G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania mexicana

UniProt:

E9AKC4_LEIMU

TriTrypDb:

LmxM.05.0200

Length:

787

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKC4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0003924	GTPase activity	7	9
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	522	526	PF00656	0.447
CLV_C14_Caspase3-7	630	634	PF00656	0.476
CLV_C14_Caspase3-7	66	70	PF00656	0.525
CLV_NRD_NRD_1	147	149	PF00675	0.333
CLV_NRD_NRD_1	21	23	PF00675	0.630
CLV_NRD_NRD_1	233	235	PF00675	0.422
CLV_NRD_NRD_1	344	346	PF00675	0.430
CLV_NRD_NRD_1	455	457	PF00675	0.220
CLV_NRD_NRD_1	500	502	PF00675	0.397
CLV_NRD_NRD_1	538	540	PF00675	0.390
CLV_NRD_NRD_1	705	707	PF00675	0.530
CLV_NRD_NRD_1	708	710	PF00675	0.548
CLV_NRD_NRD_1	764	766	PF00675	0.493
CLV_NRD_NRD_1	780	782	PF00675	0.545
CLV_PCSK_FUR_1	11	15	PF00082	0.555
CLV_PCSK_FUR_1	705	709	PF00082	0.533
CLV_PCSK_KEX2_1	122	124	PF00082	0.358
CLV_PCSK_KEX2_1	13	15	PF00082	0.577
CLV_PCSK_KEX2_1	147	149	PF00082	0.332
CLV_PCSK_KEX2_1	21	23	PF00082	0.617
CLV_PCSK_KEX2_1	233	235	PF00082	0.422
CLV_PCSK_KEX2_1	344	346	PF00082	0.515
CLV_PCSK_KEX2_1	377	379	PF00082	0.575
CLV_PCSK_KEX2_1	455	457	PF00082	0.220
CLV_PCSK_KEX2_1	500	502	PF00082	0.397
CLV_PCSK_KEX2_1	537	539	PF00082	0.379
CLV_PCSK_KEX2_1	704	706	PF00082	0.559
CLV_PCSK_KEX2_1	707	709	PF00082	0.583
CLV_PCSK_KEX2_1	760	762	PF00082	0.501
CLV_PCSK_KEX2_1	764	766	PF00082	0.493
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.434
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.553
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.540
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.543
CLV_PCSK_PC1ET2_1	760	762	PF00082	0.501
CLV_PCSK_PC7_1	340	346	PF00082	0.430
CLV_PCSK_PC7_1	704	710	PF00082	0.630
CLV_PCSK_SKI1_1	13	17	PF00082	0.614
CLV_PCSK_SKI1_1	140	144	PF00082	0.432
CLV_PCSK_SKI1_1	158	162	PF00082	0.484
CLV_PCSK_SKI1_1	217	221	PF00082	0.421
CLV_PCSK_SKI1_1	25	29	PF00082	0.469
CLV_PCSK_SKI1_1	321	325	PF00082	0.572
CLV_PCSK_SKI1_1	356	360	PF00082	0.598
CLV_PCSK_SKI1_1	456	460	PF00082	0.220
CLV_PCSK_SKI1_1	504	508	PF00082	0.408
CLV_PCSK_SKI1_1	555	559	PF00082	0.329
CLV_PCSK_SKI1_1	750	754	PF00082	0.670
CLV_PCSK_SKI1_1	765	769	PF00082	0.520
DEG_APCC_DBOX_1	146	154	PF00400	0.348
DEG_APCC_DBOX_1	682	690	PF00400	0.500
DEG_APCC_DBOX_1	763	771	PF00400	0.593
DEG_SCF_FBW7_1	436	443	PF00400	0.420
DEG_SPOP_SBC_1	266	270	PF00917	0.469
DOC_AGCK_PIF_2	196	201	PF00069	0.278
DOC_CKS1_1	160	165	PF01111	0.354
DOC_CKS1_1	405	410	PF01111	0.543
DOC_CKS1_1	741	746	PF01111	0.602
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.501
DOC_MAPK_gen_1	216	222	PF00069	0.336
