LeishMANIAdb
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Putative viscerotropic leishmaniasis antigen

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative viscerotropic leishmaniasis antigen
Gene product:
viscerotropic leishmaniasis antigen, putative
Species:
Leishmania mexicana
UniProt:
E9AKC9_LEIMU
TriTrypDb:
LmxM.05.0241
Length:
1411

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 7
GO:0005576 extracellular region 2 1

Expansion

Sequence features

E9AKC9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006810 transport 3 1
GO:0006869 lipid transport 5 1
GO:0008152 metabolic process 1 1
GO:0019538 protein metabolic process 3 1
GO:0042157 lipoprotein metabolic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0008289 lipid binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 1247 1249 PF00675 0.308
CLV_NRD_NRD_1 1336 1338 PF00675 0.464
CLV_NRD_NRD_1 1359 1361 PF00675 0.438
CLV_NRD_NRD_1 38 40 PF00675 0.385
CLV_PCSK_FUR_1 1305 1309 PF00082 0.451
CLV_PCSK_FUR_1 38 42 PF00082 0.354
CLV_PCSK_KEX2_1 1247 1249 PF00082 0.308
CLV_PCSK_KEX2_1 1307 1309 PF00082 0.488
CLV_PCSK_KEX2_1 1336 1338 PF00082 0.464
CLV_PCSK_KEX2_1 1359 1361 PF00082 0.438
CLV_PCSK_KEX2_1 38 40 PF00082 0.372
CLV_PCSK_PC1ET2_1 1307 1309 PF00082 0.488
CLV_PCSK_PC1ET2_1 40 42 PF00082 0.361
CLV_PCSK_SKI1_1 1207 1211 PF00082 0.368
CLV_PCSK_SKI1_1 1346 1350 PF00082 0.424
CLV_PCSK_SKI1_1 1360 1364 PF00082 0.361
CLV_PCSK_SKI1_1 150 154 PF00082 0.455
DEG_SPOP_SBC_1 1167 1171 PF00917 0.569
DEG_SPOP_SBC_1 76 80 PF00917 0.639
DOC_CKS1_1 1401 1406 PF01111 0.653
DOC_CKS1_1 232 237 PF01111 0.682
DOC_MAPK_gen_1 1305 1314 PF00069 0.660
DOC_MAPK_gen_1 8 18 PF00069 0.327
DOC_MAPK_MEF2A_6 11 20 PF00069 0.315
DOC_MAPK_MEF2A_6 1227 1235 PF00069 0.553
DOC_MAPK_RevD_3 25 39 PF00069 0.307
DOC_PP2B_LxvP_1 1188 1191 PF13499 0.543
DOC_PP4_FxxP_1 112 115 PF00568 0.639
DOC_PP4_MxPP_1 1190 1193 PF00568 0.538
DOC_USP7_MATH_1 1167 1171 PF00917 0.569
DOC_USP7_MATH_1 1317 1321 PF00917 0.648
DOC_USP7_MATH_1 1369 1373 PF00917 0.673
DOC_USP7_MATH_1 235 239 PF00917 0.689
DOC_USP7_MATH_1 53 57 PF00917 0.639
DOC_USP7_MATH_1 76 80 PF00917 0.643
DOC_USP7_MATH_1 87 91 PF00917 0.637
DOC_USP7_MATH_1 92 96 PF00917 0.609
DOC_WW_Pin1_4 119 124 PF00397 0.660
DOC_WW_Pin1_4 126 131 PF00397 0.625
