Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrolipoamide branched chain transacylase, putative

Species:

Leishmania mexicana

UniProt:

E9AKC2_LEIMU

TriTrypDb:

LmxM.05.0180

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKC2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0005488	binding	1	1
GO:0005504	fatty acid binding	3	1
GO:0008289	lipid binding	2	1
GO:0016407	acetyltransferase activity	5	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1
GO:0031405	lipoic acid binding	3	1
GO:0031406	carboxylic acid binding	4	1
GO:0033293	monocarboxylic acid binding	5	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0043177	organic acid binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1901681	sulfur compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	252	254	PF00675	0.301
CLV_NRD_NRD_1	332	334	PF00675	0.301
CLV_NRD_NRD_1	358	360	PF00675	0.333
CLV_PCSK_KEX2_1	252	254	PF00082	0.358
CLV_PCSK_SKI1_1	34	38	PF00082	0.550
CLV_PCSK_SKI1_1	360	364	PF00082	0.343
CLV_PCSK_SKI1_1	463	467	PF00082	0.322
DEG_APCC_DBOX_1	282	290	PF00400	0.336
DEG_Nend_UBRbox_1	1	4	PF02207	0.653
DEG_SPOP_SBC_1	153	157	PF00917	0.551
DOC_CKS1_1	169	174	PF01111	0.441
DOC_CKS1_1	343	348	PF01111	0.299
DOC_CKS1_1	403	408	PF01111	0.282
DOC_CYCLIN_RxL_1	457	470	PF00134	0.305
DOC_CYCLIN_yCln2_LP_2	408	411	PF00134	0.358
DOC_MAPK_gen_1	196	205	PF00069	0.478
DOC_MAPK_gen_1	297	305	PF00069	0.307
DOC_MAPK_gen_1	333	341	PF00069	0.332
DOC_MAPK_gen_1	359	365	PF00069	0.448
DOC_MAPK_MEF2A_6	113	121	PF00069	0.394
DOC_PP1_RVXF_1	297	303	PF00149	0.299
DOC_PP2B_LxvP_1	349	352	PF13499	0.310
DOC_PP2B_LxvP_1	408	411	PF13499	0.374
DOC_USP7_MATH_1	133	137	PF00917	0.637
DOC_USP7_MATH_1	140	144	PF00917	0.585
DOC_USP7_MATH_1	208	212	PF00917	0.707
DOC_USP7_MATH_1	326	330	PF00917	0.329
DOC_USP7_UBL2_3	287	291	PF12436	0.358
DOC_WW_Pin1_4	131	136	PF00397	0.696
DOC_WW_Pin1_4	138	143	PF00397	0.614
DOC_WW_Pin1_4	168	173	PF00397	0.441
DOC_WW_Pin1_4	213	218	PF00397	0.612
DOC_WW_Pin1_4	342	347	PF00397	0.265
DOC_WW_Pin1_4	402	407	PF00397	0.367
LIG_Actin_WH2_2	272	289	PF00022	0.265
LIG_FHA_1	109	115	PF00498	0.299
LIG_FHA_1	172	178	PF00498	0.426
LIG_FHA_1	38	44	PF00498	0.567
LIG_FHA_1	388	394	PF00498	0.310
LIG_FHA_1	402	408	PF00498	0.310
LIG_FHA_1	58	64	PF00498	0.141
LIG_FHA_1	88	94	PF00498	0.299
LIG_FHA_1	96	102	PF00498	0.299
LIG_FHA_2	196	202	PF00498	0.455
LIG_FHA_2	267	273	PF00498	0.327
LIG_FHA_2	380	386	PF00498	0.358
LIG_FHA_2	72	78	PF00498	0.288
LIG_Integrin_isoDGR_2	430	432	PF01839	0.163
LIG_LIR_Nem_3	301	305	PF02991	0.299
LIG_LIR_Nem_3	77	81	PF02991	0.276
LIG_LIR_Nem_3	94	100	PF02991	0.421
LIG_MYND_1	406	410	PF01753	0.358
LIG_Pex14_2	302	306	PF04695	0.299
LIG_REV1ctd_RIR_1	303	312	PF16727	0.299
LIG_SH2_CRK	462	466	PF00017	0.288
LIG_SH2_CRK	97	101	PF00017	0.345
LIG_SH2_STAP1	434	438	PF00017	0.333
LIG_SH2_STAT5	105	108	PF00017	0.327
LIG_SH2_STAT5	176	179	PF00017	0.480
LIG_SH2_STAT5	29	32	PF00017	0.565
LIG_SH2_STAT5	97	100	PF00017	0.390
LIG_SH3_3	400	406	PF00018	0.358
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.163
LIG_SUMO_SIM_par_1	89	95	PF11976	0.265
LIG_SxIP_EBH_1	155	167	PF03271	0.443
LIG_TRAF2_1	148	151	PF00917	0.477
LIG_WRC_WIRS_1	265	270	PF05994	0.265
MOD_CDK_SPxxK_3	168	175	PF00069	0.429
MOD_CK1_1	141	147	PF00069	0.600
MOD_CK1_1	157	163	PF00069	0.705
MOD_CK1_1	220	226	PF00069	0.618
MOD_CK1_1	264	270	PF00069	0.351
MOD_CK1_1	95	101	PF00069	0.276
MOD_CK2_1	208	214	PF00069	0.497
MOD_CK2_1	266	272	PF00069	0.327
MOD_CK2_1	71	77	PF00069	0.333
MOD_GlcNHglycan	143	146	PF01048	0.662
MOD_GlcNHglycan	163	166	PF01048	0.651
MOD_GlcNHglycan	210	213	PF01048	0.640
MOD_GlcNHglycan	219	222	PF01048	0.708
MOD_GlcNHglycan	234	237	PF01048	0.584
MOD_GlcNHglycan	327	331	PF01048	0.369
MOD_GSK3_1	149	156	PF00069	0.617
MOD_GSK3_1	157	164	PF00069	0.720
MOD_GSK3_1	213	220	PF00069	0.615
MOD_GSK3_1	232	239	PF00069	0.602
MOD_GSK3_1	264	271	PF00069	0.283
MOD_GSK3_1	380	387	PF00069	0.313
MOD_GSK3_1	83	90	PF00069	0.299
MOD_GSK3_1	91	98	PF00069	0.277
MOD_LATS_1	378	384	PF00433	0.239
MOD_NEK2_1	255	260	PF00069	0.276
MOD_NEK2_1	27	32	PF00069	0.509
MOD_NEK2_1	36	41	PF00069	0.516
MOD_NEK2_1	391	396	PF00069	0.265
MOD_PIKK_1	29	35	PF00454	0.519
MOD_PIKK_1	380	386	PF00454	0.333
MOD_PK_1	113	119	PF00069	0.358
MOD_PK_1	158	164	PF00069	0.445
MOD_PK_1	308	314	PF00069	0.333
MOD_PKA_2	195	201	PF00069	0.496
MOD_PKA_2	282	288	PF00069	0.333
MOD_PKA_2	358	364	PF00069	0.333
MOD_PKA_2	95	101	PF00069	0.336
MOD_Plk_1	274	280	PF00069	0.301
MOD_Plk_1	326	332	PF00069	0.394
MOD_Plk_2-3	358	364	PF00069	0.299
MOD_Plk_2-3	87	93	PF00069	0.299
MOD_Plk_4	113	119	PF00069	0.270
MOD_Plk_4	17	23	PF00069	0.428
MOD_Plk_4	229	235	PF00069	0.556
MOD_Plk_4	241	247	PF00069	0.286
MOD_Plk_4	298	304	PF00069	0.301
MOD_Plk_4	358	364	PF00069	0.299
MOD_Plk_4	451	457	PF00069	0.314
MOD_ProDKin_1	131	137	PF00069	0.698
MOD_ProDKin_1	138	144	PF00069	0.614
MOD_ProDKin_1	168	174	PF00069	0.441
MOD_ProDKin_1	213	219	PF00069	0.612
MOD_ProDKin_1	342	348	PF00069	0.265
MOD_ProDKin_1	402	408	PF00069	0.367
TRG_DiLeu_BaEn_1	275	280	PF01217	0.265
TRG_ENDOCYTIC_2	462	465	PF00928	0.336
TRG_ENDOCYTIC_2	97	100	PF00928	0.345
TRG_ER_diArg_1	251	253	PF00400	0.358
TRG_NES_CRM1_1	57	73	PF08389	0.206
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHV8	Leptomonas seymouri	27%	100%
A0A0N1PBB0	Leptomonas seymouri	68%	84%
A0A0S4JC61	Bodo saltans	27%	100%
A0A0S4JS90	Bodo saltans	50%	100%
A0A1X0NKN9	Trypanosomatidae	26%	100%
A0A1X0P2L7	Trypanosomatidae	42%	95%
A0A3Q8IJE7	Leishmania donovani	26%	100%
A0A3S5H5G3	Leishmania donovani	90%	100%
A4H464	Leishmania braziliensis	79%	99%
A4HPD2	Leishmania braziliensis	28%	100%
A4ICH2	Leishmania infantum	26%	100%
C9ZPW7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A3J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AG63	Leishmania infantum	90%	100%
E9AT43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
G0S4X6	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	26%	100%
O00330	Homo sapiens	26%	95%
O06159	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
O31550	Bacillus subtilis (strain 168)	25%	100%
O59816	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	99%
O66119	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	26%	100%
O94681	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P06959	Escherichia coli (strain K12)	31%	76%
P08461	Rattus norvegicus	28%	75%
P09062	Pseudomonas putida	32%	100%
P0AFG6	Escherichia coli (strain K12)	29%	100%
P0AFG7	Escherichia coli O157:H7	29%	100%
P10515	Homo sapiens	27%	74%
P10802	Azotobacter vinelandii	33%	75%
P11181	Bos taurus	44%	99%
P11182	Homo sapiens	43%	99%
P11961	Geobacillus stearothermophilus	34%	100%
P12695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	99%
P16263	Bacillus subtilis (strain 168)	30%	100%
P19262	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P20285	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	100%
P20708	Azotobacter vinelandii	30%	100%
P21883	Bacillus subtilis (strain 168)	32%	100%
P22439	Bos taurus	26%	95%
P35489	Acholeplasma laidlawii	31%	88%
P36413	Dictyostelium discoideum	28%	75%
P37942	Bacillus subtilis (strain 168)	33%	100%
P45118	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	84%
P45302	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
P52993	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	28%	100%
P53395	Mus musculus	44%	99%
P57302	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	26%	100%
P57389	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	23%	100%
P65634	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	86%
P65635	Staphylococcus aureus (strain Mu50 / ATCC 700699)	35%	100%
P65636	Staphylococcus aureus (strain N315)	35%	100%
P9WIS6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	86%
P9WIS7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	86%
Q0WQF7	Arabidopsis thaliana	25%	75%
Q19749	Caenorhabditis elegans	30%	94%
Q1RHI5	Rickettsia bellii (strain RML369-C)	31%	100%
Q1RJT3	Rickettsia bellii (strain RML369-C)	28%	100%
Q23571	Caenorhabditis elegans	45%	100%
Q2FH26	Staphylococcus aureus (strain USA300)	27%	100%
Q2FYM2	Staphylococcus aureus (strain NCTC 8325 / PS 47)	27%	100%
Q2YY06	Staphylococcus aureus (strain bovine RF122 / ET3-1)	27%	100%
Q49110	Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)	31%	100%
Q49XM4	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	27%	100%
Q4L6C3	Staphylococcus haemolyticus (strain JCSC1435)	29%	100%
Q4Q1F5	Leishmania major	27%	100%
Q4QJI5	Leishmania major	89%	100%
Q4UKI7	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	29%	100%
Q4ULG1	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	29%	100%
Q59638	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	32%	87%
Q59821	Staphylococcus aureus	35%	100%
Q5HG07	Staphylococcus aureus (strain COL)	27%	100%
Q5HGY9	Staphylococcus aureus (strain COL)	35%	100%
Q5HPC7	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	27%	100%
Q5HQ74	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	35%	100%
Q5M729	Arabidopsis thaliana	31%	88%
Q68WK6	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	28%	100%
Q68XI8	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	28%	100%
Q6ABX9	Leifsonia xyli subsp. xyli (strain CTCB07)	27%	100%
Q6FYD4	Bartonella quintana (strain Toulouse)	30%	100%
Q6G9E9	Staphylococcus aureus (strain MSSA476)	27%	100%
Q6GAB9	Staphylococcus aureus (strain MSSA476)	35%	100%
Q6GGZ6	Staphylococcus aureus (strain MRSA252)	27%	100%
Q6GHZ0	Staphylococcus aureus (strain MRSA252)	35%	100%
Q7A5N4	Staphylococcus aureus (strain N315)	27%	100%
Q89AJ6	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	24%	100%
Q89AQ9	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	29%	100%
Q8BKZ9	Mus musculus	27%	95%
Q8BMF4	Mus musculus	28%	74%
Q8CSL9	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	27%	100%
Q8CT13	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	35%	100%
Q8GCY1	Bartonella vinsonii subsp. berkhoffii	28%	100%
Q8K9N2	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	21%	100%
Q8K9T8	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	27%	100%
Q8NWR7	Staphylococcus aureus (strain MW2)	27%	100%
Q8NX76	Staphylococcus aureus (strain MW2)	35%	100%
Q8RWN9	Arabidopsis thaliana	31%	88%
Q92HK7	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	28%	100%
Q92J43	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	29%	100%
Q99U75	Staphylococcus aureus (strain Mu50 / ATCC 700699)	27%	100%
Q9C8P0	Arabidopsis thaliana	27%	100%
Q9I1M0	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	31%	100%
Q9I3D2	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	31%	100%
Q9M7Z1	Arabidopsis thaliana	37%	99%
Q9R9N3	Rhizobium meliloti (strain 1021)	29%	100%
Q9ZD20	Rickettsia prowazekii (strain Madrid E)	29%	100%
Q9ZDY4	Rickettsia prowazekii (strain Madrid E)	27%	100%
V5BFP9	Trypanosoma cruzi	27%	100%
V5BJF4	Trypanosoma cruzi	45%	100%