Putative microtubule-associated protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9AKE4_LEIMU

TriTrypDb:

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKE4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0008017	microtubule binding	5	4
GO:0008092	cytoskeletal protein binding	3	4
GO:0015631	tubulin binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.621
CLV_C14_Caspase3-7	173	177	PF00656	0.599
CLV_C14_Caspase3-7	211	215	PF00656	0.575
CLV_C14_Caspase3-7	249	253	PF00656	0.570
CLV_C14_Caspase3-7	287	291	PF00656	0.567
CLV_C14_Caspase3-7	325	329	PF00656	0.566
CLV_C14_Caspase3-7	363	367	PF00656	0.554
CLV_C14_Caspase3-7	401	405	PF00656	0.559
CLV_C14_Caspase3-7	439	443	PF00656	0.564
CLV_C14_Caspase3-7	477	481	PF00656	0.572
CLV_C14_Caspase3-7	515	519	PF00656	0.580
CLV_C14_Caspase3-7	553	557	PF00656	0.566
CLV_C14_Caspase3-7	59	63	PF00656	0.609
CLV_C14_Caspase3-7	591	595	PF00656	0.568
CLV_C14_Caspase3-7	629	633	PF00656	0.574
CLV_C14_Caspase3-7	667	671	PF00656	0.618
CLV_C14_Caspase3-7	705	709	PF00656	0.582
CLV_C14_Caspase3-7	743	747	PF00656	0.557
CLV_C14_Caspase3-7	97	101	PF00656	0.617
CLV_NRD_NRD_1	111	113	PF00675	0.589
CLV_NRD_NRD_1	149	151	PF00675	0.594
CLV_NRD_NRD_1	187	189	PF00675	0.579
CLV_NRD_NRD_1	225	227	PF00675	0.561
CLV_NRD_NRD_1	263	265	PF00675	0.544
CLV_NRD_NRD_1	301	303	PF00675	0.544
CLV_NRD_NRD_1	339	341	PF00675	0.535
CLV_NRD_NRD_1	377	379	PF00675	0.521
CLV_NRD_NRD_1	415	417	PF00675	0.515
CLV_NRD_NRD_1	453	455	PF00675	0.534
CLV_NRD_NRD_1	491	493	PF00675	0.558
CLV_NRD_NRD_1	529	531	PF00675	0.574
CLV_NRD_NRD_1	567	569	PF00675	0.747
CLV_NRD_NRD_1	605	607	PF00675	0.589
CLV_NRD_NRD_1	643	645	PF00675	0.589
CLV_NRD_NRD_1	681	683	PF00675	0.592
CLV_NRD_NRD_1	719	721	PF00675	0.585
CLV_NRD_NRD_1	73	75	PF00675	0.583
CLV_NRD_NRD_1	779	781	PF00675	0.575
CLV_PCSK_KEX2_1	111	113	PF00082	0.622
CLV_PCSK_KEX2_1	149	151	PF00082	0.627
CLV_PCSK_KEX2_1	187	189	PF00082	0.613
CLV_PCSK_KEX2_1	225	227	PF00082	0.594
CLV_PCSK_KEX2_1	263	265	PF00082	0.577
CLV_PCSK_KEX2_1	301	303	PF00082	0.578
CLV_PCSK_KEX2_1	339	341	PF00082	0.568
CLV_PCSK_KEX2_1	377	379	PF00082	0.555
CLV_PCSK_KEX2_1	415	417	PF00082	0.548
CLV_PCSK_KEX2_1	453	455	PF00082	0.567
CLV_PCSK_KEX2_1	491	493	PF00082	0.592
CLV_PCSK_KEX2_1	529	531	PF00082	0.607
CLV_PCSK_KEX2_1	567	569	PF00082	0.685
CLV_PCSK_KEX2_1	605	607	PF00082	0.584
CLV_PCSK_KEX2_1	643	645	PF00082	0.589
CLV_PCSK_KEX2_1	681	683	PF00082	0.592
CLV_PCSK_KEX2_1	719	721	PF00082	0.585
CLV_PCSK_KEX2_1	73	75	PF00082	0.617
CLV_PCSK_KEX2_1	779	781	PF00082	0.583
