LeishMANIAdb
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Phosphate carrier protein, mitochondrial-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphate carrier protein, mitochondrial-like protein
Gene product:
phosphate carrier protein, mitochondrial precursor-like protein
Species:
Leishmania mexicana
UniProt:
E9AKD5_LEIMU
TriTrypDb:
LmxM.05.0290
Length:
485

Annotations

LeishMANIAdb annotations

Forms a well-defined channel with 6 helices. Some paralogs tend to have an additional hydrophobic segment that might be a transit or signal peptide. It is unclear if the N-peptide is a signal or transit peptide. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005743 mitochondrial inner membrane 5 8
GO:0016020 membrane 2 8
GO:0019866 organelle inner membrane 4 8
GO:0031090 organelle membrane 3 8
GO:0031966 mitochondrial membrane 4 8
GO:0110165 cellular anatomical entity 1 9
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9AKD5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKD5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 9
GO:0006811 monoatomic ion transport 4 9
GO:0006817 phosphate ion transport 7 9
GO:0006820 monoatomic anion transport 5 9
GO:0009987 cellular process 1 9
GO:0015698 inorganic anion transport 6 9
GO:0034220 monoatomic ion transmembrane transport 3 9
GO:0035435 phosphate ion transmembrane transport 6 9
GO:0051179 localization 1 9
GO:0051234 establishment of localization 2 9
GO:0055085 transmembrane transport 2 9
GO:0098656 monoatomic anion transmembrane transport 4 9
GO:0098660 inorganic ion transmembrane transport 4 9
GO:0098661 inorganic anion transmembrane transport 5 9
GO:1990542 mitochondrial transmembrane transport 3 9
GO:1990547 mitochondrial phosphate ion transmembrane transport 4 9
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 9
GO:0005315 inorganic phosphate transmembrane transporter activity 4 9
GO:0015291 secondary active transmembrane transporter activity 4 9
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 9
GO:0022804 active transmembrane transporter activity 3 9
GO:0022857 transmembrane transporter activity 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 167 171 PF00656 0.524
CLV_C14_Caspase3-7 20 24 PF00656 0.755
CLV_PCSK_SKI1_1 217 221 PF00082 0.273
CLV_PCSK_SKI1_1 298 302 PF00082 0.346
CLV_Separin_Metazoa 436 440 PF03568 0.425
DEG_APCC_DBOX_1 192 200 PF00400 0.578
DEG_APCC_DBOX_1 297 305 PF00400 0.578
DEG_SPOP_SBC_1 397 401 PF00917 0.522
DEG_SPOP_SBC_1 56 60 PF00917 0.682
DOC_AGCK_PIF_2 332 337 PF00069 0.472
DOC_CYCLIN_yCln2_LP_2 149 155 PF00134 0.236
DOC_CYCLIN_yCln2_LP_2 61 64 PF00134 0.747
DOC_MAPK_gen_1 166 175 PF00069 0.516
DOC_MAPK_MEF2A_6 217 225 PF00069 0.516
DOC_MAPK_MEF2A_6 448 456 PF00069 0.539
DOC_PP1_RVXF_1 437 444 PF00149 0.442
DOC_PP1_RVXF_1 83 89 PF00149 0.618
DOC_PP2B_LxvP_1 149 152 PF13499 0.181
DOC_PP2B_LxvP_1 2 5 PF13499 0.626
DOC_PP2B_LxvP_1 61 64 PF13499 0.747
DOC_USP7_MATH_1 180 184 PF00917 0.505
DOC_USP7_MATH_1 251 255 PF00917 0.668
DOC_USP7_MATH_1 398 402 PF00917 0.523
DOC_USP7_MATH_1 425 429 PF00917 0.426
DOC_USP7_MATH_1 9 13 PF00917 0.742
DOC_WW_Pin1_4 245 250 PF00397 0.633
DOC_WW_Pin1_4 287 292 PF00397 0.578
