LeishMANIAdb
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PHM7_cyt domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PHM7_cyt domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AKG4_LEIMU
TriTrypDb:
LmxM.05.0580
Length:
787

Annotations

LeishMANIAdb annotations

This Kinetoplastid-unique protein has a 4TM central helical bundle and long cytoplasmic termini with strikingly low complexity. Its function is unknown.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0000123 histone acetyltransferase complex 4 1
GO:0000124 SAGA complex 4 1
GO:0005815 microtubule organizing center 2 1
GO:0031248 protein acetyltransferase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0036064 ciliary basal body 3 1
GO:0070461 SAGA-type complex 5 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902493 acetyltransferase complex 4 1
GO:1902494 catalytic complex 2 1
GO:1905368 peptidase complex 3 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

E9AKG4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKG4

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006357 regulation of transcription by RNA polymerase II 7 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003712 transcription coregulator activity 2 3
GO:0003713 transcription coactivator activity 3 3
GO:0140110 transcription regulator activity 1 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 762 766 PF00656 0.714
CLV_NRD_NRD_1 136 138 PF00675 0.484
CLV_NRD_NRD_1 260 262 PF00675 0.594
CLV_NRD_NRD_1 316 318 PF00675 0.392
CLV_NRD_NRD_1 449 451 PF00675 0.514
CLV_NRD_NRD_1 644 646 PF00675 0.506
CLV_NRD_NRD_1 684 686 PF00675 0.539
CLV_NRD_NRD_1 731 733 PF00675 0.513
CLV_PCSK_FUR_1 682 686 PF00082 0.536
CLV_PCSK_FUR_1 728 732 PF00082 0.445
CLV_PCSK_KEX2_1 136 138 PF00082 0.484
CLV_PCSK_KEX2_1 316 318 PF00082 0.392
CLV_PCSK_KEX2_1 492 494 PF00082 0.401
CLV_PCSK_KEX2_1 524 526 PF00082 0.355
CLV_PCSK_KEX2_1 642 644 PF00082 0.514
CLV_PCSK_KEX2_1 684 686 PF00082 0.534
CLV_PCSK_KEX2_1 728 730 PF00082 0.512
CLV_PCSK_KEX2_1 731 733 PF00082 0.515
CLV_PCSK_PC1ET2_1 492 494 PF00082 0.401
CLV_PCSK_PC1ET2_1 524 526 PF00082 0.355
CLV_PCSK_PC1ET2_1 642 644 PF00082 0.554
CLV_PCSK_PC7_1 488 494 PF00082 0.378
CLV_PCSK_PC7_1 639 645 PF00082 0.553
CLV_PCSK_PC7_1 680 686 PF00082 0.561
CLV_PCSK_SKI1_1 196 200 PF00082 0.459
CLV_PCSK_SKI1_1 261 265 PF00082 0.563
CLV_PCSK_SKI1_1 499 503 PF00082 0.398
CLV_PCSK_SKI1_1 698 702 PF00082 0.507
DEG_APCC_DBOX_1 291 299 PF00400 0.269
DEG_APCC_KENBOX_2 674 678 PF00400 0.750
DEG_Nend_UBRbox_2 1 3 PF02207 0.752
DOC_CKS1_1 101 106 PF01111 0.670
DOC_CKS1_1 396 401 PF01111 0.576
DOC_CYCLIN_RxL_1 257 266 PF00134 0.360
DOC_CYCLIN_yCln2_LP_2 480 486 PF00134 0.369
DOC_MAPK_gen_1 203 212 PF00069 0.298
