Putative ARP2/3 complex 16kDa subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ARP2/3 complex 16kDa subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AKD4_LEIMU

TriTrypDb:

LmxM.05.0285

Length:

170

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005885	Arp2/3 protein complex	2	6
GO:0032991	protein-containing complex	1	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AKD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKD4

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	6
GO:0008064	regulation of actin polymerization or depolymerization	6	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0030832	regulation of actin filament length	5	6
GO:0030833	regulation of actin filament polymerization	7	6
GO:0032271	regulation of protein polymerization	6	6
GO:0032535	regulation of cellular component size	4	6
GO:0032956	regulation of actin cytoskeleton organization	5	6
GO:0032970	regulation of actin filament-based process	4	6
GO:0033043	regulation of organelle organization	5	6
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	6
GO:0043254	regulation of protein-containing complex assembly	5	6
GO:0044087	regulation of cellular component biogenesis	4	6
GO:0045010	actin nucleation	6	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051128	regulation of cellular component organization	4	6
GO:0051493	regulation of cytoskeleton organization	6	6
GO:0065007	biological regulation	1	6
GO:0065008	regulation of biological quality	2	6
GO:0071840	cellular component organization or biogenesis	2	6
GO:0090066	regulation of anatomical structure size	3	6
GO:0097435	supramolecular fiber organization	4	6
GO:0110053	regulation of actin filament organization	6	6
GO:1902903	regulation of supramolecular fiber organization	5	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.542
CLV_C14_Caspase3-7	42	46	PF00656	0.487
CLV_NRD_NRD_1	145	147	PF00675	0.280
CLV_NRD_NRD_1	27	29	PF00675	0.352
CLV_NRD_NRD_1	35	37	PF00675	0.456
CLV_PCSK_KEX2_1	145	147	PF00082	0.280
CLV_PCSK_KEX2_1	27	29	PF00082	0.352
CLV_PCSK_KEX2_1	35	37	PF00082	0.456
CLV_PCSK_SKI1_1	35	39	PF00082	0.494
DEG_APCC_DBOX_1	34	42	PF00400	0.486
DEG_SCF_FBW7_2	120	126	PF00400	0.467
DOC_CKS1_1	120	125	PF01111	0.467
DOC_USP7_MATH_1	166	170	PF00917	0.549
DOC_USP7_MATH_1	4	8	PF00917	0.533
DOC_WW_Pin1_4	119	124	PF00397	0.492
DOC_WW_Pin1_4	137	142	PF00397	0.542
LIG_14-3-3_CanoR_1	90	94	PF00244	0.418
LIG_14-3-3_CterR_2	165	170	PF00244	0.478
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BIR_III_3	1	5	PF00653	0.687
LIG_BIR_III_4	156	160	PF00653	0.542
LIG_FHA_1	120	126	PF00498	0.405
LIG_FHA_1	21	27	PF00498	0.441
LIG_FHA_1	81	87	PF00498	0.376
LIG_FHA_1	9	15	PF00498	0.454
LIG_SH2_STAP1	110	114	PF00017	0.478
LIG_SH2_STAP1	148	152	PF00017	0.504
LIG_SH3_3	117	123	PF00018	0.575
LIG_SH3_3	135	141	PF00018	0.584
LIG_SH3_3	51	57	PF00018	0.451
MOD_CK1_1	115	121	PF00069	0.551
MOD_CK1_1	82	88	PF00069	0.557
MOD_GlcNHglycan	117	120	PF01048	0.370
MOD_GlcNHglycan	2	5	PF01048	0.603
MOD_GlcNHglycan	50	53	PF01048	0.549
MOD_GlcNHglycan	6	9	PF01048	0.492
MOD_GlcNHglycan	76	79	PF01048	0.562
MOD_GSK3_1	115	122	PF00069	0.585
MOD_GSK3_1	4	11	PF00069	0.413
MOD_NEK2_1	21	26	PF00069	0.561
MOD_NEK2_1	48	53	PF00069	0.519
MOD_NEK2_1	89	94	PF00069	0.485
MOD_NEK2_1	97	102	PF00069	0.477
MOD_PIKK_1	97	103	PF00454	0.542
MOD_PKA_2	89	95	PF00069	0.492
MOD_Plk_1	21	27	PF00069	0.505
MOD_Plk_1	95	101	PF00069	0.467
MOD_ProDKin_1	119	125	PF00069	0.492
MOD_ProDKin_1	137	143	PF00069	0.542
TRG_ENDOCYTIC_2	110	113	PF00928	0.491
TRG_ER_diArg_1	144	146	PF00400	0.480
TRG_ER_diArg_1	26	28	PF00400	0.357
TRG_ER_diArg_1	35	37	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.341
TRG_PTS2	1	48	PF00400	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W8	Leptomonas seymouri	34%	100%
A0A3S5H5H1	Leishmania donovani	84%	98%
A4HSE8	Leishmania infantum	84%	98%
Q4QJH4	Leishmania major	83%	100%