CLV_PCSK_PC7_1	775	781	PF00082	0.579
CLV_PCSK_SKI1_1	416	420	PF00082	0.539
CLV_PCSK_SKI1_1	454	458	PF00082	0.551
DOC_PP4_FxxP_1	8	11	PF00568	0.540
DOC_USP7_UBL2_3	137	141	PF12436	0.573
DOC_USP7_UBL2_3	175	179	PF12436	0.564
DOC_USP7_UBL2_3	213	217	PF12436	0.543
DOC_USP7_UBL2_3	251	255	PF12436	0.533
DOC_USP7_UBL2_3	289	293	PF12436	0.531
DOC_USP7_UBL2_3	327	331	PF12436	0.527
DOC_USP7_UBL2_3	365	369	PF12436	0.514
DOC_USP7_UBL2_3	403	407	PF12436	0.518
DOC_USP7_UBL2_3	441	445	PF12436	0.527
DOC_USP7_UBL2_3	479	483	PF12436	0.540
DOC_USP7_UBL2_3	517	521	PF12436	0.545
DOC_USP7_UBL2_3	555	559	PF12436	0.571
DOC_USP7_UBL2_3	593	597	PF12436	0.568
DOC_USP7_UBL2_3	61	65	PF12436	0.563
DOC_USP7_UBL2_3	631	635	PF12436	0.577
DOC_USP7_UBL2_3	669	673	PF12436	0.567
DOC_USP7_UBL2_3	707	711	PF12436	0.581
DOC_USP7_UBL2_3	745	749	PF12436	0.555
DOC_USP7_UBL2_3	99	103	PF12436	0.574
LIG_BIR_II_1	1	5	PF00653	0.549
LIG_FHA_2	133	139	PF00498	0.621
LIG_FHA_2	15	21	PF00498	0.533
LIG_FHA_2	171	177	PF00498	0.598
LIG_FHA_2	209	215	PF00498	0.572
LIG_FHA_2	247	253	PF00498	0.566
LIG_FHA_2	285	291	PF00498	0.564
LIG_FHA_2	323	329	PF00498	0.563
LIG_FHA_2	361	367	PF00498	0.552
LIG_FHA_2	38	44	PF00498	0.826
LIG_FHA_2	399	405	PF00498	0.556
LIG_FHA_2	437	443	PF00498	0.562
LIG_FHA_2	475	481	PF00498	0.568
LIG_FHA_2	513	519	PF00498	0.576
LIG_FHA_2	551	557	PF00498	0.561
LIG_FHA_2	57	63	PF00498	0.522
LIG_FHA_2	589	595	PF00498	0.567
LIG_FHA_2	627	633	PF00498	0.574
LIG_FHA_2	665	671	PF00498	0.801
LIG_FHA_2	703	709	PF00498	0.579
LIG_FHA_2	741	747	PF00498	0.553
LIG_FHA_2	757	763	PF00498	0.525
LIG_FHA_2	95	101	PF00498	0.617
LIG_LIR_Apic_2	7	11	PF02991	0.540
LIG_LIR_Gen_1	158	168	PF02991	0.554
LIG_LIR_Gen_1	196	206	PF02991	0.553
LIG_LIR_Gen_1	234	244	PF02991	0.538
LIG_LIR_Gen_1	272	282	PF02991	0.531
LIG_LIR_Gen_1	310	320	PF02991	0.533
LIG_LIR_Gen_1	348	358	PF02991	0.536
LIG_LIR_Gen_1	386	396	PF02991	0.539
LIG_LIR_Gen_1	424	434	PF02991	0.540
LIG_LIR_Gen_1	462	472	PF02991	0.540
LIG_LIR_Gen_1	500	510	PF02991	0.554
LIG_LIR_Gen_1	538	548	PF02991	0.568
LIG_LIR_Gen_1	576	586	PF02991	0.571
LIG_LIR_Gen_1	614	624	PF02991	0.576
LIG_LIR_Gen_1	652	662	PF02991	0.573
LIG_LIR_Gen_1	690	700	PF02991	0.579
LIG_LIR_Gen_1	728	738	PF02991	0.534
LIG_LIR_Gen_1	82	92	PF02991	0.572
LIG_LIR_Nem_3	158	163	PF02991	0.560
LIG_LIR_Nem_3	196	201	PF02991	0.575
LIG_LIR_Nem_3	234	239	PF02991	0.559
LIG_LIR_Nem_3	272	277	PF02991	0.546
LIG_LIR_Nem_3	310	315	PF02991	0.542
LIG_LIR_Nem_3	348	353	PF02991	0.541
LIG_LIR_Nem_3	366	371	PF02991	0.514