DOC_MAPK_gen_1 450 458 PF00069 0.319
DOC_PP1_RVXF_1 389 396 PF00149 0.647
DOC_PP1_RVXF_1 522 529 PF00149 0.574
DOC_PP2B_LxvP_1 480 483 PF13499 0.369
DOC_PP4_FxxP_1 247 250 PF00568 0.357
DOC_PP4_FxxP_1 332 335 PF00568 0.636
DOC_PP4_MxPP_1 575 578 PF00568 0.624
DOC_USP7_MATH_1 327 331 PF00917 0.673
DOC_USP7_MATH_1 620 624 PF00917 0.704
DOC_WW_Pin1_4 100 105 PF00397 0.625
DOC_WW_Pin1_4 131 136 PF00397 0.692
DOC_WW_Pin1_4 33 38 PF00397 0.705
DOC_WW_Pin1_4 335 340 PF00397 0.601
DOC_WW_Pin1_4 346 351 PF00397 0.584
DOC_WW_Pin1_4 395 400 PF00397 0.566
DOC_WW_Pin1_4 40 45 PF00397 0.696
DOC_WW_Pin1_4 589 594 PF00397 0.679
DOC_WW_Pin1_4 6 11 PF00397 0.736
DOC_WW_Pin1_4 615 620 PF00397 0.785
DOC_WW_Pin1_4 87 92 PF00397 0.637
LIG_14-3-3_CanoR_1 26 35 PF00244 0.700
LIG_14-3-3_CanoR_1 328 333 PF00244 0.693
LIG_14-3-3_CanoR_1 488 492 PF00244 0.570
LIG_14-3-3_CanoR_1 653 657 PF00244 0.628
LIG_AP2alpha_2 129 131 PF02296 0.623
LIG_BIR_III_4 236 240 PF00653 0.359
LIG_BRCT_BRCA1_1 372 376 PF00533 0.644
LIG_deltaCOP1_diTrp_1 153 157 PF00928 0.304
LIG_FHA_1 153 159 PF00498 0.304
LIG_FHA_1 216 222 PF00498 0.396
LIG_FHA_1 278 284 PF00498 0.327
LIG_FHA_1 292 298 PF00498 0.269
LIG_FHA_1 41 47 PF00498 0.799
LIG_FHA_1 417 423 PF00498 0.367
LIG_FHA_1 436 442 PF00498 0.223
LIG_FHA_1 453 459 PF00498 0.207
LIG_FHA_1 653 659 PF00498 0.632
LIG_FHA_1 776 782 PF00498 0.580
LIG_FHA_2 190 196 PF00498 0.403
LIG_FHA_2 535 541 PF00498 0.574
LIG_FHA_2 671 677 PF00498 0.681
LIG_LIR_Apic_2 244 250 PF02991 0.361
LIG_LIR_Apic_2 330 335 PF02991 0.639
LIG_LIR_Apic_2 394 399 PF02991 0.579
LIG_LIR_Gen_1 153 162 PF02991 0.379
LIG_LIR_Gen_1 180 191 PF02991 0.370
LIG_LIR_Gen_1 306 315 PF02991 0.374
LIG_LIR_Gen_1 343 350 PF02991 0.583
LIG_LIR_Gen_1 398 409 PF02991 0.573
LIG_LIR_Gen_1 428 434 PF02991 0.346
LIG_LIR_Gen_1 514 523 PF02991 0.578
LIG_LIR_LC3C_4 473 476 PF02991 0.270
LIG_LIR_Nem_3 146 152 PF02991 0.621
LIG_LIR_Nem_3 153 157 PF02991 0.359
LIG_LIR_Nem_3 180 186 PF02991 0.317
LIG_LIR_Nem_3 266 270 PF02991 0.391
LIG_LIR_Nem_3 306 312 PF02991 0.309
LIG_LIR_Nem_3 397 403 PF02991 0.590
LIG_LIR_Nem_3 425 429 PF02991 0.354
LIG_LIR_Nem_3 443 448 PF02991 0.307
LIG_LIR_Nem_3 514 520 PF02991 0.576
LIG_MYND_1 500 504 PF01753 0.610
LIG_Pex14_1 145 149 PF04695 0.635
LIG_Pex14_1 427 431 PF04695 0.324
LIG_Pex14_2 152 156 PF04695 0.469
LIG_Pex14_2 356 360 PF04695 0.604
LIG_Pex14_2 406 410 PF04695 0.441
LIG_Pex14_2 423 427 PF04695 0.237
LIG_Pex14_2 516 520 PF04695 0.586
LIG_SH2_CRK 302 306 PF00017 0.304
LIG_SH2_CRK 309 313 PF00017 0.304
LIG_SH2_NCK_1 396 400 PF00017 0.582
LIG_SH2_STAP1 309 313 PF00017 0.284
LIG_SH2_STAP1 448 452 PF00017 0.297
LIG_SH2_STAT3 102 105 PF00017 0.669
LIG_SH2_STAT3 15 18 PF00017 0.729
