Putative hydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrogenase, putative

Species:

Leishmania mexicana

UniProt:

E9AKC7_LEIMU

TriTrypDb:

LmxM.05.0230

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKC7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051539	4 iron, 4 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	517	521	PF00656	0.333
CLV_C14_Caspase3-7	562	566	PF00656	0.518
CLV_C14_Caspase3-7	600	604	PF00656	0.533
CLV_NRD_NRD_1	227	229	PF00675	0.268
CLV_NRD_NRD_1	295	297	PF00675	0.220
CLV_NRD_NRD_1	580	582	PF00675	0.612
CLV_PCSK_FUR_1	225	229	PF00082	0.285
CLV_PCSK_KEX2_1	225	227	PF00082	0.263
CLV_PCSK_KEX2_1	40	42	PF00082	0.770
CLV_PCSK_KEX2_1	445	447	PF00082	0.220
CLV_PCSK_KEX2_1	481	483	PF00082	0.234
CLV_PCSK_KEX2_1	579	581	PF00082	0.538
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.778
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.215
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.234
CLV_PCSK_PC7_1	477	483	PF00082	0.321
CLV_PCSK_SKI1_1	106	110	PF00082	0.518
CLV_PCSK_SKI1_1	477	481	PF00082	0.232
DEG_APCC_DBOX_1	113	121	PF00400	0.369
DEG_Nend_UBRbox_2	1	3	PF02207	0.524
DEG_SPOP_SBC_1	101	105	PF00917	0.597
DEG_SPOP_SBC_1	306	310	PF00917	0.398
DEG_SPOP_SBC_1	389	393	PF00917	0.375
DEG_SPOP_SBC_1	427	431	PF00917	0.541
DOC_ANK_TNKS_1	416	423	PF00023	0.447
DOC_CKS1_1	434	439	PF01111	0.567
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.222
DOC_PP2B_LxvP_1	132	135	PF13499	0.284
DOC_USP7_MATH_1	101	105	PF00917	0.630
DOC_USP7_MATH_1	108	112	PF00917	0.426
DOC_USP7_MATH_1	23	27	PF00917	0.658
DOC_USP7_MATH_1	265	269	PF00917	0.526
DOC_USP7_MATH_1	29	33	PF00917	0.702
DOC_USP7_MATH_1	381	385	PF00917	0.540
DOC_USP7_MATH_1	388	392	PF00917	0.525
DOC_USP7_MATH_1	425	429	PF00917	0.545
DOC_USP7_MATH_1	432	436	PF00917	0.519
DOC_USP7_MATH_1	485	489	PF00917	0.483
DOC_USP7_MATH_1	544	548	PF00917	0.647
DOC_USP7_MATH_1	561	565	PF00917	0.727
DOC_WW_Pin1_4	167	172	PF00397	0.560
DOC_WW_Pin1_4	382	387	PF00397	0.498
DOC_WW_Pin1_4	428	433	PF00397	0.531
DOC_WW_Pin1_4	97	102	PF00397	0.623
LIG_14-3-3_CanoR_1	148	156	PF00244	0.509
LIG_14-3-3_CanoR_1	487	492	PF00244	0.439
LIG_14-3-3_CanoR_1	607	611	PF00244	0.457
LIG_BRCT_BRCA1_1	390	394	PF00533	0.447
LIG_BRCT_BRCA1_1	487	491	PF00533	0.419
LIG_deltaCOP1_diTrp_1	583	589	PF00928	0.451
LIG_deltaCOP1_diTrp_1	603	610	PF00928	0.511
LIG_eIF4E_1	489	495	PF01652	0.420
LIG_FHA_1	151	157	PF00498	0.528
LIG_FHA_1	191	197	PF00498	0.389
LIG_FHA_1	322	328	PF00498	0.412
LIG_FHA_1	79	85	PF00498	0.409
LIG_FHA_2	186	192	PF00498	0.442
LIG_FHA_2	217	223	PF00498	0.420
LIG_FHA_2	336	342	PF00498	0.388
LIG_FHA_2	488	494	PF00498	0.420
LIG_FHA_2	607	613	PF00498	0.504
LIG_FHA_2	75	81	PF00498	0.386
LIG_LIR_Apic_2	2	6	PF02991	0.494
LIG_LIR_Gen_1	488	498	PF02991	0.421
LIG_LIR_Gen_1	614	621	PF02991	0.536
LIG_LIR_Nem_3	488	494	PF02991	0.421
LIG_LIR_Nem_3	583	589	PF02991	0.572
LIG_MYND_1	261	265	PF01753	0.434
LIG_MYND_1	46	50	PF01753	0.588
LIG_Pex14_1	606	610	PF04695	0.373
LIG_SH2_NCK_1	140	144	PF00017	0.403
LIG_SH2_PTP2	3	6	PF00017	0.504
LIG_SH2_STAP1	140	144	PF00017	0.468
LIG_SH2_STAP1	190	194	PF00017	0.341
LIG_SH2_STAP1	323	327	PF00017	0.420
LIG_SH2_STAP1	526	530	PF00017	0.487
LIG_SH2_STAT3	467	470	PF00017	0.420