LIG_LIR_Nem_3	386	391	PF02991	0.501
LIG_LIR_Nem_3	404	409	PF02991	0.513
LIG_LIR_Nem_3	424	429	PF02991	0.557
LIG_LIR_Nem_3	462	467	PF02991	0.552
LIG_LIR_Nem_3	500	505	PF02991	0.570
LIG_LIR_Nem_3	518	523	PF02991	0.551
LIG_LIR_Nem_3	538	543	PF02991	0.527
LIG_LIR_Nem_3	576	581	PF02991	0.730
LIG_LIR_Nem_3	594	599	PF02991	0.526
LIG_LIR_Nem_3	614	619	PF02991	0.585
LIG_LIR_Nem_3	652	657	PF02991	0.579
LIG_LIR_Nem_3	690	695	PF02991	0.584
LIG_LIR_Nem_3	728	733	PF02991	0.553
LIG_LIR_Nem_3	746	751	PF02991	0.511
LIG_LIR_Nem_3	82	87	PF02991	0.580
LIG_NRP_CendR_1	783	784	PF00754	0.567
LIG_SH2_NCK_1	160	164	PF00017	0.564
LIG_SH2_NCK_1	198	202	PF00017	0.573
LIG_SH2_NCK_1	236	240	PF00017	0.562
LIG_SH2_NCK_1	24	28	PF00017	0.488
LIG_SH2_NCK_1	274	278	PF00017	0.549
LIG_SH2_NCK_1	312	316	PF00017	0.544
LIG_SH2_NCK_1	350	354	PF00017	0.541
LIG_SH2_NCK_1	388	392	PF00017	0.544
LIG_SH2_NCK_1	426	430	PF00017	0.545
LIG_SH2_NCK_1	464	468	PF00017	0.546
LIG_SH2_NCK_1	502	506	PF00017	0.564
LIG_SH2_NCK_1	540	544	PF00017	0.572
LIG_SH2_NCK_1	578	582	PF00017	0.574
LIG_SH2_NCK_1	616	620	PF00017	0.583
LIG_SH2_NCK_1	654	658	PF00017	0.580
LIG_SH2_NCK_1	692	696	PF00017	0.658
LIG_SH2_NCK_1	730	734	PF00017	0.555
LIG_SH2_NCK_1	84	88	PF00017	0.578
LIG_SH2_SRC	24	27	PF00017	0.530
LIG_SH2_STAP1	24	28	PF00017	0.488
LIG_SH2_STAT5	756	759	PF00017	0.569
LIG_SH3_1	31	37	PF00018	0.581
LIG_SH3_3	123	129	PF00018	0.728
LIG_SH3_3	161	167	PF00018	0.711
LIG_SH3_3	199	205	PF00018	0.707
LIG_SH3_3	237	243	PF00018	0.690
LIG_SH3_3	275	281	PF00018	0.682
LIG_SH3_3	31	37	PF00018	0.581
LIG_SH3_3	313	319	PF00018	0.687
LIG_SH3_3	351	357	PF00018	0.689
LIG_SH3_3	389	395	PF00018	0.690
LIG_SH3_3	427	433	PF00018	0.691
LIG_SH3_3	465	471	PF00018	0.690
LIG_SH3_3	47	53	PF00018	0.589
LIG_SH3_3	503	509	PF00018	0.707
LIG_SH3_3	541	547	PF00018	0.569
LIG_SH3_3	579	585	PF00018	0.571
LIG_SH3_3	617	623	PF00018	0.578
LIG_SH3_3	655	661	PF00018	0.759
LIG_SH3_3	693	699	PF00018	0.592
LIG_SH3_3	731	737	PF00018	0.573
LIG_SH3_3	85	91	PF00018	0.726
LIG_WRC_WIRS_1	5	10	PF05994	0.544
MOD_CK2_1	14	20	PF00069	0.542
MOD_CK2_1	756	762	PF00069	0.561
MOD_CK2_1	775	781	PF00069	0.754
MOD_GlcNHglycan	1	4	PF01048	0.595
MOD_GSK3_1	770	777	PF00069	0.626
MOD_N-GLC_1	132	137	PF02516	0.577
MOD_N-GLC_1	170	175	PF02516	0.597
MOD_N-GLC_1	208	213	PF02516	0.523
MOD_N-GLC_1	246	251	PF02516	0.562
MOD_N-GLC_1	284	289	PF02516	0.560
MOD_N-GLC_1	322	327	PF02516	0.560
MOD_N-GLC_1	360	365	PF02516	0.548
MOD_N-GLC_1	398	403	PF02516	0.552
MOD_N-GLC_1	436	441	PF02516	0.557
MOD_N-GLC_1	474	479	PF02516	0.563
