Conserved oligomeric Golgi complex subunit 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COG4 transport protein, putative

Species:

Leishmania mexicana

UniProt:

E9AKG6_LEIMU

TriTrypDb:

LmxM.05.0600

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	12
GO:0016020	membrane	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AKG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKG6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.623
CLV_C14_Caspase3-7	337	341	PF00656	0.463
CLV_C14_Caspase3-7	437	441	PF00656	0.399
CLV_MEL_PAP_1	894	900	PF00089	0.241
CLV_NRD_NRD_1	255	257	PF00675	0.309
CLV_NRD_NRD_1	26	28	PF00675	0.491
CLV_NRD_NRD_1	324	326	PF00675	0.395
CLV_NRD_NRD_1	376	378	PF00675	0.297
CLV_NRD_NRD_1	400	402	PF00675	0.415
CLV_NRD_NRD_1	658	660	PF00675	0.747
CLV_NRD_NRD_1	809	811	PF00675	0.386
CLV_NRD_NRD_1	820	822	PF00675	0.374
CLV_NRD_NRD_1	88	90	PF00675	0.510
CLV_NRD_NRD_1	900	902	PF00675	0.432
CLV_PCSK_FUR_1	86	90	PF00082	0.598
CLV_PCSK_KEX2_1	26	28	PF00082	0.477
CLV_PCSK_KEX2_1	324	326	PF00082	0.301
CLV_PCSK_KEX2_1	376	378	PF00082	0.297
CLV_PCSK_KEX2_1	657	659	PF00082	0.747
CLV_PCSK_KEX2_1	809	811	PF00082	0.376
CLV_PCSK_KEX2_1	822	824	PF00082	0.371
CLV_PCSK_KEX2_1	85	87	PF00082	0.493
CLV_PCSK_KEX2_1	88	90	PF00082	0.495
CLV_PCSK_PC1ET2_1	822	824	PF00082	0.474
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.593
CLV_PCSK_SKI1_1	141	145	PF00082	0.512
CLV_PCSK_SKI1_1	198	202	PF00082	0.348
CLV_PCSK_SKI1_1	326	330	PF00082	0.341
CLV_PCSK_SKI1_1	682	686	PF00082	0.516
CLV_PCSK_SKI1_1	810	814	PF00082	0.431
CLV_PCSK_SKI1_1	840	844	PF00082	0.370
CLV_PCSK_SKI1_1	855	859	PF00082	0.386
CLV_PCSK_SKI1_1	891	895	PF00082	0.362
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DOC_CKS1_1	668	673	PF01111	0.544
DOC_MAPK_gen_1	890	898	PF00069	0.421
DOC_MAPK_gen_1	901	908	PF00069	0.497
DOC_MAPK_HePTP_8	898	910	PF00069	0.525
DOC_MAPK_MEF2A_6	891	900	PF00069	0.504
DOC_MAPK_MEF2A_6	901	910	PF00069	0.523
DOC_PP1_RVXF_1	895	901	PF00149	0.410
DOC_PP2B_LxvP_1	460	463	PF13499	0.176
DOC_PP4_FxxP_1	668	671	PF00568	0.473
DOC_USP7_MATH_1	115	119	PF00917	0.588
DOC_USP7_MATH_1	170	174	PF00917	0.511
DOC_USP7_MATH_1	229	233	PF00917	0.424
DOC_USP7_MATH_1	270	274	PF00917	0.335
DOC_USP7_MATH_1	282	286	PF00917	0.383
DOC_USP7_MATH_1	336	340	PF00917	0.316
DOC_USP7_MATH_1	416	420	PF00917	0.455
DOC_USP7_MATH_1	518	522	PF00917	0.361
DOC_USP7_MATH_1	539	543	PF00917	0.371
DOC_USP7_MATH_1	566	570	PF00917	0.415
DOC_USP7_MATH_1	613	617	PF00917	0.320
DOC_USP7_MATH_1	648	652	PF00917	0.743
DOC_USP7_MATH_1	75	79	PF00917	0.494
DOC_USP7_MATH_1	755	759	PF00917	0.472
DOC_USP7_MATH_1	80	84	PF00917	0.461
