MRP-L46 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKG3_LEIMU

TriTrypDb:

LmxM.05.0570

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.745
CLV_NRD_NRD_1	222	224	PF00675	0.557
CLV_PCSK_FUR_1	220	224	PF00082	0.513
CLV_PCSK_KEX2_1	211	213	PF00082	0.503
CLV_PCSK_KEX2_1	219	221	PF00082	0.511
CLV_PCSK_KEX2_1	222	224	PF00082	0.512
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.518
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.483
CLV_PCSK_SKI1_1	158	162	PF00082	0.420
CLV_PCSK_SKI1_1	18	22	PF00082	0.565
CLV_PCSK_SKI1_1	378	382	PF00082	0.425
CLV_PCSK_SKI1_1	54	58	PF00082	0.526
CLV_Separin_Metazoa	166	170	PF03568	0.461
DEG_Nend_UBRbox_1	1	4	PF02207	0.609
DOC_CYCLIN_RxL_1	155	164	PF00134	0.502
DOC_MAPK_DCC_7	306	315	PF00069	0.407
DOC_MAPK_gen_1	262	269	PF00069	0.380
DOC_MAPK_gen_1	54	63	PF00069	0.556
DOC_MAPK_MEF2A_6	262	271	PF00069	0.344
DOC_MAPK_MEF2A_6	306	315	PF00069	0.410
DOC_MAPK_MEF2A_6	351	359	PF00069	0.465
DOC_MAPK_MEF2A_6	57	65	PF00069	0.660
DOC_PP1_RVXF_1	356	362	PF00149	0.358
DOC_PP2B_LxvP_1	383	386	PF13499	0.494
DOC_USP7_MATH_1	119	123	PF00917	0.424
DOC_USP7_MATH_1	132	136	PF00917	0.478
DOC_USP7_MATH_1	93	97	PF00917	0.528
DOC_USP7_UBL2_3	21	25	PF12436	0.640
DOC_WW_Pin1_4	238	243	PF00397	0.582
LIG_14-3-3_CanoR_1	2	11	PF00244	0.606
LIG_14-3-3_CanoR_1	222	229	PF00244	0.525
LIG_14-3-3_CanoR_1	293	301	PF00244	0.467
LIG_BRCT_BRCA1_1	294	298	PF00533	0.400
LIG_deltaCOP1_diTrp_1	175	181	PF00928	0.371
LIG_deltaCOP1_diTrp_1	228	233	PF00928	0.504
LIG_deltaCOP1_diTrp_1	352	361	PF00928	0.375
LIG_FHA_1	10	16	PF00498	0.708
LIG_FHA_1	255	261	PF00498	0.386
LIG_FHA_1	275	281	PF00498	0.406
LIG_FHA_1	40	46	PF00498	0.384
LIG_FHA_1	48	54	PF00498	0.474
LIG_FHA_2	105	111	PF00498	0.487
LIG_FHA_2	200	206	PF00498	0.515
LIG_FHA_2	239	245	PF00498	0.512
LIG_FHA_2	367	373	PF00498	0.462
LIG_Integrin_RGD_1	169	171	PF01839	0.495
LIG_LIR_Gen_1	109	119	PF02991	0.384
LIG_LIR_Gen_1	256	265	PF02991	0.364
LIG_LIR_Gen_1	295	304	PF02991	0.400
LIG_LIR_Gen_1	352	361	PF02991	0.375
LIG_LIR_Nem_3	109	115	PF02991	0.384
LIG_LIR_Nem_3	256	261	PF02991	0.370
LIG_LIR_Nem_3	352	357	PF02991	0.390
LIG_LIR_Nem_3	404	410	PF02991	0.545
LIG_PALB2_WD40_1	144	152	PF16756	0.399
LIG_Pex14_1	177	181	PF04695	0.380
LIG_Pex14_1	229	233	PF04695	0.505
LIG_SH2_STAP1	317	321	PF00017	0.460
LIG_SH2_STAP1	32	36	PF00017	0.445
