Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKD6_LEIMU

TriTrypDb:

LmxM.05.0300

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.608
CLV_C14_Caspase3-7	59	63	PF00656	0.529
CLV_C14_Caspase3-7	645	649	PF00656	0.540
CLV_C14_Caspase3-7	670	674	PF00656	0.583
CLV_C14_Caspase3-7	730	734	PF00656	0.498
CLV_NRD_NRD_1	168	170	PF00675	0.665
CLV_NRD_NRD_1	365	367	PF00675	0.676
CLV_NRD_NRD_1	413	415	PF00675	0.646
CLV_NRD_NRD_1	423	425	PF00675	0.638
CLV_NRD_NRD_1	459	461	PF00675	0.574
CLV_NRD_NRD_1	544	546	PF00675	0.688
CLV_NRD_NRD_1	632	634	PF00675	0.612
CLV_NRD_NRD_1	74	76	PF00675	0.536
CLV_PCSK_KEX2_1	168	170	PF00082	0.794
CLV_PCSK_KEX2_1	365	367	PF00082	0.676
CLV_PCSK_KEX2_1	413	415	PF00082	0.646
CLV_PCSK_KEX2_1	422	424	PF00082	0.636
CLV_PCSK_KEX2_1	459	461	PF00082	0.574
CLV_PCSK_KEX2_1	544	546	PF00082	0.682
CLV_PCSK_KEX2_1	631	633	PF00082	0.630
CLV_PCSK_SKI1_1	201	205	PF00082	0.578
CLV_PCSK_SKI1_1	407	411	PF00082	0.587
CLV_PCSK_SKI1_1	706	710	PF00082	0.590
CLV_PCSK_SKI1_1	717	721	PF00082	0.533
CLV_PCSK_SKI1_1	727	731	PF00082	0.530
DEG_Nend_UBRbox_2	1	3	PF02207	0.488
DEG_SPOP_SBC_1	519	523	PF00917	0.561
DEG_SPOP_SBC_1	91	95	PF00917	0.486
DOC_ANK_TNKS_1	57	64	PF00023	0.531
DOC_CDC14_PxL_1	104	112	PF14671	0.489
DOC_CYCLIN_RxL_1	703	712	PF00134	0.593
DOC_CYCLIN_RxL_1	722	733	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.621
DOC_CYCLIN_yCln2_LP_2	512	518	PF00134	0.642
DOC_MAPK_gen_1	365	373	PF00069	0.663
DOC_MAPK_gen_1	722	731	PF00069	0.574
DOC_PP1_RVXF_1	30	36	PF00149	0.503
DOC_PP1_RVXF_1	725	732	PF00149	0.568
DOC_PP2B_LxvP_1	103	106	PF13499	0.606
DOC_PP2B_LxvP_1	147	150	PF13499	0.609
DOC_PP2B_LxvP_1	386	389	PF13499	0.619
DOC_PP2B_LxvP_1	512	515	PF13499	0.611
DOC_PP2B_LxvP_1	595	598	PF13499	0.669
DOC_PP2B_LxvP_1	702	705	PF13499	0.553
DOC_PP2B_LxvP_1	713	716	PF13499	0.598
DOC_PP4_FxxP_1	476	479	PF00568	0.497
DOC_USP7_MATH_1	112	116	PF00917	0.733
DOC_USP7_MATH_1	141	145	PF00917	0.591
DOC_USP7_MATH_1	156	160	PF00917	0.600
DOC_USP7_MATH_1	182	186	PF00917	0.637
DOC_USP7_MATH_1	223	227	PF00917	0.641
DOC_USP7_MATH_1	305	309	PF00917	0.684
DOC_USP7_MATH_1	331	335	PF00917	0.612
DOC_USP7_MATH_1	364	368	PF00917	0.570
DOC_USP7_MATH_1	405	409	PF00917	0.703
DOC_USP7_MATH_1	490	494	PF00917	0.602
DOC_USP7_MATH_1	519	523	PF00917	0.634
DOC_USP7_MATH_1	643	647	PF00917	0.665
DOC_USP7_MATH_1	66	70	PF00917	0.611
DOC_USP7_MATH_1	79	83	PF00917	0.521
DOC_WW_Pin1_4	120	125	PF00397	0.659
DOC_WW_Pin1_4	21	26	PF00397	0.509
