SURP motif domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surp module, putative

Species:

Leishmania mexicana

UniProt:

E9AKG7_LEIMU

TriTrypDb:

LmxM.05.0610

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKG7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.539
CLV_C14_Caspase3-7	462	466	PF00656	0.544
CLV_NRD_NRD_1	245	247	PF00675	0.472
CLV_NRD_NRD_1	308	310	PF00675	0.665
CLV_NRD_NRD_1	323	325	PF00675	0.543
CLV_NRD_NRD_1	477	479	PF00675	0.496
CLV_NRD_NRD_1	654	656	PF00675	0.646
CLV_NRD_NRD_1	661	663	PF00675	0.594
CLV_NRD_NRD_1	697	699	PF00675	0.438
CLV_PCSK_FUR_1	305	309	PF00082	0.660
CLV_PCSK_FUR_1	651	655	PF00082	0.644
CLV_PCSK_KEX2_1	193	195	PF00082	0.298
CLV_PCSK_KEX2_1	245	247	PF00082	0.472
CLV_PCSK_KEX2_1	307	309	PF00082	0.667
CLV_PCSK_KEX2_1	323	325	PF00082	0.679
CLV_PCSK_KEX2_1	477	479	PF00082	0.468
CLV_PCSK_KEX2_1	653	655	PF00082	0.648
CLV_PCSK_KEX2_1	661	663	PF00082	0.594
CLV_PCSK_KEX2_1	696	698	PF00082	0.444
CLV_PCSK_KEX2_1	891	893	PF00082	0.502
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.269
CLV_PCSK_PC1ET2_1	891	893	PF00082	0.482
CLV_PCSK_PC7_1	657	663	PF00082	0.685
CLV_PCSK_SKI1_1	434	438	PF00082	0.528
CLV_PCSK_SKI1_1	484	488	PF00082	0.467
CLV_PCSK_SKI1_1	58	62	PF00082	0.485
CLV_PCSK_SKI1_1	713	717	PF00082	0.693
CLV_PCSK_SKI1_1	816	820	PF00082	0.554
DEG_APCC_DBOX_1	218	226	PF00400	0.469
DEG_SCF_FBW7_1	769	776	PF00400	0.618
DEG_SPOP_SBC_1	740	744	PF00917	0.632
DEG_SPOP_SBC_1	800	804	PF00917	0.645
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	271	277	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	451	457	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	85	88	PF00134	0.660
DOC_MAPK_gen_1	158	167	PF00069	0.426
DOC_MAPK_gen_1	245	251	PF00069	0.434
DOC_MAPK_MEF2A_6	667	676	PF00069	0.465
DOC_MAPK_MEF2A_6	816	823	PF00069	0.507
DOC_PP2B_LxvP_1	150	153	PF13499	0.487
DOC_PP2B_LxvP_1	154	157	PF13499	0.462
DOC_PP2B_LxvP_1	159	162	PF13499	0.408
DOC_PP2B_LxvP_1	251	254	PF13499	0.300
DOC_PP2B_LxvP_1	418	421	PF13499	0.554
DOC_PP2B_LxvP_1	829	832	PF13499	0.584
DOC_PP2B_LxvP_1	85	88	PF13499	0.629
DOC_PP2B_PxIxI_1	109	115	PF00149	0.485
DOC_PP4_FxxP_1	210	213	PF00568	0.469
DOC_PP4_FxxP_1	71	74	PF00568	0.640
DOC_USP7_MATH_1	121	125	PF00917	0.649
DOC_USP7_MATH_1	132	136	PF00917	0.562
DOC_USP7_MATH_1	398	402	PF00917	0.705
DOC_USP7_MATH_1	404	408	PF00917	0.777
DOC_USP7_MATH_1	521	525	PF00917	0.626
DOC_USP7_MATH_1	527	531	PF00917	0.471
DOC_USP7_MATH_1	555	559	PF00917	0.678
DOC_USP7_MATH_1	583	587	PF00917	0.689
DOC_USP7_MATH_1	618	622	PF00917	0.637
DOC_USP7_MATH_1	74	78	PF00917	0.788
DOC_USP7_MATH_1	740	744	PF00917	0.718
DOC_USP7_MATH_1	784	788	PF00917	0.708
DOC_USP7_MATH_1	799	803	PF00917	0.614
DOC_USP7_MATH_1	835	839	PF00917	0.680
