ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKD1_LEIMU

TriTrypDb:

LmxM.05.0260

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.742
CLV_C14_Caspase3-7	45	49	PF00656	0.385
CLV_C14_Caspase3-7	60	64	PF00656	0.620
CLV_NRD_NRD_1	309	311	PF00675	0.506
CLV_NRD_NRD_1	326	328	PF00675	0.535
CLV_NRD_NRD_1	350	352	PF00675	0.620
CLV_PCSK_KEX2_1	153	155	PF00082	0.542
CLV_PCSK_KEX2_1	221	223	PF00082	0.513
CLV_PCSK_KEX2_1	309	311	PF00082	0.570
CLV_PCSK_KEX2_1	322	324	PF00082	0.437
CLV_PCSK_KEX2_1	326	328	PF00082	0.430
CLV_PCSK_KEX2_1	350	352	PF00082	0.620
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.610
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.572
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.545
CLV_PCSK_SKI1_1	153	157	PF00082	0.451
CLV_PCSK_SKI1_1	47	51	PF00082	0.550
DEG_APCC_DBOX_1	170	178	PF00400	0.436
DEG_Nend_UBRbox_3	1	3	PF02207	0.584
DOC_MAPK_MEF2A_6	176	185	PF00069	0.732
DOC_SPAK_OSR1_1	243	247	PF12202	0.512
DOC_USP7_MATH_1	101	105	PF00917	0.582
DOC_USP7_MATH_1	204	208	PF00917	0.688
DOC_USP7_MATH_1	360	364	PF00917	0.687
DOC_WW_Pin1_4	175	180	PF00397	0.652
DOC_WW_Pin1_4	225	230	PF00397	0.491
DOC_WW_Pin1_4	279	284	PF00397	0.525
DOC_WW_Pin1_4	33	38	PF00397	0.632
LIG_14-3-3_CanoR_1	162	166	PF00244	0.510
LIG_Actin_WH2_2	75	91	PF00022	0.510
LIG_CtBP_PxDLS_1	182	186	PF00389	0.592
LIG_FHA_1	15	21	PF00498	0.516
LIG_FHA_1	164	170	PF00498	0.564
LIG_FHA_1	178	184	PF00498	0.622
LIG_FHA_1	251	257	PF00498	0.475
LIG_FHA_1	293	299	PF00498	0.626
LIG_FHA_2	120	126	PF00498	0.592
LIG_FHA_2	43	49	PF00498	0.381
LIG_LIR_Apic_2	31	37	PF02991	0.596
LIG_LIR_Gen_1	314	324	PF02991	0.613
LIG_LIR_Nem_3	186	191	PF02991	0.546
LIG_LIR_Nem_3	314	320	PF02991	0.612
LIG_Pex14_1	34	38	PF04695	0.581
LIG_SH2_CRK	152	156	PF00017	0.499
LIG_SH2_CRK	188	192	PF00017	0.523
LIG_SH2_STAT5	121	124	PF00017	0.598
LIG_SH2_STAT5	331	334	PF00017	0.665
LIG_SH3_1	176	182	PF00018	0.462
LIG_SH3_3	176	182	PF00018	0.462
LIG_SUMO_SIM_anti_2	295	300	PF11976	0.520
LIG_SUMO_SIM_par_1	294	300	PF11976	0.507
LIG_TRAF2_1	304	307	PF00917	0.548
LIG_TRAF2_1	311	314	PF00917	0.523
LIG_TRAF2_1	381	384	PF00917	0.752
LIG_TYR_ITIM	150	155	PF00017	0.512
MOD_CDK_SPxK_1	279	285	PF00069	0.632
MOD_CK1_1	207	213	PF00069	0.693
MOD_CK1_1	220	226	PF00069	0.453
MOD_CK1_1	292	298	PF00069	0.466
MOD_CK1_1	363	369	PF00069	0.725
MOD_CK2_1	101	107	PF00069	0.677
MOD_CK2_1	110	116	PF00069	0.641
MOD_CK2_1	161	167	PF00069	0.610
MOD_CK2_1	190	196	PF00069	0.635
MOD_CK2_1	371	377	PF00069	0.747
MOD_GlcNHglycan	103	106	PF01048	0.578
MOD_GlcNHglycan	112	115	PF01048	0.616
MOD_GlcNHglycan	30	33	PF01048	0.685
MOD_GlcNHglycan	365	368	PF01048	0.784
MOD_GlcNHglycan	373	376	PF01048	0.676
MOD_GlcNHglycan	42	45	PF01048	0.438
MOD_N-GLC_1	289	294	PF02516	0.536
MOD_N-GLC_1	40	45	PF02516	0.377
MOD_PIKK_1	119	125	PF00454	0.603
MOD_PKA_2	161	167	PF00069	0.535
MOD_Plk_1	183	189	PF00069	0.671
MOD_Plk_1	207	213	PF00069	0.718
MOD_Plk_1	360	366	PF00069	0.471
MOD_Plk_4	183	189	PF00069	0.671
MOD_ProDKin_1	175	181	PF00069	0.647
MOD_ProDKin_1	225	231	PF00069	0.411
MOD_ProDKin_1	279	285	PF00069	0.531
MOD_ProDKin_1	33	39	PF00069	0.636
MOD_SUMO_rev_2	271	278	PF00179	0.406
MOD_SUMO_rev_2	380	388	PF00179	0.522
TRG_DiLeu_BaEn_2	312	318	PF01217	0.618
TRG_DiLeu_BaEn_3	313	319	PF01217	0.555
TRG_DiLeu_BaEn_4	77	83	PF01217	0.576
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.603
TRG_ENDOCYTIC_2	152	155	PF00928	0.459
TRG_ENDOCYTIC_2	188	191	PF00928	0.519
TRG_ER_diArg_1	222	225	PF00400	0.560
TRG_NLS_MonoExtN_4	219	225	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	154	159	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU8	Leptomonas seymouri	44%	94%
A0A3S7WP15	Leishmania donovani	85%	100%
A4H470	Leishmania braziliensis	79%	100%
A4HSE5	Leishmania infantum	85%	100%
Q4QJH7	Leishmania major	85%	100%