DOC_WW_Pin1_4	247	252	PF00397	0.629
DOC_WW_Pin1_4	254	259	PF00397	0.591
DOC_WW_Pin1_4	281	286	PF00397	0.585
DOC_WW_Pin1_4	412	417	PF00397	0.689
DOC_WW_Pin1_4	45	50	PF00397	0.542
DOC_WW_Pin1_4	468	473	PF00397	0.644
DOC_WW_Pin1_4	491	496	PF00397	0.631
DOC_WW_Pin1_4	618	623	PF00397	0.679
DOC_WW_Pin1_4	700	705	PF00397	0.588
DOC_WW_Pin1_4	707	712	PF00397	0.529
DOC_WW_Pin1_4	77	82	PF00397	0.510
LIG_14-3-3_CanoR_1	116	121	PF00244	0.687
LIG_14-3-3_CanoR_1	126	130	PF00244	0.535
LIG_14-3-3_CanoR_1	168	175	PF00244	0.602
LIG_14-3-3_CanoR_1	365	373	PF00244	0.553
LIG_14-3-3_CanoR_1	407	416	PF00244	0.513
LIG_14-3-3_CanoR_1	547	555	PF00244	0.550
LIG_14-3-3_CanoR_1	717	726	PF00244	0.560
LIG_14-3-3_CanoR_1	727	732	PF00244	0.516
LIG_BIR_III_4	214	218	PF00653	0.505
LIG_BRCT_BRCA1_1	27	31	PF00533	0.461
LIG_eIF4E_1	104	110	PF01652	0.487
LIG_FHA_1	239	245	PF00498	0.441
LIG_FHA_1	267	273	PF00498	0.635
LIG_FHA_1	413	419	PF00498	0.615
LIG_FHA_1	469	475	PF00498	0.574
LIG_FHA_1	502	508	PF00498	0.540
LIG_FHA_1	612	618	PF00498	0.582
LIG_FHA_1	730	736	PF00498	0.529
LIG_FHA_1	93	99	PF00498	0.554
LIG_FHA_2	57	63	PF00498	0.557
LIG_FHA_2	643	649	PF00498	0.663
LIG_FHA_2	668	674	PF00498	0.605
LIG_FHA_2	728	734	PF00498	0.574
LIG_LIR_Apic_2	379	385	PF02991	0.603
LIG_LIR_Apic_2	473	479	PF02991	0.588
LIG_LIR_Gen_1	115	124	PF02991	0.623
LIG_LIR_Gen_1	528	537	PF02991	0.521
LIG_LIR_Nem_3	115	120	PF02991	0.634
LIG_LIR_Nem_3	473	478	PF02991	0.593
LIG_LIR_Nem_3	528	533	PF02991	0.538
LIG_LIR_Nem_3	573	579	PF02991	0.457
LIG_LIR_Nem_3	638	642	PF02991	0.663
LIG_LIR_Nem_3	693	698	PF02991	0.668
LIG_MYND_1	108	112	PF01753	0.595
LIG_PDZ_Class_3	739	744	PF00595	0.546
LIG_Pex14_1	575	579	PF04695	0.478
LIG_Pex14_2	31	35	PF04695	0.457
LIG_Pex14_2	454	458	PF04695	0.634
LIG_SH2_CRK	431	435	PF00017	0.516
LIG_SH2_CRK	530	534	PF00017	0.517
LIG_SH2_NCK_1	465	469	PF00017	0.653
LIG_SH2_PTP2	11	14	PF00017	0.482
LIG_SH2_PTP2	639	642	PF00017	0.602
LIG_SH2_SRC	104	107	PF00017	0.488
LIG_SH2_SRC	11	14	PF00017	0.482
LIG_SH2_SRC	329	332	PF00017	0.637
LIG_SH2_STAP1	27	31	PF00017	0.461
LIG_SH2_STAP1	530	534	PF00017	0.557
LIG_SH2_STAP1	549	553	PF00017	0.654
LIG_SH2_STAP1	87	91	PF00017	0.599
LIG_SH2_STAT5	104	107	PF00017	0.488
LIG_SH2_STAT5	11	14	PF00017	0.482
LIG_SH2_STAT5	329	332	PF00017	0.748
LIG_SH2_STAT5	342	345	PF00017	0.447
LIG_SH2_STAT5	352	355	PF00017	0.553
LIG_SH2_STAT5	465	468	PF00017	0.656
LIG_SH2_STAT5	532	535	PF00017	0.503
LIG_SH2_STAT5	639	642	PF00017	0.587
LIG_SH3_1	11	17	PF00018	0.481