LIG_SH2_STAT5	131	134	PF00017	0.417
LIG_SH2_STAT5	204	207	PF00017	0.405
LIG_SH2_STAT5	251	254	PF00017	0.420
LIG_SH2_STAT5	3	6	PF00017	0.506
LIG_SH2_STAT5	323	326	PF00017	0.420
LIG_SH2_STAT5	489	492	PF00017	0.420
LIG_SH3_2	342	347	PF14604	0.485
LIG_SH3_3	339	345	PF00018	0.521
LIG_SH3_3	431	437	PF00018	0.509
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.420
LIG_SUMO_SIM_par_1	116	122	PF11976	0.322
LIG_SUMO_SIM_par_1	204	209	PF11976	0.509
LIG_SUMO_SIM_par_1	238	244	PF11976	0.521
LIG_WW_1	201	204	PF00397	0.447
MOD_CDK_SPK_2	167	172	PF00069	0.408
MOD_CK1_1	100	106	PF00069	0.668
MOD_CK1_1	119	125	PF00069	0.319
MOD_CK1_1	181	187	PF00069	0.556
MOD_CK1_1	384	390	PF00069	0.398
MOD_CK1_1	428	434	PF00069	0.546
MOD_CK1_1	547	553	PF00069	0.699
MOD_CK2_1	194	200	PF00069	0.447
MOD_CK2_1	216	222	PF00069	0.420
MOD_CK2_1	326	332	PF00069	0.450
MOD_CK2_1	487	493	PF00069	0.420
MOD_CK2_1	74	80	PF00069	0.452
MOD_CK2_1	85	91	PF00069	0.400
MOD_GlcNHglycan	110	113	PF01048	0.590
MOD_GlcNHglycan	17	20	PF01048	0.608
MOD_GlcNHglycan	178	183	PF01048	0.322
MOD_GlcNHglycan	214	217	PF01048	0.321
MOD_GlcNHglycan	25	28	PF01048	0.536
MOD_GlcNHglycan	256	259	PF01048	0.297
MOD_GlcNHglycan	267	270	PF01048	0.312
MOD_GlcNHglycan	33	36	PF01048	0.634
MOD_GlcNHglycan	405	408	PF01048	0.165
MOD_GlcNHglycan	421	425	PF01048	0.288
MOD_GlcNHglycan	547	550	PF01048	0.675
MOD_GlcNHglycan	557	560	PF01048	0.566
MOD_GlcNHglycan	7	10	PF01048	0.640
MOD_GlcNHglycan	72	75	PF01048	0.450
MOD_GlcNHglycan	93	96	PF01048	0.497
MOD_GSK3_1	100	107	PF00069	0.612
MOD_GSK3_1	11	18	PF00069	0.539
MOD_GSK3_1	178	185	PF00069	0.553
MOD_GSK3_1	186	193	PF00069	0.467
MOD_GSK3_1	212	219	PF00069	0.428
MOD_GSK3_1	23	30	PF00069	0.577
MOD_GSK3_1	307	314	PF00069	0.525
MOD_GSK3_1	317	324	PF00069	0.485
MOD_GSK3_1	384	391	PF00069	0.396
MOD_GSK3_1	426	433	PF00069	0.528
MOD_GSK3_1	44	51	PF00069	0.462
MOD_GSK3_1	540	547	PF00069	0.691
MOD_GSK3_1	590	597	PF00069	0.552
MOD_GSK3_1	70	77	PF00069	0.389
MOD_GSK3_1	91	98	PF00069	0.492
MOD_N-GLC_1	352	357	PF02516	0.298
MOD_NEK2_1	147	152	PF00069	0.336
MOD_NEK2_1	15	20	PF00069	0.574
MOD_NEK2_1	240	245	PF00069	0.426
MOD_NEK2_1	403	408	PF00069	0.420
MOD_NEK2_1	555	560	PF00069	0.667
MOD_NEK2_1	70	75	PF00069	0.401
MOD_NEK2_1	96	101	PF00069	0.457
MOD_NEK2_2	606	611	PF00069	0.550
MOD_PIKK_1	119	125	PF00454	0.386
MOD_PIKK_1	371	377	PF00454	0.475
MOD_PK_1	116	122	PF00069	0.447
MOD_PKA_2	147	153	PF00069	0.476
MOD_PKA_2	606	612	PF00069	0.447
MOD_PKB_1	114	122	PF00069	0.461
MOD_Plk_1	190	196	PF00069	0.386
MOD_Plk_1	317	323	PF00069	0.464
MOD_Plk_1	352	358	PF00069	0.359
MOD_Plk_1	590	596	PF00069	0.475
MOD_Plk_2-3	335	341	PF00069	0.341
MOD_Plk_4	11	17	PF00069	0.602
MOD_Plk_4	317	323	PF00069	0.344
MOD_Plk_4	409	415	PF00069	0.379
MOD_Plk_4	487	493	PF00069	0.442
MOD_Plk_4	78	84	PF00069	0.432
MOD_ProDKin_1	167	173	PF00069	0.560
MOD_ProDKin_1	382	388	PF00069	0.498
MOD_ProDKin_1	428	434	PF00069	0.531
MOD_ProDKin_1	97	103	PF00069	0.634
MOD_SUMO_rev_2	289	298	PF00179	0.420
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.485
TRG_ENDOCYTIC_2	131	134	PF00928	0.387
TRG_ENDOCYTIC_2	140	143	PF00928	0.387
TRG_ENDOCYTIC_2	489	492	PF00928	0.420
TRG_ER_diArg_1	114	117	PF00400	0.484
TRG_ER_diArg_1	225	228	PF00400	0.463