LIG_SH2_STAT5 102 105 PF00017 0.669
LIG_SH2_STAT5 151 154 PF00017 0.602
LIG_SH2_STAT5 201 204 PF00017 0.313
LIG_SH2_STAT5 431 434 PF00017 0.308
LIG_SH2_STAT5 448 451 PF00017 0.283
LIG_SH2_STAT5 510 513 PF00017 0.570
LIG_SH3_3 121 127 PF00018 0.620
LIG_SH3_3 132 138 PF00018 0.644
LIG_SH3_3 497 503 PF00018 0.601
LIG_SH3_3 587 593 PF00018 0.691
LIG_SH3_3 702 708 PF00018 0.706
LIG_SH3_3 754 760 PF00018 0.750
LIG_SUMO_SIM_anti_2 303 309 PF11976 0.304
LIG_SUMO_SIM_anti_2 455 460 PF11976 0.316
LIG_SUMO_SIM_anti_2 473 479 PF11976 0.201
LIG_SUMO_SIM_par_1 171 176 PF11976 0.464
LIG_SUMO_SIM_par_1 453 460 PF11976 0.251
LIG_TRAF2_1 138 141 PF00917 0.623
LIG_TYR_ITIM 307 312 PF00017 0.304
LIG_WRC_WIRS_1 264 269 PF05994 0.378
LIG_WRC_WIRS_1 423 428 PF05994 0.275
LIG_WRC_WIRS_1 441 446 PF05994 0.302
MOD_CDK_SPK_2 131 136 PF00069 0.692
MOD_CDK_SPxK_1 131 137 PF00069 0.692
MOD_CK1_1 100 106 PF00069 0.604
MOD_CK1_1 215 221 PF00069 0.357
MOD_CK1_1 291 297 PF00069 0.287
MOD_CK1_1 303 309 PF00069 0.472
MOD_CK1_1 320 326 PF00069 0.674
MOD_CK1_1 36 42 PF00069 0.730
MOD_CK1_1 4 10 PF00069 0.792
MOD_CK1_1 411 417 PF00069 0.304
MOD_CK1_1 425 431 PF00069 0.356
MOD_CK1_1 589 595 PF00069 0.661
MOD_CK1_1 73 79 PF00069 0.690
MOD_CK1_1 87 93 PF00069 0.611
MOD_CK2_1 263 269 PF00069 0.386
MOD_CK2_1 534 540 PF00069 0.585
MOD_CK2_1 670 676 PF00069 0.654
MOD_GlcNHglycan 10 13 PF01048 0.604
MOD_GlcNHglycan 319 322 PF01048 0.392
MOD_GlcNHglycan 372 375 PF01048 0.545
MOD_GlcNHglycan 38 41 PF01048 0.570
MOD_GlcNHglycan 410 413 PF01048 0.304
MOD_GlcNHglycan 600 603 PF01048 0.473
MOD_GlcNHglycan 62 65 PF01048 0.554
MOD_GlcNHglycan 666 669 PF01048 0.533
MOD_GlcNHglycan 68 71 PF01048 0.573
MOD_GlcNHglycan 73 76 PF01048 0.458
MOD_GlcNHglycan 750 755 PF01048 0.516
MOD_GlcNHglycan 86 89 PF01048 0.432
MOD_GSK3_1 212 219 PF00069 0.399
MOD_GSK3_1 225 232 PF00069 0.524
MOD_GSK3_1 36 43 PF00069 0.801
MOD_GSK3_1 4 11 PF00069 0.765
MOD_GSK3_1 615 622 PF00069 0.674
MOD_GSK3_1 659 666 PF00069 0.784
MOD_GSK3_1 66 73 PF00069 0.721
MOD_GSK3_1 684 691 PF00069 0.769
MOD_GSK3_1 731 738 PF00069 0.731
MOD_LATS_1 688 694 PF00433 0.757
MOD_LATS_1 735 741 PF00433 0.706
MOD_N-GLC_1 189 194 PF02516 0.650
MOD_N-GLC_1 215 220 PF02516 0.586
MOD_N-GLC_1 26 31 PF02516 0.500
MOD_N-GLC_1 288 293 PF02516 0.423
MOD_N-GLC_1 317 322 PF02516 0.314
MOD_N-GLC_1 676 681 PF02516 0.554
MOD_N-GLC_2 78 80 PF02516 0.487
MOD_NEK2_1 1 6 PF00069 0.742
MOD_NEK2_1 152 157 PF00069 0.469
MOD_NEK2_1 212 217 PF00069 0.344
MOD_NEK2_1 243 248 PF00069 0.364
MOD_NEK2_1 263 268 PF00069 0.373
MOD_NEK2_1 300 305 PF00069 0.304
MOD_NEK2_1 416 421 PF00069 0.304
MOD_NEK2_1 422 427 PF00069 0.304
MOD_NEK2_1 452 457 PF00069 0.336
MOD_NEK2_1 526 531 PF00069 0.581
MOD_NEK2_1 571 576 PF00069 0.653
MOD_NEK2_1 598 603 PF00069 0.718
MOD_NEK2_1 66 71 PF00069 0.684
MOD_NEK2_1 670 675 PF00069 0.694
MOD_NEK2_2 144 149 PF00069 0.593
MOD_NEK2_2 256 261 PF00069 0.290
MOD_PIKK_1 103 109 PF00454 0.662
MOD_PIKK_1 112 118 PF00454 0.601
MOD_PIKK_1 26 32 PF00454 0.701
MOD_PIKK_1 375 381 PF00454 0.656
MOD_PIKK_1 502 508 PF00454 0.569
MOD_PIKK_1 556 562 PF00454 0.634
MOD_PIKK_1 703 709 PF00454 0.705
MOD_PKA_1 205 211 PF00069 0.302
MOD_PKA_1 684 690 PF00069 0.757
MOD_PKA_1 731 737 PF00069 0.647
MOD_PKA_2 25 31 PF00069 0.615
MOD_PKA_2 291 297 PF00069 0.269
MOD_PKA_2 327 333 PF00069 0.722
MOD_PKA_2 434 440 PF00069 0.357
MOD_PKA_2 487 493 PF00069 0.574
MOD_PKA_2 652 658 PF00069 0.664
MOD_PKA_2 684 690 PF00069 0.757
MOD_PKA_2 731 737 PF00069 0.732
MOD_PKA_2 760 766 PF00069 0.709
MOD_PKB_1 643 651 PF00069 0.708
MOD_PKB_1 682 690 PF00069 0.743
MOD_PKB_1 729 737 PF00069 0.662
MOD_Plk_1 1 7 PF00069 0.740
MOD_Plk_1 152 158 PF00069 0.504
MOD_Plk_1 226 232 PF00069 0.378
MOD_Plk_1 243 249 PF00069 0.547
MOD_Plk_1 452 458 PF00069 0.356
MOD_Plk_2-3 548 554 PF00069 0.646
MOD_Plk_4 144 150 PF00069 0.597
MOD_Plk_4 163 169 PF00069 0.343
MOD_Plk_4 217 223 PF00069 0.366
MOD_Plk_4 226 232 PF00069 0.332
MOD_Plk_4 283 289 PF00069 0.346
MOD_Plk_4 291 297 PF00069 0.238
MOD_Plk_4 300 306 PF00069 0.249
MOD_Plk_4 328 334 PF00069 0.644
MOD_Plk_4 440 446 PF00069 0.334
MOD_Plk_4 452 458 PF00069 0.294
MOD_Plk_4 571 577 PF00069 0.608
MOD_Plk_4 586 592 PF00069 0.672
MOD_Plk_4 620 626 PF00069 0.668
MOD_Plk_4 97 103 PF00069 0.673
MOD_ProDKin_1 100 106 PF00069 0.624
MOD_ProDKin_1 131 137 PF00069 0.692
MOD_ProDKin_1 33 39 PF00069 0.705
MOD_ProDKin_1 335 341 PF00069 0.598
MOD_ProDKin_1 346 352 PF00069 0.581
MOD_ProDKin_1 395 401 PF00069 0.562
MOD_ProDKin_1 40 46 PF00069 0.696
MOD_ProDKin_1 589 595 PF00069 0.681
MOD_ProDKin_1 6 12 PF00069 0.736
MOD_ProDKin_1 615 621 PF00069 0.785
MOD_ProDKin_1 87 93 PF00069 0.634
MOD_SUMO_rev_2 519 526 PF00179 0.573
TRG_DiLeu_BaEn_1 473 478 PF01217 0.369
TRG_ENDOCYTIC_2 149 152 PF00928 0.612
TRG_ENDOCYTIC_2 302 305 PF00928 0.304
TRG_ENDOCYTIC_2 309 312 PF00928 0.304
TRG_ENDOCYTIC_2 401 404 PF00928 0.550
TRG_ENDOCYTIC_2 431 434 PF00928 0.318
TRG_ER_diArg_1 135 137 PF00400 0.693
TRG_ER_diArg_1 315 317 PF00400 0.587
TRG_ER_diArg_1 643 645 PF00400 0.709
TRG_ER_diArg_1 682 685 PF00400 0.737
TRG_ER_diArg_1 727 730 PF00400 0.704
TRG_NLS_MonoCore_2 641 646 PF00514 0.753
TRG_NLS_MonoExtN_4 639 646 PF00514 0.753

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I288 Leptomonas seymouri 52% 91%
A0A3S7WP32 Leishmania donovani 87% 100%
A4H4A9 Leishmania braziliensis 65% 99%
A4HSI0 Leishmania infantum 87% 100%
Q4QJE4 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS