C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fip1 motif/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania mexicana

UniProt:

E9AKC3_LEIMU

TriTrypDb:

LmxM.05.0190

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AKC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKC3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006379	mRNA cleavage	7	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.822
CLV_PCSK_KEX2_1	357	359	PF00082	0.722
CLV_PCSK_KEX2_1	72	74	PF00082	0.411
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.722
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.411
CLV_PCSK_PC7_1	353	359	PF00082	0.719
DEG_Nend_UBRbox_2	1	3	PF02207	0.669
DOC_CKS1_1	292	297	PF01111	0.719
DOC_CYCLIN_yCln2_LP_2	316	319	PF00134	0.668
DOC_PP2B_LxvP_1	316	319	PF13499	0.668
DOC_PP4_FxxP_1	352	355	PF00568	0.724
DOC_PP4_MxPP_1	245	248	PF00568	0.512
DOC_WW_Pin1_4	291	296	PF00397	0.721
LIG_14-3-3_CanoR_1	211	217	PF00244	0.347
LIG_BRCT_BRCA1_1	59	63	PF00533	0.645
LIG_BRCT_BRCA1_1	82	86	PF00533	0.389
LIG_FHA_1	112	118	PF00498	0.546
LIG_FHA_2	32	38	PF00498	0.767
LIG_Integrin_RGD_1	223	225	PF01839	0.383
LIG_LIR_Apic_2	350	355	PF02991	0.829
LIG_LIR_Nem_3	83	88	PF02991	0.411
LIG_LIR_Nem_3	92	98	PF02991	0.413
LIG_MLH1_MIPbox_1	82	86	PF16413	0.389
LIG_Pex14_2	86	90	PF04695	0.411
LIG_PTB_Apo_2	202	209	PF02174	0.623
LIG_PTB_Apo_2	84	91	PF02174	0.411
LIG_PTB_Phospho_1	202	208	PF10480	0.637
LIG_SH2_CRK	183	187	PF00017	0.828
LIG_SH2_CRK	293	297	PF00017	0.684
LIG_SH2_GRB2like	85	88	PF00017	0.411
LIG_SH2_NCK_1	293	297	PF00017	0.804
LIG_SH2_SRC	65	68	PF00017	0.411
LIG_SH2_STAP1	65	69	PF00017	0.513
LIG_SH2_STAT3	171	174	PF00017	0.824
LIG_SH2_STAT3	367	370	PF00017	0.709
LIG_SH2_STAT5	293	296	PF00017	0.804
LIG_SH2_STAT5	315	318	PF00017	0.713
LIG_SH2_STAT5	85	88	PF00017	0.411
LIG_SH2_STAT5	98	101	PF00017	0.411
LIG_SH3_1	183	189	PF00018	0.819
LIG_SH3_1	292	298	PF00018	0.809
LIG_SH3_1	353	359	PF00018	0.821
LIG_SH3_3	183	189	PF00018	0.819
LIG_SH3_3	241	247	PF00018	0.815
LIG_SH3_3	292	298	PF00018	0.767
LIG_SH3_3	334	340	PF00018	0.693
LIG_SH3_3	353	359	PF00018	0.767
LIG_SH3_3	363	369	PF00018	0.660
LIG_SUMO_SIM_anti_2	66	71	PF11976	0.513
LIG_TRAF2_1	100	103	PF00917	0.513
LIG_TRAF2_1	131	134	PF00917	0.651
MOD_CK1_1	59	65	PF00069	0.614
MOD_CK2_1	212	218	PF00069	0.347
MOD_CK2_1	31	37	PF00069	0.707
MOD_GlcNHglycan	270	273	PF01048	0.797
MOD_GlcNHglycan	343	346	PF01048	0.799
MOD_GlcNHglycan	349	352	PF01048	0.704
MOD_GlcNHglycan	59	62	PF01048	0.645
MOD_N-GLC_1	111	116	PF02516	0.627
MOD_NEK2_1	120	125	PF00069	0.455
MOD_NEK2_1	212	217	PF00069	0.347
MOD_NEK2_1	268	273	PF00069	0.578
MOD_Plk_1	105	111	PF00069	0.605
MOD_Plk_1	91	97	PF00069	0.411
MOD_Plk_4	105	111	PF00069	0.605
MOD_ProDKin_1	291	297	PF00069	0.720
TRG_ENDOCYTIC_2	98	101	PF00928	0.411
TRG_NES_CRM1_1	37	51	PF08389	0.635
TRG_NLS_MonoCore_2	356	361	PF00514	0.824
TRG_NLS_MonoExtC_3	356	362	PF00514	0.722
TRG_NLS_MonoExtN_4	355	361	PF00514	0.720

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N7	Leptomonas seymouri	53%	100%
A0A3S5H5G4	Leishmania donovani	87%	100%
A4H465	Leishmania braziliensis	77%	94%
A4HSD3	Leishmania infantum	87%	100%
Q4QJI4	Leishmania major	86%	98%