DOC_WW_Pin1_4 1313 1318 PF00397 0.639
DOC_WW_Pin1_4 1321 1326 PF00397 0.618
DOC_WW_Pin1_4 1400 1405 PF00397 0.700
DOC_WW_Pin1_4 150 155 PF00397 0.657
DOC_WW_Pin1_4 173 178 PF00397 0.733
DOC_WW_Pin1_4 208 213 PF00397 0.667
DOC_WW_Pin1_4 231 236 PF00397 0.676
DOC_WW_Pin1_4 56 61 PF00397 0.619
DOC_WW_Pin1_4 72 77 PF00397 0.636
LIG_14-3-3_CanoR_1 11 15 PF00244 0.284
LIG_14-3-3_CanoR_1 1179 1188 PF00244 0.560
LIG_14-3-3_CanoR_1 126 130 PF00244 0.689
LIG_14-3-3_CanoR_1 1283 1292 PF00244 0.535
LIG_14-3-3_CanoR_1 1342 1350 PF00244 0.572
LIG_14-3-3_CanoR_1 1360 1369 PF00244 0.596
LIG_14-3-3_CanoR_1 1370 1376 PF00244 0.644
LIG_14-3-3_CanoR_1 159 166 PF00244 0.696
LIG_EVH1_2 1192 1196 PF00568 0.540
LIG_FHA_1 11 17 PF00498 0.292
LIG_FHA_1 178 184 PF00498 0.722
LIG_FHA_1 217 223 PF00498 0.644
LIG_FHA_1 234 240 PF00498 0.621
LIG_FHA_2 1401 1407 PF00498 0.657
LIG_LIR_Apic_2 111 115 PF02991 0.638
LIG_LIR_Apic_2 1399 1404 PF02991 0.639
LIG_LIR_Nem_3 63 69 PF02991 0.636
LIG_RPA_C_Fungi 34 46 PF08784 0.425
LIG_SH2_CRK 1401 1405 PF00017 0.629
LIG_SH2_NCK_1 1401 1405 PF00017 0.629
LIG_SH2_SRC 1239 1242 PF00017 0.331
LIG_SH2_STAP1 1272 1276 PF00017 0.440
LIG_SH2_STAT5 1239 1242 PF00017 0.331
LIG_SH2_STAT5 1285 1288 PF00017 0.391
LIG_SH2_STAT5 1291 1294 PF00017 0.394
LIG_SH2_STAT5 1354 1357 PF00017 0.487
LIG_SH2_STAT5 1401 1404 PF00017 0.623
LIG_SH3_1 1189 1195 PF00018 0.396
LIG_SH3_3 107 113 PF00018 0.570
LIG_SH3_3 1189 1195 PF00018 0.396
LIG_SH3_3 1311 1317 PF00018 0.515
LIG_SH3_3 1322 1328 PF00018 0.493
LIG_SH3_3 149 155 PF00018 0.612
LIG_SUMO_SIM_par_1 1208 1213 PF11976 0.463
LIG_TRAF2_1 1007 1010 PF00917 0.432
LIG_TRAF2_1 1020 1023 PF00917 0.401
LIG_TRAF2_1 1040 1043 PF00917 0.428
LIG_TRAF2_1 1053 1056 PF00917 0.394
LIG_TRAF2_1 1073 1076 PF00917 0.483
LIG_TRAF2_1 1086 1089 PF00917 0.349
LIG_TRAF2_1 1106 1109 PF00917 0.347
LIG_TRAF2_1 1119 1122 PF00917 0.426
LIG_TRAF2_1 1139 1142 PF00917 0.490
LIG_TRAF2_1 1152 1155 PF00917 0.434
LIG_TRAF2_1 241 244 PF00917 0.580
LIG_TRAF2_1 261 264 PF00917 0.485
LIG_TRAF2_1 274 277 PF00917 0.439
LIG_TRAF2_1 294 297 PF00917 0.523
LIG_TRAF2_1 307 310 PF00917 0.425
LIG_TRAF2_1 327 330 PF00917 0.524
LIG_TRAF2_1 340 343 PF00917 0.437
LIG_TRAF2_1 360 363 PF00917 0.352
LIG_TRAF2_1 373 376 PF00917 0.416
LIG_TRAF2_1 393 396 PF00917 0.435
LIG_TRAF2_1 406 409 PF00917 0.399
