LeishMANIAdb
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Putative viscerotropic leishmaniasis antigen

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative viscerotropic leishmaniasis antigen
Gene product:
viscerotropic leishmaniasis antigen, putative
Species:
Leishmania mexicana
UniProt:
E9AKC8_LEIMU
TriTrypDb:
LmxM.05.0240
Length:
1127

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9AKC8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKC8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 1046 1048 PF00675 0.635
CLV_NRD_NRD_1 1069 1071 PF00675 0.622
CLV_NRD_NRD_1 957 959 PF00675 0.372
CLV_NRD_NRD_1 98 100 PF00675 0.494
CLV_PCSK_FUR_1 1015 1019 PF00082 0.592
CLV_PCSK_FUR_1 98 102 PF00082 0.413
CLV_PCSK_KEX2_1 1017 1019 PF00082 0.597
CLV_PCSK_KEX2_1 1046 1048 PF00082 0.635
CLV_PCSK_KEX2_1 1069 1071 PF00082 0.622
CLV_PCSK_KEX2_1 957 959 PF00082 0.372
CLV_PCSK_KEX2_1 98 100 PF00082 0.447
CLV_PCSK_PC1ET2_1 100 102 PF00082 0.412
CLV_PCSK_PC1ET2_1 1017 1019 PF00082 0.597
CLV_PCSK_SKI1_1 1056 1060 PF00082 0.614
CLV_PCSK_SKI1_1 1070 1074 PF00082 0.470
CLV_PCSK_SKI1_1 210 214 PF00082 0.528
CLV_PCSK_SKI1_1 917 921 PF00082 0.454
DEG_SPOP_SBC_1 136 140 PF00917 0.739
DEG_SPOP_SBC_1 877 881 PF00917 0.631
DOC_CKS1_1 1117 1122 PF01111 0.729
DOC_CKS1_1 292 297 PF01111 0.724
DOC_MAPK_gen_1 1015 1024 PF00069 0.823
DOC_MAPK_gen_1 68 78 PF00069 0.499
DOC_MAPK_MEF2A_6 71 80 PF00069 0.394
DOC_MAPK_MEF2A_6 937 945 PF00069 0.656
DOC_MAPK_RevD_3 85 99 PF00069 0.355
DOC_PP2B_LxvP_1 31 34 PF13499 0.392
DOC_PP2B_LxvP_1 898 901 PF13499 0.645
DOC_PP4_FxxP_1 172 175 PF00568 0.734
DOC_PP4_MxPP_1 900 903 PF00568 0.610
DOC_USP7_MATH_1 1027 1031 PF00917 0.822
DOC_USP7_MATH_1 1079 1083 PF00917 0.775
DOC_USP7_MATH_1 113 117 PF00917 0.760
DOC_USP7_MATH_1 136 140 PF00917 0.744
DOC_USP7_MATH_1 147 151 PF00917 0.674
DOC_USP7_MATH_1 152 156 PF00917 0.636
DOC_USP7_MATH_1 295 299 PF00917 0.715
DOC_USP7_MATH_1 877 881 PF00917 0.631
DOC_WW_Pin1_4 1023 1028 PF00397 0.781
DOC_WW_Pin1_4 1031 1036 PF00397 0.763
DOC_WW_Pin1_4 1116 1121 PF00397 0.833
DOC_WW_Pin1_4 116 121 PF00397 0.762
DOC_WW_Pin1_4 132 137 PF00397 0.622
DOC_WW_Pin1_4 179 184 PF00397 0.754
DOC_WW_Pin1_4 186 191 PF00397 0.685
DOC_WW_Pin1_4 210 215 PF00397 0.710
DOC_WW_Pin1_4 233 238 PF00397 0.743
DOC_WW_Pin1_4 268 273 PF00397 0.688
DOC_WW_Pin1_4 291 296 PF00397 0.722
LIG_14-3-3_CanoR_1 1052 1060 PF00244 0.748
LIG_14-3-3_CanoR_1 1070 1079 PF00244 0.701
LIG_14-3-3_CanoR_1 1080 1086 PF00244 0.730
LIG_14-3-3_CanoR_1 186 190 PF00244 0.728
LIG_14-3-3_CanoR_1 219 226 PF00244 0.806
