Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKF5_LEIMU

TriTrypDb:

LmxM.05.0490

Length:

167

Annotations

LeishMANIAdb annotations

Probably not embedded into the membranes.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AKF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.609
CLV_NRD_NRD_1	111	113	PF00675	0.399
CLV_PCSK_KEX2_1	111	113	PF00082	0.399
CLV_PCSK_KEX2_1	31	33	PF00082	0.345
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.346
CLV_PCSK_SKI1_1	10	14	PF00082	0.359
CLV_PCSK_SKI1_1	112	116	PF00082	0.352
CLV_PCSK_SKI1_1	57	61	PF00082	0.286
CLV_PCSK_SKI1_1	63	67	PF00082	0.278
CLV_PCSK_SKI1_1	94	98	PF00082	0.315
DOC_ANK_TNKS_1	49	56	PF00023	0.608
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.580
DOC_MAPK_MEF2A_6	10	18	PF00069	0.630
DOC_MAPK_MEF2A_6	40	48	PF00069	0.513
DOC_PP4_FxxP_1	12	15	PF00568	0.633
DOC_WW_Pin1_4	119	124	PF00397	0.598
DOC_WW_Pin1_4	161	166	PF00397	0.560
LIG_14-3-3_CanoR_1	111	115	PF00244	0.613
LIG_14-3-3_CanoR_1	148	156	PF00244	0.492
LIG_Actin_WH2_2	122	140	PF00022	0.513
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_EH1_1	102	110	PF00400	0.400
LIG_FHA_1	11	17	PF00498	0.633
LIG_FHA_1	18	24	PF00498	0.632
LIG_FHA_1	43	49	PF00498	0.585
LIG_FHA_1	95	101	PF00498	0.268
LIG_FHA_2	83	89	PF00498	0.249
LIG_LIR_Nem_3	113	118	PF02991	0.564
LIG_MYND_1	116	120	PF01753	0.571
LIG_SH2_SRC	52	55	PF00017	0.601
LIG_SH2_STAT5	52	55	PF00017	0.512
LIG_SH2_STAT5	73	76	PF00017	0.330
LIG_SH3_3	117	123	PF00018	0.607
LIG_SUMO_SIM_par_1	13	20	PF11976	0.480
MOD_Cter_Amidation	109	112	PF01082	0.500
MOD_GlcNHglycan	75	78	PF01048	0.370
MOD_GSK3_1	110	117	PF00069	0.570
MOD_GSK3_1	157	164	PF00069	0.700
MOD_N-GLC_1	148	153	PF02516	0.448
MOD_NEK2_2	110	115	PF00069	0.559
MOD_PKA_2	110	116	PF00069	0.562
MOD_Plk_1	42	48	PF00069	0.508
MOD_Plk_1	82	88	PF00069	0.424
MOD_ProDKin_1	119	125	PF00069	0.593
MOD_ProDKin_1	161	167	PF00069	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTD3	Leptomonas seymouri	73%	100%
A0A0S4JQI6	Bodo saltans	29%	100%
A0A1X0NJU2	Trypanosomatidae	50%	100%
A0A1X0NR99	Trypanosomatidae	34%	100%
A0A3S7WP26	Leishmania donovani	94%	100%
A0A3S7X736	Leishmania donovani	32%	100%
A0A422N2T1	Trypanosoma rangeli	54%	100%
A0A422NKR0	Trypanosoma rangeli	33%	100%
A4H495	Leishmania braziliensis	88%	100%
A4HLZ1	Leishmania braziliensis	31%	100%
A4I9C1	Leishmania infantum	32%	100%
C9ZJA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZUD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B4C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q3Q5	Leishmania major	32%	100%
V5BJW3	Trypanosoma cruzi	50%	100%
V5DB75	Trypanosoma cruzi	32%	100%