Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKE3_LEIMU

TriTrypDb:

LmxM.05.0370

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.555
CLV_NRD_NRD_1	245	247	PF00675	0.822
CLV_PCSK_KEX2_1	245	247	PF00082	0.822
CLV_PCSK_KEX2_1	320	322	PF00082	0.611
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.510
CLV_PCSK_SKI1_1	129	133	PF00082	0.646
CLV_PCSK_SKI1_1	246	250	PF00082	0.727
DEG_SPOP_SBC_1	111	115	PF00917	0.523
DEG_SPOP_SBC_1	180	184	PF00917	0.752
DEG_SPOP_SBC_1	217	221	PF00917	0.713
DEG_SPOP_SBC_1	237	241	PF00917	0.685
DOC_MAPK_MEF2A_6	320	327	PF00069	0.603
DOC_PP1_RVXF_1	127	134	PF00149	0.645
DOC_PP4_FxxP_1	12	15	PF00568	0.797
DOC_PP4_FxxP_1	52	55	PF00568	0.639
DOC_USP7_MATH_1	180	184	PF00917	0.752
DOC_USP7_MATH_1	216	220	PF00917	0.683
DOC_USP7_MATH_1	237	241	PF00917	0.719
DOC_USP7_MATH_1	267	271	PF00917	0.621
DOC_USP7_MATH_1	98	102	PF00917	0.695
DOC_WW_Pin1_4	112	117	PF00397	0.527
DOC_WW_Pin1_4	168	173	PF00397	0.535
DOC_WW_Pin1_4	181	186	PF00397	0.775
DOC_WW_Pin1_4	238	243	PF00397	0.650
DOC_WW_Pin1_4	308	313	PF00397	0.716
LIG_14-3-3_CanoR_1	251	259	PF00244	0.730
LIG_14-3-3_CanoR_1	88	94	PF00244	0.586
LIG_BRCT_BRCA1_1	218	222	PF00533	0.800
LIG_Clathr_ClatBox_1	132	136	PF01394	0.757
LIG_eIF4E_1	16	22	PF01652	0.611
LIG_FHA_1	17	23	PF00498	0.760
LIG_FHA_1	192	198	PF00498	0.509
LIG_FHA_1	72	78	PF00498	0.640
LIG_FHA_2	147	153	PF00498	0.622
LIG_FHA_2	182	188	PF00498	0.529
LIG_FHA_2	309	315	PF00498	0.719
LIG_IBAR_NPY_1	14	16	PF08397	0.779
LIG_LIR_Apic_2	10	15	PF02991	0.802
LIG_LIR_Apic_2	49	55	PF02991	0.480
LIG_LIR_Gen_1	203	213	PF02991	0.547
LIG_LIR_Nem_3	152	157	PF02991	0.621
LIG_LIR_Nem_3	203	208	PF02991	0.548
LIG_SH2_CRK	205	209	PF00017	0.763
LIG_SH2_GRB2like	159	162	PF00017	0.470
LIG_SH2_NCK_1	205	209	PF00017	0.661
LIG_SH2_SRC	159	162	PF00017	0.470
LIG_SH2_STAP1	75	79	PF00017	0.627
LIG_SH3_3	135	141	PF00018	0.662
LIG_SH3_3	279	285	PF00018	0.751
LIG_SxIP_EBH_1	236	246	PF03271	0.534
MOD_CDK_SPxxK_3	238	245	PF00069	0.622
MOD_CK1_1	269	275	PF00069	0.740
MOD_CK2_1	308	314	PF00069	0.716
MOD_GlcNHglycan	175	178	PF01048	0.773
MOD_GlcNHglycan	231	234	PF01048	0.640
MOD_GlcNHglycan	269	272	PF01048	0.706
MOD_GlcNHglycan	273	276	PF01048	0.720
MOD_GlcNHglycan	6	10	PF01048	0.804
MOD_GlcNHglycan	90	93	PF01048	0.789
MOD_GSK3_1	146	153	PF00069	0.647
MOD_GSK3_1	218	225	PF00069	0.584
MOD_GSK3_1	231	238	PF00069	0.651
MOD_GSK3_1	262	269	PF00069	0.789
MOD_GSK3_1	83	90	PF00069	0.642
MOD_N-GLC_1	111	116	PF02516	0.522
MOD_N-GLC_1	168	173	PF02516	0.531
MOD_N-GLC_1	17	22	PF02516	0.676
MOD_N-GLC_1	235	240	PF02516	0.552
MOD_NEK2_1	104	109	PF00069	0.739
MOD_NEK2_1	204	209	PF00069	0.763
MOD_NEK2_1	222	227	PF00069	0.486
MOD_NEK2_1	229	234	PF00069	0.533
MOD_NEK2_1	259	264	PF00069	0.715
MOD_NEK2_1	266	271	PF00069	0.693
MOD_NEK2_1	70	75	PF00069	0.635
MOD_NEK2_1	83	88	PF00069	0.615
MOD_NEK2_2	218	223	PF00069	0.691
MOD_PIKK_1	83	89	PF00454	0.712
MOD_PKA_2	104	110	PF00069	0.690
MOD_PKA_2	222	228	PF00069	0.525
MOD_PKA_2	87	93	PF00069	0.516
MOD_Plk_1	17	23	PF00069	0.679
MOD_Plk_4	162	168	PF00069	0.476
MOD_Plk_4	17	23	PF00069	0.658
MOD_Plk_4	99	105	PF00069	0.797
MOD_ProDKin_1	112	118	PF00069	0.528
MOD_ProDKin_1	168	174	PF00069	0.536
MOD_ProDKin_1	181	187	PF00069	0.777
MOD_ProDKin_1	238	244	PF00069	0.645
MOD_ProDKin_1	308	314	PF00069	0.716
TRG_ENDOCYTIC_2	154	157	PF00928	0.650
TRG_ENDOCYTIC_2	205	208	PF00928	0.662
TRG_ER_diArg_1	244	246	PF00400	0.739
TRG_ER_diArg_1	288	291	PF00400	0.764
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H3	Leptomonas seymouri	38%	100%
A0A3S7WP10	Leishmania donovani	84%	100%
A4H482	Leishmania braziliensis	61%	99%
A4HSF9	Leishmania infantum	83%	100%
Q4QJG5	Leishmania major	84%	100%