LIG_14-3-3_CanoR_1 28 34 PF00244 0.361
LIG_14-3-3_CanoR_1 71 75 PF00244 0.389
LIG_14-3-3_CanoR_1 889 898 PF00244 0.639
LIG_14-3-3_CanoR_1 993 1002 PF00244 0.570
LIG_BIR_II_1 1 5 PF00653 0.441
LIG_EVH1_2 902 906 PF00568 0.589
LIG_FHA_1 238 244 PF00498 0.753
LIG_FHA_1 277 283 PF00498 0.730
LIG_FHA_1 294 300 PF00498 0.648
LIG_FHA_1 40 46 PF00498 0.383
LIG_FHA_1 71 77 PF00498 0.302
LIG_FHA_2 1117 1123 PF00498 0.729
LIG_LIR_Apic_2 1115 1120 PF02991 0.727
LIG_LIR_Apic_2 171 175 PF02991 0.733
LIG_LIR_Gen_1 44 55 PF02991 0.406
LIG_LIR_Nem_3 123 129 PF02991 0.747
LIG_LIR_Nem_3 44 50 PF02991 0.373
LIG_RPA_C_Fungi 94 106 PF08784 0.499
LIG_SH2_CRK 1117 1121 PF00017 0.814
LIG_SH2_NCK_1 1117 1121 PF00017 0.814
LIG_SH2_NCK_1 47 51 PF00017 0.515
LIG_SH2_SRC 949 952 PF00017 0.449
LIG_SH2_STAP1 982 986 PF00017 0.577
LIG_SH2_STAT5 1001 1004 PF00017 0.423
LIG_SH2_STAT5 1064 1067 PF00017 0.778
LIG_SH2_STAT5 1117 1120 PF00017 0.810
LIG_SH2_STAT5 40 43 PF00017 0.394
LIG_SH2_STAT5 949 952 PF00017 0.449
LIG_SH2_STAT5 995 998 PF00017 0.513
LIG_SH3_1 899 905 PF00018 0.497
LIG_SH3_3 1021 1027 PF00018 0.696
LIG_SH3_3 1032 1038 PF00018 0.699
LIG_SH3_3 16 22 PF00018 0.511
LIG_SH3_3 167 173 PF00018 0.728
LIG_SH3_3 209 215 PF00018 0.772
LIG_SH3_3 899 905 PF00018 0.497
LIG_SUMO_SIM_par_1 918 923 PF11976 0.576
LIG_TRAF2_1 301 304 PF00917 0.627
LIG_TRAF2_1 321 324 PF00917 0.661
LIG_TRAF2_1 334 337 PF00917 0.509
LIG_TRAF2_1 354 357 PF00917 0.350
LIG_TRAF2_1 367 370 PF00917 0.458
LIG_TRAF2_1 387 390 PF00917 0.461
LIG_TRAF2_1 400 403 PF00917 0.512
LIG_TRAF2_1 420 423 PF00917 0.491
LIG_TRAF2_1 433 436 PF00917 0.506
LIG_TRAF2_1 453 456 PF00917 0.453
LIG_TRAF2_1 466 469 PF00917 0.512
LIG_TRAF2_1 486 489 PF00917 0.409
LIG_TRAF2_1 499 502 PF00917 0.584
LIG_TRAF2_1 519 522 PF00917 0.422
LIG_TRAF2_1 532 535 PF00917 0.554
LIG_TRAF2_1 552 555 PF00917 0.395
LIG_TRAF2_1 565 568 PF00917 0.525
LIG_TRAF2_1 585 588 PF00917 0.552
LIG_TRAF2_1 598 601 PF00917 0.529
LIG_TRAF2_1 618 621 PF00917 0.390
LIG_TRAF2_1 631 634 PF00917 0.535
LIG_TRAF2_1 651 654 PF00917 0.415
LIG_TRAF2_1 664 667 PF00917 0.516
LIG_TRAF2_1 684 687 PF00917 0.473
LIG_TRAF2_1 697 700 PF00917 0.500
LIG_TRAF2_1 717 720 PF00917 0.484
LIG_TRAF2_1 730 733 PF00917 0.544
LIG_TRAF2_1 750 753 PF00917 0.386
LIG_TRAF2_1 763 766 PF00917 0.510
LIG_TRAF2_1 783 786 PF00917 0.551
LIG_TRAF2_1 796 799 PF00917 0.536
LIG_TRAF2_1 816 819 PF00917 0.382
LIG_TRAF2_1 829 832 PF00917 0.490
LIG_TRAF2_1 849 852 PF00917 0.501
LIG_TRAF2_1 862 865 PF00917 0.518
LIG_TYR_ITIM 45 50 PF00017 0.489
LIG_WW_3 901 905 PF00397 0.481
