Nuclear receptor binding factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear receptor binding factor-like protein

Species:

Leishmania mexicana

UniProt:

E9AKF8_LEIMU

TriTrypDb:

LmxM.05.0520

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AKF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKF8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0003960	NADPH:quinone reductase activity	5	2
GO:0016491	oxidoreductase activity	2	4
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	2
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	2
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	2
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	2
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.456
CLV_NRD_NRD_1	331	333	PF00675	0.388
CLV_NRD_NRD_1	58	60	PF00675	0.423
CLV_PCSK_KEX2_1	220	222	PF00082	0.443
CLV_PCSK_KEX2_1	60	62	PF00082	0.415
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.438
CLV_PCSK_SKI1_1	178	182	PF00082	0.284
CLV_PCSK_SKI1_1	195	199	PF00082	0.328
DEG_SCF_FBW7_2	28	33	PF00400	0.301
DEG_SCF_SKP2-CKS1_1	25	32	PF00560	0.474
DEG_SPOP_SBC_1	87	91	PF00917	0.385
DOC_CDC14_PxL_1	310	318	PF14671	0.481
DOC_MAPK_gen_1	148	156	PF00069	0.380
DOC_MAPK_gen_1	220	227	PF00069	0.401
DOC_PP1_RVXF_1	291	297	PF00149	0.432
DOC_PP2B_LxvP_1	276	279	PF13499	0.339
DOC_USP7_MATH_1	131	135	PF00917	0.414
DOC_USP7_MATH_1	87	91	PF00917	0.502
DOC_USP7_UBL2_3	333	337	PF12436	0.253
DOC_WW_Pin1_4	181	186	PF00397	0.323
DOC_WW_Pin1_4	26	31	PF00397	0.436
DOC_WW_Pin1_4	88	93	PF00397	0.540
LIG_14-3-3_CanoR_1	61	70	PF00244	0.283
LIG_BIR_II_1	1	5	PF00653	0.352
LIG_BRCT_BRCA1_1	200	204	PF00533	0.312
LIG_FHA_1	96	102	PF00498	0.366
LIG_FHA_2	290	296	PF00498	0.240
LIG_IRF3_LxIS_1	257	262	PF10401	0.382
LIG_LIR_Apic_2	97	103	PF02991	0.303
LIG_LIR_Gen_1	144	154	PF02991	0.373
LIG_LIR_Gen_1	22	30	PF02991	0.447
LIG_LIR_Gen_1	265	276	PF02991	0.413
LIG_LIR_Gen_1	321	328	PF02991	0.446
LIG_LIR_Nem_3	144	149	PF02991	0.418
LIG_LIR_Nem_3	22	26	PF02991	0.411
LIG_LIR_Nem_3	265	271	PF02991	0.433
LIG_LIR_Nem_3	321	326	PF02991	0.420
LIG_LIR_Nem_3	65	70	PF02991	0.353
LIG_LYPXL_yS_3	308	311	PF13949	0.348
LIG_Pex14_1	323	327	PF04695	0.305
LIG_Pex14_2	277	281	PF04695	0.362
LIG_SH2_CRK	146	150	PF00017	0.490
LIG_SH2_GRB2like	226	229	PF00017	0.299
LIG_SH2_GRB2like	327	330	PF00017	0.282
LIG_SH2_NCK_1	268	272	PF00017	0.352
LIG_SH2_SRC	226	229	PF00017	0.325
LIG_SH2_SRC	327	330	PF00017	0.282
LIG_SH2_STAP1	199	203	PF00017	0.274
LIG_SH2_STAT3	251	254	PF00017	0.332
LIG_SH2_STAT5	226	229	PF00017	0.325
LIG_SH2_STAT5	234	237	PF00017	0.289
LIG_SH2_STAT5	327	330	PF00017	0.458
LIG_SH3_3	308	314	PF00018	0.349
LIG_SH3_3	77	83	PF00018	0.448
LIG_TRAF2_1	300	303	PF00917	0.499
LIG_TYR_ITIM	266	271	PF00017	0.356
LIG_TYR_ITIM	306	311	PF00017	0.409
MOD_CDC14_SPxK_1	91	94	PF00782	0.511
MOD_CDK_SPxK_1	26	32	PF00069	0.445
MOD_CDK_SPxK_1	88	94	PF00069	0.549
MOD_CDK_SPxxK_3	181	188	PF00069	0.342
MOD_CK1_1	161	167	PF00069	0.273
MOD_CK1_1	262	268	PF00069	0.429
MOD_CK2_1	283	289	PF00069	0.320
MOD_Cter_Amidation	218	221	PF01082	0.440
MOD_Cter_Amidation	330	333	PF01082	0.352
MOD_Cter_Amidation	57	60	PF01082	0.417
MOD_GlcNHglycan	168	171	PF01048	0.309
MOD_GlcNHglycan	261	264	PF01048	0.335
MOD_GlcNHglycan	5	8	PF01048	0.422
MOD_GSK3_1	15	22	PF00069	0.512
MOD_GSK3_1	158	165	PF00069	0.348
MOD_GSK3_1	277	284	PF00069	0.392
MOD_LATS_1	196	202	PF00433	0.362
MOD_N-GLC_1	52	57	PF02516	0.337
MOD_N-GLC_1	62	67	PF02516	0.384
MOD_NEK2_1	104	109	PF00069	0.400
MOD_NEK2_1	129	134	PF00069	0.349
MOD_NEK2_1	166	171	PF00069	0.352
MOD_NEK2_1	259	264	PF00069	0.374
MOD_NEK2_1	281	286	PF00069	0.449
MOD_PIKK_1	114	120	PF00454	0.469
MOD_PIKK_1	15	21	PF00454	0.423
MOD_PKA_2	289	295	PF00069	0.290
MOD_Plk_1	269	275	PF00069	0.315
MOD_Plk_1	62	68	PF00069	0.278
MOD_Plk_4	234	240	PF00069	0.259
MOD_Plk_4	262	268	PF00069	0.393
MOD_Plk_4	277	283	PF00069	0.325
MOD_Plk_4	95	101	PF00069	0.313
MOD_ProDKin_1	181	187	PF00069	0.335
MOD_ProDKin_1	26	32	PF00069	0.445
MOD_ProDKin_1	88	94	PF00069	0.535
TRG_ENDOCYTIC_2	146	149	PF00928	0.485
TRG_ENDOCYTIC_2	23	26	PF00928	0.394
TRG_ENDOCYTIC_2	268	271	PF00928	0.314
TRG_ENDOCYTIC_2	308	311	PF00928	0.348
TRG_ER_diArg_1	59	62	PF00400	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X4	Leptomonas seymouri	30%	76%
A0A0N1PA01	Leptomonas seymouri	78%	100%
A0A0S4ILA6	Bodo saltans	52%	100%
A0A0S4J2L6	Bodo saltans	29%	78%
A0A1X0NK33	Trypanosomatidae	63%	100%
A0A1X0NL46	Trypanosomatidae	26%	74%
A0A3R7KI38	Trypanosoma rangeli	26%	85%
A0A3S5H593	Leishmania donovani	29%	76%
A0A3S5H5I3	Leishmania donovani	94%	100%
A4H3U9	Leishmania braziliensis	28%	100%
A4H498	Leishmania braziliensis	91%	100%
A4HS24	Leishmania infantum	29%	76%
A4HSH5	Leishmania infantum	94%	100%
C9ZUD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
C9ZY17	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	76%
E9AK11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O45903	Caenorhabditis elegans	28%	99%
Q28GQ2	Xenopus tropicalis	25%	97%
Q39173	Arabidopsis thaliana	24%	99%
Q4QJF0	Leishmania major	94%	100%
Q54YT4	Dictyostelium discoideum	26%	97%
Q6BLV6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	90%
Q6GQN8	Danio rerio	25%	90%
Q7YS70	Bos taurus	24%	91%
Q8LCU7	Arabidopsis thaliana	27%	91%
Q8NJJ9	Kluyveromyces marxianus	26%	89%
Q9BV79	Homo sapiens	24%	91%
Q9DCS3	Mus musculus	25%	91%
Q9V6U9	Drosophila melanogaster	22%	95%
Q9XXC8	Caenorhabditis elegans	27%	98%
Q9XZY9	Leishmania major	29%	100%
Q9Z311	Rattus norvegicus	25%	91%
V5D9R3	Trypanosoma cruzi	30%	75%
V5DBG0	Trypanosoma cruzi	63%	100%