MSP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKG2_LEIMU

TriTrypDb:

LmxM.05.0560

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AKG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.665
CLV_C14_Caspase3-7	15	19	PF00656	0.442
CLV_C14_Caspase3-7	249	253	PF00656	0.670
CLV_C14_Caspase3-7	343	347	PF00656	0.701
CLV_NRD_NRD_1	265	267	PF00675	0.534
CLV_NRD_NRD_1	283	285	PF00675	0.447
CLV_NRD_NRD_1	382	384	PF00675	0.666
CLV_PCSK_KEX2_1	265	267	PF00082	0.522
CLV_PCSK_KEX2_1	283	285	PF00082	0.404
CLV_PCSK_KEX2_1	358	360	PF00082	0.423
CLV_PCSK_KEX2_1	382	384	PF00082	0.666
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.423
CLV_PCSK_SKI1_1	226	230	PF00082	0.572
CLV_PCSK_SKI1_1	383	387	PF00082	0.735
CLV_PCSK_SKI1_1	405	409	PF00082	0.585
DEG_SPOP_SBC_1	103	107	PF00917	0.753
DOC_MAPK_gen_1	358	364	PF00069	0.598
DOC_MAPK_MEF2A_6	358	366	PF00069	0.612
DOC_MAPK_NFAT4_5	363	371	PF00069	0.480
DOC_MAPK_RevD_3	367	383	PF00069	0.285
DOC_PP2B_LxvP_1	215	218	PF13499	0.654
DOC_PP4_MxPP_1	321	324	PF00568	0.595
DOC_SPAK_OSR1_1	125	129	PF12202	0.565
DOC_USP7_MATH_1	196	200	PF00917	0.684
DOC_USP7_MATH_1	218	222	PF00917	0.730
DOC_USP7_MATH_1	293	297	PF00917	0.732
DOC_USP7_MATH_1	330	334	PF00917	0.741
DOC_USP7_MATH_1	34	38	PF00917	0.560
DOC_USP7_MATH_1	68	72	PF00917	0.658
DOC_WW_Pin1_4	113	118	PF00397	0.748
DOC_WW_Pin1_4	241	246	PF00397	0.774
DOC_WW_Pin1_4	285	290	PF00397	0.737
DOC_WW_Pin1_4	299	304	PF00397	0.770
DOC_WW_Pin1_4	408	413	PF00397	0.382
DOC_WW_Pin1_4	66	71	PF00397	0.667
DOC_WW_Pin1_4	91	96	PF00397	0.785
LIG_14-3-3_CanoR_1	100	104	PF00244	0.751
LIG_14-3-3_CanoR_1	111	120	PF00244	0.705
LIG_14-3-3_CanoR_1	152	160	PF00244	0.528
LIG_14-3-3_CanoR_1	223	233	PF00244	0.738
LIG_14-3-3_CanoR_1	234	239	PF00244	0.721
LIG_14-3-3_CanoR_1	290	298	PF00244	0.697
LIG_14-3-3_CanoR_1	382	391	PF00244	0.493
LIG_APCC_ABBA_1	182	187	PF00400	0.570
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_BRCT_BRCA1_1	36	40	PF00533	0.547
LIG_EH1_1	364	372	PF00400	0.426
LIG_eIF4E_1	365	371	PF01652	0.426
LIG_FHA_1	152	158	PF00498	0.620
LIG_FHA_1	203	209	PF00498	0.677
LIG_FHA_1	258	264	PF00498	0.805
LIG_FHA_1	34	40	PF00498	0.602
LIG_FHA_1	371	377	PF00498	0.213
LIG_FHA_1	73	79	PF00498	0.581
LIG_FHA_2	384	390	PF00498	0.497
LIG_LIR_Gen_1	129	138	PF02991	0.573
LIG_LIR_Gen_1	332	342	PF02991	0.745
LIG_LIR_Gen_1	373	381	PF02991	0.401
LIG_LIR_LC3C_4	212	217	PF02991	0.607
LIG_LIR_Nem_3	129	133	PF02991	0.548
LIG_LIR_Nem_3	332	338	PF02991	0.744
LIG_LIR_Nem_3	373	378	PF02991	0.355
LIG_MYND_1	239	243	PF01753	0.739
LIG_SH2_CRK	365	369	PF00017	0.383
LIG_SH2_CRK	56	60	PF00017	0.538
LIG_SH2_PTP2	130	133	PF00017	0.584
LIG_SH2_PTP2	375	378	PF00017	0.467
LIG_SH2_STAP1	335	339	PF00017	0.707
LIG_SH2_STAP1	406	410	PF00017	0.537
LIG_SH2_STAT3	406	409	PF00017	0.538
LIG_SH2_STAT5	11	14	PF00017	0.532
LIG_SH2_STAT5	130	133	PF00017	0.519
LIG_SH2_STAT5	375	378	PF00017	0.347
LIG_SH3_3	114	120	PF00018	0.752
LIG_SH3_3	205	211	PF00018	0.544
LIG_SH3_3	28	34	PF00018	0.644
LIG_SH3_3	348	354	PF00018	0.586
LIG_SH3_4	311	318	PF00018	0.614