DOC_MAPK_gen_1	321	330	PF00069	0.512
DOC_MAPK_gen_1	442	451	PF00069	0.420
DOC_MAPK_gen_1	552	562	PF00069	0.330
DOC_MAPK_MEF2A_6	180	188	PF00069	0.300
DOC_MAPK_MEF2A_6	555	562	PF00069	0.325
DOC_MAPK_MEF2A_6	724	732	PF00069	0.585
DOC_MAPK_NFAT4_5	555	563	PF00069	0.333
DOC_PP2B_LxvP_1	118	121	PF13499	0.328
DOC_PP2B_LxvP_1	324	327	PF13499	0.514
DOC_PP2B_LxvP_1	449	452	PF13499	0.420
DOC_USP7_MATH_1	266	270	PF00917	0.749
DOC_USP7_MATH_1	289	293	PF00917	0.540
DOC_USP7_MATH_1	364	368	PF00917	0.541
DOC_USP7_MATH_1	371	375	PF00917	0.545
DOC_USP7_MATH_1	597	601	PF00917	0.647
DOC_USP7_MATH_1	772	776	PF00917	0.408
DOC_USP7_UBL2_3	212	216	PF12436	0.494
DOC_USP7_UBL2_3	49	53	PF12436	0.574
DOC_USP7_UBL2_3	555	559	PF12436	0.423
DOC_USP7_UBL2_3	754	758	PF12436	0.550
DOC_WW_Pin1_4	159	164	PF00397	0.367
DOC_WW_Pin1_4	285	290	PF00397	0.487
DOC_WW_Pin1_4	404	409	PF00397	0.427
DOC_WW_Pin1_4	436	441	PF00397	0.420
DOC_WW_Pin1_4	592	597	PF00397	0.673
DOC_WW_Pin1_4	740	745	PF00397	0.510
LIG_14-3-3_CanoR_1	147	151	PF00244	0.438
LIG_14-3-3_CanoR_1	356	363	PF00244	0.587
LIG_14-3-3_CanoR_1	365	375	PF00244	0.480
LIG_14-3-3_CanoR_1	47	56	PF00244	0.536
LIG_14-3-3_CanoR_1	645	650	PF00244	0.524
LIG_14-3-3_CanoR_1	678	682	PF00244	0.587
LIG_APCC_ABBA_1	558	563	PF00400	0.333
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_BIR_III_4	621	625	PF00653	0.704
LIG_BRCT_BRCA1_1	197	201	PF00533	0.378
LIG_BRCT_BRCA1_2	197	203	PF00533	0.389
LIG_Clathr_ClatBox_1	686	690	PF01394	0.492
LIG_deltaCOP1_diTrp_1	169	175	PF00928	0.301
LIG_FHA_1	446	452	PF00498	0.420
LIG_FHA_1	487	493	PF00498	0.411
LIG_FHA_1	56	62	PF00498	0.447
LIG_FHA_2	111	117	PF00498	0.503
LIG_FHA_2	160	166	PF00498	0.355
LIG_FHA_2	357	363	PF00498	0.475
LIG_FHA_2	380	386	PF00498	0.421
LIG_FHA_2	485	491	PF00498	0.373
LIG_FHA_2	680	686	PF00498	0.425
LIG_FHA_2	698	704	PF00498	0.464
LIG_GBD_Chelix_1	527	535	PF00786	0.428
LIG_IBAR_NPY_1	332	334	PF08397	0.457
LIG_Integrin_RGD_1	243	245	PF01839	0.432
LIG_IRF3_LxIS_1	507	514	PF10401	0.395
LIG_LIR_Gen_1	110	118	PF02991	0.395
LIG_LIR_Gen_1	379	389	PF02991	0.418
LIG_LIR_Gen_1	391	400	PF02991	0.326
LIG_LIR_Gen_1	443	452	PF02991	0.420
LIG_LIR_Gen_1	563	573	PF02991	0.434
LIG_LIR_Gen_1	62	70	PF02991	0.440
LIG_LIR_Gen_1	633	641	PF02991	0.507
LIG_LIR_Gen_1	682	691	PF02991	0.498
LIG_LIR_Nem_3	110	114	PF02991	0.412
LIG_LIR_Nem_3	169	174	PF02991	0.303
LIG_LIR_Nem_3	198	204	PF02991	0.364
LIG_LIR_Nem_3	245	250	PF02991	0.347
LIG_LIR_Nem_3	379	384	PF02991	0.450
LIG_LIR_Nem_3	391	396	PF02991	0.417
LIG_LIR_Nem_3	443	449	PF02991	0.420
LIG_LIR_Nem_3	563	569	PF02991	0.430
LIG_LIR_Nem_3	62	67	PF02991	0.444
LIG_LIR_Nem_3	633	638	PF02991	0.504
LIG_LIR_Nem_3	679	684	PF02991	0.541
LIG_LIR_Nem_3	717	722	PF02991	0.553
LIG_LYPXL_yS_3	416	419	PF13949	0.420
LIG_Pex14_1	236	240	PF04695	0.313
LIG_REV1ctd_RIR_1	247	253	PF16727	0.420
LIG_RPA_C_Fungi	690	702	PF08784	0.515
LIG_SH2_CRK	671	675	PF00017	0.477
LIG_SH2_CRK	719	723	PF00017	0.539
LIG_SH2_PTP2	568	571	PF00017	0.367
LIG_SH2_SRC	561	564	PF00017	0.334
LIG_SH2_SRC	568	571	PF00017	0.333
LIG_SH2_STAP1	164	168	PF00017	0.314
LIG_SH2_STAP1	656	660	PF00017	0.650
LIG_SH2_STAT3	239	242	PF00017	0.343
LIG_SH2_STAT3	587	590	PF00017	0.585
LIG_SH2_STAT5	204	207	PF00017	0.391
LIG_SH2_STAT5	239	242	PF00017	0.328
LIG_SH2_STAT5	561	564	PF00017	0.428
LIG_SH2_STAT5	565	568	PF00017	0.329
LIG_SH2_STAT5	719	722	PF00017	0.541
LIG_SH2_STAT5	75	78	PF00017	0.565
LIG_SH3_3	118	124	PF00018	0.341
LIG_SH3_3	251	257	PF00018	0.490
LIG_SH3_3	327	333	PF00018	0.481
LIG_SH3_3	380	386	PF00018	0.382
LIG_SH3_3	402	408	PF00018	0.471
LIG_SH3_3	411	417	PF00018	0.261
LIG_SH3_3	566	572	PF00018	0.402
LIG_SH3_3	745	751	PF00018	0.628
LIG_SH3_4	756	763	PF00018	0.582
LIG_SUMO_SIM_anti_2	182	189	PF11976	0.293
LIG_SUMO_SIM_par_1	733	743	PF11976	0.606
LIG_TRAF2_1	299	302	PF00917	0.656
LIG_TRAF2_1	359	362	PF00917	0.532
LIG_TRAF2_1	608	611	PF00917	0.767
LIG_TRAF2_1	70	73	PF00917	0.529
LIG_TRAF2_2	386	391	PF00917	0.332
LIG_TYR_ITIM	414	419	PF00017	0.257
LIG_WRC_WIRS_1	196	201	PF05994	0.278
LIG_WRC_WIRS_1	467	472	PF05994	0.346
LIG_WW_1	572	575	PF00397	0.381
MOD_CDK_SPxK_1	436	442	PF00069	0.257
MOD_CDK_SPxxK_3	159	166	PF00069	0.354
MOD_CK1_1	270	276	PF00069	0.574
MOD_CK1_1	469	475	PF00069	0.367
MOD_CK1_1	697	703	PF00069	0.475
MOD_CK2_1	110	116	PF00069	0.457
MOD_CK2_1	128	134	PF00069	0.368
MOD_CK2_1	159	165	PF00069	0.374
MOD_CK2_1	208	214	PF00069	0.499
MOD_CK2_1	356	362	PF00069	0.482
MOD_CK2_1	364	370	PF00069	0.441
MOD_CK2_1	51	57	PF00069	0.433
MOD_CK2_1	523	529	PF00069	0.383
MOD_CK2_1	679	685	PF00069	0.464
MOD_CK2_1	697	703	PF00069	0.572
MOD_Cter_Amidation	19	22	PF01082	0.553
MOD_GlcNHglycan	130	133	PF01048	0.402
MOD_GlcNHglycan	250	253	PF01048	0.382
MOD_GlcNHglycan	336	339	PF01048	0.472
MOD_GlcNHglycan	436	439	PF01048	0.266
MOD_GlcNHglycan	592	595	PF01048	0.621
MOD_GlcNHglycan	600	603	PF01048	0.641
MOD_GlcNHglycan	639	642	PF01048	0.575
MOD_GlcNHglycan	696	699	PF01048	0.365
MOD_GSK3_1	110	117	PF00069	0.438
MOD_GSK3_1	204	211	PF00069	0.442
MOD_GSK3_1	222	229	PF00069	0.324
MOD_GSK3_1	266	273	PF00069	0.672
MOD_GSK3_1	285	292	PF00069	0.695
MOD_GSK3_1	400	407	PF00069	0.474
MOD_GSK3_1	436	443	PF00069	0.257
MOD_GSK3_1	466	473	PF00069	0.384
MOD_GSK3_1	47	54	PF00069	0.554
MOD_GSK3_1	484	491	PF00069	0.409
MOD_GSK3_1	9	16	PF00069	0.472
MOD_LATS_1	312	318	PF00433	0.575
MOD_N-GLC_1	222	227	PF02516	0.325
MOD_N-GLC_1	511	516	PF02516	0.373
MOD_N-GLC_1	654	659	PF02516	0.530
MOD_NEK2_1	1	6	PF00069	0.495
MOD_NEK2_1	114	119	PF00069	0.427
MOD_NEK2_1	248	253	PF00069	0.425
MOD_NEK2_1	470	475	PF00069	0.403
MOD_NEK2_1	492	497	PF00069	0.545
MOD_NEK2_1	511	516	PF00069	0.254
MOD_NEK2_1	677	682	PF00069	0.529
MOD_NEK2_1	9	14	PF00069	0.449
MOD_PIKK_1	205	211	PF00454	0.315
MOD_PIKK_1	47	53	PF00454	0.561
MOD_PKA_1	13	19	PF00069	0.497
MOD_PKA_1	707	713	PF00069	0.538
MOD_PKA_2	13	19	PF00069	0.506
MOD_PKA_2	146	152	PF00069	0.439
MOD_PKA_2	205	211	PF00069	0.391
MOD_PKA_2	364	370	PF00069	0.460
MOD_PKA_2	677	683	PF00069	0.584
MOD_PKA_2	694	700	PF00069	0.517
MOD_PKA_2	707	713	PF00069	0.573
MOD_Plk_1	511	517	PF00069	0.382
MOD_Plk_1	654	660	PF00069	0.538
MOD_Plk_2-3	110	116	PF00069	0.300
MOD_Plk_2-3	379	385	PF00069	0.432
MOD_Plk_2-3	523	529	PF00069	0.418
MOD_Plk_2-3	626	632	PF00069	0.609
MOD_Plk_2-3	654	660	PF00069	0.644
MOD_Plk_4	182	188	PF00069	0.385
MOD_Plk_4	371	377	PF00069	0.366
MOD_Plk_4	445	451	PF00069	0.268
MOD_Plk_4	51	57	PF00069	0.433
MOD_Plk_4	717	723	PF00069	0.555
MOD_ProDKin_1	159	165	PF00069	0.357
MOD_ProDKin_1	285	291	PF00069	0.486
MOD_ProDKin_1	404	410	PF00069	0.419
MOD_ProDKin_1	436	442	PF00069	0.257
MOD_ProDKin_1	592	598	PF00069	0.674
MOD_ProDKin_1	740	746	PF00069	0.515
MOD_SUMO_for_1	352	355	PF00179	0.652
MOD_SUMO_for_1	376	379	PF00179	0.537
MOD_SUMO_rev_2	125	131	PF00179	0.440
MOD_SUMO_rev_2	133	143	PF00179	0.550
MOD_SUMO_rev_2	154	160	PF00179	0.513
MOD_SUMO_rev_2	211	218	PF00179	0.487
TRG_DiLeu_BaEn_1	156	161	PF01217	0.498
TRG_DiLeu_BaEn_2	138	144	PF01217	0.338
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.374
TRG_ENDOCYTIC_2	416	419	PF00928	0.257
TRG_ENDOCYTIC_2	684	687	PF00928	0.492
TRG_ENDOCYTIC_2	719	722	PF00928	0.541
TRG_ER_diArg_1	146	148	PF00400	0.341
TRG_ER_diArg_1	343	345	PF00400	0.403
TRG_ER_diArg_1	455	457	PF00400	0.257
TRG_ER_diArg_1	500	502	PF00400	0.397
TRG_ER_diArg_1	537	539	PF00400	0.379
TRG_ER_diArg_1	704	706	PF00400	0.526
TRG_NLS_MonoCore_2	705	710	PF00514	0.521
TRG_NLS_MonoExtN_4	704	711	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	765	769	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S3	Leptomonas seymouri	75%	99%
A0A3S5H5G5	Leishmania donovani	93%	100%
A0A422NYH3	Trypanosoma rangeli	52%	100%
A4H466	Leishmania braziliensis	85%	100%
A4HSD4	Leishmania infantum	93%	100%
C9ZPW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
Q2YDM7	Bos taurus	36%	100%
Q3UM18	Mus musculus	36%	100%
Q4QJI3	Leishmania major	91%	100%
Q6NY89	Danio rerio	37%	100%
Q9H089	Homo sapiens	34%	100%