MOD_N-GLC_1	512	517	PF02516	0.569
MOD_N-GLC_1	550	555	PF02516	0.652
MOD_N-GLC_1	56	61	PF02516	0.613
MOD_N-GLC_1	588	593	PF02516	0.569
MOD_N-GLC_1	626	631	PF02516	0.575
MOD_N-GLC_1	664	669	PF02516	0.570
MOD_N-GLC_1	702	707	PF02516	0.580
MOD_N-GLC_1	740	745	PF02516	0.570
MOD_N-GLC_1	94	99	PF02516	0.618
MOD_NEK2_1	131	136	PF00069	0.605
MOD_NEK2_1	14	19	PF00069	0.547
MOD_NEK2_1	169	174	PF00069	0.580
MOD_NEK2_1	207	212	PF00069	0.549
MOD_NEK2_1	245	250	PF00069	0.540
MOD_NEK2_1	283	288	PF00069	0.539
MOD_NEK2_1	321	326	PF00069	0.541
MOD_NEK2_1	359	364	PF00069	0.533
MOD_NEK2_1	397	402	PF00069	0.535
MOD_NEK2_1	435	440	PF00069	0.540
MOD_NEK2_1	473	478	PF00069	0.543
MOD_NEK2_1	511	516	PF00069	0.551
MOD_NEK2_1	549	554	PF00069	0.584
MOD_NEK2_1	55	60	PF00069	0.598
MOD_NEK2_1	587	592	PF00069	0.563
MOD_NEK2_1	625	630	PF00069	0.833
MOD_NEK2_1	663	668	PF00069	0.570
MOD_NEK2_1	701	706	PF00069	0.859
MOD_NEK2_1	739	744	PF00069	0.611
MOD_NEK2_1	93	98	PF00069	0.601
MOD_PIKK_1	37	43	PF00454	0.728
MOD_PKA_2	774	780	PF00069	0.584
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.546
TRG_ENDOCYTIC_2	160	163	PF00928	0.564
TRG_ENDOCYTIC_2	198	201	PF00928	0.577
TRG_ENDOCYTIC_2	236	239	PF00928	0.565
TRG_ENDOCYTIC_2	274	277	PF00928	0.548
TRG_ENDOCYTIC_2	312	315	PF00928	0.543
TRG_ENDOCYTIC_2	350	353	PF00928	0.539
TRG_ENDOCYTIC_2	388	391	PF00928	0.542
TRG_ENDOCYTIC_2	426	429	PF00928	0.545
TRG_ENDOCYTIC_2	464	467	PF00928	0.547
TRG_ENDOCYTIC_2	502	505	PF00928	0.569
TRG_ENDOCYTIC_2	540	543	PF00928	0.727
TRG_ENDOCYTIC_2	578	581	PF00928	0.729
TRG_ENDOCYTIC_2	616	619	PF00928	0.589
TRG_ENDOCYTIC_2	654	657	PF00928	0.583
TRG_ENDOCYTIC_2	692	695	PF00928	0.661
TRG_ENDOCYTIC_2	730	733	PF00928	0.557
TRG_ENDOCYTIC_2	84	87	PF00928	0.584
TRG_ER_diArg_1	110	112	PF00400	0.592
TRG_ER_diArg_1	148	150	PF00400	0.592
TRG_ER_diArg_1	186	188	PF00400	0.587
TRG_ER_diArg_1	224	226	PF00400	0.569
TRG_ER_diArg_1	262	264	PF00400	0.547
TRG_ER_diArg_1	300	302	PF00400	0.546
TRG_ER_diArg_1	338	340	PF00400	0.536
TRG_ER_diArg_1	376	378	PF00400	0.524
TRG_ER_diArg_1	414	416	PF00400	0.517
TRG_ER_diArg_1	452	454	PF00400	0.533
TRG_ER_diArg_1	490	492	PF00400	0.553
TRG_ER_diArg_1	528	530	PF00400	0.581
TRG_ER_diArg_1	566	568	PF00400	0.598
TRG_ER_diArg_1	604	606	PF00400	0.582
TRG_ER_diArg_1	642	644	PF00400	0.592
TRG_ER_diArg_1	680	682	PF00400	0.592
TRG_ER_diArg_1	718	720	PF00400	0.591
TRG_ER_diArg_1	72	74	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H483	Leishmania braziliensis	67%	92%
D0A4H4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%