TRG_ER_diArg_1	417	420	PF00400	0.398
TRG_ER_diArg_1	579	581	PF00400	0.681
TRG_NLS_MonoExtN_4	477	484	PF00514	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2B2	Leptomonas seymouri	54%	98%
A0A0S4J2N1	Bodo saltans	35%	100%
A0A1X0P0T4	Trypanosomatidae	39%	100%
A0A3S7WP18	Leishmania donovani	88%	100%
A0A422NE31	Trypanosoma rangeli	38%	100%
A1CWD8	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	27%	100%
A2Q9A9	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	27%	100%
A3LYR2	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	24%	100%
A4FV58	Bos taurus	28%	100%
A4H468	Leishmania braziliensis	76%	100%
A4HSF5	Leishmania infantum	88%	100%
A5DKC0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	100%
A5DSI2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	27%	100%
A6ZRK3	Saccharomyces cerevisiae (strain YJM789)	24%	100%
A7SDA8	Nematostella vectensis	26%	100%
A7TQP0	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	25%	100%
A8WH18	Xenopus tropicalis	25%	100%
B0Y4F9	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	26%	100%
B3N018	Drosophila ananassae	27%	100%
B3NKH7	Drosophila erecta	28%	100%
B4GXC8	Drosophila persimilis	28%	100%
B4IMH3	Drosophila sechellia	26%	100%
B4ISL0	Drosophila yakuba	28%	100%
B4JBE6	Drosophila grimshawi	28%	100%
B4KFU7	Drosophila mojavensis	27%	100%
B4LQR5	Drosophila virilis	28%	100%
B4MUM8	Drosophila willistoni	26%	100%
B4NSS7	Drosophila simulans	26%	100%
B5DK31	Drosophila pseudoobscura pseudoobscura	28%	100%
B6HUC4	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	27%	100%
B6K2N0	Schizosaccharomyces japonicus (strain yFS275 / FY16936)	26%	100%
B6QQH9	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	27%	100%
B8N122	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	28%	100%
D0A4K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
P0CP10	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	97%
P0CP11	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	97%
P23503	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P53998	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q0CR17	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	27%	100%
Q0UM75	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	28%	100%
Q1E736	Coccidioides immitis (strain RS)	27%	100%
Q2HEF1	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	29%	100%
Q2UJY8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	28%	100%
Q2YDU6	Rattus norvegicus	26%	100%
Q4QJI0	Leishmania major	85%	100%
Q4WQ87	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	100%
Q5B748	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
Q5BK18	Rattus norvegicus	27%	100%
Q5RF36	Pongo abelii	28%	100%
Q6BUI4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	100%
Q6CFR3	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	100%
Q6DHP6	Danio rerio	24%	100%
Q6FP07	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q6GP25	Xenopus laevis	26%	100%
Q7SGW5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	100%
Q8SYS7	Drosophila melanogaster	26%	100%
Q94CL6	Arabidopsis thaliana	28%	100%
Q9CYQ7	Mus musculus	26%	100%
Q9H6Q4	Homo sapiens	29%	100%
Q9UHQ1	Homo sapiens	26%	100%
Q9Y7N7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
V5DC01	Trypanosoma cruzi	38%	100%