Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AKF3_LEIMU

TriTrypDb:

LmxM.05.0470

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.550
CLV_NRD_NRD_1	188	190	PF00675	0.567
CLV_NRD_NRD_1	191	193	PF00675	0.539
CLV_NRD_NRD_1	210	212	PF00675	0.648
CLV_NRD_NRD_1	223	225	PF00675	0.592
CLV_NRD_NRD_1	229	231	PF00675	0.604
CLV_PCSK_FUR_1	189	193	PF00082	0.552
CLV_PCSK_FUR_1	227	231	PF00082	0.599
CLV_PCSK_KEX2_1	142	144	PF00082	0.814
CLV_PCSK_KEX2_1	188	190	PF00082	0.567
CLV_PCSK_KEX2_1	191	193	PF00082	0.539
CLV_PCSK_KEX2_1	210	212	PF00082	0.648
CLV_PCSK_KEX2_1	229	231	PF00082	0.604
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.814
CLV_PCSK_SKI1_1	150	154	PF00082	0.817
CLV_PCSK_SKI1_1	191	195	PF00082	0.567
CLV_PCSK_SKI1_1	57	61	PF00082	0.542
CLV_Separin_Metazoa	214	218	PF03568	0.664
DEG_APCC_DBOX_1	190	198	PF00400	0.566
DOC_CKS1_1	151	156	PF01111	0.715
DOC_CYCLIN_RxL_1	188	200	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.606
DOC_MAPK_gen_1	188	196	PF00069	0.668
DOC_PP1_RVXF_1	190	197	PF00149	0.592
DOC_PP2B_LxvP_1	102	105	PF13499	0.723
DOC_USP7_MATH_1	112	116	PF00917	0.700
DOC_USP7_MATH_1	136	140	PF00917	0.725
DOC_USP7_MATH_1	141	145	PF00917	0.743
DOC_WW_Pin1_4	119	124	PF00397	0.727
DOC_WW_Pin1_4	150	155	PF00397	0.826
LIG_14-3-3_CanoR_1	107	114	PF00244	0.601
LIG_14-3-3_CanoR_1	143	152	PF00244	0.808
LIG_14-3-3_CanoR_1	92	97	PF00244	0.609
LIG_BRCT_BRCA1_1	40	44	PF00533	0.696
LIG_FHA_1	76	82	PF00498	0.759
LIG_FHA_2	159	165	PF00498	0.741
LIG_FHA_2	59	65	PF00498	0.499
LIG_GBD_Chelix_1	13	21	PF00786	0.550
LIG_SH2_CRK	31	35	PF00017	0.637
LIG_SH2_GRB2like	204	207	PF00017	0.546
LIG_SH2_STAP1	31	35	PF00017	0.637
LIG_SH2_STAT5	204	207	PF00017	0.546
LIG_SH3_2	138	143	PF14604	0.703
LIG_SH3_3	130	136	PF00018	0.821
LIG_SH3_3	148	154	PF00018	0.527
LIG_SH3_3	173	179	PF00018	0.771
LIG_SH3_3	66	72	PF00018	0.658
LIG_SH3_3	84	90	PF00018	0.725
LIG_SH3_3	98	104	PF00018	0.680
MOD_CDK_SPK_2	150	155	PF00069	0.780
MOD_CK1_1	115	121	PF00069	0.683
MOD_CK1_1	144	150	PF00069	0.751
MOD_CK1_1	3	9	PF00069	0.638
MOD_GlcNHglycan	108	111	PF01048	0.697
MOD_GlcNHglycan	117	120	PF01048	0.647
MOD_GlcNHglycan	143	146	PF01048	0.796
MOD_GlcNHglycan	180	183	PF01048	0.530
MOD_GSK3_1	113	120	PF00069	0.683
MOD_GSK3_1	124	131	PF00069	0.701
MOD_N-GLC_1	3	8	PF02516	0.726
MOD_NEK2_1	106	111	PF00069	0.711
MOD_NEK2_1	128	133	PF00069	0.751
MOD_PIKK_1	136	142	PF00454	0.528
MOD_PK_1	82	88	PF00069	0.473
MOD_PKA_2	106	112	PF00069	0.630
MOD_Plk_1	3	9	PF00069	0.723
MOD_Plk_1	57	63	PF00069	0.499
MOD_Plk_2-3	58	64	PF00069	0.524
MOD_Plk_4	49	55	PF00069	0.625
MOD_Plk_4	82	88	PF00069	0.473
MOD_ProDKin_1	119	125	PF00069	0.728
MOD_ProDKin_1	150	156	PF00069	0.821
MOD_SUMO_for_1	182	185	PF00179	0.502
MOD_SUMO_for_1	70	73	PF00179	0.672
TRG_ENDOCYTIC_2	31	34	PF00928	0.640
TRG_ER_diArg_1	188	191	PF00400	0.581
TRG_ER_diArg_1	227	230	PF00400	0.607
TRG_NLS_Bipartite_1	210	228	PF00514	0.597
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZW8	Leptomonas seymouri	33%	100%
A0A3S5H5I0	Leishmania donovani	89%	100%
A4H493	Leishmania braziliensis	60%	82%
A4HSG9	Leishmania infantum	89%	100%
Q4QJF5	Leishmania major	90%	100%