LIG_SH2_STAT5	251	254	PF00017	0.426
LIG_SH3_3	249	255	PF00018	0.427
LIG_SH3_3	277	283	PF00018	0.404
LIG_TRAF2_1	107	110	PF00917	0.496
LIG_TRAF2_1	202	205	PF00917	0.490
LIG_TRAF2_1	369	372	PF00917	0.414
LIG_UBA3_1	260	264	PF00899	0.352
LIG_UBA3_1	301	308	PF00899	0.404
LIG_WW_3	155	159	PF00397	0.347
MOD_CK1_1	159	165	PF00069	0.421
MOD_CK1_1	197	203	PF00069	0.639
MOD_CK2_1	104	110	PF00069	0.531
MOD_CK2_1	199	205	PF00069	0.514
MOD_CK2_1	238	244	PF00069	0.514
MOD_CK2_1	366	372	PF00069	0.490
MOD_CK2_1	390	396	PF00069	0.556
MOD_GlcNHglycan	15	18	PF01048	0.713
MOD_GlcNHglycan	161	164	PF01048	0.376
MOD_GlcNHglycan	5	8	PF01048	0.726
MOD_GlcNHglycan	66	69	PF01048	0.620
MOD_GlcNHglycan	73	76	PF01048	0.626
MOD_GlcNHglycan	86	89	PF01048	0.721
MOD_GSK3_1	19	26	PF00069	0.671
MOD_GSK3_1	315	322	PF00069	0.467
MOD_GSK3_1	386	393	PF00069	0.555
MOD_GSK3_1	48	55	PF00069	0.620
MOD_GSK3_1	71	78	PF00069	0.651
MOD_GSK3_1	9	16	PF00069	0.651
MOD_N-GLC_1	315	320	PF02516	0.443
MOD_N-GLC_1	391	396	PF02516	0.547
MOD_NEK2_1	315	320	PF00069	0.423
MOD_NEK2_1	388	393	PF00069	0.593
MOD_NEK2_1	48	53	PF00069	0.537
MOD_PIKK_1	274	280	PF00454	0.419
MOD_PIKK_1	336	342	PF00454	0.386
MOD_PIKK_1	386	392	PF00454	0.567
MOD_PIKK_1	76	82	PF00454	0.654
MOD_PKA_1	222	228	PF00069	0.541
MOD_PKA_2	222	228	PF00069	0.553
MOD_PKA_2	292	298	PF00069	0.462
MOD_PKB_1	220	228	PF00069	0.513
MOD_Plk_1	110	116	PF00069	0.403
MOD_Plk_1	177	183	PF00069	0.424
MOD_Plk_1	315	321	PF00069	0.434
MOD_Plk_1	391	397	PF00069	0.566
MOD_Plk_4	111	117	PF00069	0.332
MOD_Plk_4	132	138	PF00069	0.379
MOD_ProDKin_1	238	244	PF00069	0.582
MOD_SUMO_for_1	210	213	PF00179	0.575
MOD_SUMO_for_1	253	256	PF00179	0.444
MOD_SUMO_rev_2	193	203	PF00179	0.536
MOD_SUMO_rev_2	213	221	PF00179	0.497
TRG_DiLeu_BaEn_4	352	358	PF01217	0.404
TRG_ENDOCYTIC_2	37	40	PF00928	0.403
TRG_ENDOCYTIC_2	407	410	PF00928	0.563
TRG_ER_diArg_1	220	223	PF00400	0.521
TRG_NLS_MonoExtN_4	54	61	PF00514	0.549
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZT4	Leptomonas seymouri	81%	100%
A0A0S4IKX2	Bodo saltans	60%	100%
A0A1X0NJW6	Trypanosomatidae	66%	98%
A0A3S5H5I6	Leishmania donovani	96%	100%
A0A422ND56	Trypanosoma rangeli	65%	100%
A4H4A8	Leishmania braziliensis	89%	100%
A4HSH9	Leishmania infantum	96%	100%
C9ZUC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
Q4QJE5	Leishmania major	94%	100%
V5AVB4	Trypanosoma cruzi	68%	100%