Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKE9_LEIMU

TriTrypDb:

LmxM.05.0430

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKE9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	499	503	PF00656	0.369
CLV_NRD_NRD_1	10	12	PF00675	0.320
CLV_NRD_NRD_1	153	155	PF00675	0.494
CLV_NRD_NRD_1	222	224	PF00675	0.312
CLV_NRD_NRD_1	282	284	PF00675	0.377
CLV_NRD_NRD_1	3	5	PF00675	0.522
CLV_NRD_NRD_1	520	522	PF00675	0.439
CLV_NRD_NRD_1	614	616	PF00675	0.501
CLV_PCSK_FUR_1	8	12	PF00082	0.427
CLV_PCSK_KEX2_1	10	12	PF00082	0.321
CLV_PCSK_KEX2_1	152	154	PF00082	0.491
CLV_PCSK_KEX2_1	222	224	PF00082	0.312
CLV_PCSK_KEX2_1	282	284	PF00082	0.410
CLV_PCSK_KEX2_1	3	5	PF00082	0.521
CLV_PCSK_KEX2_1	520	522	PF00082	0.529
CLV_PCSK_KEX2_1	614	616	PF00082	0.501
CLV_PCSK_KEX2_1	674	676	PF00082	0.598
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.491
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.621
CLV_PCSK_SKI1_1	146	150	PF00082	0.408
CLV_PCSK_SKI1_1	216	220	PF00082	0.549
CLV_PCSK_SKI1_1	626	630	PF00082	0.448
DEG_APCC_DBOX_1	282	290	PF00400	0.414
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DEG_SPOP_SBC_1	42	46	PF00917	0.434
DEG_SPOP_SBC_1	593	597	PF00917	0.499
DOC_ANK_TNKS_1	576	583	PF00023	0.425
DOC_CYCLIN_RxL_1	143	150	PF00134	0.404
DOC_MAPK_gen_1	152	161	PF00069	0.487
DOC_MAPK_gen_1	520	528	PF00069	0.488
DOC_MAPK_MEF2A_6	154	163	PF00069	0.479
DOC_MAPK_MEF2A_6	343	351	PF00069	0.403
DOC_MAPK_MEF2A_6	521	530	PF00069	0.347
DOC_PP1_RVXF_1	117	123	PF00149	0.475
DOC_PP1_RVXF_1	31	38	PF00149	0.321
DOC_PP2B_LxvP_1	196	199	PF13499	0.484
DOC_SPAK_OSR1_1	414	418	PF12202	0.211
DOC_USP7_MATH_1	43	47	PF00917	0.724
DOC_USP7_MATH_1	503	507	PF00917	0.338
DOC_USP7_MATH_1	549	553	PF00917	0.576
DOC_USP7_MATH_1	593	597	PF00917	0.502
DOC_USP7_MATH_1	640	644	PF00917	0.502
DOC_USP7_MATH_1	68	72	PF00917	0.693
DOC_USP7_UBL2_3	670	674	PF12436	0.731
DOC_WW_Pin1_4	182	187	PF00397	0.426
DOC_WW_Pin1_4	237	242	PF00397	0.689
DOC_WW_Pin1_4	396	401	PF00397	0.606
DOC_WW_Pin1_4	485	490	PF00397	0.368
LIG_14-3-3_CanoR_1	10	15	PF00244	0.335
LIG_14-3-3_CanoR_1	614	620	PF00244	0.570
LIG_14-3-3_CanoR_1	626	635	PF00244	0.409
LIG_APCC_ABBA_1	567	572	PF00400	0.455
LIG_BRCT_BRCA1_1	561	565	PF00533	0.429
LIG_CaM_IQ_9	613	628	PF13499	0.398
LIG_CSL_BTD_1	386	389	PF09270	0.469
LIG_deltaCOP1_diTrp_1	407	415	PF00928	0.239
LIG_deltaCOP1_diTrp_1	634	638	PF00928	0.299
LIG_FHA_1	199	205	PF00498	0.661
LIG_FHA_1	257	263	PF00498	0.341
LIG_FHA_1	486	492	PF00498	0.372
LIG_FHA_1	88	94	PF00498	0.742
LIG_FHA_2	14	20	PF00498	0.307
LIG_FHA_2	305	311	PF00498	0.567
LIG_FHA_2	497	503	PF00498	0.520
LIG_FHA_2	627	633	PF00498	0.375
LIG_Integrin_isoDGR_2	63	65	PF01839	0.514
LIG_LIR_Gen_1	106	115	PF02991	0.568
LIG_LIR_Gen_1	19	29	PF02991	0.406
LIG_LIR_Gen_1	581	591	PF02991	0.491
LIG_LIR_Nem_3	106	112	PF02991	0.601
LIG_LIR_Nem_3	19	25	PF02991	0.342
LIG_LIR_Nem_3	566	570	PF02991	0.439
LIG_LIR_Nem_3	581	587	PF02991	0.437
LIG_LYPXL_S_1	173	177	PF13949	0.495
LIG_LYPXL_yS_3	174	177	PF13949	0.499
LIG_MYND_3	369	373	PF01753	0.406
LIG_Pex14_1	267	271	PF04695	0.391
LIG_Pex14_2	151	155	PF04695	0.479
LIG_Pex14_2	514	518	PF04695	0.504
LIG_SH2_CRK	109	113	PF00017	0.413
LIG_SH2_CRK	9	13	PF00017	0.394
LIG_SH2_PTP2	437	440	PF00017	0.479
LIG_SH2_PTP2	461	464	PF00017	0.329
LIG_SH2_SRC	105	108	PF00017	0.493
LIG_SH2_SRC	339	342	PF00017	0.346
LIG_SH2_SRC	437	440	PF00017	0.431
LIG_SH2_STAP1	377	381	PF00017	0.362
LIG_SH2_STAT3	377	380	PF00017	0.496
LIG_SH2_STAT3	469	472	PF00017	0.376
LIG_SH2_STAT5	109	112	PF00017	0.474
LIG_SH2_STAT5	14	17	PF00017	0.334
LIG_SH2_STAT5	24	27	PF00017	0.263
LIG_SH2_STAT5	341	344	PF00017	0.297
LIG_SH2_STAT5	437	440	PF00017	0.409
LIG_SH2_STAT5	461	464	PF00017	0.335
LIG_SH2_STAT5	469	472	PF00017	0.341
LIG_SH2_STAT5	507	510	PF00017	0.416
LIG_SH2_STAT5	578	581	PF00017	0.391
LIG_SH3_3	453	459	PF00018	0.397
LIG_SH3_3	545	551	PF00018	0.486
LIG_SH3_3	582	588	PF00018	0.474
LIG_SUMO_SIM_par_1	111	116	PF11976	0.516
LIG_TRAF2_1	392	395	PF00917	0.474
LIG_TRFH_1	194	198	PF08558	0.560
LIG_TYR_ITIM	337	342	PF00017	0.280
LIG_WW_3	47	51	PF00397	0.579
MOD_CK1_1	13	19	PF00069	0.474
MOD_CK1_1	140	146	PF00069	0.382
MOD_CK1_1	200	206	PF00069	0.632
MOD_CK1_1	250	256	PF00069	0.557
MOD_CK1_1	327	333	PF00069	0.441
MOD_CK1_1	401	407	PF00069	0.549
MOD_CK1_1	596	602	PF00069	0.710
MOD_CK2_1	13	19	PF00069	0.303
MOD_CK2_1	205	211	PF00069	0.637
MOD_CK2_1	304	310	PF00069	0.600
MOD_CK2_1	373	379	PF00069	0.413
MOD_CK2_1	598	604	PF00069	0.489
MOD_CK2_1	626	632	PF00069	0.402
MOD_GlcNHglycan	252	255	PF01048	0.626
MOD_GlcNHglycan	329	332	PF01048	0.248
MOD_GlcNHglycan	400	403	PF01048	0.556
MOD_GlcNHglycan	472	475	PF01048	0.324
MOD_GlcNHglycan	51	54	PF01048	0.550
MOD_GlcNHglycan	561	564	PF01048	0.367
MOD_GlcNHglycan	600	603	PF01048	0.684
MOD_GlcNHglycan	642	645	PF01048	0.542
MOD_GlcNHglycan	70	73	PF01048	0.714
MOD_GlcNHglycan	77	80	PF01048	0.713
MOD_GSK3_1	198	205	PF00069	0.589
MOD_GSK3_1	256	263	PF00069	0.439
MOD_GSK3_1	368	375	PF00069	0.494
MOD_GSK3_1	37	44	PF00069	0.420
MOD_GSK3_1	470	477	PF00069	0.388
MOD_GSK3_1	589	596	PF00069	0.538
MOD_GSK3_1	622	629	PF00069	0.500
MOD_GSK3_1	640	647	PF00069	0.381
MOD_GSK3_1	92	99	PF00069	0.791
MOD_N-GLC_1	250	255	PF02516	0.401
MOD_N-GLC_1	361	366	PF02516	0.446
MOD_N-GLC_1	56	61	PF02516	0.722
MOD_NEK2_1	372	377	PF00069	0.509
MOD_NEK2_1	470	475	PF00069	0.324
MOD_NEK2_1	93	98	PF00069	0.634
MOD_NEK2_2	189	194	PF00069	0.331
MOD_PIKK_1	613	619	PF00454	0.544
MOD_PIKK_1	87	93	PF00454	0.595
MOD_PKA_1	10	16	PF00069	0.379
MOD_PKA_2	10	16	PF00069	0.325
MOD_PKA_2	49	55	PF00069	0.517
MOD_PKA_2	613	619	PF00069	0.484
MOD_PKA_2	654	660	PF00069	0.565
MOD_PKB_1	8	16	PF00069	0.392
MOD_Plk_1	113	119	PF00069	0.458
MOD_Plk_1	140	146	PF00069	0.392
MOD_Plk_1	189	195	PF00069	0.339
MOD_Plk_1	372	378	PF00069	0.515
MOD_Plk_1	503	509	PF00069	0.381
MOD_Plk_1	622	628	PF00069	0.584
MOD_Plk_2-3	373	379	PF00069	0.515
MOD_Plk_4	189	195	PF00069	0.339
MOD_Plk_4	260	266	PF00069	0.288
MOD_Plk_4	324	330	PF00069	0.382
MOD_Plk_4	345	351	PF00069	0.370
MOD_Plk_4	449	455	PF00069	0.364
MOD_Plk_4	549	555	PF00069	0.343
MOD_ProDKin_1	182	188	PF00069	0.425
MOD_ProDKin_1	237	243	PF00069	0.690
MOD_ProDKin_1	396	402	PF00069	0.607
MOD_ProDKin_1	485	491	PF00069	0.366
TRG_ENDOCYTIC_2	109	112	PF00928	0.564
TRG_ENDOCYTIC_2	174	177	PF00928	0.499
TRG_ENDOCYTIC_2	215	218	PF00928	0.474
TRG_ENDOCYTIC_2	339	342	PF00928	0.281
TRG_ENDOCYTIC_2	461	464	PF00928	0.384
TRG_ENDOCYTIC_2	9	12	PF00928	0.552
TRG_ER_diArg_1	153	155	PF00400	0.494
TRG_ER_diArg_1	2	4	PF00400	0.529
TRG_ER_diArg_1	222	225	PF00400	0.318
TRG_ER_diArg_1	613	615	PF00400	0.460
TRG_ER_diArg_1	9	11	PF00400	0.359
TRG_ER_diLys_1	672	676	PF00400	0.713
TRG_NES_CRM1_1	340	352	PF08389	0.451
TRG_NLS_MonoExtC_3	151	156	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P332	Leptomonas seymouri	53%	98%
A0A0S4IZM9	Bodo saltans	27%	100%
A0A0S4J2Q8	Bodo saltans	29%	100%
A0A1X0P0G0	Trypanosomatidae	35%	100%
A0A3S5H5H7	Leishmania donovani	89%	100%
A0A422N0S3	Trypanosoma rangeli	37%	100%
A4H489	Leishmania braziliensis	78%	100%
A4HSG5	Leishmania infantum	88%	100%
D0A4G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QJF9	Leishmania major	88%	100%
V5B0Z2	Trypanosoma cruzi	36%	100%