DOC_USP7_MATH_1	866	870	PF00917	0.745
DOC_USP7_UBL2_3	567	571	PF12436	0.531
DOC_USP7_UBL2_3	727	731	PF12436	0.693
DOC_WW_Pin1_4	124	129	PF00397	0.662
DOC_WW_Pin1_4	393	398	PF00397	0.637
DOC_WW_Pin1_4	402	407	PF00397	0.642
DOC_WW_Pin1_4	551	556	PF00397	0.714
DOC_WW_Pin1_4	619	624	PF00397	0.667
DOC_WW_Pin1_4	630	635	PF00397	0.626
DOC_WW_Pin1_4	660	665	PF00397	0.612
DOC_WW_Pin1_4	769	774	PF00397	0.627
DOC_WW_Pin1_4	775	780	PF00397	0.697
DOC_WW_Pin1_4	831	836	PF00397	0.662
LIG_14-3-3_CanoR_1	221	226	PF00244	0.469
LIG_14-3-3_CanoR_1	428	437	PF00244	0.663
LIG_14-3-3_CanoR_1	912	916	PF00244	0.544
LIG_14-3-3_CanoR_1	97	107	PF00244	0.608
LIG_BRCT_BRCA1_1	913	917	PF00533	0.506
LIG_Clathr_ClatBox_1	881	885	PF01394	0.622
LIG_CSL_BTD_1	249	252	PF09270	0.443
LIG_deltaCOP1_diTrp_1	536	542	PF00928	0.438
LIG_eIF4E_1	895	901	PF01652	0.574
LIG_EVH1_1	251	255	PF00568	0.310
LIG_FHA_1	145	151	PF00498	0.612
LIG_FHA_1	168	174	PF00498	0.441
LIG_FHA_1	447	453	PF00498	0.526
LIG_FHA_1	745	751	PF00498	0.666
LIG_FHA_1	869	875	PF00498	0.633
LIG_FHA_2	129	135	PF00498	0.515
LIG_FHA_2	169	175	PF00498	0.304
LIG_FHA_2	184	190	PF00498	0.469
LIG_FHA_2	34	40	PF00498	0.556
LIG_FHA_2	403	409	PF00498	0.640
LIG_FHA_2	460	466	PF00498	0.547
LIG_FHA_2	468	474	PF00498	0.445
LIG_FHA_2	586	592	PF00498	0.551
LIG_FHA_2	676	682	PF00498	0.501
LIG_GSK3_LRP6_1	831	836	PF00069	0.559
LIG_IBAR_NPY_1	453	455	PF08397	0.518
LIG_Integrin_RGD_1	378	380	PF01839	0.603
LIG_LIR_Apic_2	208	213	PF02991	0.469
LIG_LIR_Apic_2	69	74	PF02991	0.649
LIG_LIR_Apic_2	75	81	PF02991	0.611
LIG_LIR_Gen_1	446	456	PF02991	0.472
LIG_LIR_Gen_1	603	614	PF02991	0.653
LIG_LIR_Gen_1	911	917	PF02991	0.509
LIG_LIR_Nem_3	446	451	PF02991	0.457
LIG_LIR_Nem_3	536	542	PF02991	0.438
LIG_LIR_Nem_3	603	609	PF02991	0.647
LIG_LIR_Nem_3	911	916	PF02991	0.546
LIG_MYND_1	83	87	PF01753	0.645
LIG_NRBOX	171	177	PF00104	0.304
LIG_NRBOX	221	227	PF00104	0.469
LIG_NRBOX	498	504	PF00104	0.409
LIG_PCNA_yPIPBox_3	47	58	PF02747	0.611
LIG_PDZ_Class_2	912	917	PF00595	0.509
LIG_Pex14_1	814	818	PF04695	0.549
LIG_Pex14_2	818	822	PF04695	0.566
LIG_PTB_Apo_2	197	204	PF02174	0.455
LIG_SH2_CRK	223	227	PF00017	0.509
LIG_SH2_CRK	78	82	PF00017	0.664
LIG_SH2_CRK	895	899	PF00017	0.585
LIG_SH2_CRK	913	917	PF00017	0.506
LIG_SH2_GRB2like	90	93	PF00017	0.626
LIG_SH2_NCK_1	455	459	PF00017	0.511
LIG_SH2_PTP2	248	251	PF00017	0.390
LIG_SH2_STAP1	913	917	PF00017	0.506
LIG_SH2_STAT3	361	364	PF00017	0.530
LIG_SH2_STAT3	42	45	PF00017	0.604
LIG_SH2_STAT5	248	251	PF00017	0.422
LIG_SH2_STAT5	35	38	PF00017	0.568
LIG_SH2_STAT5	511	514	PF00017	0.522
LIG_SH2_STAT5	533	536	PF00017	0.482
LIG_SH2_STAT5	540	543	PF00017	0.405
LIG_SH2_STAT5	90	93	PF00017	0.669
LIG_SH3_2	252	257	PF14604	0.505
LIG_SH3_3	114	120	PF00018	0.603
LIG_SH3_3	246	252	PF00018	0.406
LIG_SH3_3	413	419	PF00018	0.598
LIG_SH3_3	573	579	PF00018	0.560
LIG_SH3_3	620	626	PF00018	0.738
LIG_SH3_3	671	677	PF00018	0.509
LIG_SH3_3	714	720	PF00018	0.683
LIG_SH3_3	776	782	PF00018	0.569
LIG_SH3_3	825	831	PF00018	0.596
LIG_SH3_3	845	851	PF00018	0.627
LIG_SH3_4	387	394	PF00018	0.533
LIG_SUMO_SIM_anti_2	170	177	PF11976	0.369
LIG_SUMO_SIM_anti_2	670	676	PF11976	0.541
LIG_TRAF2_1	186	189	PF00917	0.469
LIG_TRAF2_1	291	294	PF00917	0.626
LIG_TRAF2_1	588	591	PF00917	0.566
LIG_TYR_ITIM	538	543	PF00017	0.443
LIG_UBA3_1	811	816	PF00899	0.495
LIG_WW_1	87	90	PF00397	0.644
MOD_CDK_SPxxK_3	660	667	PF00069	0.522
MOD_CK1_1	124	130	PF00069	0.611
MOD_CK1_1	135	141	PF00069	0.561
MOD_CK1_1	23	29	PF00069	0.671
MOD_CK1_1	233	239	PF00069	0.483
MOD_CK1_1	343	349	PF00069	0.641
MOD_CK1_1	350	356	PF00069	0.728
MOD_CK1_1	371	377	PF00069	0.574
MOD_CK1_1	558	564	PF00069	0.787
MOD_CK1_1	595	601	PF00069	0.488
MOD_CK1_1	633	639	PF00069	0.639
MOD_CK1_1	739	745	PF00069	0.719
MOD_CK1_1	775	781	PF00069	0.669
MOD_CK1_1	787	793	PF00069	0.663
MOD_CK1_1	802	808	PF00069	0.518
MOD_CK2_1	128	134	PF00069	0.552
MOD_CK2_1	183	189	PF00069	0.469
MOD_CK2_1	322	328	PF00069	0.685
MOD_CK2_1	33	39	PF00069	0.555
MOD_CK2_1	343	349	PF00069	0.565
MOD_CK2_1	353	359	PF00069	0.732
MOD_CK2_1	371	377	PF00069	0.598
MOD_CK2_1	402	408	PF00069	0.640
MOD_CK2_1	467	473	PF00069	0.406
MOD_CK2_1	585	591	PF00069	0.547
MOD_CK2_1	660	666	PF00069	0.600
MOD_CK2_1	675	681	PF00069	0.521
MOD_GlcNHglycan	117	120	PF01048	0.619
MOD_GlcNHglycan	123	126	PF01048	0.582
MOD_GlcNHglycan	134	137	PF01048	0.506
MOD_GlcNHglycan	25	28	PF01048	0.570
MOD_GlcNHglycan	312	315	PF01048	0.665
MOD_GlcNHglycan	340	343	PF01048	0.722
MOD_GlcNHglycan	370	373	PF01048	0.677
MOD_GlcNHglycan	4	7	PF01048	0.559
MOD_GlcNHglycan	400	403	PF01048	0.650
MOD_GlcNHglycan	421	424	PF01048	0.533
MOD_GlcNHglycan	523	526	PF01048	0.441
MOD_GlcNHglycan	556	560	PF01048	0.727
MOD_GlcNHglycan	585	588	PF01048	0.764
MOD_GlcNHglycan	647	650	PF01048	0.654
MOD_GlcNHglycan	738	741	PF01048	0.788
MOD_GlcNHglycan	782	785	PF01048	0.706
MOD_GlcNHglycan	786	789	PF01048	0.723
MOD_GlcNHglycan	790	793	PF01048	0.758
MOD_GlcNHglycan	804	807	PF01048	0.535
MOD_GlcNHglycan	837	840	PF01048	0.786
MOD_GlcNHglycan	901	904	PF01048	0.517
MOD_GlcNHglycan	94	97	PF01048	0.608
MOD_GSK3_1	120	127	PF00069	0.616
MOD_GSK3_1	128	135	PF00069	0.565
MOD_GSK3_1	23	30	PF00069	0.622
MOD_GSK3_1	318	325	PF00069	0.679
MOD_GSK3_1	336	343	PF00069	0.736
MOD_GSK3_1	344	351	PF00069	0.553
MOD_GSK3_1	383	390	PF00069	0.670
MOD_GSK3_1	398	405	PF00069	0.574
MOD_GSK3_1	424	431	PF00069	0.593
MOD_GSK3_1	551	558	PF00069	0.725
MOD_GSK3_1	591	598	PF00069	0.636
MOD_GSK3_1	618	625	PF00069	0.580
MOD_GSK3_1	641	648	PF00069	0.649
MOD_GSK3_1	684	691	PF00069	0.577
MOD_GSK3_1	736	743	PF00069	0.631
MOD_GSK3_1	767	774	PF00069	0.667
MOD_GSK3_1	780	787	PF00069	0.597
MOD_GSK3_1	795	802	PF00069	0.817
MOD_GSK3_1	831	838	PF00069	0.632
MOD_LATS_1	310	316	PF00433	0.641
MOD_N-GLC_1	336	341	PF02516	0.636
MOD_N-GLC_1	549	554	PF02516	0.520
MOD_NEK2_1	167	172	PF00069	0.396
MOD_NEK2_1	4	9	PF00069	0.579
MOD_NEK2_1	549	554	PF00069	0.520
MOD_NEK2_1	741	746	PF00069	0.632
MOD_NEK2_2	66	71	PF00069	0.568
MOD_NEK2_2	754	759	PF00069	0.617
MOD_PIKK_1	233	239	PF00454	0.483
MOD_PIKK_1	387	393	PF00454	0.653
MOD_PIKK_1	696	702	PF00454	0.612
MOD_PIKK_1	76	82	PF00454	0.666
MOD_PIKK_1	885	891	PF00454	0.633
MOD_PKA_1	696	702	PF00069	0.448
MOD_PKA_2	322	328	PF00069	0.537
MOD_PKA_2	696	702	PF00069	0.448
MOD_PKA_2	911	917	PF00069	0.559
MOD_PKB_1	158	166	PF00069	0.405
MOD_PKB_1	219	227	PF00069	0.469
MOD_PKB_1	338	346	PF00069	0.649
MOD_Plk_1	167	173	PF00069	0.387
MOD_Plk_1	74	80	PF00069	0.626
MOD_Plk_1	866	872	PF00069	0.595
MOD_Plk_2-3	168	174	PF00069	0.376
MOD_Plk_2-3	459	465	PF00069	0.480
MOD_Plk_4	168	174	PF00069	0.376
MOD_Plk_4	221	227	PF00069	0.469
MOD_Plk_4	33	39	PF00069	0.574
MOD_Plk_4	49	55	PF00069	0.584
MOD_Plk_4	497	503	PF00069	0.414
MOD_Plk_4	641	647	PF00069	0.518
MOD_Plk_4	66	72	PF00069	0.502
MOD_Plk_4	675	681	PF00069	0.532
MOD_Plk_4	850	856	PF00069	0.682
MOD_Plk_4	877	883	PF00069	0.605
MOD_Plk_4	911	917	PF00069	0.535
MOD_ProDKin_1	124	130	PF00069	0.663
MOD_ProDKin_1	393	399	PF00069	0.636
MOD_ProDKin_1	402	408	PF00069	0.644
MOD_ProDKin_1	551	557	PF00069	0.722
MOD_ProDKin_1	619	625	PF00069	0.669
MOD_ProDKin_1	630	636	PF00069	0.625
MOD_ProDKin_1	660	666	PF00069	0.526
MOD_ProDKin_1	769	775	PF00069	0.628
MOD_ProDKin_1	778	784	PF00069	0.736
MOD_ProDKin_1	831	837	PF00069	0.657
MOD_SUMO_for_1	192	195	PF00179	0.469
MOD_SUMO_rev_2	52	60	PF00179	0.604
TRG_DiLeu_BaEn_1	168	173	PF01217	0.380
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.658
TRG_DiLeu_BaLyEn_6	896	901	PF01217	0.556
TRG_ENDOCYTIC_2	223	226	PF00928	0.522
TRG_ENDOCYTIC_2	248	251	PF00928	0.408
TRG_ENDOCYTIC_2	35	38	PF00928	0.593
TRG_ENDOCYTIC_2	540	543	PF00928	0.437
TRG_ENDOCYTIC_2	606	609	PF00928	0.737
TRG_ENDOCYTIC_2	913	916	PF00928	0.496
TRG_ER_diArg_1	157	160	PF00400	0.435
TRG_ER_diArg_1	305	308	PF00400	0.658
TRG_ER_diArg_1	323	326	PF00400	0.545
TRG_ER_diArg_1	415	418	PF00400	0.594
TRG_ER_diArg_1	476	478	PF00400	0.459
TRG_ER_diArg_1	650	653	PF00400	0.644
TRG_ER_diArg_1	654	657	PF00400	0.644
TRG_ER_diArg_1	696	698	PF00400	0.444
TRG_NES_CRM1_1	493	504	PF08389	0.438
TRG_Pf-PMV_PEXEL_1	474	479	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAE1	Leptomonas seymouri	41%	97%
A0A3S7WP43	Leishmania donovani	88%	94%
A4HD48	Leishmania braziliensis	71%	100%
A4HSI3	Leishmania infantum	88%	94%
Q4QJE1	Leishmania major	87%	99%