LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Dual specificity phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dual specificity phosphatase-like protein
Gene product:
dual specificity phosphatase-like protein
Species:
Leishmania mexicana
UniProt:
E9AKC6_LEIMU
TriTrypDb:
LmxM.05.0220
Length:
627

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AKC6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKC6

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 6
GO:0016311 dephosphorylation 5 6
GO:0019538 protein metabolic process 3 6
GO:0036211 protein modification process 4 6
GO:0043170 macromolecule metabolic process 3 6
GO:0043412 macromolecule modification 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0071704 organic substance metabolic process 2 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:0009966 regulation of signal transduction 4 1
GO:0009968 negative regulation of signal transduction 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010648 negative regulation of cell communication 5 1
GO:0023051 regulation of signaling 3 1
GO:0023057 negative regulation of signaling 4 1
GO:0043408 regulation of MAPK cascade 6 1
GO:0043409 negative regulation of MAPK cascade 7 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048585 negative regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902532 negative regulation of intracellular signal transduction 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0004721 phosphoprotein phosphatase activity 3 6
GO:0004725 protein tyrosine phosphatase activity 4 6
GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4 6
GO:0016787 hydrolase activity 2 6
GO:0016788 hydrolase activity, acting on ester bonds 3 6
GO:0016791 phosphatase activity 5 6
GO:0042578 phosphoric ester hydrolase activity 4 6
GO:0140096 catalytic activity, acting on a protein 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 225 229 PF00656 0.525
CLV_C14_Caspase3-7 463 467 PF00656 0.696
CLV_C14_Caspase3-7 54 58 PF00656 0.388
CLV_NRD_NRD_1 134 136 PF00675 0.388
CLV_NRD_NRD_1 166 168 PF00675 0.424
CLV_NRD_NRD_1 328 330 PF00675 0.719
CLV_NRD_NRD_1 397 399 PF00675 0.694
CLV_NRD_NRD_1 531 533 PF00675 0.644
CLV_PCSK_KEX2_1 134 136 PF00082 0.388
CLV_PCSK_KEX2_1 166 168 PF00082 0.424
CLV_PCSK_KEX2_1 328 330 PF00082 0.719
CLV_PCSK_KEX2_1 397 399 PF00082 0.694
CLV_PCSK_KEX2_1 5 7 PF00082 0.607
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.607
CLV_PCSK_SKI1_1 161 165 PF00082 0.388
CLV_PCSK_SKI1_1 397 401 PF00082 0.648
CLV_PCSK_SKI1_1 429 433 PF00082 0.519
CLV_PCSK_SKI1_1 532 536 PF00082 0.664
CLV_PCSK_SKI1_1 70 74 PF00082 0.388
DEG_APCC_DBOX_1 396 404 PF00400 0.693
DEG_SCF_FBW7_2 366 373 PF00400 0.651
DEG_SCF_TRCP1_1 228 233 PF00400 0.540
DEG_SPOP_SBC_1 207 211 PF00917 0.550
DEG_SPOP_SBC_1 290 294 PF00917 0.601
DEG_SPOP_SBC_1 338 342 PF00917 0.556
DEG_SPOP_SBC_1 431 435 PF00917 0.629
DEG_SPOP_SBC_1 437 441 PF00917 0.584
DEG_SPOP_SBC_1 513 517 PF00917 0.540
DOC_CKS1_1 367 372 PF01111 0.567
DOC_CYCLIN_yCln2_LP_2 249 252 PF00134 0.599
DOC_MAPK_gen_1 166 174 PF00069 0.388
DOC_MAPK_MEF2A_6 166 174 PF00069 0.388
DOC_PP2B_LxvP_1 248 251 PF13499 0.638
DOC_PP4_FxxP_1 190 193 PF00568 0.561
DOC_USP7_MATH_1 208 212 PF00917 0.651
