C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fip1 motif/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania mexicana

UniProt:

E9AKC3_LEIMU

TriTrypDb:

LmxM.05.0190

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

E9AKC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKC3

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006379	mRNA cleavage	7	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.822
CLV_PCSK_KEX2_1	357	359	PF00082	0.722
CLV_PCSK_KEX2_1	72	74	PF00082	0.411
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.722
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.411
CLV_PCSK_PC7_1	353	359	PF00082	0.719
DEG_Nend_UBRbox_2	1	3	PF02207	0.669
DOC_CKS1_1	292	297	PF01111	0.719
DOC_CYCLIN_yCln2_LP_2	316	319	PF00134	0.668
DOC_PP2B_LxvP_1	316	319	PF13499	0.668

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N7	Leptomonas seymouri	53%	100%
A0A3S5H5G4	Leishmania donovani	87%	100%
A4H465	Leishmania braziliensis	77%	94%
A4HSD3	Leishmania infantum	87%	100%
Q4QJI4	Leishmania major	86%	98%

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