242	254	PF02747	0.244
LIG_PTB_Apo_2	129	136	PF02174	0.244
LIG_PTB_Apo_2	265	272	PF02174	0.343
LIG_PTB_Phospho_1	129	135	PF10480	0.244
LIG_REV1ctd_RIR_1	277	288	PF16727	0.470
LIG_SH2_CRK	197	201	PF00017	0.352
LIG_SH2_NCK_1	197	201	PF00017	0.343
LIG_SH2_SRC	75	78	PF00017	0.509
LIG_SH2_STAP1	197	201	PF00017	0.343
LIG_SH2_STAT5	141	144	PF00017	0.244
LIG_SH2_STAT5	159	162	PF00017	0.294
LIG_SH2_STAT5	197	200	PF00017	0.343
LIG_SH2_STAT5	75	78	PF00017	0.487
LIG_SH3_3	11	17	PF00018	0.617
LIG_SH3_3	219	225	PF00018	0.270
LIG_SH3_3	250	256	PF00018	0.291
LIG_SH3_3	299	305	PF00018	0.350
LIG_Sin3_3	187	194	PF02671	0.468
LIG_SUMO_SIM_anti_2	295	301	PF11976	0.354
LIG_SUMO_SIM_par_1	292	298	PF11976	0.343
LIG_TYR_ITIM	195	200	PF00017	0.343
MOD_CDC14_SPxK_1	46	49	PF00782	0.505
MOD_CDK_SPxK_1	118	124	PF00069	0.244
MOD_CDK_SPxK_1	43	49	PF00069	0.487
MOD_CK1_1	118	124	PF00069	0.287
MOD_CK1_1	131	137	PF00069	0.287
MOD_CK1_1	178	184	PF00069	0.481
MOD_CK2_1	317	323	PF00069	0.244
MOD_CK2_1	335	341	PF00069	0.244
MOD_CK2_1	6	12	PF00069	0.610
MOD_GlcNHglycan	144	147	PF01048	0.444
MOD_GlcNHglycan	177	180	PF01048	0.305
MOD_GlcNHglycan	185	188	PF01048	0.179
MOD_GlcNHglycan	236	239	PF01048	0.531
MOD_GlcNHglycan	89	92	PF01048	0.285
MOD_GSK3_1	162	169	PF00069	0.357
MOD_GSK3_1	171	178	PF00069	0.266
MOD_GSK3_1	2	9	PF00069	0.583
MOD_GSK3_1	35	42	PF00069	0.448
MOD_N-GLC_1	131	136	PF02516	0.444
MOD_N-GLC_1	142	147	PF02516	0.444
MOD_N-GLC_2	110	112	PF02516	0.343
MOD_N-GLC_2	140	142	PF02516	0.444
MOD_NEK2_1	155	160	PF00069	0.268
MOD_NEK2_1	322	327	PF00069	0.304
MOD_NEK2_1	98	103	PF00069	0.487
MOD_NEK2_2	66	71	PF00069	0.505
MOD_PIKK_1	115	121	PF00454	0.343
MOD_PKA_2	98	104	PF00069	0.444
MOD_Plk_1	131	137	PF00069	0.244
MOD_Plk_1	22	28	PF00069	0.488
MOD_Plk_1	322	328	PF00069	0.305
MOD_Plk_4	292	298	PF00069	0.371
MOD_Plk_4	312	318	PF00069	0.148
MOD_ProDKin_1	118	124	PF00069	0.250
MOD_ProDKin_1	2	8	PF00069	0.591
MOD_ProDKin_1	43	49	PF00069	0.487
MOD_SUMO_rev_2	230	237	PF00179	0.268
TRG_ENDOCYTIC_2	197	200	PF00928	0.343
TRG_ER_diArg_1	283	285	PF00400	0.414
TRG_ER_diArg_1	79	82	PF00400	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P786	Leptomonas seymouri	76%	100%
A0A0N1I4E4	Leptomonas seymouri	29%	100%
A0A0S4IJR6	Bodo saltans	44%	100%
A0A1X0P3C3	Trypanosomatidae	29%	100%
A0A3R7KD90	Trypanosoma rangeli	29%	100%
A0A3S5H4W1	Leishmania donovani	29%	100%
A0A3S5H5J2	Leishmania donovani	97%	100%
A4H380	Leishmania braziliensis	28%	99%
A4H4B2	Leishmania braziliensis	88%	100%
A4HRI0	Leishmania infantum	29%	100%
A4HSJ0	Leishmania infantum	97%	100%
A5A761	Sus scrofa	32%	100%
A6QP55	Bos taurus	32%	100%
A8E7G5	Danio rerio	27%	100%
B2LU20	Ovis aries	34%	100%
C9ZXK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AC48	Leishmania major	29%	99%
E9AJE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	99%
O13793	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q09201	Caenorhabditis elegans	31%	100%
Q12029	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q3T0M2	Bos taurus	27%	100%
Q4QJD4	Leishmania major	96%	100%
Q54NQ9	Dictyostelium discoideum	32%	100%
Q5E9M8	Bos taurus	34%	100%
Q5EA43	Bos taurus	31%	100%
Q5FC79	Caenorhabditis elegans	32%	100%
Q5RD16	Pongo abelii	33%	100%
Q63965	Rattus norvegicus	33%	100%
Q6P4A7	Homo sapiens	23%	100%
Q8CFD0	Rattus norvegicus	32%	100%
Q8TD22	Homo sapiens	32%	100%
Q91V61	Mus musculus	33%	100%
Q925N0	Mus musculus	32%	100%
Q925N2	Mus musculus	30%	100%
Q96NB2	Homo sapiens	31%	100%
Q99JR1	Mus musculus	33%	100%
Q9BWM7	Homo sapiens	32%	100%
Q9H9B4	Homo sapiens	32%	100%
Q9JHY2	Rattus norvegicus	33%	100%
Q9VN13	Drosophila melanogaster	29%	100%
Q9VVW3	Drosophila melanogaster	29%	100%
V5BCG0	Trypanosoma cruzi	28%	100%