DOC_USP7_MATH_1 232 236 PF00917 0.795
DOC_USP7_MATH_1 284 288 PF00917 0.609
DOC_USP7_MATH_1 338 342 PF00917 0.597
DOC_USP7_MATH_1 343 347 PF00917 0.533
DOC_USP7_MATH_1 476 480 PF00917 0.651
DOC_USP7_MATH_1 506 510 PF00917 0.583
DOC_USP7_MATH_1 51 55 PF00917 0.358
DOC_USP7_MATH_1 513 517 PF00917 0.532
DOC_USP7_MATH_2 251 257 PF00917 0.611
DOC_WW_Pin1_4 203 208 PF00397 0.658
DOC_WW_Pin1_4 330 335 PF00397 0.561
DOC_WW_Pin1_4 366 371 PF00397 0.615
DOC_WW_Pin1_4 387 392 PF00397 0.642
DOC_WW_Pin1_4 485 490 PF00397 0.789
DOC_WW_Pin1_4 514 519 PF00397 0.731
DOC_WW_Pin1_4 563 568 PF00397 0.660
DOC_WW_Pin1_4 602 607 PF00397 0.683
DOC_WW_Pin1_4 609 614 PF00397 0.622
LIG_14-3-3_CanoR_1 121 130 PF00244 0.475
LIG_14-3-3_CanoR_1 166 174 PF00244 0.375
LIG_14-3-3_CanoR_1 179 185 PF00244 0.233
LIG_14-3-3_CanoR_1 349 359 PF00244 0.681
LIG_14-3-3_CanoR_1 410 419 PF00244 0.556
LIG_14-3-3_CanoR_1 621 626 PF00244 0.604
LIG_Actin_WH2_2 4 21 PF00022 0.588
LIG_BIR_II_1 1 5 PF00653 0.443
LIG_BRCT_BRCA1_1 185 189 PF00533 0.545
LIG_BRCT_BRCA1_1 535 539 PF00533 0.527
LIG_FHA_1 103 109 PF00498 0.391
LIG_FHA_1 334 340 PF00498 0.704
LIG_FHA_1 351 357 PF00498 0.620
LIG_FHA_1 437 443 PF00498 0.672
LIG_FHA_1 45 51 PF00498 0.469
LIG_FHA_2 25 31 PF00498 0.565
LIG_FHA_2 308 314 PF00498 0.749
LIG_LIR_Apic_2 187 193 PF02991 0.539
LIG_LIR_Gen_1 210 221 PF02991 0.613
LIG_LIR_Nem_3 210 216 PF02991 0.618
LIG_LIR_Nem_3 253 257 PF02991 0.546
LIG_MLH1_MIPbox_1 186 190 PF16413 0.500
LIG_MYND_1 247 251 PF01753 0.606
LIG_PCNA_yPIPBox_3 85 98 PF02747 0.388
LIG_RPA_C_Fungi 130 142 PF08784 0.388
LIG_SH2_CRK 254 258 PF00017 0.542
LIG_SH2_SRC 156 159 PF00017 0.388
LIG_SH2_STAP1 156 160 PF00017 0.455
LIG_SH2_STAT3 590 593 PF00017 0.613
LIG_SH2_STAT5 147 150 PF00017 0.388
LIG_SH2_STAT5 71 74 PF00017 0.388
LIG_SH3_3 382 388 PF00018 0.776
LIG_SH3_3 486 492 PF00018 0.645
LIG_SH3_3 600 606 PF00018 0.794
LIG_SUMO_SIM_par_1 47 54 PF11976 0.438
LIG_SUMO_SIM_par_1 542 549 PF11976 0.524
LIG_TRAF2_1 155 158 PF00917 0.226
LIG_TRAF2_1 175 178 PF00917 0.334
LIG_TRAF2_1 20 23 PF00917 0.573
LIG_TRAF2_1 240 243 PF00917 0.649
LIG_TRAF2_1 81 84 PF00917 0.523
LIG_TRAF2_2 240 245 PF00917 0.649
LIG_UBA3_1 446 451 PF00899 0.528
LIG_WW_1 251 254 PF00397 0.520
MOD_CDK_SPK_2 485 490 PF00069 0.706
MOD_CK1_1 124 130 PF00069 0.334
MOD_CK1_1 168 174 PF00069 0.388
MOD_CK1_1 206 212 PF00069 0.739
MOD_CK1_1 233 239 PF00069 0.603
MOD_CK1_1 289 295 PF00069 0.702
MOD_CK1_1 296 302 PF00069 0.674
MOD_CK1_1 303 309 PF00069 0.627
MOD_CK1_1 333 339 PF00069 0.681
MOD_CK1_1 374 380 PF00069 0.747
MOD_CK1_1 411 417 PF00069 0.791
MOD_CK1_1 44 50 PF00069 0.390
MOD_CK1_1 472 478 PF00069 0.699
MOD_CK1_1 549 555 PF00069 0.589
MOD_CK1_1 565 571 PF00069 0.521
MOD_CK1_1 605 611 PF00069 0.649
MOD_CK1_1 620 626 PF00069 0.726
MOD_CK2_1 152 158 PF00069 0.245
MOD_CK2_1 24 30 PF00069 0.548
MOD_CK2_1 307 313 PF00069 0.670
MOD_CK2_1 542 548 PF00069 0.631
MOD_CK2_1 56 62 PF00069 0.408
MOD_Cter_Amidation 395 398 PF01082 0.695
MOD_GlcNHglycan 139 142 PF01048 0.516
MOD_GlcNHglycan 228 231 PF01048 0.835
MOD_GlcNHglycan 264 267 PF01048 0.667
MOD_GlcNHglycan 288 291 PF01048 0.654
MOD_GlcNHglycan 295 298 PF01048 0.622
MOD_GlcNHglycan 302 305 PF01048 0.601
MOD_GlcNHglycan 330 333 PF01048 0.670
MOD_GlcNHglycan 346 349 PF01048 0.610
MOD_GlcNHglycan 360 363 PF01048 0.666
MOD_GlcNHglycan 411 414 PF01048 0.680
MOD_GlcNHglycan 425 428 PF01048 0.600
MOD_GlcNHglycan 474 477 PF01048 0.748
MOD_GlcNHglycan 496 499 PF01048 0.710
MOD_GlcNHglycan 507 511 PF01048 0.584
MOD_GlcNHglycan 535 538 PF01048 0.756
MOD_GSK3_1 148 155 PF00069 0.388
MOD_GSK3_1 161 168 PF00069 0.265
MOD_GSK3_1 203 210 PF00069 0.671
MOD_GSK3_1 212 219 PF00069 0.563
MOD_GSK3_1 222 229 PF00069 0.573
MOD_GSK3_1 253 260 PF00069 0.699
MOD_GSK3_1 262 269 PF00069 0.540
MOD_GSK3_1 284 291 PF00069 0.670
MOD_GSK3_1 292 299 PF00069 0.642
MOD_GSK3_1 303 310 PF00069 0.611
MOD_GSK3_1 324 331 PF00069 0.643
MOD_GSK3_1 333 340 PF00069 0.590
MOD_GSK3_1 41 48 PF00069 0.472
MOD_GSK3_1 419 426 PF00069 0.578
MOD_GSK3_1 432 439 PF00069 0.661
MOD_GSK3_1 471 478 PF00069 0.694
MOD_GSK3_1 508 515 PF00069 0.640
MOD_GSK3_1 517 524 PF00069 0.561
MOD_GSK3_1 533 540 PF00069 0.614
MOD_GSK3_1 542 549 PF00069 0.570
MOD_GSK3_1 563 570 PF00069 0.679
MOD_GSK3_1 585 592 PF00069 0.647
MOD_GSK3_1 604 611 PF00069 0.718
MOD_GSK3_1 616 623 PF00069 0.695
MOD_GSK3_1 98 105 PF00069 0.410
MOD_N-GLC_1 258 263 PF02516 0.581
MOD_N-GLC_1 408 413 PF02516 0.523
MOD_N-GLC_1 476 481 PF02516 0.648
MOD_N-GLC_1 537 542 PF02516 0.645
MOD_N-GLC_1 546 551 PF02516 0.643
MOD_N-GLC_1 563 568 PF02516 0.547
MOD_NEK2_1 100 105 PF00069 0.388
MOD_NEK2_1 271 276 PF00069 0.536
MOD_NEK2_1 312 317 PF00069 0.589
MOD_NEK2_1 337 342 PF00069 0.640
MOD_NEK2_1 350 355 PF00069 0.532
MOD_NEK2_1 419 424 PF00069 0.562
MOD_NEK2_1 432 437 PF00069 0.644
MOD_NEK2_1 438 443 PF00069 0.621
MOD_NEK2_1 447 452 PF00069 0.529
MOD_NEK2_1 521 526 PF00069 0.542
MOD_NEK2_1 585 590 PF00069 0.598
MOD_PIKK_1 102 108 PF00454 0.388
MOD_PIKK_1 192 198 PF00454 0.679
MOD_PIKK_1 233 239 PF00454 0.663
MOD_PIKK_1 269 275 PF00454 0.699
MOD_PIKK_1 522 528 PF00454 0.640
MOD_PIKK_1 589 595 PF00454 0.671
MOD_PKA_1 328 334 PF00069 0.655
MOD_PKA_2 165 171 PF00069 0.388
MOD_PKA_2 178 184 PF00069 0.246
MOD_PKA_2 284 290 PF00069 0.706
MOD_PKA_2 299 305 PF00069 0.695
MOD_PKA_2 328 334 PF00069 0.814
MOD_PKA_2 409 415 PF00069 0.603
MOD_PKA_2 469 475 PF00069 0.769
MOD_PKA_2 494 500 PF00069 0.697
MOD_PKA_2 620 626 PF00069 0.605
MOD_Plk_1 124 130 PF00069 0.334
MOD_Plk_1 30 36 PF00069 0.608
MOD_Plk_1 44 50 PF00069 0.312
MOD_Plk_2-3 152 158 PF00069 0.388
MOD_Plk_4 212 218 PF00069 0.605
MOD_Plk_4 24 30 PF00069 0.649
MOD_Plk_4 442 448 PF00069 0.643
MOD_Plk_4 45 51 PF00069 0.469
MOD_ProDKin_1 203 209 PF00069 0.656
MOD_ProDKin_1 330 336 PF00069 0.561
MOD_ProDKin_1 366 372 PF00069 0.613
MOD_ProDKin_1 387 393 PF00069 0.643
MOD_ProDKin_1 485 491 PF00069 0.786
MOD_ProDKin_1 514 520 PF00069 0.730
MOD_ProDKin_1 563 569 PF00069 0.659
MOD_ProDKin_1 602 608 PF00069 0.685
MOD_ProDKin_1 609 615 PF00069 0.624
MOD_SUMO_rev_2 78 87 PF00179 0.388
TRG_DiLeu_BaEn_3 157 163 PF01217 0.263
TRG_DiLeu_BaLyEn_6 244 249 PF01217 0.644
TRG_ENDOCYTIC_2 254 257 PF00928 0.546
TRG_ER_diArg_1 529 532 PF00400 0.630

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H5G7 Leishmania donovani 83% 94%
A4H479 Leishmania braziliensis 59% 100%
A4HSF4 Leishmania infantum 83% 93%
Q4QJI1 Leishmania major 83% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS