Tudor domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKD2_LEIMU

TriTrypDb:

LmxM.05.0270

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	264	266	PF00675	0.578
CLV_NRD_NRD_1	314	316	PF00675	0.690
CLV_PCSK_FUR_1	270	274	PF00082	0.596
CLV_PCSK_KEX2_1	264	266	PF00082	0.595
CLV_PCSK_KEX2_1	272	274	PF00082	0.635
CLV_PCSK_KEX2_1	312	314	PF00082	0.641
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.642
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.658
CLV_PCSK_SKI1_1	286	290	PF00082	0.635
CLV_PCSK_SKI1_1	83	87	PF00082	0.396
DEG_Kelch_Keap1_1	87	92	PF01344	0.646
DEG_SCF_FBW7_1	212	219	PF00400	0.398
DEG_SPOP_SBC_1	216	220	PF00917	0.650
DEG_SPOP_SBC_1	229	233	PF00917	0.666
DOC_ANK_TNKS_1	22	29	PF00023	0.560
DOC_CKS1_1	213	218	PF01111	0.603
DOC_CKS1_1	75	80	PF01111	0.578
DOC_USP7_MATH_1	171	175	PF00917	0.580
DOC_USP7_MATH_1	216	220	PF00917	0.699
DOC_USP7_MATH_1	224	228	PF00917	0.700
DOC_USP7_UBL2_3	82	86	PF12436	0.606
DOC_WW_Pin1_4	108	113	PF00397	0.706
DOC_WW_Pin1_4	212	217	PF00397	0.618
DOC_WW_Pin1_4	222	227	PF00397	0.748
DOC_WW_Pin1_4	74	79	PF00397	0.506
DOC_WW_Pin1_4	84	89	PF00397	0.535
LIG_14-3-3_CanoR_1	18	23	PF00244	0.564
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BIR_III_4	37	41	PF00653	0.740
LIG_DLG_GKlike_1	18	25	PF00625	0.546
LIG_EH1_1	154	162	PF00400	0.454
LIG_FHA_1	132	138	PF00498	0.404
LIG_FHA_1	173	179	PF00498	0.636
LIG_FHA_1	205	211	PF00498	0.438
LIG_FHA_1	230	236	PF00498	0.515
LIG_FHA_1	71	77	PF00498	0.480
LIG_FHA_1	88	94	PF00498	0.549
LIG_FHA_2	2	8	PF00498	0.637
LIG_FHA_2	201	207	PF00498	0.573
LIG_FHA_2	255	261	PF00498	0.572
LIG_GBD_Chelix_1	25	33	PF00786	0.581
LIG_LIR_Apic_2	96	102	PF02991	0.534
LIG_LIR_Gen_1	292	302	PF02991	0.527
LIG_LIR_Nem_3	127	132	PF02991	0.416
LIG_LIR_Nem_3	21	25	PF02991	0.449
LIG_LIR_Nem_3	292	297	PF02991	0.508
LIG_LYPXL_yS_3	129	132	PF13949	0.484
LIG_MYND_1	112	116	PF01753	0.541
LIG_NRBOX	63	69	PF00104	0.525
LIG_PCNA_yPIPBox_3	289	302	PF02747	0.635
LIG_RPA_C_Plants	275	286	PF08784	0.648
LIG_SH2_CRK	248	252	PF00017	0.550
LIG_SH2_SRC	194	197	PF00017	0.545
LIG_SH2_STAP1	119	123	PF00017	0.462
LIG_SH2_STAP1	162	166	PF00017	0.492
LIG_SH2_STAT5	194	197	PF00017	0.545
LIG_SH3_1	99	105	PF00018	0.542
LIG_SH3_3	165	171	PF00018	0.446
LIG_SH3_3	183	189	PF00018	0.533
LIG_SH3_3	207	213	PF00018	0.542
LIG_SH3_3	232	238	PF00018	0.548
LIG_SH3_3	82	88	PF00018	0.620
LIG_SH3_3	99	105	PF00018	0.601
LIG_TRAF2_1	14	17	PF00917	0.510
LIG_TRAF2_1	203	206	PF00917	0.627
LIG_TRAF2_1	257	260	PF00917	0.579
LIG_TRAF2_1	5	8	PF00917	0.717
MOD_CDK_SPxxK_3	108	115	PF00069	0.600
MOD_CK1_1	106	112	PF00069	0.664
MOD_CK1_1	217	223	PF00069	0.762
MOD_CK1_1	225	231	PF00069	0.641
MOD_CK1_1	87	93	PF00069	0.557
MOD_CK2_1	1	7	PF00069	0.727
MOD_CK2_1	11	17	PF00069	0.531
MOD_CK2_1	18	24	PF00069	0.479
MOD_CK2_1	200	206	PF00069	0.593
MOD_CK2_1	254	260	PF00069	0.569
MOD_GlcNHglycan	222	225	PF01048	0.758
MOD_GSK3_1	103	110	PF00069	0.712
MOD_GSK3_1	169	176	PF00069	0.622
MOD_GSK3_1	200	207	PF00069	0.456
MOD_GSK3_1	212	219	PF00069	0.537
MOD_GSK3_1	220	227	PF00069	0.441
MOD_GSK3_1	229	236	PF00069	0.417
MOD_GSK3_1	70	77	PF00069	0.504
MOD_NEK2_1	1	6	PF00069	0.735
MOD_NEK2_1	204	209	PF00069	0.468
MOD_NEK2_2	180	185	PF00069	0.550
MOD_PIKK_1	246	252	PF00454	0.635
MOD_PKB_1	252	260	PF00069	0.667
MOD_Plk_1	204	210	PF00069	0.468
MOD_Plk_1	70	76	PF00069	0.589
MOD_Plk_2-3	200	206	PF00069	0.498
MOD_Plk_4	204	210	PF00069	0.460
MOD_Plk_4	293	299	PF00069	0.488
MOD_Plk_4	93	99	PF00069	0.508
MOD_ProDKin_1	108	114	PF00069	0.692
MOD_ProDKin_1	212	218	PF00069	0.631
MOD_ProDKin_1	222	228	PF00069	0.746
MOD_ProDKin_1	74	80	PF00069	0.507
MOD_ProDKin_1	84	90	PF00069	0.533
MOD_SUMO_for_1	255	258	PF00179	0.692
MOD_SUMO_for_1	271	274	PF00179	0.382
TRG_DiLeu_BaEn_1	205	210	PF01217	0.577
TRG_DiLeu_BaEn_1	8	13	PF01217	0.583
TRG_ENDOCYTIC_2	119	122	PF00928	0.411
TRG_ENDOCYTIC_2	129	132	PF00928	0.320
TRG_ENDOCYTIC_2	22	25	PF00928	0.449
TRG_ENDOCYTIC_2	248	251	PF00928	0.477
TRG_ER_diArg_1	251	254	PF00400	0.516
TRG_ER_diArg_1	313	315	PF00400	0.684
TRG_NES_CRM1_1	48	60	PF08389	0.576
TRG_NLS_MonoCore_2	311	316	PF00514	0.685
TRG_NLS_MonoExtN_4	309	316	PF00514	0.672
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H6	Leptomonas seymouri	68%	100%
A0A0S4J6H5	Bodo saltans	32%	100%
A0A1X0P0L2	Trypanosomatidae	42%	100%
A0A3R7LUJ2	Trypanosoma rangeli	43%	100%
A0A3S5H5G9	Leishmania donovani	91%	99%
A4H471	Leishmania braziliensis	85%	100%
A4HSE6	Leishmania infantum	91%	79%
D0A4J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4QJH6	Leishmania major	90%	100%
V5BBA9	Trypanosoma cruzi	42%	99%