DOC_WW_Pin1_4	144	149	PF00397	0.598
DOC_WW_Pin1_4	667	672	PF00397	0.560
DOC_WW_Pin1_4	702	707	PF00397	0.570
DOC_WW_Pin1_4	849	854	PF00397	0.502
LIG_14-3-3_CanoR_1	141	148	PF00244	0.517
LIG_14-3-3_CanoR_1	401	410	PF00244	0.444
LIG_14-3-3_CanoR_1	444	451	PF00244	0.415
LIG_14-3-3_CanoR_1	682	687	PF00244	0.475
LIG_14-3-3_CanoR_1	809	819	PF00244	0.377
LIG_14-3-3_CanoR_1	821	827	PF00244	0.453
LIG_14-3-3_CanoR_1	96	104	PF00244	0.578
LIG_APCC_ABBA_1	747	752	PF00400	0.482
LIG_APCC_ABBAyCdc20_2	35	41	PF00400	0.611
LIG_BH_BH3_1	679	695	PF00452	0.503
LIG_FHA_1	127	133	PF00498	0.362
LIG_FHA_1	217	223	PF00498	0.311
LIG_FHA_1	642	648	PF00498	0.559
LIG_FHA_1	813	819	PF00498	0.466
LIG_FHA_1	862	868	PF00498	0.322
LIG_FHA_1	872	878	PF00498	0.485
LIG_FHA_1	98	104	PF00498	0.530
LIG_FHA_2	106	112	PF00498	0.368
LIG_FHA_2	379	385	PF00498	0.246
LIG_FHA_2	395	401	PF00498	0.490
LIG_FHA_2	402	408	PF00498	0.415
LIG_FHA_2	583	589	PF00498	0.313
LIG_FHA_2	668	674	PF00498	0.538
LIG_FHA_2	703	709	PF00498	0.554
LIG_FHA_2	723	729	PF00498	0.389
LIG_FHA_2	884	890	PF00498	0.425
LIG_GBD_Chelix_1	247	255	PF00786	0.433
LIG_LIR_Gen_1	288	299	PF02991	0.351
LIG_LIR_Gen_1	736	746	PF02991	0.409
LIG_LIR_Gen_1	752	761	PF02991	0.315
LIG_LIR_Gen_1	856	865	PF02991	0.377
LIG_LIR_Nem_3	288	294	PF02991	0.430
LIG_LIR_Nem_3	466	471	PF02991	0.368
LIG_LIR_Nem_3	574	578	PF02991	0.384
LIG_LIR_Nem_3	588	594	PF02991	0.237
LIG_LIR_Nem_3	710	715	PF02991	0.530
LIG_LIR_Nem_3	736	741	PF02991	0.405
LIG_LIR_Nem_3	752	757	PF02991	0.316
LIG_LIR_Nem_3	763	769	PF02991	0.358
LIG_LIR_Nem_3	825	830	PF02991	0.364
LIG_LIR_Nem_3	856	861	PF02991	0.369
LIG_LRP6_Inhibitor_1	29	35	PF00058	0.515
LIG_NRBOX	89	95	PF00104	0.465
LIG_PCNA_PIPBox_1	454	463	PF02747	0.362
LIG_PCNA_PIPBox_1	529	538	PF02747	0.313
LIG_PCNA_yPIPBox_3	189	203	PF02747	0.477
LIG_PDZ_Class_2	905	910	PF00595	0.380
LIG_Pex14_1	734	738	PF04695	0.378
LIG_PTB_Apo_2	50	57	PF02174	0.573
LIG_PTB_Phospho_1	50	56	PF10480	0.572
LIG_REV1ctd_RIR_1	589	599	PF16727	0.333
LIG_REV1ctd_RIR_1	840	850	PF16727	0.369
LIG_RPA_C_Fungi	187	199	PF08784	0.290
LIG_RPA_C_Fungi	228	240	PF08784	0.272
LIG_SH2_NCK_1	136	140	PF00017	0.445
LIG_SH2_PTP2	461	464	PF00017	0.433
LIG_SH2_STAP1	235	239	PF00017	0.389
LIG_SH2_STAP1	406	410	PF00017	0.433
LIG_SH2_STAP1	473	477	PF00017	0.415
LIG_SH2_STAT3	789	792	PF00017	0.509
LIG_SH2_STAT5	395	398	PF00017	0.365
LIG_SH2_STAT5	461	464	PF00017	0.338
LIG_SH2_STAT5	468	471	PF00017	0.288
LIG_SH2_STAT5	577	580	PF00017	0.411
LIG_SH2_STAT5	62	65	PF00017	0.590
LIG_SH2_STAT5	686	689	PF00017	0.443
LIG_SH2_STAT5	789	792	PF00017	0.456
LIG_SH3_3	517	523	PF00018	0.336
LIG_SH3_3	581	587	PF00018	0.399
LIG_SH3_3	743	749	PF00018	0.408
LIG_Sin3_3	800	807	PF02671	0.389
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.333
LIG_SUMO_SIM_anti_2	267	273	PF11976	0.319
LIG_SUMO_SIM_par_1	864	871	PF11976	0.353
LIG_TRAF2_1	285	288	PF00917	0.418
LIG_TRAF2_1	381	384	PF00917	0.268
LIG_TRAF2_1	876	879	PF00917	0.554
LIG_TRFH_1	56	60	PF08558	0.587
LIG_TYR_ITSM	464	471	PF00017	0.351
LIG_UBA3_1	826	834	PF00899	0.463
LIG_WRC_WIRS_1	395	400	PF05994	0.357
LIG_WRC_WIRS_1	572	577	PF05994	0.351
MOD_CDC14_SPxK_1	852	855	PF00782	0.253
MOD_CDK_SPxK_1	849	855	PF00069	0.504
MOD_CK1_1	147	153	PF00069	0.655
MOD_CK1_1	308	314	PF00069	0.313
MOD_CK1_1	350	356	PF00069	0.267
MOD_CK1_1	424	430	PF00069	0.402
MOD_CK1_1	521	527	PF00069	0.356
MOD_CK1_1	649	655	PF00069	0.747
MOD_CK2_1	105	111	PF00069	0.333
MOD_CK2_1	282	288	PF00069	0.418
MOD_CK2_1	378	384	PF00069	0.295
MOD_CK2_1	394	400	PF00069	0.460
MOD_CK2_1	401	407	PF00069	0.366
MOD_CK2_1	416	422	PF00069	0.340
MOD_CK2_1	44	50	PF00069	0.584
MOD_CK2_1	539	545	PF00069	0.364
MOD_CK2_1	667	673	PF00069	0.555
MOD_CK2_1	75	81	PF00069	0.495
MOD_CK2_1	883	889	PF00069	0.447
MOD_Cter_Amidation	655	658	PF01082	0.722
MOD_GlcNHglycan	122	125	PF01048	0.522
MOD_GlcNHglycan	144	147	PF01048	0.561
MOD_GlcNHglycan	172	175	PF01048	0.647
MOD_GlcNHglycan	259	263	PF01048	0.468
MOD_GlcNHglycan	336	339	PF01048	0.355
MOD_GlcNHglycan	342	345	PF01048	0.311
MOD_GlcNHglycan	349	352	PF01048	0.312
MOD_GlcNHglycan	418	421	PF01048	0.388
MOD_GlcNHglycan	515	518	PF01048	0.329
MOD_GlcNHglycan	520	523	PF01048	0.319
MOD_GlcNHglycan	529	532	PF01048	0.313
MOD_GlcNHglycan	541	544	PF01048	0.244
MOD_GlcNHglycan	555	558	PF01048	0.418
MOD_GlcNHglycan	563	567	PF01048	0.379
MOD_GlcNHglycan	610	613	PF01048	0.280
MOD_GlcNHglycan	615	618	PF01048	0.273
MOD_GlcNHglycan	65	68	PF01048	0.468
MOD_GlcNHglycan	651	654	PF01048	0.747
MOD_GlcNHglycan	702	705	PF01048	0.507
MOD_GSK3_1	116	123	PF00069	0.593
MOD_GSK3_1	165	172	PF00069	0.649
MOD_GSK3_1	229	236	PF00069	0.438
MOD_GSK3_1	260	267	PF00069	0.351
MOD_GSK3_1	336	343	PF00069	0.321
MOD_GSK3_1	383	390	PF00069	0.297
MOD_GSK3_1	39	46	PF00069	0.446
MOD_GSK3_1	434	441	PF00069	0.195
MOD_GSK3_1	463	470	PF00069	0.418
MOD_GSK3_1	503	510	PF00069	0.376
MOD_GSK3_1	527	534	PF00069	0.314
MOD_GSK3_1	562	569	PF00069	0.485
MOD_GSK3_1	604	611	PF00069	0.193
MOD_GSK3_1	637	644	PF00069	0.568
MOD_GSK3_1	698	705	PF00069	0.558
MOD_GSK3_1	718	725	PF00069	0.459
MOD_GSK3_1	810	817	PF00069	0.358
MOD_GSK3_1	859	866	PF00069	0.401
MOD_GSK3_1	867	874	PF00069	0.466
MOD_LATS_1	820	826	PF00433	0.248
MOD_N-GLC_1	513	518	PF02516	0.383
MOD_N-GLC_1	649	654	PF02516	0.729
MOD_N-GLC_1	75	80	PF02516	0.596