MOD_CDK_SPxxK_3 120 127 PF00069 0.608
MOD_CDK_SPxxK_3 179 186 PF00069 0.700
MOD_CK1_1 1026 1032 PF00069 0.777
MOD_CK1_1 1054 1060 PF00069 0.783
MOD_CK1_1 1063 1069 PF00069 0.638
MOD_CK1_1 116 122 PF00069 0.616
MOD_CK1_1 138 144 PF00069 0.741
MOD_CK1_1 150 156 PF00069 0.592
MOD_CK1_1 182 188 PF00069 0.742
MOD_CK1_1 236 242 PF00069 0.677
MOD_CK1_1 268 274 PF00069 0.660
MOD_CK1_1 32 38 PF00069 0.524
MOD_CK1_1 893 899 PF00069 0.661
MOD_CK2_1 1036 1042 PF00069 0.656
MOD_CK2_1 1071 1077 PF00069 0.804
MOD_CK2_1 1116 1122 PF00069 0.660
MOD_CK2_1 628 634 PF00069 0.487
MOD_CK2_1 727 733 PF00069 0.476
MOD_CK2_1 907 913 PF00069 0.579
MOD_Cter_Amidation 1015 1018 PF01082 0.789
MOD_DYRK1A_RPxSP_1 210 214 PF00069 0.660
MOD_GlcNHglycan 1053 1056 PF01048 0.794
MOD_GlcNHglycan 1066 1069 PF01048 0.581
MOD_GlcNHglycan 114 118 PF01048 0.629
MOD_GlcNHglycan 15 18 PF01048 0.533
MOD_GlcNHglycan 154 157 PF01048 0.648
MOD_GlcNHglycan 31 34 PF01048 0.508
MOD_GlcNHglycan 630 633 PF01048 0.484
MOD_GlcNHglycan 729 732 PF01048 0.468
MOD_GlcNHglycan 892 895 PF01048 0.539
MOD_GSK3_1 1023 1030 PF00069 0.757
MOD_GSK3_1 1046 1053 PF00069 0.695
MOD_GSK3_1 1059 1066 PF00069 0.573
MOD_GSK3_1 116 123 PF00069 0.733
MOD_GSK3_1 131 138 PF00069 0.525
MOD_GSK3_1 182 189 PF00069 0.692
MOD_GSK3_1 233 240 PF00069 0.729
MOD_GSK3_1 243 250 PF00069 0.734
MOD_GSK3_1 256 263 PF00069 0.753
MOD_GSK3_1 291 298 PF00069 0.737
MOD_LATS_1 1007 1013 PF00433 0.652
MOD_LATS_1 291 297 PF00433 0.652
MOD_N-GLC_1 10 15 PF02516 0.671
MOD_N-GLC_1 29 34 PF02516 0.495
MOD_N-GLC_1 50 55 PF02516 0.499
MOD_NEK2_1 1051 1056 PF00069 0.734
MOD_NEK2_1 1059 1064 PF00069 0.586
MOD_NEK2_1 260 265 PF00069 0.786
MOD_NEK2_1 29 34 PF00069 0.527
MOD_NEK2_1 890 895 PF00069 0.514
MOD_PIKK_1 1010 1016 PF00454 0.592
MOD_PIKK_1 286 292 PF00454 0.644
MOD_PK_1 15 21 PF00069 0.511
MOD_PKA_1 1046 1052 PF00069 0.807
MOD_PKA_2 1046 1052 PF00069 0.772
MOD_PKA_2 1079 1085 PF00069 0.732
MOD_PKA_2 185 191 PF00069 0.698
MOD_PKA_2 218 224 PF00069 0.766
MOD_PKA_2 70 76 PF00069 0.465
MOD_PKB_1 1078 1086 PF00069 0.779
MOD_Plk_1 177 183 PF00069 0.680
MOD_Plk_1 256 262 PF00069 0.735
MOD_Plk_1 50 56 PF00069 0.380
MOD_Plk_4 1060 1066 PF00069 0.691
MOD_Plk_4 15 21 PF00069 0.395
MOD_Plk_4 260 266 PF00069 0.715
MOD_ProDKin_1 1023 1029 PF00069 0.734
MOD_ProDKin_1 1031 1037 PF00069 0.710
MOD_ProDKin_1 1116 1122 PF00069 0.807
MOD_ProDKin_1 116 122 PF00069 0.706
MOD_ProDKin_1 132 138 PF00069 0.510
MOD_ProDKin_1 179 185 PF00069 0.698
MOD_ProDKin_1 186 192 PF00069 0.599
MOD_ProDKin_1 210 216 PF00069 0.637