LIG_TRAF2_1 426 429 PF00917 0.437
LIG_TRAF2_1 439 442 PF00917 0.401
LIG_TRAF2_1 459 462 PF00917 0.300
LIG_TRAF2_1 472 475 PF00917 0.371
LIG_TRAF2_1 492 495 PF00917 0.406
LIG_TRAF2_1 505 508 PF00917 0.405
LIG_TRAF2_1 525 528 PF00917 0.515
LIG_TRAF2_1 538 541 PF00917 0.441
LIG_TRAF2_1 558 561 PF00917 0.497
LIG_TRAF2_1 571 574 PF00917 0.425
LIG_TRAF2_1 591 594 PF00917 0.501
LIG_TRAF2_1 604 607 PF00917 0.430
LIG_TRAF2_1 624 627 PF00917 0.516
LIG_TRAF2_1 637 640 PF00917 0.441
LIG_TRAF2_1 657 660 PF00917 0.443
LIG_TRAF2_1 670 673 PF00917 0.394
LIG_TRAF2_1 690 693 PF00917 0.461
LIG_TRAF2_1 703 706 PF00917 0.420
LIG_TRAF2_1 723 726 PF00917 0.491
LIG_TRAF2_1 736 739 PF00917 0.418
LIG_TRAF2_1 756 759 PF00917 0.432
LIG_TRAF2_1 769 772 PF00917 0.404
LIG_TRAF2_1 789 792 PF00917 0.295
LIG_TRAF2_1 802 805 PF00917 0.414
LIG_TRAF2_1 822 825 PF00917 0.426
LIG_TRAF2_1 835 838 PF00917 0.396
LIG_TRAF2_1 855 858 PF00917 0.428
LIG_TRAF2_1 868 871 PF00917 0.398
LIG_TRAF2_1 888 891 PF00917 0.484
LIG_TRAF2_1 901 904 PF00917 0.423
LIG_TRAF2_1 921 924 PF00917 0.323
LIG_TRAF2_1 941 944 PF00917 0.404
LIG_TRAF2_1 954 957 PF00917 0.400
LIG_TRAF2_1 974 977 PF00917 0.484
LIG_TRAF2_1 987 990 PF00917 0.415
LIG_WW_3 1191 1195 PF00397 0.395
MOD_CDK_SPxxK_3 119 126 PF00069 0.567
MOD_CDK_SPxxK_3 60 67 PF00069 0.467
MOD_CK1_1 1183 1189 PF00069 0.498
MOD_CK1_1 122 128 PF00069 0.573
MOD_CK1_1 1316 1322 PF00069 0.518
MOD_CK1_1 1344 1350 PF00069 0.500
MOD_CK1_1 1353 1359 PF00069 0.409
MOD_CK1_1 176 182 PF00069 0.601
MOD_CK1_1 208 214 PF00069 0.563
MOD_CK1_1 56 62 PF00069 0.470
MOD_CK1_1 78 84 PF00069 0.574
MOD_CK1_1 90 96 PF00069 0.517
MOD_CK2_1 1197 1203 PF00069 0.467
MOD_CK2_1 1326 1332 PF00069 0.502
MOD_CK2_1 1361 1367 PF00069 0.574
MOD_CK2_1 1400 1406 PF00069 0.549
MOD_Cter_Amidation 1305 1308 PF01082 0.566
MOD_DYRK1A_RPxSP_1 150 154 PF00069 0.557
MOD_GlcNHglycan 1182 1185 PF01048 0.434
MOD_GlcNHglycan 1343 1346 PF01048 0.521
MOD_GlcNHglycan 1356 1359 PF01048 0.383
MOD_GlcNHglycan 54 58 PF01048 0.496
MOD_GlcNHglycan 94 97 PF01048 0.533
MOD_GSK3_1 122 129 PF00069 0.571
MOD_GSK3_1 1313 1320 PF00069 0.638
MOD_GSK3_1 1336 1343 PF00069 0.480
MOD_GSK3_1 1349 1356 PF00069 0.358
MOD_GSK3_1 173 180 PF00069 0.700
MOD_GSK3_1 183 190 PF00069 0.560
MOD_GSK3_1 196 203 PF00069 0.614
MOD_GSK3_1 231 238 PF00069 0.592
MOD_GSK3_1 56 63 PF00069 0.524
MOD_GSK3_1 71 78 PF00069 0.503
MOD_LATS_1 1297 1303 PF00433 0.505
MOD_LATS_1 231 237 PF00433 0.590
MOD_NEK2_1 1180 1185 PF00069 0.428
MOD_NEK2_1 1341 1346 PF00069 0.525
MOD_NEK2_1 1349 1354 PF00069 0.378
MOD_NEK2_1 200 205 PF00069 0.642
MOD_PIKK_1 1300 1306 PF00454 0.439
MOD_PIKK_1 226 232 PF00454 0.551
MOD_PKA_1 1336 1342 PF00069 0.560
MOD_PKA_2 10 16 PF00069 0.347
MOD_PKA_2 125 131 PF00069 0.557
MOD_PKA_2 1336 1342 PF00069 0.536
MOD_PKA_2 1369 1375 PF00069 0.589
MOD_PKA_2 158 164 PF00069 0.630
MOD_PKB_1 1368 1376 PF00069 0.632
MOD_Plk_1 117 123 PF00069 0.550
MOD_Plk_1 196 202 PF00069 0.621
MOD_Plk_4 1350 1356 PF00069 0.440
MOD_Plk_4 200 206 PF00069 0.585
MOD_ProDKin_1 119 125 PF00069 0.566
MOD_ProDKin_1 126 132 PF00069 0.513
MOD_ProDKin_1 1313 1319 PF00069 0.532
MOD_ProDKin_1 1321 1327 PF00069 0.507
MOD_ProDKin_1 1400 1406 PF00069 0.626
MOD_ProDKin_1 150 156 PF00069 0.562
MOD_ProDKin_1 173 179 PF00069 0.666
MOD_ProDKin_1 208 214 PF00069 0.568
MOD_ProDKin_1 231 237 PF00069 0.590
MOD_ProDKin_1 56 62 PF00069 0.505
MOD_ProDKin_1 72 78 PF00069 0.532
MOD_SUMO_for_1 1362 1365 PF00179 0.491
TRG_DiLeu_BaEn_1 1206 1211 PF01217 0.421
TRG_DiLeu_BaEn_4 1009 1015 PF01217 0.424
TRG_DiLeu_BaEn_4 1022 1028 PF01217 0.417
TRG_DiLeu_BaEn_4 1042 1048 PF01217 0.419
TRG_DiLeu_BaEn_4 1055 1061 PF01217 0.428
TRG_DiLeu_BaEn_4 1075 1081 PF01217 0.442
TRG_DiLeu_BaEn_4 1088 1094 PF01217 0.364
TRG_DiLeu_BaEn_4 1108 1114 PF01217 0.285
TRG_DiLeu_BaEn_4 1121 1127 PF01217 0.415
TRG_DiLeu_BaEn_4 1141 1147 PF01217 0.454
TRG_DiLeu_BaEn_4 1154 1160 PF01217 0.394
TRG_DiLeu_BaEn_4 243 249 PF01217 0.560
TRG_DiLeu_BaEn_4 263 269 PF01217 0.480
TRG_DiLeu_BaEn_4 276 282 PF01217 0.457
TRG_DiLeu_BaEn_4 296 302 PF01217 0.511
TRG_DiLeu_BaEn_4 309 315 PF01217 0.382
TRG_DiLeu_BaEn_4 329 335 PF01217 0.514
TRG_DiLeu_BaEn_4 342 348 PF01217 0.454
TRG_DiLeu_BaEn_4 362 368 PF01217 0.341
TRG_DiLeu_BaEn_4 375 381 PF01217 0.432
TRG_DiLeu_BaEn_4 395 401 PF01217 0.426
TRG_DiLeu_BaEn_4 408 414 PF01217 0.416
TRG_DiLeu_BaEn_4 428 434 PF01217 0.428
TRG_DiLeu_BaEn_4 441 447 PF01217 0.417
TRG_DiLeu_BaEn_4 461 467 PF01217 0.290
TRG_DiLeu_BaEn_4 474 480 PF01217 0.389
TRG_DiLeu_BaEn_4 494 500 PF01217 0.399
TRG_DiLeu_BaEn_4 507 513 PF01217 0.425
TRG_DiLeu_BaEn_4 527 533 PF01217 0.508
