Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

basal body component, putative

Species:

Leishmania mexicana

UniProt:

E9AKC1_LEIMU

TriTrypDb:

LmxM.05.0170

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.367
CLV_NRD_NRD_1	139	141	PF00675	0.518
CLV_NRD_NRD_1	15	17	PF00675	0.567
CLV_NRD_NRD_1	181	183	PF00675	0.542
CLV_NRD_NRD_1	219	221	PF00675	0.702
CLV_NRD_NRD_1	369	371	PF00675	0.766
CLV_NRD_NRD_1	414	416	PF00675	0.740
CLV_NRD_NRD_1	645	647	PF00675	0.759
CLV_NRD_NRD_1	675	677	PF00675	0.784
CLV_PCSK_FUR_1	673	677	PF00082	0.688
CLV_PCSK_KEX2_1	139	141	PF00082	0.546
CLV_PCSK_KEX2_1	181	183	PF00082	0.515
CLV_PCSK_KEX2_1	219	221	PF00082	0.702
CLV_PCSK_KEX2_1	369	371	PF00082	0.766
CLV_PCSK_KEX2_1	414	416	PF00082	0.740
CLV_PCSK_KEX2_1	42	44	PF00082	0.525
CLV_PCSK_KEX2_1	645	647	PF00082	0.759
CLV_PCSK_KEX2_1	675	677	PF00082	0.780
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.525
CLV_PCSK_SKI1_1	395	399	PF00082	0.730
CLV_PCSK_SKI1_1	423	427	PF00082	0.680
CLV_PCSK_SKI1_1	645	649	PF00082	0.839
CLV_PCSK_SKI1_1	676	680	PF00082	0.771
CLV_PCSK_SKI1_1	747	751	PF00082	0.556
CLV_Separin_Metazoa	420	424	PF03568	0.646
DEG_APCC_DBOX_1	314	322	PF00400	0.694
DEG_APCC_DBOX_1	414	422	PF00400	0.785
DEG_SPOP_SBC_1	687	691	PF00917	0.553
DEG_SPOP_SBC_1	720	724	PF00917	0.671
DOC_CDC14_PxL_1	398	406	PF14671	0.696
DOC_CKS1_1	374	379	PF01111	0.750
DOC_CKS1_1	587	592	PF01111	0.790
DOC_CYCLIN_RxL_1	485	496	PF00134	0.809
DOC_CYCLIN_yCln2_LP_2	421	427	PF00134	0.662
DOC_MAPK_DCC_7	478	487	PF00069	0.727
DOC_MAPK_gen_1	139	145	PF00069	0.672
DOC_MAPK_gen_1	181	187	PF00069	0.530
DOC_MAPK_gen_1	478	487	PF00069	0.727
DOC_MAPK_MEF2A_6	478	487	PF00069	0.727
DOC_PP2B_LxvP_1	526	529	PF13499	0.798
DOC_PP2B_LxvP_1	558	561	PF13499	0.653
DOC_USP7_MATH_1	188	192	PF00917	0.720
DOC_USP7_MATH_1	353	357	PF00917	0.670
DOC_USP7_MATH_1	473	477	PF00917	0.809
DOC_USP7_MATH_1	532	536	PF00917	0.667
DOC_USP7_MATH_1	539	543	PF00917	0.688
DOC_USP7_MATH_1	547	551	PF00917	0.819
DOC_USP7_MATH_1	652	656	PF00917	0.818
DOC_USP7_MATH_1	660	664	PF00917	0.749
DOC_USP7_MATH_1	720	724	PF00917	0.739
DOC_USP7_MATH_1	728	732	PF00917	0.637
DOC_WW_Pin1_4	198	203	PF00397	0.517
DOC_WW_Pin1_4	330	335	PF00397	0.553
DOC_WW_Pin1_4	360	365	PF00397	0.721
DOC_WW_Pin1_4	373	378	PF00397	0.699
DOC_WW_Pin1_4	440	445	PF00397	0.702
DOC_WW_Pin1_4	457	462	PF00397	0.818
DOC_WW_Pin1_4	467	472	PF00397	0.721
DOC_WW_Pin1_4	512	517	PF00397	0.760
DOC_WW_Pin1_4	551	556	PF00397	0.786
DOC_WW_Pin1_4	567	572	PF00397	0.759
DOC_WW_Pin1_4	583	588	PF00397	0.580
DOC_WW_Pin1_4	599	604	PF00397	0.728
DOC_WW_Pin1_4	654	659	PF00397	0.767
DOC_WW_Pin1_4	665	670	PF00397	0.643
DOC_WW_Pin1_4	676	681	PF00397	0.802
DOC_WW_Pin1_4	683	688	PF00397	0.703
DOC_WW_Pin1_4	700	705	PF00397	0.751
LIG_14-3-3_CanoR_1	181	186	PF00244	0.770
LIG_14-3-3_CanoR_1	220	230	PF00244	0.691
LIG_14-3-3_CanoR_1	292	297	PF00244	0.686
LIG_14-3-3_CanoR_1	415	425	PF00244	0.703
LIG_14-3-3_CanoR_1	500	507	PF00244	0.696
LIG_14-3-3_CanoR_1	564	571	PF00244	0.573
LIG_14-3-3_CanoR_1	673	681	PF00244	0.771
LIG_Actin_WH2_2	401	416	PF00022	0.504
LIG_BIR_III_2	209	213	PF00653	0.625
LIG_BRCT_BRCA1_1	459	463	PF00533	0.824
LIG_EVH1_1	526	530	PF00568	0.738
LIG_FHA_1	144	150	PF00498	0.637
LIG_FHA_1	237	243	PF00498	0.747
LIG_FHA_1	464	470	PF00498	0.731
LIG_FHA_2	120	126	PF00498	0.468
LIG_FHA_2	241	247	PF00498	0.743
LIG_FHA_2	517	523	PF00498	0.547
LIG_FHA_2	612	618	PF00498	0.547
LIG_FHA_2	688	694	PF00498	0.843
LIG_Pex14_2	394	398	PF04695	0.622
LIG_SH2_NCK_1	432	436	PF00017	0.686
LIG_SH2_NCK_1	98	102	PF00017	0.449
LIG_SH2_SRC	98	101	PF00017	0.452
LIG_SH2_STAP1	89	93	PF00017	0.572
LIG_SH2_STAT3	38	41	PF00017	0.539
LIG_SH2_STAT3	634	637	PF00017	0.831
LIG_SH2_STAT5	121	124	PF00017	0.564
LIG_SH2_STAT5	387	390	PF00017	0.713
LIG_SH3_1	480	486	PF00018	0.699
LIG_SH3_2	483	488	PF14604	0.698
LIG_SH3_3	182	188	PF00018	0.702
LIG_SH3_3	209	215	PF00018	0.682
LIG_SH3_3	374	380	PF00018	0.592
LIG_SH3_3	396	402	PF00018	0.654
LIG_SH3_3	436	442	PF00018	0.703
LIG_SH3_3	458	464	PF00018	0.809
LIG_SH3_3	480	486	PF00018	0.699
LIG_SH3_3	524	530	PF00018	0.724
LIG_SH3_3	584	590	PF00018	0.696
LIG_SH3_3	600	606	PF00018	0.715
LIG_SH3_CIN85_PxpxPR_1	528	533	PF14604	0.785
LIG_SUMO_SIM_par_1	580	586	PF11976	0.814
LIG_SUMO_SIM_par_1	637	642	PF11976	0.529
LIG_TRAF2_1	244	247	PF00917	0.814
LIG_TRAF2_1	328	331	PF00917	0.710
LIG_TRAF2_1	578	581	PF00917	0.706
LIG_TRAF2_1	97	100	PF00917	0.656
MOD_CDC14_SPxK_1	554	557	PF00782	0.824
MOD_CDC14_SPxK_1	572	575	PF00782	0.788
MOD_CDK_SPxK_1	373	379	PF00069	0.759
MOD_CDK_SPxK_1	551	557	PF00069	0.820
MOD_CDK_SPxK_1	569	575	PF00069	0.794
MOD_CK1_1	163	169	PF00069	0.664
MOD_CK1_1	191	197	PF00069	0.683
MOD_CK1_1	356	362	PF00069	0.781
MOD_CK1_1	457	463	PF00069	0.570
MOD_CK1_1	586	592	PF00069	0.792
MOD_CK1_1	602	608	PF00069	0.490
MOD_CK1_1	659	665	PF00069	0.734
MOD_CK1_1	682	688	PF00069	0.795
MOD_CK1_1	699	705	PF00069	0.620
MOD_CK1_1	710	716	PF00069	0.687
MOD_CK1_1	721	727	PF00069	0.764
MOD_CK1_1	731	737	PF00069	0.609
MOD_CK2_1	240	246	PF00069	0.745
MOD_CK2_1	515	521	PF00069	0.675
MOD_CK2_1	611	617	PF00069	0.546
MOD_CK2_1	660	666	PF00069	0.752
MOD_CK2_1	687	693	PF00069	0.840
MOD_Cter_Amidation	336	339	PF01082	0.644
MOD_Cter_Amidation	643	646	PF01082	0.762
MOD_DYRK1A_RPxSP_1	676	680	PF00069	0.771
MOD_GlcNHglycan	262	265	PF01048	0.665
MOD_GlcNHglycan	334	337	PF01048	0.812
MOD_GlcNHglycan	452	455	PF01048	0.718
MOD_GlcNHglycan	456	459	PF01048	0.703
MOD_GlcNHglycan	471	474	PF01048	0.641
MOD_GlcNHglycan	475	478	PF01048	0.724
MOD_GlcNHglycan	496	499	PF01048	0.782
MOD_GlcNHglycan	535	538	PF01048	0.809
MOD_GlcNHglycan	545	548	PF01048	0.542
MOD_GlcNHglycan	620	623	PF01048	0.663
MOD_GlcNHglycan	641	644	PF01048	0.672
MOD_GlcNHglycan	648	651	PF01048	0.808
MOD_GlcNHglycan	654	657	PF01048	0.733
MOD_GlcNHglycan	658	661	PF01048	0.674
MOD_GlcNHglycan	676	679	PF01048	0.849
MOD_GlcNHglycan	698	701	PF01048	0.733
MOD_GlcNHglycan	726	729	PF01048	0.626
MOD_GlcNHglycan	730	733	PF01048	0.588
MOD_GlcNHglycan	758	761	PF01048	0.622
MOD_GSK3_1	163	170	PF00069	0.630
MOD_GSK3_1	236	243	PF00069	0.727
MOD_GSK3_1	344	351	PF00069	0.672
MOD_GSK3_1	353	360	PF00069	0.689
MOD_GSK3_1	450	457	PF00069	0.716
MOD_GSK3_1	459	466	PF00069	0.829
MOD_GSK3_1	469	476	PF00069	0.756
MOD_GSK3_1	512	519	PF00069	0.810
MOD_GSK3_1	539	546	PF00069	0.756
MOD_GSK3_1	547	554	PF00069	0.791
MOD_GSK3_1	563	570	PF00069	0.747
MOD_GSK3_1	618	625	PF00069	0.597
MOD_GSK3_1	652	659	PF00069	0.718
MOD_GSK3_1	676	683	PF00069	0.859
MOD_GSK3_1	685	692	PF00069	0.800
MOD_GSK3_1	696	703	PF00069	0.770
MOD_GSK3_1	707	714	PF00069	0.717
MOD_GSK3_1	720	727	PF00069	0.649
MOD_GSK3_1	752	759	PF00069	0.570
MOD_LATS_1	179	185	PF00433	0.510
MOD_N-GLC_1	360	365	PF02516	0.840
MOD_N-GLC_1	652	657	PF02516	0.632
MOD_NEK2_1	162	167	PF00069	0.628
MOD_NEK2_1	543	548	PF00069	0.530
MOD_NEK2_1	618	623	PF00069	0.672
MOD_NEK2_1	639	644	PF00069	0.592
MOD_NEK2_1	698	703	PF00069	0.772
MOD_NEK2_2	611	616	PF00069	0.550
MOD_PIKK_1	443	449	PF00454	0.542
MOD_PK_1	181	187	PF00069	0.530
MOD_PKA_1	181	187	PF00069	0.530
MOD_PKA_1	645	651	PF00069	0.760
MOD_PKA_2	10	16	PF00069	0.413
MOD_PKA_2	143	149	PF00069	0.614
MOD_PKA_2	181	187	PF00069	0.779
MOD_PKA_2	221	227	PF00069	0.680
MOD_PKA_2	240	246	PF00069	0.721
MOD_PKA_2	494	500	PF00069	0.748
MOD_PKA_2	532	538	PF00069	0.748
MOD_PKA_2	563	569	PF00069	0.781
MOD_PKA_2	645	651	PF00069	0.787
MOD_PKA_2	674	680	PF00069	0.748
MOD_PKA_2	73	79	PF00069	0.556
MOD_PKB_1	754	762	PF00069	0.593
MOD_Plk_1	248	254	PF00069	0.709
MOD_Plk_4	163	169	PF00069	0.669
MOD_Plk_4	292	298	PF00069	0.693
MOD_Plk_4	660	666	PF00069	0.756
MOD_ProDKin_1	198	204	PF00069	0.519
MOD_ProDKin_1	330	336	PF00069	0.553
MOD_ProDKin_1	360	366	PF00069	0.721
MOD_ProDKin_1	373	379	PF00069	0.695
MOD_ProDKin_1	440	446	PF00069	0.705
MOD_ProDKin_1	457	463	PF00069	0.818
MOD_ProDKin_1	467	473	PF00069	0.722
MOD_ProDKin_1	512	518	PF00069	0.758
MOD_ProDKin_1	551	557	PF00069	0.790
MOD_ProDKin_1	567	573	PF00069	0.752
MOD_ProDKin_1	583	589	PF00069	0.579
MOD_ProDKin_1	599	605	PF00069	0.726
MOD_ProDKin_1	654	660	PF00069	0.766
MOD_ProDKin_1	665	671	PF00069	0.647
MOD_ProDKin_1	676	682	PF00069	0.803
MOD_ProDKin_1	683	689	PF00069	0.701
MOD_ProDKin_1	700	706	PF00069	0.751
MOD_SUMO_for_1	388	391	PF00179	0.698
MOD_SUMO_rev_2	504	512	PF00179	0.534
TRG_DiLeu_BaEn_4	580	586	PF01217	0.818
TRG_ER_diArg_1	114	117	PF00400	0.516
TRG_ER_diArg_1	180	182	PF00400	0.515
TRG_ER_diArg_1	218	220	PF00400	0.798
TRG_ER_diArg_1	369	371	PF00400	0.766
TRG_ER_diArg_1	413	415	PF00400	0.732
TRG_ER_diArg_1	478	481	PF00400	0.736
TRG_ER_diArg_1	673	676	PF00400	0.849
TRG_ER_diArg_1	751	754	PF00400	0.564
TRG_NES_CRM1_1	429	441	PF08389	0.693
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.810
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	616	620	PF00026	0.749

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWW2	Leptomonas seymouri	44%	100%
A0A3S7WNZ4	Leishmania donovani	87%	100%
A4H463	Leishmania braziliensis	65%	98%
A4HSD2	Leishmania infantum	88%	100%
Q4QJI6	Leishmania major	86%	99%