MOD_ProDKin_1 233 239 PF00069 0.680
MOD_ProDKin_1 268 274 PF00069 0.595
MOD_ProDKin_1 291 297 PF00069 0.652
MOD_SUMO_for_1 1072 1075 PF00179 0.646
TRG_DiLeu_BaEn_1 916 921 PF01217 0.607
TRG_DiLeu_BaEn_4 303 309 PF01217 0.634
TRG_DiLeu_BaEn_4 323 329 PF01217 0.639
TRG_DiLeu_BaEn_4 336 342 PF01217 0.472
TRG_DiLeu_BaEn_4 356 362 PF01217 0.350
TRG_DiLeu_BaEn_4 369 375 PF01217 0.466
TRG_DiLeu_BaEn_4 389 395 PF01217 0.461
TRG_DiLeu_BaEn_4 402 408 PF01217 0.521
TRG_DiLeu_BaEn_4 422 428 PF01217 0.482
TRG_DiLeu_BaEn_4 435 441 PF01217 0.515
TRG_DiLeu_BaEn_4 455 461 PF01217 0.450
TRG_DiLeu_BaEn_4 468 474 PF01217 0.525
TRG_DiLeu_BaEn_4 488 494 PF01217 0.411
TRG_DiLeu_BaEn_4 501 507 PF01217 0.552
TRG_DiLeu_BaEn_4 521 527 PF01217 0.430
TRG_DiLeu_BaEn_4 534 540 PF01217 0.557
TRG_DiLeu_BaEn_4 554 560 PF01217 0.387
TRG_DiLeu_BaEn_4 567 573 PF01217 0.545
TRG_DiLeu_BaEn_4 587 593 PF01217 0.453
TRG_DiLeu_BaEn_4 600 606 PF01217 0.497
TRG_DiLeu_BaEn_4 620 626 PF01217 0.392
TRG_DiLeu_BaEn_4 633 639 PF01217 0.509
TRG_DiLeu_BaEn_4 653 659 PF01217 0.418
TRG_DiLeu_BaEn_4 666 672 PF01217 0.518
TRG_DiLeu_BaEn_4 686 692 PF01217 0.468
TRG_DiLeu_BaEn_4 699 705 PF01217 0.507
TRG_DiLeu_BaEn_4 719 725 PF01217 0.471
TRG_DiLeu_BaEn_4 732 738 PF01217 0.511
TRG_DiLeu_BaEn_4 752 758 PF01217 0.400
TRG_DiLeu_BaEn_4 765 771 PF01217 0.518
TRG_DiLeu_BaEn_4 785 791 PF01217 0.586
TRG_DiLeu_BaEn_4 798 804 PF01217 0.541
TRG_DiLeu_BaEn_4 818 824 PF01217 0.372
TRG_DiLeu_BaEn_4 831 837 PF01217 0.491
TRG_DiLeu_BaEn_4 851 857 PF01217 0.483
TRG_DiLeu_BaEn_4 864 870 PF01217 0.478
TRG_ENDOCYTIC_2 1001 1004 PF00928 0.435
TRG_ENDOCYTIC_2 47 50 PF00928 0.473
TRG_ER_diArg_1 1045 1047 PF00400 0.810
TRG_ER_diArg_1 1069 1071 PF00400 0.636
TRG_ER_diArg_1 350 353 PF00400 0.511
TRG_ER_diArg_1 383 386 PF00400 0.517
TRG_ER_diArg_1 449 452 PF00400 0.441
TRG_ER_diArg_1 548 551 PF00400 0.553
TRG_ER_diArg_1 614 617 PF00400 0.469
TRG_ER_diArg_1 713 716 PF00400 0.473
TRG_ER_diArg_1 886 889 PF00400 0.518
TRG_ER_diArg_1 957 959 PF00400 0.441
TRG_ER_diArg_1 97 99 PF00400 0.492
TRG_NES_CRM1_1 940 951 PF08389 0.560
TRG_Pf-PMV_PEXEL_1 353 357 PF00026 0.506
TRG_Pf-PMV_PEXEL_1 386 390 PF00026 0.523
TRG_Pf-PMV_PEXEL_1 452 456 PF00026 0.517
TRG_Pf-PMV_PEXEL_1 551 555 PF00026 0.550
TRG_Pf-PMV_PEXEL_1 617 621 PF00026 0.468
TRG_Pf-PMV_PEXEL_1 716 720 PF00026 0.470

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H5G8 Leishmania donovani 72% 100%
E9AKC9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 80%
Q4QJH9 Leishmania major 63% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS