DUF3519 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKE0_LEIMU

TriTrypDb:

LmxM.05.0340

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

E9AKE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKE0

PDB structure(s): 7ane_f

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.630
CLV_C14_Caspase3-7	213	217	PF00656	0.397
CLV_C14_Caspase3-7	49	53	PF00656	0.577
CLV_C14_Caspase3-7	75	79	PF00656	0.740
CLV_NRD_NRD_1	10	12	PF00675	0.528
CLV_NRD_NRD_1	246	248	PF00675	0.401
CLV_NRD_NRD_1	26	28	PF00675	0.481
CLV_PCSK_KEX2_1	10	12	PF00082	0.528
CLV_PCSK_KEX2_1	245	247	PF00082	0.413
CLV_PCSK_KEX2_1	259	261	PF00082	0.431
CLV_PCSK_KEX2_1	26	28	PF00082	0.496
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.446
CLV_PCSK_SKI1_1	259	263	PF00082	0.422
CLV_PCSK_SKI1_1	270	274	PF00082	0.470
CLV_PCSK_SKI1_1	367	371	PF00082	0.503
CLV_Separin_Metazoa	229	233	PF03568	0.390
DEG_Nend_Nbox_1	1	3	PF02207	0.656
DEG_SPOP_SBC_1	167	171	PF00917	0.738
DOC_ANK_TNKS_1	148	155	PF00023	0.619
DOC_CDC14_PxL_1	25	33	PF14671	0.497
DOC_MAPK_gen_1	232	242	PF00069	0.355
DOC_MAPK_gen_1	316	326	PF00069	0.403
DOC_MAPK_MEF2A_6	235	242	PF00069	0.434
DOC_MAPK_MEF2A_6	316	324	PF00069	0.411
DOC_USP7_MATH_1	155	159	PF00917	0.737
DOC_USP7_MATH_1	166	170	PF00917	0.646
DOC_USP7_MATH_1	209	213	PF00917	0.690
DOC_USP7_MATH_1	67	71	PF00917	0.717
DOC_WW_Pin1_4	205	210	PF00397	0.605
DOC_WW_Pin1_4	353	358	PF00397	0.435
LIG_14-3-3_CanoR_1	198	204	PF00244	0.333
LIG_14-3-3_CanoR_1	245	251	PF00244	0.389
LIG_APCC_ABBAyCdc20_2	17	23	PF00400	0.514
LIG_BRCT_BRCA1_1	233	237	PF00533	0.550
LIG_CaM_IQ_9	113	128	PF13499	0.624
LIG_eIF4E_1	256	262	PF01652	0.548
LIG_eIF4E_1	41	47	PF01652	0.517
LIG_FHA_1	247	253	PF00498	0.361
LIG_FHA_2	148	154	PF00498	0.616
LIG_FHA_2	211	217	PF00498	0.548
LIG_FHA_2	73	79	PF00498	0.636
LIG_Integrin_isoDGR_2	331	333	PF01839	0.400
LIG_Integrin_RGD_1	280	282	PF01839	0.601
LIG_LIR_Gen_1	234	243	PF02991	0.392
LIG_LIR_LC3C_4	321	324	PF02991	0.381
LIG_LIR_Nem_3	23	28	PF02991	0.473
LIG_LIR_Nem_3	234	240	PF02991	0.389
LIG_Pex14_2	195	199	PF04695	0.454
LIG_SH2_CRK	201	205	PF00017	0.479
LIG_SH2_CRK	25	29	PF00017	0.495
LIG_SH2_GRB2like	295	298	PF00017	0.418
LIG_SH2_GRB2like	41	44	PF00017	0.581
LIG_SH2_NCK_1	250	254	PF00017	0.391
LIG_SH2_STAP1	233	237	PF00017	0.438
LIG_SH2_STAP1	250	254	PF00017	0.376
LIG_SH2_STAT5	194	197	PF00017	0.441
LIG_SH2_STAT5	241	244	PF00017	0.360
LIG_SH2_STAT5	265	268	PF00017	0.442
LIG_SH2_STAT5	295	298	PF00017	0.388
LIG_SH2_STAT5	351	354	PF00017	0.427
LIG_SH2_STAT5	41	44	PF00017	0.518
LIG_SH3_3	360	366	PF00018	0.490
LIG_SH3_3	94	100	PF00018	0.623
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.385
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.591
LIG_TRAF2_1	115	118	PF00917	0.517
MOD_CK1_1	169	175	PF00069	0.771
MOD_CK2_1	108	114	PF00069	0.537
MOD_CK2_1	155	161	PF00069	0.632
MOD_CK2_1	168	174	PF00069	0.685
MOD_Cter_Amidation	257	260	PF01082	0.446
MOD_GlcNHglycan	309	312	PF01048	0.605
MOD_GlcNHglycan	48	51	PF01048	0.562
MOD_GlcNHglycan	62	65	PF01048	0.753
MOD_GlcNHglycan	69	72	PF01048	0.767
MOD_GSK3_1	162	169	PF00069	0.690
MOD_GSK3_1	205	212	PF00069	0.606
MOD_LATS_1	145	151	PF00433	0.578
MOD_NEK2_1	1	6	PF00069	0.574
MOD_NEK2_1	199	204	PF00069	0.462
MOD_NEK2_1	46	51	PF00069	0.489
MOD_PIKK_1	128	134	PF00454	0.568
MOD_PIKK_1	147	153	PF00454	0.654
MOD_PKA_1	246	252	PF00069	0.383
MOD_PKA_2	231	237	PF00069	0.375
MOD_PKA_2	246	252	PF00069	0.383
MOD_Plk_1	155	161	PF00069	0.438
MOD_Plk_1	90	96	PF00069	0.692
MOD_Plk_4	199	205	PF00069	0.476
MOD_Plk_4	2	8	PF00069	0.628
MOD_Plk_4	290	296	PF00069	0.417
MOD_ProDKin_1	205	211	PF00069	0.603
MOD_ProDKin_1	353	359	PF00069	0.442
MOD_SUMO_rev_2	114	123	PF00179	0.621
MOD_SUMO_rev_2	255	261	PF00179	0.580
TRG_AP2beta_CARGO_1	236	246	PF09066	0.390
TRG_DiLeu_BaEn_1	318	323	PF01217	0.406
TRG_DiLeu_BaEn_4	118	124	PF01217	0.388
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.547
TRG_ENDOCYTIC_2	201	204	PF00928	0.470
TRG_ENDOCYTIC_2	221	224	PF00928	0.293
TRG_ENDOCYTIC_2	25	28	PF00928	0.496
TRG_ER_diArg_1	107	110	PF00400	0.566
TRG_ER_diArg_1	14	17	PF00400	0.503
TRG_ER_diArg_1	245	247	PF00400	0.413
TRG_ER_diArg_1	25	27	PF00400	0.505
TRG_ER_diArg_1	347	350	PF00400	0.540
TRG_ER_diArg_1	9	11	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUU3	Leptomonas seymouri	69%	98%
A0A0S4J6I9	Bodo saltans	51%	100%
A0A1X0P0T0	Trypanosomatidae	59%	100%
A0A3S5H5H3	Leishmania donovani	93%	100%
A0A422NDL4	Trypanosoma rangeli	60%	100%
A4H478	Leishmania braziliensis	79%	97%
A4HSF3	Leishmania infantum	93%	100%
D0A4H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
Q4QJG8	Leishmania major	91%	100%
V5AZT2	Trypanosoma cruzi	59%	100%