DOC_WW_Pin1_4 74 79 PF00397 0.731
LIG_14-3-3_CanoR_1 126 131 PF00244 0.371
LIG_14-3-3_CanoR_1 13 17 PF00244 0.753
LIG_14-3-3_CanoR_1 286 291 PF00244 0.507
LIG_14-3-3_CanoR_1 32 39 PF00244 0.739
LIG_14-3-3_CanoR_1 394 398 PF00244 0.578
LIG_AP2alpha_1 168 172 PF02296 0.508
LIG_BRCT_BRCA1_1 206 210 PF00533 0.539
LIG_BRCT_BRCA1_1 289 293 PF00533 0.517
LIG_BRCT_BRCA1_1 333 337 PF00533 0.472
LIG_Clathr_ClatBox_1 175 179 PF01394 0.522
LIG_deltaCOP1_diTrp_1 440 447 PF00928 0.527
LIG_eIF4E_1 185 191 PF01652 0.522
LIG_FHA_1 120 126 PF00498 0.422
LIG_FHA_1 240 246 PF00498 0.584
LIG_FHA_1 305 311 PF00498 0.565
LIG_FHA_1 56 62 PF00498 0.712
LIG_FHA_1 75 81 PF00498 0.724
LIG_FHA_1 99 105 PF00498 0.418
LIG_FHA_2 350 356 PF00498 0.478
LIG_FHA_2 407 413 PF00498 0.522
LIG_FHA_2 46 52 PF00498 0.705
LIG_FHA_2 477 483 PF00498 0.461
LIG_GBD_Chelix_1 141 149 PF00786 0.218
LIG_IRF3_LxIS_1 359 366 PF10401 0.218
LIG_LIR_Gen_1 129 138 PF02991 0.266
LIG_LIR_Gen_1 170 180 PF02991 0.522
LIG_LIR_Gen_1 211 221 PF02991 0.539
LIG_LIR_Gen_1 254 264 PF02991 0.539
LIG_LIR_Gen_1 333 342 PF02991 0.322
LIG_LIR_Gen_1 344 354 PF02991 0.340
LIG_LIR_LC3C_4 101 106 PF02991 0.278
LIG_LIR_Nem_3 129 135 PF02991 0.266
LIG_LIR_Nem_3 164 168 PF02991 0.477
LIG_LIR_Nem_3 170 175 PF02991 0.457
LIG_LIR_Nem_3 183 188 PF02991 0.395
LIG_LIR_Nem_3 207 213 PF02991 0.500
LIG_LIR_Nem_3 214 219 PF02991 0.495
LIG_LIR_Nem_3 254 260 PF02991 0.610
LIG_LIR_Nem_3 333 338 PF02991 0.320
LIG_LIR_Nem_3 344 349 PF02991 0.328
LIG_LIR_Nem_3 440 446 PF02991 0.390
LIG_LIR_Nem_3 467 471 PF02991 0.378
LIG_LIR_Nem_3 74 79 PF02991 0.576
LIG_NRBOX 144 150 PF00104 0.181
LIG_Pex14_2 133 137 PF04695 0.370
LIG_Pex14_2 168 172 PF04695 0.548
LIG_Pex14_2 191 195 PF04695 0.525
LIG_Pex14_2 260 264 PF04695 0.578
LIG_REV1ctd_RIR_1 189 196 PF16727 0.522
LIG_SH2_CRK 135 139 PF00017 0.418
LIG_SH2_CRK 185 189 PF00017 0.532
LIG_SH2_CRK 314 318 PF00017 0.496
LIG_SH2_PTP2 218 221 PF00017 0.522
LIG_SH2_STAT3 108 111 PF00017 0.383
LIG_SH2_STAT3 202 205 PF00017 0.505
LIG_SH2_STAT5 108 111 PF00017 0.409
LIG_SH2_STAT5 132 135 PF00017 0.312
LIG_SH2_STAT5 202 205 PF00017 0.522
LIG_SH2_STAT5 218 221 PF00017 0.351
LIG_SH2_STAT5 327 330 PF00017 0.320
LIG_SH3_3 288 294 PF00018 0.576
LIG_SH3_3 377 383 PF00018 0.337
LIG_SUMO_SIM_anti_2 101 107 PF11976 0.278
LIG_SUMO_SIM_par_1 101 107 PF11976 0.389
LIG_SUMO_SIM_par_1 220 226 PF11976 0.499
LIG_SUMO_SIM_par_1 453 459 PF11976 0.418
LIG_UBA3_1 221 230 PF00899 0.540
LIG_WRC_WIRS_1 165 170 PF05994 0.578
LIG_WRC_WIRS_1 332 337 PF05994 0.337
MOD_CDK_SPxxK_3 245 252 PF00069 0.515
MOD_CK1_1 12 18 PF00069 0.768
MOD_CK1_1 244 250 PF00069 0.646
MOD_CK1_1 396 402 PF00069 0.568
MOD_CK1_1 74 80 PF00069 0.704
MOD_CK2_1 208 214 PF00069 0.565
MOD_CK2_1 330 336 PF00069 0.418
MOD_CK2_1 349 355 PF00069 0.448
MOD_GlcNHglycan 113 116 PF01048 0.627
MOD_GlcNHglycan 253 256 PF01048 0.403
MOD_GlcNHglycan 298 301 PF01048 0.308
MOD_GlcNHglycan 395 398 PF01048 0.378
MOD_GlcNHglycan 400 403 PF01048 0.189
MOD_GlcNHglycan 427 430 PF01048 0.311
MOD_GlcNHglycan 479 482 PF01048 0.602
MOD_GlcNHglycan 53 56 PF01048 0.494
MOD_GlcNHglycan 65 68 PF01048 0.447
MOD_GSK3_1 204 211 PF00069 0.578
MOD_GSK3_1 241 248 PF00069 0.648
MOD_GSK3_1 341 348 PF00069 0.417
MOD_GSK3_1 392 399 PF00069 0.526
MOD_GSK3_1 406 413 PF00069 0.516
MOD_GSK3_1 51 58 PF00069 0.720
MOD_N-GLC_1 17 22 PF02516 0.605
MOD_NEK2_1 104 109 PF00069 0.376
MOD_NEK2_1 262 267 PF00069 0.477
MOD_NEK2_1 330 335 PF00069 0.401
MOD_NEK2_1 345 350 PF00069 0.306
MOD_NEK2_1 363 368 PF00069 0.323
MOD_NEK2_1 406 411 PF00069 0.530
MOD_NEK2_1 456 461 PF00069 0.376
MOD_NEK2_2 180 185 PF00069 0.522
MOD_NEK2_2 341 346 PF00069 0.549
MOD_PIKK_1 410 416 PF00454 0.566
MOD_PKA_2 12 18 PF00069 0.787
MOD_PKA_2 251 257 PF00069 0.532
MOD_PKA_2 31 37 PF00069 0.593
MOD_PKA_2 393 399 PF00069 0.578
MOD_Plk_2-3 164 170 PF00069 0.578
MOD_Plk_4 104 110 PF00069 0.401
MOD_Plk_4 180 186 PF00069 0.511
MOD_Plk_4 325 331 PF00069 0.331
MOD_Plk_4 341 347 PF00069 0.337
MOD_Plk_4 383 389 PF00069 0.374
MOD_Plk_4 57 63 PF00069 0.741
MOD_ProDKin_1 245 251 PF00069 0.629
MOD_ProDKin_1 287 293 PF00069 0.578
MOD_ProDKin_1 74 80 PF00069 0.722
TRG_DiLeu_BaEn_4 355 361 PF01217 0.257
TRG_DiLeu_BaLyEn_6 450 455 PF01217 0.418
TRG_ENDOCYTIC_2 135 138 PF00928 0.346
TRG_ENDOCYTIC_2 165 168 PF00928 0.505
TRG_ENDOCYTIC_2 185 188 PF00928 0.342
TRG_ENDOCYTIC_2 213 216 PF00928 0.463
TRG_ENDOCYTIC_2 218 221 PF00928 0.463
TRG_ENDOCYTIC_2 257 260 PF00928 0.619
TRG_ENDOCYTIC_2 314 317 PF00928 0.493
TRG_ENDOCYTIC_2 327 330 PF00928 0.283
TRG_ENDOCYTIC_2 468 471 PF00928 0.281
TRG_NES_CRM1_1 214 226 PF08389 0.370

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3H8 Leptomonas seymouri 54% 100%
A0A0S4JBC4 Bodo saltans 42% 100%
A0A0S4JNX4 Bodo saltans 34% 100%
A0A1D6N272 Zea mays 23% 100%
A0A3S7WP13 Leishmania donovani 91% 100%
A2CEQ0 Danio rerio 21% 100%
A4H474 Leishmania braziliensis 70% 100%
A4HSE9 Leishmania infantum 91% 100%
A4RPU0 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 22% 100%
B4F8I5 Zea mays 24% 100%
B4FIJ0 Zea mays 22% 100%
D0A4I3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AFR9 Leishmania major 33% 93%
O04619 Arabidopsis thaliana 24% 100%
O61703 Choristoneura fumiferana 34% 100%
O94502 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
O95258 Homo sapiens 21% 100%
P12234 Bos taurus 35% 100%
P16036 Rattus norvegicus 34% 100%
P16260 Homo sapiens 23% 100%
P40614 Caenorhabditis elegans 38% 100%
Q00325 Homo sapiens 35% 100%
Q03829 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 20% 100%
Q19529 Caenorhabditis elegans 22% 91%
Q2H608 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 23% 100%
Q4QDA4 Leishmania major 23% 100%
Q4QJH3 Leishmania major 88% 100%
Q54S10 Dictyostelium discoideum 21% 100%
Q5R7W2 Pongo abelii 35% 100%
Q628Z2 Caenorhabditis briggsae 22% 91%
Q6DFK2 Xenopus laevis 21% 100%
Q7T292 Danio rerio 24% 100%
Q8C0K5 Mus musculus 23% 100%
Q8RXZ9 Arabidopsis thaliana 22% 100%
Q8VEM8 Mus musculus 34% 100%
Q96A46 Homo sapiens 23% 100%
Q96U08 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 23% 100%
Q9FI43 Arabidopsis thaliana 25% 100%
Q9FI73 Arabidopsis thaliana 23% 100%
Q9FLS8 Arabidopsis thaliana 23% 100%
Q9FMU6 Arabidopsis thaliana 34% 100%
Q9LY28 Arabidopsis thaliana 24% 100%
Q9M2Z8 Arabidopsis thaliana 33% 100%
Q9NYZ2 Homo sapiens 22% 100%
Q9Z2B2 Mus musculus 21% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS