Putative dynein-light chain-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein-light chain-protein, putative

Species:

Leishmania mexicana

UniProt:

E9AKE8_LEIMU

TriTrypDb:

LmxM.05.0420

Length:

111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AKE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKE8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.286
DOC_MAPK_gen_1	56	65	PF00069	0.384
DOC_MAPK_MEF2A_6	59	67	PF00069	0.303
DOC_USP7_UBL2_3	56	60	PF12436	0.384
DOC_USP7_UBL2_3	94	98	PF12436	0.309
LIG_14-3-3_CanoR_1	50	58	PF00244	0.243
LIG_14-3-3_CanoR_1	6	10	PF00244	0.475
LIG_BIR_II_1	1	5	PF00653	0.532
LIG_FHA_2	6	12	PF00498	0.321
LIG_PDZ_Class_2	106	111	PF00595	0.312
LIG_PTB_Apo_2	19	26	PF02174	0.309
LIG_SH2_CRK	101	105	PF00017	0.245
LIG_SH2_PTP2	61	64	PF00017	0.398
LIG_SH2_STAT5	101	104	PF00017	0.379
LIG_SH2_STAT5	61	64	PF00017	0.286
LIG_SH2_STAT5	91	94	PF00017	0.253
LIG_SUMO_SIM_anti_2	3	12	PF11976	0.359
LIG_SUMO_SIM_par_1	61	66	PF11976	0.303
MOD_CK1_1	26	32	PF00069	0.401
MOD_CK1_1	41	47	PF00069	0.328
MOD_CK1_1	79	85	PF00069	0.253
MOD_GlcNHglycan	40	43	PF01048	0.402
MOD_GSK3_1	79	86	PF00069	0.397
MOD_NEK2_1	77	82	PF00069	0.358
MOD_NEK2_2	102	107	PF00069	0.238
MOD_PIKK_1	49	55	PF00454	0.272
MOD_PKA_2	49	55	PF00069	0.253
MOD_PKA_2	5	11	PF00069	0.490
MOD_Plk_1	11	17	PF00069	0.433
MOD_Plk_2-3	5	11	PF00069	0.345
MOD_Plk_4	11	17	PF00069	0.425
MOD_Plk_4	63	69	PF00069	0.384
TRG_ENDOCYTIC_2	101	104	PF00928	0.303
TRG_ENDOCYTIC_2	61	64	PF00928	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U1	Leptomonas seymouri	75%	100%
A0A0S4J526	Bodo saltans	31%	92%
A0A0S4JG65	Bodo saltans	49%	100%
A0A1X0P0S0	Trypanosomatidae	55%	100%
A0A3S7WP25	Leishmania donovani	95%	100%
A0A422N0S8	Trypanosoma rangeli	56%	100%
A4H488	Leishmania braziliensis	86%	100%
A4HSG4	Leishmania infantum	95%	100%
D0A4G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
P51807	Mus musculus	34%	98%
P51808	Homo sapiens	30%	96%
P56387	Mus musculus	29%	96%
P63171	Bos taurus	34%	98%
P63172	Homo sapiens	34%	98%
Q4QJG0	Leishmania major	95%	100%
Q54PG1	Dictyostelium discoideum	35%	100%
Q5NVF5	Pongo abelii	30%	96%
Q6XXL8	Ovis aries	28%	96%
Q8SPS9	Canis lupus familiaris	28%	96%
Q94524	Drosophila melanogaster	37%	100%
Q9Z336	Rattus norvegicus	35%	98%
V5D183	Trypanosoma cruzi	60%	100%