LIG_Sin3_3	213	220	PF02671	0.636
LIG_SUMO_SIM_par_1	368	373	PF11976	0.293
LIG_TRAF2_1	121	124	PF00917	0.658
LIG_TRAF2_1	401	404	PF00917	0.447
LIG_TYR_ITIM	128	133	PF00017	0.562
MOD_CDK_SPK_2	241	246	PF00069	0.800
MOD_CDK_SPK_2	285	290	PF00069	0.666
MOD_CDK_SPK_2	408	413	PF00069	0.382
MOD_CDK_SPxxK_3	304	311	PF00069	0.763
MOD_CK1_1	110	116	PF00069	0.679
MOD_CK1_1	259	265	PF00069	0.726
MOD_CK1_1	301	307	PF00069	0.793
MOD_CK1_1	72	78	PF00069	0.677
MOD_CK1_1	99	105	PF00069	0.766
MOD_CK2_1	330	336	PF00069	0.712
MOD_CK2_1	383	389	PF00069	0.489
MOD_CK2_1	408	414	PF00069	0.536
MOD_GlcNHglycan	113	116	PF01048	0.537
MOD_GlcNHglycan	165	168	PF01048	0.414
MOD_GlcNHglycan	198	201	PF01048	0.506
MOD_GlcNHglycan	226	229	PF01048	0.494
MOD_GlcNHglycan	248	251	PF01048	0.567
MOD_GlcNHglycan	285	288	PF01048	0.556
MOD_GlcNHglycan	324	327	PF01048	0.425
MOD_GlcNHglycan	392	395	PF01048	0.788
MOD_GlcNHglycan	86	89	PF01048	0.554
MOD_GSK3_1	107	114	PF00069	0.728
MOD_GSK3_1	159	166	PF00069	0.590
MOD_GSK3_1	257	264	PF00069	0.648
MOD_GSK3_1	285	292	PF00069	0.706
MOD_GSK3_1	298	305	PF00069	0.720
MOD_GSK3_1	408	415	PF00069	0.486
MOD_GSK3_1	62	69	PF00069	0.630
MOD_GSK3_1	72	79	PF00069	0.486
MOD_GSK3_1	99	106	PF00069	0.773
MOD_N-GLC_1	299	304	PF02516	0.602
MOD_N-GLC_1	34	39	PF02516	0.407
MOD_N-GLC_1	72	77	PF02516	0.412
MOD_NEK2_1	163	168	PF00069	0.620
MOD_NEK2_1	257	262	PF00069	0.789
MOD_NEK2_1	298	303	PF00069	0.606
MOD_NEK2_1	3	8	PF00069	0.563
MOD_NEK2_1	370	375	PF00069	0.324
MOD_NEK2_1	82	87	PF00069	0.671
MOD_PIKK_1	234	240	PF00454	0.652
MOD_PIKK_1	412	418	PF00454	0.381
MOD_PKA_1	283	289	PF00069	0.730
MOD_PKA_2	107	113	PF00069	0.725
MOD_PKA_2	151	157	PF00069	0.564
MOD_PKA_2	283	289	PF00069	0.742
MOD_PKA_2	412	418	PF00069	0.381
MOD_PKA_2	82	88	PF00069	0.675
MOD_PKA_2	99	105	PF00069	0.757
MOD_Plk_1	229	235	PF00069	0.601
MOD_Plk_1	331	337	PF00069	0.680
MOD_Plk_1	34	40	PF00069	0.605
MOD_Plk_4	293	299	PF00069	0.664
MOD_Plk_4	34	40	PF00069	0.556
MOD_Plk_4	370	376	PF00069	0.288
MOD_ProDKin_1	113	119	PF00069	0.743
MOD_ProDKin_1	241	247	PF00069	0.777
MOD_ProDKin_1	285	291	PF00069	0.739
MOD_ProDKin_1	299	305	PF00069	0.768
MOD_ProDKin_1	408	414	PF00069	0.383
MOD_ProDKin_1	66	72	PF00069	0.669
MOD_ProDKin_1	91	97	PF00069	0.788
MOD_SUMO_for_1	133	136	PF00179	0.598
MOD_SUMO_rev_2	389	393	PF00179	0.378
TRG_DiLeu_BaEn_4	403	409	PF01217	0.385
TRG_ENDOCYTIC_2	130	133	PF00928	0.526
TRG_ENDOCYTIC_2	335	338	PF00928	0.740
TRG_ENDOCYTIC_2	365	368	PF00928	0.438
TRG_ENDOCYTIC_2	375	378	PF00928	0.395
TRG_ENDOCYTIC_2	56	59	PF00928	0.538
TRG_ER_diArg_1	233	236	PF00400	0.788
TRG_ER_diArg_1	282	284	PF00400	0.664
TRG_ER_diArg_1	381	383	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2J2	Leptomonas seymouri	52%	100%
A0A0S4IL26	Bodo saltans	25%	100%
A0A1X0NKC1	Trypanosomatidae	34%	100%
A0A3S5H5I5	Leishmania donovani	86%	100%
A0A422ND80	Trypanosoma rangeli	31%	100%
A4H4A2	Leishmania braziliensis	71%	99%
A4HSH8	Leishmania infantum	86%	100%
Q4QJE6	Leishmania major	84%	100%
V5BAR1	Trypanosoma cruzi	29%	100%