LIG_SH3_1	310	316	PF00018	0.682
LIG_SH3_1	431	437	PF00018	0.517
LIG_SH3_1	75	81	PF00018	0.522
LIG_SH3_3	10	16	PF00018	0.541
LIG_SH3_3	19	25	PF00018	0.506
LIG_SH3_3	310	316	PF00018	0.682
LIG_SH3_3	431	437	PF00018	0.740
LIG_SH3_3	504	510	PF00018	0.556
LIG_SH3_3	581	587	PF00018	0.484
LIG_SH3_3	691	697	PF00018	0.733
LIG_SH3_3	75	81	PF00018	0.522
LIG_SH3_4	436	443	PF00018	0.536
LIG_SUMO_SIM_anti_2	241	248	PF11976	0.541
LIG_SUMO_SIM_par_1	138	144	PF11976	0.642
LIG_SxIP_EBH_1	91	101	PF03271	0.480
LIG_TRAF2_1	590	593	PF00917	0.531
LIG_TRAF2_1	68	71	PF00917	0.618
LIG_TRAF2_1	739	742	PF00917	0.553
LIG_TRFH_1	700	704	PF08558	0.559
LIG_WRC_WIRS_1	142	147	PF05994	0.646
LIG_WW_3	703	707	PF00397	0.634
LIG_WW_3	722	726	PF00397	0.429
MOD_CDC14_SPxK_1	123	126	PF00782	0.585
MOD_CDC14_SPxK_1	703	706	PF00782	0.594
MOD_CDK_SPK_2	412	417	PF00069	0.689
MOD_CDK_SPxK_1	120	126	PF00069	0.597
MOD_CDK_SPxK_1	700	706	PF00069	0.598
MOD_CDK_SPxxK_3	247	254	PF00069	0.582
MOD_CK1_1	159	165	PF00069	0.629
MOD_CK1_1	242	248	PF00069	0.536
MOD_CK1_1	250	256	PF00069	0.571
MOD_CK1_1	332	338	PF00069	0.650
MOD_CK1_1	480	486	PF00069	0.676
MOD_CK1_1	491	497	PF00069	0.581
MOD_CK1_1	499	505	PF00069	0.521
MOD_CK1_1	528	534	PF00069	0.607
MOD_CK1_1	570	576	PF00069	0.521
MOD_CK1_1	623	629	PF00069	0.671
MOD_CK1_1	707	713	PF00069	0.555
MOD_CK1_1	82	88	PF00069	0.594
MOD_CK1_1	93	99	PF00069	0.494
MOD_CK2_1	159	165	PF00069	0.692
MOD_CK2_1	405	411	PF00069	0.700
MOD_CK2_1	502	508	PF00069	0.538
MOD_DYRK1A_RPxSP_1	254	258	PF00069	0.611
MOD_GlcNHglycan	184	187	PF01048	0.651
MOD_GlcNHglycan	209	212	PF01048	0.678
MOD_GlcNHglycan	241	244	PF01048	0.438
MOD_GlcNHglycan	281	284	PF01048	0.477
MOD_GlcNHglycan	307	310	PF01048	0.511
MOD_GlcNHglycan	334	337	PF01048	0.571
MOD_GlcNHglycan	354	357	PF01048	0.607
MOD_GlcNHglycan	362	365	PF01048	0.685
MOD_GlcNHglycan	379	382	PF01048	0.593
MOD_GlcNHglycan	398	401	PF01048	0.527
MOD_GlcNHglycan	490	493	PF01048	0.611
MOD_GlcNHglycan	498	501	PF01048	0.614
MOD_GlcNHglycan	527	530	PF01048	0.735
MOD_GlcNHglycan	549	552	PF01048	0.523
MOD_GlcNHglycan	645	648	PF01048	0.718
MOD_GlcNHglycan	650	653	PF01048	0.616
MOD_GlcNHglycan	656	659	PF01048	0.501
MOD_GSK3_1	112	119	PF00069	0.665
MOD_GSK3_1	164	171	PF00069	0.555
MOD_GSK3_1	203	210	PF00069	0.576
MOD_GSK3_1	21	28	PF00069	0.505
MOD_GSK3_1	238	245	PF00069	0.536
MOD_GSK3_1	250	257	PF00069	0.575
MOD_GSK3_1	325	332	PF00069	0.549
MOD_GSK3_1	360	367	PF00069	0.535
MOD_GSK3_1	45	52	PF00069	0.539
MOD_GSK3_1	466	473	PF00069	0.658
MOD_GSK3_1	528	535	PF00069	0.556
MOD_GSK3_1	543	550	PF00069	0.554
MOD_GSK3_1	616	623	PF00069	0.645
MOD_GSK3_1	643	650	PF00069	0.625
MOD_GSK3_1	700	707	PF00069	0.683
MOD_GSK3_1	77	84	PF00069	0.702
MOD_GSK3_1	93	100	PF00069	0.529
MOD_N-GLC_1	567	572	PF02516	0.618
MOD_NEK2_1	140	145	PF00069	0.645
MOD_NEK2_1	203	208	PF00069	0.572
MOD_NEK2_1	266	271	PF00069	0.704
MOD_NEK2_1	617	622	PF00069	0.658
MOD_NEK2_1	642	647	PF00069	0.701
MOD_NEK2_1	92	97	PF00069	0.509
MOD_NEK2_2	27	32	PF00069	0.462
MOD_PIKK_1	169	175	PF00454	0.567
MOD_PIKK_1	66	72	PF00454	0.582
MOD_PIKK_1	79	85	PF00454	0.524
MOD_PK_1	116	122	PF00069	0.700
MOD_PKA_1	168	174	PF00069	0.527
MOD_PKA_2	112	118	PF00069	0.691
MOD_PKA_2	125	131	PF00069	0.540
MOD_PKA_2	168	174	PF00069	0.649
MOD_PKA_2	364	370	PF00069	0.556
MOD_PKA_2	377	383	PF00069	0.655
MOD_PKA_2	543	549	PF00069	0.629
MOD_PKB_1	545	553	PF00069	0.547
MOD_PKB_1	725	733	PF00069	0.524
MOD_Plk_1	558	564	PF00069	0.646
MOD_Plk_4	125	131	PF00069	0.585
MOD_Plk_4	150	156	PF00069	0.495
MOD_Plk_4	242	248	PF00069	0.525
MOD_Plk_4	261	267	PF00069	0.706
MOD_Plk_4	325	331	PF00069	0.539
MOD_Plk_4	470	476	PF00069	0.620
MOD_Plk_4	477	483	PF00069	0.522
MOD_Plk_4	502	508	PF00069	0.538
MOD_Plk_4	528	534	PF00069	0.607
MOD_Plk_4	635	641	PF00069	0.577
MOD_ProDKin_1	120	126	PF00069	0.657
MOD_ProDKin_1	21	27	PF00069	0.509
MOD_ProDKin_1	247	253	PF00069	0.626
MOD_ProDKin_1	254	260	PF00069	0.589
MOD_ProDKin_1	281	287	PF00069	0.583
MOD_ProDKin_1	412	418	PF00069	0.689
MOD_ProDKin_1	45	51	PF00069	0.543
MOD_ProDKin_1	468	474	PF00069	0.637
MOD_ProDKin_1	491	497	PF00069	0.630
MOD_ProDKin_1	618	624	PF00069	0.679
MOD_ProDKin_1	700	706	PF00069	0.590
MOD_ProDKin_1	707	713	PF00069	0.534
MOD_ProDKin_1	77	83	PF00069	0.511
MOD_SUMO_for_1	272	275	PF00179	0.573
TRG_DiLeu_BaEn_1	508	513	PF01217	0.599
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.591
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.522
TRG_ENDOCYTIC_2	530	533	PF00928	0.524
TRG_ENDOCYTIC_2	639	642	PF00928	0.663
TRG_ER_diArg_1	412	414	PF00400	0.809
TRG_ER_diArg_1	421	424	PF00400	0.650
TRG_ER_diArg_1	458	460	PF00400	0.646
TRG_ER_diArg_1	544	547	PF00400	0.682
TRG_ER_diArg_1	630	633	PF00400	0.630
TRG_ER_diArg_1	724	727	PF00400	0.614
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ8	Leptomonas seymouri	34%	100%
A0A3S7WP11	Leishmania donovani	79%	79%
A4H475	Leishmania braziliensis	69%	100%
A4HSF0	Leishmania infantum	79%	96%
Q4QJH2	Leishmania major	78%	100%