TRG_DiLeu_BaEn_4 540 546 PF01217 0.460
TRG_DiLeu_BaEn_4 560 566 PF01217 0.488
TRG_DiLeu_BaEn_4 573 579 PF01217 0.442
TRG_DiLeu_BaEn_4 593 599 PF01217 0.495
TRG_DiLeu_BaEn_4 606 612 PF01217 0.383
TRG_DiLeu_BaEn_4 626 632 PF01217 0.509
TRG_DiLeu_BaEn_4 639 645 PF01217 0.462
TRG_DiLeu_BaEn_4 659 665 PF01217 0.434
TRG_DiLeu_BaEn_4 672 678 PF01217 0.507
TRG_DiLeu_BaEn_4 692 698 PF01217 0.337
TRG_DiLeu_BaEn_4 705 711 PF01217 0.492
TRG_DiLeu_BaEn_4 725 731 PF01217 0.481
TRG_DiLeu_BaEn_4 738 744 PF01217 0.435
TRG_DiLeu_BaEn_4 758 764 PF01217 0.422
TRG_DiLeu_BaEn_4 771 777 PF01217 0.420
TRG_DiLeu_BaEn_4 791 797 PF01217 0.285
TRG_DiLeu_BaEn_4 804 810 PF01217 0.552
TRG_DiLeu_BaEn_4 824 830 PF01217 0.282
TRG_DiLeu_BaEn_4 837 843 PF01217 0.364
TRG_DiLeu_BaEn_4 857 863 PF01217 0.285
TRG_DiLeu_BaEn_4 870 876 PF01217 0.366
TRG_DiLeu_BaEn_4 890 896 PF01217 0.344
TRG_DiLeu_BaEn_4 903 909 PF01217 0.439
TRG_DiLeu_BaEn_4 923 929 PF01217 0.318
TRG_DiLeu_BaEn_4 943 949 PF01217 0.396
TRG_DiLeu_BaEn_4 956 962 PF01217 0.372
TRG_DiLeu_BaEn_4 976 982 PF01217 0.338
TRG_DiLeu_BaEn_4 989 995 PF01217 0.432
TRG_ENDOCYTIC_2 1291 1294 PF00928 0.406
TRG_ER_diArg_1 1176 1179 PF00400 0.431
TRG_ER_diArg_1 1247 1249 PF00400 0.351
TRG_ER_diArg_1 1335 1337 PF00400 0.572
TRG_ER_diArg_1 1359 1361 PF00400 0.453
TRG_ER_diArg_1 290 293 PF00400 0.462
TRG_ER_diArg_1 323 326 PF00400 0.461
TRG_ER_diArg_1 37 39 PF00400 0.398
TRG_ER_diArg_1 488 491 PF00400 0.396
TRG_ER_diArg_1 521 524 PF00400 0.397
TRG_ER_diArg_1 620 623 PF00400 0.453
TRG_ER_diArg_1 653 656 PF00400 0.390
TRG_ER_diArg_1 686 689 PF00400 0.397
TRG_ER_diArg_1 937 940 PF00400 0.396
TRG_NES_CRM1_1 1230 1241 PF08389 0.409
TRG_Pf-PMV_PEXEL_1 293 297 PF00026 0.444
TRG_Pf-PMV_PEXEL_1 326 330 PF00026 0.446
TRG_Pf-PMV_PEXEL_1 491 495 PF00026 0.382
TRG_Pf-PMV_PEXEL_1 524 528 PF00026 0.437
TRG_Pf-PMV_PEXEL_1 623 627 PF00026 0.438
TRG_Pf-PMV_PEXEL_1 656 660 PF00026 0.366
TRG_Pf-PMV_PEXEL_1 689 693 PF00026 0.383
TRG_Pf-PMV_PEXEL_1 940 944 PF00026 0.380

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X0C7 Leishmania donovani 54% 87%
A4H3R9 Leishmania braziliensis 31% 100%
E9AKC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9AYS6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
Q4QJH9 Leishmania major 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS