Nitroreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nitroreductase-like protein

Species:

Leishmania mexicana

UniProt:

E9AKH2_LEIMU

TriTrypDb:

LmxM.05.0660

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKH2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.619
CLV_PCSK_KEX2_1	268	270	PF00082	0.375
CLV_PCSK_KEX2_1	296	298	PF00082	0.622
CLV_PCSK_KEX2_1	6	8	PF00082	0.619
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.434
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.622
CLV_PCSK_SKI1_1	140	144	PF00082	0.349
CLV_PCSK_SKI1_1	268	272	PF00082	0.447
CLV_PCSK_SKI1_1	303	307	PF00082	0.593
CLV_PCSK_SKI1_1	6	10	PF00082	0.648

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M3	Leptomonas seymouri	68%	100%
A0A1X0NKR5	Trypanosomatidae	54%	100%
A0A3R7M8G7	Trypanosoma rangeli	58%	100%
A0A3S5H5J0	Leishmania donovani	93%	98%
A4H4B0	Leishmania braziliensis	81%	100%
A4HSI8	Leishmania infantum	90%	98%
C9ZUB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
Q4QJD6	Leishmania major	88%	100%
V5BAS5	Trypanosoma cruzi	58%	99%

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