MOD_N-GLC_2	740	742	PF02516	0.239
MOD_NEK2_1	216	221	PF00069	0.349
MOD_NEK2_1	258	263	PF00069	0.415
MOD_NEK2_1	44	49	PF00069	0.587
MOD_NEK2_1	450	455	PF00069	0.313
MOD_NEK2_1	464	469	PF00069	0.313
MOD_NEK2_1	674	679	PF00069	0.356
MOD_NEK2_1	69	74	PF00069	0.494
MOD_NEK2_1	722	727	PF00069	0.454
MOD_NEK2_1	861	866	PF00069	0.392
MOD_NEK2_2	531	536	PF00069	0.385
MOD_PIKK_1	270	276	PF00454	0.433
MOD_PIKK_1	604	610	PF00454	0.187
MOD_PKA_1	401	407	PF00069	0.433
MOD_PKA_1	822	828	PF00069	0.435
MOD_PKA_2	34	40	PF00069	0.609
MOD_PKA_2	443	449	PF00069	0.415
MOD_PKA_2	81	87	PF00069	0.485
MOD_PKA_2	822	828	PF00069	0.439
MOD_Plk_1	126	132	PF00069	0.396
MOD_Plk_1	240	246	PF00069	0.297
MOD_Plk_1	287	293	PF00069	0.351
MOD_Plk_1	378	384	PF00069	0.296
MOD_Plk_1	698	704	PF00069	0.561
MOD_Plk_1	707	713	PF00069	0.507
MOD_Plk_1	75	81	PF00069	0.596
MOD_Plk_1	813	819	PF00069	0.242
MOD_Plk_2-3	287	293	PF00069	0.351
MOD_Plk_4	116	122	PF00069	0.539
MOD_Plk_4	394	400	PF00069	0.397
MOD_Plk_4	438	444	PF00069	0.179
MOD_Plk_4	464	470	PF00069	0.320
MOD_Plk_4	524	530	PF00069	0.333
MOD_Plk_4	531	537	PF00069	0.333
MOD_Plk_4	571	577	PF00069	0.415
MOD_Plk_4	682	688	PF00069	0.507
MOD_Plk_4	742	748	PF00069	0.460
MOD_Plk_4	814	820	PF00069	0.386
MOD_Plk_4	822	828	PF00069	0.356
MOD_Plk_4	863	869	PF00069	0.360
MOD_ProDKin_1	144	150	PF00069	0.606
MOD_ProDKin_1	667	673	PF00069	0.555
MOD_ProDKin_1	702	708	PF00069	0.562
MOD_ProDKin_1	849	855	PF00069	0.504
MOD_SUMO_rev_2	888	893	PF00179	0.513
TRG_DiLeu_BaEn_3	383	389	PF01217	0.415
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.437
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.433
TRG_ENDOCYTIC_2	291	294	PF00928	0.351
TRG_ENDOCYTIC_2	395	398	PF00928	0.299
TRG_ENDOCYTIC_2	461	464	PF00928	0.401
TRG_ENDOCYTIC_2	468	471	PF00928	0.409
TRG_ENDOCYTIC_2	56	59	PF00928	0.590
TRG_ER_diArg_1	657	659	PF00400	0.738
TRG_ER_diArg_1	809	811	PF00400	0.387
TRG_ER_diArg_1	821	824	PF00400	0.440
TRG_ER_diArg_1	86	89	PF00400	0.501
TRG_NLS_Bipartite_1	809	825	PF00514	0.497
TRG_NLS_MonoExtC_3	84	89	PF00514	0.592
TRG_NLS_MonoExtN_4	82	89	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	624	628	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	724	728	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU85	Leptomonas seymouri	65%	98%
A0A0S4IPR3	Bodo saltans	29%	100%
A0A1X0NK43	Trypanosomatidae	37%	94%
A0A3R7LU72	Trypanosoma rangeli	38%	100%
A0A3S7WP44	Leishmania donovani	89%	100%
A4HD49	Leishmania braziliensis	79%	98%
A4HSI2	Leishmania infantum	89%	100%
C9ZUC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	90%
Q4QJE2	Leishmania major	90%	99%
V5BAR5	Trypanosoma cruzi	35%	99%